| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0545059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0472689 |
| RPS4X | ribosomal protein S4, X-linked | 0.0425626 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0383579 |
| FLNB | filamin B, beta | 0.0321588 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0266597 |
| PRELID2 | PRELI domain containing 2 | 0.0265851 |
| MXI1 | MAX interactor 1, dimerization protein | 0.02542 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0245044 |
| SPAG9 | sperm associated antigen 9 | 0.0243789 |
| MORF4L2 | mortality factor 4 like 2 | 0.0239633 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0228763 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0227615 |
| UBAP2L | ubiquitin associated protein 2-like | 0.020094 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0198907 |
| APP | amyloid beta (A4) precursor protein | 0.0189866 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0180854 |
| ARRDC3 | arrestin domain containing 3 | 0.0180685 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0170174 |
| CTBP2 | C-terminal binding protein 2 | 0.015882 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0158474 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0154552 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0153221 |
| NUP58 | nucleoporin 58 | 0.0153121 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0148735 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0147866 |
| FAM13A | family with sequence similarity 13, member A | 0.0141574 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0140354 |
| LDHA | lactate dehydrogenase A | 0.0138322 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0138187 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0136701 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0135445 |
| NONO | non-POU domain containing, octamer-binding | 0.0134439 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.013342 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0133277 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0132862 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0130102 |
| FLNA | filamin A, alpha | 0.0129994 |
| SUCO | SUN domain containing ossification factor | 0.0129758 |
| RPS2 | ribosomal protein S2 | 0.0129553 |
| SLC16A6 | solute carrier family 16, member 6 | 0.0128073 |
| UBQLN1 | ubiquilin 1 | 0.0127594 |
| SFTPA2 | surfactant protein A2 | 0.0127224 |
| EZR | ezrin | 0.0125076 |
| DNER | delta/notch-like EGF repeat containing | 0.0123509 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0122377 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0119138 |
| EFNA1 | ephrin-A1 | 0.0118434 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0117261 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0111087 |
| RPS12 | ribosomal protein S12 | 0.0110324 |
| FUS | FUS RNA binding protein | 0.0110163 |
| SQSTM1 | sequestosome 1 | 0.0108552 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0107463 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.0106729 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0106711 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0104044 |
| USP34 | ubiquitin specific peptidase 34 | 0.010312 |
| HELZ | helicase with zinc finger | 0.0103036 |
| NDRG1 | N-myc downstream regulated 1 | 0.0103012 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0102345 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0101265 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0098775 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.00971106 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00970745 |
| SURF4 | surfeit 4 | 0.00965556 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.00958101 |
| NGLY1 | N-glycanase 1 | 0.00949651 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.00939582 |
| ZNF292 | zinc finger protein 292 | 0.00936021 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00933352 |
| SET | SET nuclear proto-oncogene | 0.00928387 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.00924144 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00913656 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.00911106 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.00907249 |
| CEP95 | centrosomal protein 95kDa | 0.00899386 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00894446 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00893554 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.00882632 |
| TENM2 | teneurin transmembrane protein 2 | 0.00872932 |
| RACK1 | receptor for activated C kinase 1 | 0.00859646 |
| SERINC1 | serine incorporator 1 | 0.00853974 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.00846206 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.00836318 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.00830485 |
| ANXA5 | annexin A5 | 0.00826552 |
| ARGLU1 | arginine and glutamate rich 1 | 0.00822779 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.00822691 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0081621 |
| NOP58 | NOP58 ribonucleoprotein | 0.00813684 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00810624 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.00808352 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00799871 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.00798457 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.00793502 |
| FAM168B | family with sequence similarity 168, member B | 0.00786279 |
| ANGPTL4 | angiopoietin-like 4 | 0.00780944 |
| ANKRD10 | ankyrin repeat domain 10 | 0.00779692 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.00779448 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.18045 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.179241 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.171082 |
| GDA | guanine deaminase | -0.139344 |
| COL5A2 | collagen, type V, alpha 2 | -0.130876 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.106612 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.105847 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0843756 |
| ASPH | aspartate beta-hydroxylase | -0.0831307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0733882 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0703715 |
| DST | dystonin | -0.0699287 |
| EFNA5 | ephrin-A5 | -0.0696748 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0689253 |
| POTEF | POTE ankyrin domain family, member F | -0.0684092 |
| VIM | vimentin | -0.0675377 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0655127 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0627974 |
| KYNU | kynureninase | -0.0622833 |
| TXNRD1 | thioredoxin reductase 1 | -0.061393 |
| SMYD3 | SET and MYND domain containing 3 | -0.0605341 |
| PM20D1 | peptidase M20 domain containing 1 | -0.060236 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0594499 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0586412 |
| FTL | ferritin, light polypeptide | -0.0578956 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0567118 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0541759 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0540278 |
| FN1 | fibronectin 1 | -0.0531524 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.050987 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.048947 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0483174 |
| PDE10A | phosphodiesterase 10A | -0.046161 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0449692 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.044916 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0445355 |
| RTN1 | reticulon 1 | -0.0434324 |
| MYOF | myoferlin | -0.0432444 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0432247 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.042707 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0426565 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0423573 |
| NRCAM | neuronal cell adhesion molecule | -0.0420543 |
| TMSB10 | thymosin beta 10 | -0.0403333 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0401933 |
| PTMA | prothymosin, alpha | -0.0400854 |
| RPS6 | ribosomal protein S6 | -0.0396279 |
| VCL | vinculin | -0.0395229 |
| MFF | mitochondrial fission factor | -0.039342 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0391244 |
| PALLD | palladin, cytoskeletal associated protein | -0.039065 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0388831 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0386816 |
| RPLP0 | ribosomal protein, large, P0 | -0.0381719 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0379948 |
| NEK7 | NIMA-related kinase 7 | -0.037619 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.037522 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0366298 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.035868 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0355841 |
| RPLP1 | ribosomal protein, large, P1 | -0.0346485 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0345352 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0341636 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0341267 |
| CD109 | CD109 molecule | -0.0341083 |
| PTEN | phosphatase and tensin homolog | -0.0337386 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0320819 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0314143 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0305085 |
| GRAMD1B | GRAM domain containing 1B | -0.0298524 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0296137 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0285938 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0283237 |
| CTSC | cathepsin C | -0.0282833 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0263187 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0260018 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0258859 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0255175 |
| PFN1 | profilin 1 | -0.0254724 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0253285 |
| S100A6 | S100 calcium binding protein A6 | -0.0252684 |
| RTN4 | reticulon 4 | -0.0252117 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.025079 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.025074 |
| ACTG1 | actin gamma 1 | -0.0249194 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0247787 |
| RPL35A | ribosomal protein L35a | -0.0245927 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0245646 |
| ENAH | enabled homolog (Drosophila) | -0.0240741 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0237492 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0237453 |
| JMJD1C | jumonji domain containing 1C | -0.0236562 |
| NTN4 | netrin 4 | -0.0234485 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0231652 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0230953 |
| RPS23 | ribosomal protein S23 | -0.0230397 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.0228714 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0227948 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0226408 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0225594 |
