Bestatin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS4X ribosomal protein S4, X-linked 0.130639
RPS12 ribosomal protein S12 0.109072
RPL23 ribosomal protein L23 0.0737841
RPL37A ribosomal protein L37a 0.0717268
RPS3 ribosomal protein S3 0.068492
MORF4L2 mortality factor 4 like 2 0.0618369
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0604177
MXI1 MAX interactor 1, dimerization protein 0.0578557
NAV2 neuron navigator 2 0.057353
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0562245
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0554605
RACK1 receptor for activated C kinase 1 0.0530979
RPL26 ribosomal protein L26 0.0523575
SERINC1 serine incorporator 1 0.0491529
RPS8 ribosomal protein S8 0.0487989
MT2A metallothionein 2A 0.0455061
KLF6 Kruppel-like factor 6 0.0454947
APP amyloid beta (A4) precursor protein 0.0445215
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0444369
ERRFI1 ERBB receptor feedback inhibitor 1 0.0434557
ARRDC3 arrestin domain containing 3 0.0423746
MKI67 marker of proliferation Ki-67 0.0416908
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0402364
RPS2 ribosomal protein S2 0.0390954
RPL5 ribosomal protein L5 0.038455
EIF1 eukaryotic translation initiation factor 1 0.0378509
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0376831
SET SET nuclear proto-oncogene 0.0374312
NACA nascent polypeptide-associated complex alpha subunit 0.0364433
RPS17 ribosomal protein S17 0.0355012
NONO non-POU domain containing, octamer-binding 0.0350625
ANLN anillin, actin binding protein 0.034814
SEPTIN9 septin 9 0.0345525
TPT1 tumor protein, translationally-controlled 1 0.0342649
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.034199
TUBB tubulin, beta class I 0.0332689
SFTPA2 surfactant protein A2 0.0313116
SRGN serglycin 0.0301841
HSPA8 heat shock 70kDa protein 8 0.0298276
MYH9 myosin, heavy chain 9, non-muscle 0.0288059
RPL12 ribosomal protein L12 0.0286235
TRIO trio Rho guanine nucleotide exchange factor 0.0264892
RPL14 ribosomal protein L14 0.0261418
PRRC2C proline-rich coiled-coil 2C 0.0260589
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0258677
RPL9 ribosomal protein L9 0.0256685
RPL37 ribosomal protein L37 0.0254319
RPL36 ribosomal protein L36 0.0249203
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248958
ACTN1 actinin, alpha 1 0.0244407
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242916
FUS FUS RNA binding protein 0.0242663
RPL7 ribosomal protein L7 0.023732
RPL35 ribosomal protein L35 0.0234131
UBQLN1 ubiquilin 1 0.0231282
RB1CC1 RB1-inducible coiled-coil 1 0.0229064
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0224212
RAI1 retinoic acid induced 1 0.022174
PTMA prothymosin, alpha 0.0221474
RPL32 ribosomal protein L32 0.0219907
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0218046
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0217995
RPL10A ribosomal protein L10a 0.0216998
RPL31 ribosomal protein L31 0.0213804
RPS6 ribosomal protein S6 0.0213325
CALU calumenin 0.0206709
EZR ezrin 0.0205492
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0205409
RPLP2 ribosomal protein, large, P2 0.020356
AMPD3 adenosine monophosphate deaminase 3 0.0201235
FLNB filamin B, beta 0.0200703
CLTC clathrin, heavy chain (Hc) 0.0199351
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0198957
RPL11 ribosomal protein L11 0.0197152
FLNA filamin A, alpha 0.0196094
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0195043
RPS19 ribosomal protein S19 0.0193771
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0191305
KIF4A kinesin family member 4A 0.0188382
TBC1D22A TBC1 domain family, member 22A 0.018833
RPL23A ribosomal protein L23a 0.0186514
NAP1L1 nucleosome assembly protein 1-like 1 0.0185708
LDHA lactate dehydrogenase A 0.0178466
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0178008
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0177848
HLA-B major histocompatibility complex, class I, B 0.0177455
TPM3 tropomyosin 3 0.0176135
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0175497
CAPN2 calpain 2, (m/II) large subunit 0.0173951
CEP250 centrosomal protein 250kDa 0.0173424
RPS16 ribosomal protein S16 0.0172822
KRT18 keratin 18, type I 0.0172649
RPS27 ribosomal protein S27 0.0171864
UBAP2L ubiquitin associated protein 2-like 0.0166951
GUK1 guanylate kinase 1 0.016397
BUB3 BUB3 mitotic checkpoint protein 0.0161718
CLTA clathrin, light chain A 0.0160604
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0159955
CALR calreticulin 0.0158668
YBX1 Y box binding protein 1 0.0156861

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.260842
FTH1 ferritin, heavy polypeptide 1 -0.155761
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150122
UGCG UDP-glucose ceramide glucosyltransferase -0.143779
FN1 fibronectin 1 -0.131955
FNDC3B fibronectin type III domain containing 3B -0.123536
GLIS3 GLIS family zinc finger 3 -0.119517
VCL vinculin -0.110517
CD44 CD44 molecule (Indian blood group) -0.102449
EXT1 exostosin glycosyltransferase 1 -0.0886259
VEGFA vascular endothelial growth factor A -0.0824902
BICC1 BicC family RNA binding protein 1 -0.0815298
PGK1 phosphoglycerate kinase 1 -0.080998
LOC112694756 uncharaterized LOC112694756 -0.077731
SMAD3 SMAD family member 3 -0.0737763
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0734295
FRMD4A FERM domain containing 4A -0.0674349
VCAN versican -0.0673751
TSC22D2 TSC22 domain family, member 2 -0.0662852
PDE10A phosphodiesterase 10A -0.0656832
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0638624
TAPBP TAP binding protein (tapasin) -0.0624131
KYNU kynureninase -0.0618095
CTSD cathepsin D -0.0593691
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0588752
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0579328
C3 complement component 3 -0.0576654
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.057351
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0567696
COL6A3 collagen, type VI, alpha 3 -0.0538844
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0534396
VIM vimentin -0.0526399
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0525529
TNS3 tensin 3 -0.0521456
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0521036
PLIN2 perilipin 2 -0.0520764
EGR1 early growth response 1 -0.0518236
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0505509
ADM adrenomedullin -0.0491902
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0484167
SDK1 sidekick cell adhesion molecule 1 -0.0480306
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0476352
QKI QKI, KH domain containing, RNA binding -0.0466839
RAI14 retinoic acid induced 14 -0.046567
ZBTB20 zinc finger and BTB domain containing 20 -0.0457927
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0448428
MSN moesin -0.0447763
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0442274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0435958
EPAS1 endothelial PAS domain protein 1 -0.0434971
NAMPT nicotinamide phosphoribosyltransferase -0.0434708
SLC38A2 solute carrier family 38, member 2 -0.0432029
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0421937
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0415375
TXNIP thioredoxin interacting protein -0.0407915
AKAP12 A kinase (PRKA) anchor protein 12 -0.0406121
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0400903
PTPRK protein tyrosine phosphatase, receptor type, K -0.0393085
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0386574
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0384805
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0379901
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0379773
DIAPH2 diaphanous-related formin 2 -0.0375166
IER3 immediate early response 3 -0.0371352
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0362662
RNF213 ring finger protein 213 -0.0356448
AGTPBP1 ATP/GTP binding protein 1 -0.0355638
DST dystonin -0.0354391
ERBIN erbb2 interacting protein -0.0348997
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0343665
HILPDA hypoxia inducible lipid droplet-associated -0.034349
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0341041
SCARB1 scavenger receptor class B, member 1 -0.0339702
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0336791
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0331445
WASF2 WAS protein family, member 2 -0.0327763
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0327415
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0323947
NDRG1 N-myc downstream regulated 1 -0.0320369
ANXA2 annexin A2 -0.0319928
SETD5 SET domain containing 5 -0.0319274
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.03162
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0315211
PDIA3 protein disulfide isomerase family A, member 3 -0.0315164
ATXN1 ataxin 1 -0.0314414
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0314162
HLA-A major histocompatibility complex, class I, A -0.0309486
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.030919
HMGA2 high mobility group AT-hook 2 -0.0305764
MAML2 mastermind-like 2 (Drosophila) -0.0305583
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0305455
EEF1G eukaryotic translation elongation factor 1 gamma -0.0299931
FTL ferritin, light polypeptide -0.0296382
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0293677
MYOF myoferlin -0.0293052
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0290427
UBC ubiquitin C -0.0285319
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0285111
ZNF207 zinc finger protein 207 -0.0283392
RTN4 reticulon 4 -0.0282875