Betamethasone dipropionate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Betamethasone dipropionate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.111104
FBN1 fibrillin 1 0.0545809
FTH1 ferritin, heavy polypeptide 1 0.0511122
ERRFI1 ERBB receptor feedback inhibitor 1 0.0409973
SOD2 superoxide dismutase 2, mitochondrial 0.036718
FNDC3B fibronectin type III domain containing 3B 0.0339839
PRELID2 PRELI domain containing 2 0.0275701
NAV2 neuron navigator 2 0.0269706
FKBP5 FK506 binding protein 5 0.0248033
MT1X metallothionein 1X 0.0245573
SBF2 SET binding factor 2 0.0214353
HIPK2 homeodomain interacting protein kinase 2 0.0213782
SAA2 serum amyloid A2 0.0208727
ZNF292 zinc finger protein 292 0.0195226
TNIP1 TNFAIP3 interacting protein 1 0.0193683
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0190244
SSBP2 single-stranded DNA binding protein 2 0.0188713
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186511
NEBL nebulette 0.0176467
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0173611
NFE2L1 nuclear factor, erythroid 2-like 1 0.0171499
GPC6 glypican 6 0.0168197
CD109 CD109 molecule 0.0165688
DNER delta/notch-like EGF repeat containing 0.0163983
ABLIM3 actin binding LIM protein family, member 3 0.016212
FAM13A family with sequence similarity 13, member A 0.0160638
C1D C1D nuclear receptor corepressor 0.0157031
ZMYND8 zinc finger, MYND-type containing 8 0.01557
GLIS3 GLIS family zinc finger 3 0.0154908
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0151606
MYOF myoferlin 0.0150911
LDHA lactate dehydrogenase A 0.0150066
COL5A2 collagen, type V, alpha 2 0.0149751
NAMPT nicotinamide phosphoribosyltransferase 0.0149445
HELZ helicase with zinc finger 0.0145945
COL4A2 collagen, type IV, alpha 2 0.0143841
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0142168
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0141793
ADAM9 ADAM metallopeptidase domain 9 0.0139179
ARRDC3 arrestin domain containing 3 0.0137686
XPO1 exportin 1 0.0136401
FNIP1 folliculin interacting protein 1 0.0135991
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0134525
CYLD cylindromatosis (turban tumor syndrome) 0.0132761
OPTN optineurin 0.0132013
ESYT2 extended synaptotagmin-like protein 2 0.0132006
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0131289
YEATS2 YEATS domain containing 2 0.0130033
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0128947
ANKRD36 ankyrin repeat domain 36 0.0128006
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0127813
PFKP phosphofructokinase, platelet 0.0127007
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.012469
NRP1 neuropilin 1 0.0124212
MYH9 myosin, heavy chain 9, non-muscle 0.0122161
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0121786
MMP12 matrix metallopeptidase 12 0.0120652
HMGB2 high mobility group box 2 0.0117769
MEF2A myocyte enhancer factor 2A 0.0117673
WTAP Wilms tumor 1 associated protein 0.0114951
HPS3 Hermansky-Pudlak syndrome 3 0.0111128
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0108839
DPYSL3 dihydropyrimidinase-like 3 0.0107532
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0107493
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0107096
CFLAR CASP8 and FADD-like apoptosis regulator 0.0106297
JCAD junctional cadherin 5 associated 0.0106264
CLU clusterin 0.0106105
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0105876
ADAM17 ADAM metallopeptidase domain 17 0.0105394
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0104559
TRIM22 tripartite motif containing 22 0.0104266
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.010376
ZFP36L1 ZFP36 ring finger protein-like 1 0.0102973
TNRC6A trinucleotide repeat containing 6A 0.0101753
PCGF5 polycomb group ring finger 5 0.0101091
ATP13A3 ATPase type 13A3 0.010104
CD46 CD46 molecule, complement regulatory protein 0.0100748
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.00990925
OGA O-GlcNAcase 0.00988864
C1ORF21 chromosome 1 open reading frame 21 0.00980103
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.00978121
SDK1 sidekick cell adhesion molecule 1 0.00973565
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00971073
TRAM2 translocation associated membrane protein 2 0.00963672
ZEB2 zinc finger E-box binding homeobox 2 0.00961899
UGCG UDP-glucose ceramide glucosyltransferase 0.00954627
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.00927128
TUT7 terminal uridylyl transferase 7 0.00921882
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.00914756
JAK1 Janus kinase 1 0.00906712
UGP2 UDP-glucose pyrophosphorylase 2 0.00904597
DDR2 discoidin domain receptor tyrosine kinase 2 0.00878749
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00878547
TBC1D5 TBC1 domain family, member 5 0.00877896
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.00873847
EIF4H eukaryotic translation initiation factor 4H 0.00870453
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.00868248
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00868147
GLS2 glutaminase 2 (liver, mitochondrial) 0.0086746

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.281942
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.175592
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145039
TMSB10 thymosin beta 10 -0.139766
IGFBP3 insulin-like growth factor binding protein 3 -0.112676
S100A10 S100 calcium binding protein A10 -0.0957213
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0882929
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0861453
PODXL podocalyxin-like -0.0847072
PTMA prothymosin, alpha -0.0793104
CDH13 cadherin 13 -0.0720763
PLAT plasminogen activator, tissue -0.0718141
NDRG1 N-myc downstream regulated 1 -0.0668622
CSTB cystatin B (stefin B) -0.0656316
HLA-B major histocompatibility complex, class I, B -0.0639016
SLC39A11 solute carrier family 39, member 11 -0.0578083
S100A6 S100 calcium binding protein A6 -0.0559836
LMNA lamin A/C -0.0552354
TPT1 tumor protein, translationally-controlled 1 -0.0535414
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0528315
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.049027
CAVIN1 caveolae associated protein 1 -0.0441012
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0425128
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0424976
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0373176
B2M beta-2-microglobulin -0.0369032
PRSS23 protease, serine, 23 -0.0367287
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0366693
CCND1 cyclin D1 -0.0363609
RPL35A ribosomal protein L35a -0.0348424
ACTG1 actin gamma 1 -0.0346576
SUCNR1 succinate receptor 1 -0.0345572
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.034368
SLC38A1 solute carrier family 38, member 1 -0.0336677
TPM4 tropomyosin 4 -0.0333053
NAV1 neuron navigator 1 -0.0329482
CALR calreticulin -0.032877
ASPH aspartate beta-hydroxylase -0.0328351
FTL ferritin, light polypeptide -0.0320137
CD44 CD44 molecule (Indian blood group) -0.0319663
ABI3BP ABI family, member 3 (NESH) binding protein -0.031557
RPS24 ribosomal protein S24 -0.0311265
DLG1 discs, large homolog 1 (Drosophila) -0.030523
IFITM3 interferon induced transmembrane protein 3 -0.0295996
RPLP2 ribosomal protein, large, P2 -0.0285095
RPL37A ribosomal protein L37a -0.0282839
TM4SF1 transmembrane 4 L six family member 1 -0.0282515
S100A11 S100 calcium binding protein A11 -0.0277755
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0274543
ISG15 ISG15 ubiquitin-like modifier -0.0272583
RIGI RNA sensor RIG-I -0.0272039
RPS8 ribosomal protein S8 -0.0271605
IFI6 interferon, alpha-inducible protein 6 -0.0269189
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0268652
HLA-C major histocompatibility complex, class I, C -0.0267593
EGFR epidermal growth factor receptor -0.026629
PBX3 pre-B-cell leukemia homeobox 3 -0.0262885
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0261856
RPL28 ribosomal protein L28 -0.0259103
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.024845
RPLP1 ribosomal protein, large, P1 -0.0245372
COL5A1 collagen, type V, alpha 1 -0.0242756
RPS6 ribosomal protein S6 -0.0239248
IFITM1 interferon induced transmembrane protein 1 -0.0238781
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0236745
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0236569
CUX1 cut-like homeobox 1 -0.0231317
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.023123
SQSTM1 sequestosome 1 -0.0229289
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0225001
MAP1B microtubule-associated protein 1B -0.0223536
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.022184
RPL23 ribosomal protein L23 -0.0220587
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.021437
MX2 MX dynamin-like GTPase 2 -0.0212952
DGKG diacylglycerol kinase, gamma 90kDa -0.0210154
TUBB4B tubulin, beta 4B class IVb -0.0210018
RPS27A ribosomal protein S27a -0.0207155
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0207095
ANXA2 annexin A2 -0.0205708
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0204042
SEC61G Sec61 gamma subunit -0.0201405
EIF1 eukaryotic translation initiation factor 1 -0.019936
ENO1 enolase 1, (alpha) -0.0198324
SPDL1 spindle apparatus coiled-coil protein 1 -0.0197982
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0197787
RPL34 ribosomal protein L34 -0.0196933
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0196757
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0194282
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0193974
RPL31 ribosomal protein L31 -0.0192893
SH3KBP1 SH3-domain kinase binding protein 1 -0.0192691
VDAC1 voltage-dependent anion channel 1 -0.0192646
VCL vinculin -0.0191909
KRT81 keratin 81, type II -0.0191491
FSTL1 follistatin-like 1 -0.018907
ALCAM activated leukocyte cell adhesion molecule -0.0188424
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0188381
CD59 CD59 molecule, complement regulatory protein -0.0187566
PEA15 phosphoprotein enriched in astrocytes 15 -0.0187332