Bestatin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

193 genes differentially expressed following the Bestatin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.377451
VIM vimentin 0.231132
TMSB10 thymosin beta 10 0.225825
RPS12 ribosomal protein S12 0.137094
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120438
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.117095
ASPH aspartate beta-hydroxylase 0.115269
MT2A metallothionein 2A 0.112342
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.110598
RPL23 ribosomal protein L23 0.109302
PABPC1 poly(A) binding protein, cytoplasmic 1 0.107283
EEF2 eukaryotic translation elongation factor 2 0.0867399
RPS3 ribosomal protein S3 0.0864373
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0851482
RPL12 ribosomal protein L12 0.0837544
FTL ferritin, light polypeptide 0.0789519
PSD3 pleckstrin and Sec7 domain containing 3 0.0789364
ELL2 elongation factor, RNA polymerase II, 2 0.0786218
RPS13 ribosomal protein S13 0.0760551
RPL37 ribosomal protein L37 0.0750504
NDRG1 N-myc downstream regulated 1 0.0711065
RPL8 ribosomal protein L8 0.0695835
EGFR epidermal growth factor receptor 0.0670708
CXCL8 chemokine (C-X-C motif) ligand 8 0.0655537
EIF4A1 eukaryotic translation initiation factor 4A1 0.0650474
RPL11 ribosomal protein L11 0.0613979
EIF1 eukaryotic translation initiation factor 1 0.060817
EFNA5 ephrin-A5 0.0593328
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0568815
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0560292
RPS17 ribosomal protein S17 0.0550114
RPS24 ribosomal protein S24 0.0542959
RPL37A ribosomal protein L37a 0.0531081
PTMA prothymosin, alpha 0.0526517
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0486792
RPS8 ribosomal protein S8 0.0483573
RPS6 ribosomal protein S6 0.0457637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0428932
RPS19 ribosomal protein S19 0.0414062
PDE4D phosphodiesterase 4D, cAMP-specific 0.0394773
NAMPT nicotinamide phosphoribosyltransferase 0.0389575
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0389527
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0388762
PRRC2C proline-rich coiled-coil 2C 0.0384192
RACK1 receptor for activated C kinase 1 0.0380518
RPL35A ribosomal protein L35a 0.0363106
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0359285
POTEF POTE ankyrin domain family, member F 0.0352766
IGFBP3 insulin-like growth factor binding protein 3 0.0347693
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0332843
RPLP1 ribosomal protein, large, P1 0.0329261
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0324901
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0314276
NUP58 nucleoporin 58 0.0289736
FNDC3B fibronectin type III domain containing 3B 0.0283468
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0275967
ANKRD12 ankyrin repeat domain 12 0.0258227
PGK1 phosphoglycerate kinase 1 0.0250373
APP amyloid beta (A4) precursor protein 0.0218234
ERRFI1 ERBB receptor feedback inhibitor 1 0.0211012
TTC3 tetratricopeptide repeat domain 3 0.0207825
TPT1 tumor protein, translationally-controlled 1 0.0202431
UGCG UDP-glucose ceramide glucosyltransferase 0.0201586
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0186797
PICALM phosphatidylinositol binding clathrin assembly protein 0.017708
COG5 component of oligomeric golgi complex 5 0.01721
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0151862
ENO1 enolase 1, (alpha) 0.0150128
USP34 ubiquitin specific peptidase 34 0.0150018
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0148609
BCLAF1 BCL2-associated transcription factor 1 0.0144257
CANX calnexin 0.0135621
SRRM2 serine/arginine repetitive matrix 2 0.0118104
YBX1 Y box binding protein 1 0.0114777
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0114706
RPS20 ribosomal protein S20 0.0106207
SEC31A SEC31 homolog A (S. cerevisiae) 0.00996347
ITCH itchy E3 ubiquitin protein ligase 0.00939864
FMNL2 formin-like 2 0.00713323
KMT2E lysine (K)-specific methyltransferase 2E 0.00628065
ANKHD1 ankyrin repeat and KH domain containing 1 0.00604531
AKAP9 A kinase (PRKA) anchor protein 9 0.00591256
RBM25 RNA binding motif protein 25 0.00586263
MARCHF6 membrane associated ring-CH-type finger 6 0.005842
PTK2 protein tyrosine kinase 2 0.00526648
TRIO trio Rho guanine nucleotide exchange factor 0.00414196
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00397121
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00383094
WAC WW domain containing adaptor with coiled-coil 0.00342841
ANXA2 annexin A2 0.0031983
LDHA lactate dehydrogenase A 0.00319677
DSCAM Down syndrome cell adhesion molecule 0.00229598
MACF1 microtubule-actin crosslinking factor 1 1.3346E-4

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.146777
FN1 fibronectin 1 -0.101398
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0976645
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0869378
FOXP1 forkhead box P1 -0.0851376
ZFAND3 zinc finger, AN1-type domain 3 -0.0843315
CNKSR3 CNKSR family member 3 -0.0842182
VCL vinculin -0.0825839
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0772423
RIGI RNA sensor RIG-I -0.0758941
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0757574
NABP1 nucleic acid binding protein 1 -0.074119
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0730021
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0720747
MAML2 mastermind-like 2 (Drosophila) -0.071861
RUNX1 runt-related transcription factor 1 -0.0706792
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0704438
PTPRG protein tyrosine phosphatase, receptor type, G -0.069831
JARID2 jumonji, AT rich interactive domain 2 -0.0665018
NCOR2 nuclear receptor corepressor 2 -0.0643384
EXT1 exostosin glycosyltransferase 1 -0.0613535
PDLIM5 PDZ and LIM domain 5 -0.0604368
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0598979
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0585701
MBD5 methyl-CpG binding domain protein 5 -0.0552764
SMYD3 SET and MYND domain containing 3 -0.0544706
RNF213 ring finger protein 213 -0.0542592
ANO6 anoctamin 6 -0.0541095
CALU calumenin -0.0538112
NKD1 naked cuticle homolog 1 (Drosophila) -0.0529347
FRMD5 FERM domain containing 5 -0.0525638
TAS2R14 taste receptor, type 2, member 14 -0.051777
DOCK4 dedicator of cytokinesis 4 -0.051573
TBC1D5 TBC1 domain family, member 5 -0.0511856
CAMKMT calmodulin-lysine N-methyltransferase -0.0511657
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0503465
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0501226
SLC38A2 solute carrier family 38, member 2 -0.0490148
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0481458
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0477274
GLIS3 GLIS family zinc finger 3 -0.0467736
CD2AP CD2-associated protein -0.046699
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0463898
YAP1 Yes-associated protein 1 -0.0452169
SQSTM1 sequestosome 1 -0.0450285
SOD2 superoxide dismutase 2, mitochondrial -0.0442841
OSBPL8 oxysterol binding protein-like 8 -0.0432814
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0420234
CLIP2 CAP-GLY domain containing linker protein 2 -0.0416838
ANKRD28 ankyrin repeat domain 28 -0.0405564
NAP1L1 nucleosome assembly protein 1-like 1 -0.0384377
ALCAM activated leukocyte cell adhesion molecule -0.0383078
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0379712
ARB2A ARB2 cotranscriptional regulator A -0.0376586
MBNL2 muscleblind-like splicing regulator 2 -0.0365791
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0362944
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0360087
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0356582
NPAS2 neuronal PAS domain protein 2 -0.0336631
STK24 serine/threonine kinase 24 -0.0329726
COL5A2 collagen, type V, alpha 2 -0.0328516
AKAP12 A kinase (PRKA) anchor protein 12 -0.0327673
VMP1 vacuole membrane protein 1 -0.0324973
WSB1 WD repeat and SOCS box containing 1 -0.0323541
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0322267
ZBTB20 zinc finger and BTB domain containing 20 -0.0316245
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0314928
MYO1E myosin IE -0.0302015
ZNF292 zinc finger protein 292 -0.0297137
PKM pyruvate kinase, muscle -0.0295978
PTPRM protein tyrosine phosphatase, receptor type, M -0.0293833
TBC1D22A TBC1 domain family, member 22A -0.0293767
KDM4C lysine (K)-specific demethylase 4C -0.029159
RB1CC1 RB1-inducible coiled-coil 1 -0.0269921
IQGAP1 IQ motif containing GTPase activating protein 1 -0.026611
STRN3 striatin, calmodulin binding protein 3 -0.0264867
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0263939
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.026369
PRKCA protein kinase C, alpha -0.0252405
RTN4 reticulon 4 -0.0249774
FNDC3A fibronectin type III domain containing 3A -0.0244023
PRELID2 PRELI domain containing 2 -0.0242355
JMJD1C jumonji domain containing 1C -0.0241171
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0239043
KMT2C lysine (K)-specific methyltransferase 2C -0.023809
NF1 neurofibromin 1 -0.0237246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0228816
PARD3 par-3 family cell polarity regulator -0.0224992
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0224225
ANKRD11 ankyrin repeat domain 11 -0.0220626
GLG1 golgi glycoprotein 1 -0.0215675
PDE10A phosphodiesterase 10A -0.0207245
FBXO11 F-box protein 11 -0.0206578
NIPBL Nipped-B homolog (Drosophila) -0.0201666
ACTG1 actin gamma 1 -0.0181121
RAP1B RAP1B, member of RAS oncogene family -0.0177758
ARHGAP12 Rho GTPase activating protein 12 -0.0177567
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0171871
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0167689
RBM39 RNA binding motif protein 39 -0.0162567