| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0876338 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0737024 |
| MKI67 | marker of proliferation Ki-67 | 0.0626918 |
| CENPF | centromere protein F, 350/400kDa | 0.0572018 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0515392 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.047397 |
| TPX2 | TPX2, microtubule-associated | 0.0435376 |
| CENPE | centromere protein E, 312kDa | 0.0370472 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0367887 |
| ANXA1 | annexin A1 | 0.0329696 |
| H2AZ2 | H2A.Z variant histone 2 | 0.0306837 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0300089 |
| PLS3 | plastin 3 | 0.0271174 |
| SMC4 | structural maintenance of chromosomes 4 | 0.027091 |
| USP1 | ubiquitin specific peptidase 1 | 0.0265107 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0261705 |
| RBM39 | RNA binding motif protein 39 | 0.0256739 |
| YBX1 | Y box binding protein 1 | 0.0249236 |
| TPM3 | tropomyosin 3 | 0.0244418 |
| TLN1 | talin 1 | 0.0240639 |
| CALU | calumenin | 0.0240079 |
| TTK | TTK protein kinase | 0.0236285 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.0236226 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.0227873 |
| PNN | pinin, desmosome associated protein | 0.022499 |
| STIL | SCL/TAL1 interrupting locus | 0.0224289 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0224047 |
| DBF4 | DBF4 zinc finger | 0.0221958 |
| ANXA5 | annexin A5 | 0.0219545 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0218649 |
| KNL1 | kinetochore scaffold 1 | 0.021803 |
| ZNF217 | zinc finger protein 217 | 0.0217307 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0213076 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.021025 |
| DIAPH3 | diaphanous-related formin 3 | 0.0208819 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0208784 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0208656 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0205289 |
| FBXO27 | F-box protein 27 | 0.0204975 |
| NUP155 | nucleoporin 155kDa | 0.0202425 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0201614 |
| COPA | coatomer protein complex, subunit alpha | 0.0199491 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0198947 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0197482 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0196149 |
| VCP | valosin containing protein | 0.0194665 |
| BMP5 | bone morphogenetic protein 5 | 0.0194318 |
| RAB18 | RAB18, member RAS oncogene family | 0.0194124 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0193306 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0191749 |
| COASY | CoA synthase | 0.0191182 |
| MORF4L2 | mortality factor 4 like 2 | 0.0191162 |
| NDC80 | NDC80 kinetochore complex component | 0.0190531 |
| PCM1 | pericentriolar material 1 | 0.0190304 |
| CDCA2 | cell division cycle associated 2 | 0.0189967 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0189532 |
| BRD7 | bromodomain containing 7 | 0.0188684 |
| CANX | calnexin | 0.0187577 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | 0.0187507 |
| KNTC1 | kinetochore associated 1 | 0.0187455 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.0186168 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.0185074 |
| STX16 | syntaxin 16 | 0.0184227 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0183397 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0181886 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0181658 |
| HMGB2 | high mobility group box 2 | 0.018136 |
| SPAG5 | sperm associated antigen 5 | 0.0181034 |
| ANLN | anillin, actin binding protein | 0.0180526 |
| NUP58 | nucleoporin 58 | 0.0180476 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0178287 |
| KIF23 | kinesin family member 23 | 0.0177303 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0176308 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0176053 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.0175734 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0175405 |
| NDC1 | NDC1 transmembrane nucleoporin | 0.0174774 |
| RPL5 | ribosomal protein L5 | 0.0174548 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0173543 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0173393 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0172956 |
| ARHGAP11A | Rho GTPase activating protein 11A | 0.0172414 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.0172144 |
| SQLE | squalene epoxidase | 0.0170702 |
| KIF18A | kinesin family member 18A | 0.016823 |
| BUB3 | BUB3 mitotic checkpoint protein | 0.0166634 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0166481 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0166458 |
| RPS2 | ribosomal protein S2 | 0.0166285 |
| RPL21 | ribosomal protein L21 | 0.0166268 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0166112 |
| RPS4X | ribosomal protein S4, X-linked | 0.0165706 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 0.0165671 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.0165645 |
| SLK | STE20-like kinase | 0.0165634 |
| NONO | non-POU domain containing, octamer-binding | 0.0165131 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0163306 |
| MYOZ2 | myozenin 2 | 0.016218 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.016019 |
| ECT2 | epithelial cell transforming 2 | 0.0160107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -0.169039 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.164126 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.16256 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.147045 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.140093 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.131917 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.122169 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.117803 |
| CADM2 | cell adhesion molecule 2 | -0.106576 |
| TSC22D2 | TSC22 domain family, member 2 | -0.100002 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0979244 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0962825 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0926253 |
| TENM3 | teneurin transmembrane protein 3 | -0.090552 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0901643 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.089858 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.088771 |
| PHIP | pleckstrin homology domain interacting protein | -0.0855342 |
| GPC3 | glypican 3 | -0.0837532 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0813072 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0790337 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.078936 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.075051 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0742882 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0712809 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0674501 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0674375 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0663841 |
| MPG | N-methylpurine-DNA glycosylase | -0.0663197 |
| PLPP1 | phospholipid phosphatase 1 | -0.0653056 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.063494 |
| IGF1R | insulin-like growth factor 1 receptor | -0.06347 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.061917 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0614991 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.060984 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0598078 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0585101 |
| RASAL2 | RAS protein activator like 2 | -0.0563663 |
| ITGAV | integrin, alpha V | -0.0559963 |
| TMSB10 | thymosin beta 10 | -0.0539177 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0523637 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0523089 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0516545 |
| MAP4 | microtubule-associated protein 4 | -0.0495364 |
| GNAS | GNAS complex locus | -0.0495062 |
| ANKRD33B | ankyrin repeat domain 33B | -0.04941 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0453909 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0452085 |
| COL1A2 | collagen, type I, alpha 2 | -0.0446623 |
| CDH19 | cadherin 19, type 2 | -0.0442549 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0438113 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0436592 |
| NRG1 | neuregulin 1 | -0.0430869 |
| RBM20 | RNA binding motif protein 20 | -0.0422815 |
| FBXO11 | F-box protein 11 | -0.0422587 |
| UTRN | utrophin | -0.0422079 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0421603 |
| THBS1 | thrombospondin 1 | -0.0416571 |
| PCDH7 | protocadherin 7 | -0.0416218 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0415675 |
| AHNAK | AHNAK nucleoprotein | -0.040905 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0406987 |
| GAB2 | GRB2-associated binding protein 2 | -0.04035 |
| ZNF292 | zinc finger protein 292 | -0.0397185 |
| PFN1 | profilin 1 | -0.0392718 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0392548 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0391425 |
| PTMA | prothymosin, alpha | -0.0388134 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0386555 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0386456 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0385247 |
| TENM2 | teneurin transmembrane protein 2 | -0.0384703 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0383797 |
| NHSL1 | NHS-like 1 | -0.03835 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.0382913 |
| RPL35A | ribosomal protein L35a | -0.0382688 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0380839 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0379715 |
| FOXO1 | forkhead box O1 | -0.0377098 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.037604 |
| MED12L | mediator complex subunit 12-like | -0.0374191 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0371673 |
| RPS27A | ribosomal protein S27a | -0.0370752 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0370613 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0370102 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0367777 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0366447 |
| LPIN2 | lipin 2 | -0.0364654 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0361923 |
| VIM | vimentin | -0.0357718 |
| SRPK2 | SRSF protein kinase 2 | -0.0357577 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.035542 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0352002 |
| RAD51B | RAD51 paralog B | -0.0350395 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0349644 |
| HMCN1 | hemicentin 1 | -0.0349048 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0348623 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.034511 |
| JMJD1C | jumonji domain containing 1C | -0.034408 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0343078 |
