Betamethasone dipropionate_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Betamethasone dipropionate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0694187
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0649232
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.043638
POTEF POTE ankyrin domain family, member F 0.0393151
PCBP2 poly(rC) binding protein 2 0.0377974
VIM vimentin 0.0288594
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0266822
RPS12 ribosomal protein S12 0.02515
CPOX coproporphyrinogen oxidase 0.0249833
EEF2 eukaryotic translation elongation factor 2 0.0247347
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0246583
YBX1 Y box binding protein 1 0.0236353
AREG amphiregulin 0.0235844
FTL ferritin, light polypeptide 0.0232932
PABPC1 poly(A) binding protein, cytoplasmic 1 0.023168
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0222112
RPS6 ribosomal protein S6 0.0221386
CCNL1 cyclin L1 0.0221112
EEF1G eukaryotic translation elongation factor 1 gamma 0.0205301
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0202319
TUBA1B tubulin, alpha 1b 0.0195804
TBK1 TANK-binding kinase 1 0.0188794
PTMS parathymosin 0.0184337
PFN1 profilin 1 0.018314
SMC4 structural maintenance of chromosomes 4 0.0180303
RRM2 ribonucleotide reductase M2 0.0178617
SET SET nuclear proto-oncogene 0.0174669
HMGA1 high mobility group AT-hook 1 0.0168986
FTH1 ferritin, heavy polypeptide 1 0.0164114
RPL3 ribosomal protein L3 0.016376
LOC112694756 uncharaterized LOC112694756 0.0159927
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.01593
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0157448
HDGF hepatoma-derived growth factor 0.015733
ATP5F1B ATP synthase F1 subunit beta 0.0155805
DEK DEK proto-oncogene 0.0155613
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0152642
AKAP9 A kinase (PRKA) anchor protein 9 0.0150145
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0146816
PCM1 pericentriolar material 1 0.01462
RPS2 ribosomal protein S2 0.0145516
FXR1 fragile X mental retardation, autosomal homolog 1 0.0142726
KTN1 kinectin 1 (kinesin receptor) 0.0141913
BRD2 bromodomain containing 2 0.0141384
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0140662
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0137319
RPL23 ribosomal protein L23 0.0135956
RPS4X ribosomal protein S4, X-linked 0.0134216
HSPA8 heat shock 70kDa protein 8 0.0134178
PEG10 paternally expressed 10 0.0132712
CENPF centromere protein F, 350/400kDa 0.0132558
RPS23 ribosomal protein S23 0.0131676
RBM25 RNA binding motif protein 25 0.0129433
APLP2 amyloid beta (A4) precursor-like protein 2 0.0126968
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0123951
CAMTA1 calmodulin binding transcription activator 1 0.0122408
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.012221
LDHB lactate dehydrogenase B 0.0121142
TRA2A transformer 2 alpha homolog (Drosophila) 0.0120713
PER1 period circadian clock 1 0.011823
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0117467
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0114537
RPLP2 ribosomal protein, large, P2 0.01123
ATP5F1E ATP synthase F1 subunit epsilon 0.0111845
ADAM17 ADAM metallopeptidase domain 17 0.0111163
FOXM1 forkhead box M1 0.0111059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0108414
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0108114
GOLIM4 golgi integral membrane protein 4 0.0107694
CLDND1 claudin domain containing 1 0.0106913
NACA nascent polypeptide-associated complex alpha subunit 0.0106744
CHD1 chromodomain helicase DNA binding protein 1 0.0106372
TPM3 tropomyosin 3 0.0105485
RPS26 ribosomal protein S26 0.0105153
KMT2E lysine (K)-specific methyltransferase 2E 0.0103979
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0103562
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.010354
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0103537
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0102699
DCAF7 DDB1 and CUL4 associated factor 7 0.010245
LOC102724023 ES1 protein homolog, mitochondrial 0.0101467
UBA6 ubiquitin-like modifier activating enzyme 6 0.0101377
NAMPT nicotinamide phosphoribosyltransferase 0.00994443
ERRFI1 ERBB receptor feedback inhibitor 1 0.00991517
RPS14 ribosomal protein S14 0.00991062
TFG TRK-fused gene 0.00984923
THOC1 THO complex 1 0.00981526
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.00979599
RHOA ras homolog family member A 0.00975237
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00975193
H2AZ1 H2A.Z variant histone 1 0.00972105
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.00970514
SRSF11 serine/arginine-rich splicing factor 11 0.0096972
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.00962218
RNPS1 RNA binding protein S1, serine-rich domain 0.00959537
RPL8 ribosomal protein L8 0.00958944
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.00958892
WWOX WW domain containing oxidoreductase 0.00956709
RPS8 ribosomal protein S8 0.00955422
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00955258

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.226452
NLGN1 neuroligin 1 -0.137535
PDE4D phosphodiesterase 4D, cAMP-specific -0.0904847
DST dystonin -0.0811729
MMP12 matrix metallopeptidase 12 -0.0799824
PCDH7 protocadherin 7 -0.0771666
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0748531
DPYD dihydropyrimidine dehydrogenase -0.0715823
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0693427
RASAL2 RAS protein activator like 2 -0.0641388
CELF2 CUGBP, Elav-like family member 2 -0.0616821
NEBL nebulette -0.061041
EHBP1 EH domain binding protein 1 -0.0609332
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0583709
ZNF804A zinc finger protein 804A -0.05613
HMGA2 high mobility group AT-hook 2 -0.0548097
CLDN1 claudin 1 -0.0496331
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0476995
DLC1 DLC1 Rho GTPase activating protein -0.0473419
CMIP c-Maf inducing protein -0.0471999
TENM3 teneurin transmembrane protein 3 -0.0437597
AHNAK AHNAK nucleoprotein -0.0430913
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0423612
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0423473
SLC38A2 solute carrier family 38, member 2 -0.0420165
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0416806
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0390798
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0388753
RABGAP1L RAB GTPase activating protein 1-like -0.0385532
MTAP methylthioadenosine phosphorylase -0.037854
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0371136
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0365644
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0360444
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0359125
CARD16 caspase recruitment domain family, member 16 -0.0358731
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0356631
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0355651
TAS2R14 taste receptor, type 2, member 14 -0.0353371
ZBTB20 zinc finger and BTB domain containing 20 -0.035308
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0345664
ADGRG6 adhesion G protein-coupled receptor G6 -0.0343369
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0326685
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0322552
BCHE butyrylcholinesterase -0.0319825
ANKRD28 ankyrin repeat domain 28 -0.0309676
CCSER1 coiled-coil serine-rich protein 1 -0.0286132
PDGFC platelet derived growth factor C -0.0284355
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0283448
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0281028
SPIDR scaffolding protein involved in DNA repair -0.0264509
SYT1 synaptotagmin I -0.0264045
RIMS2 regulating synaptic membrane exocytosis 2 -0.025881
IFIH1 interferon induced with helicase C domain 1 -0.0253642
LPP LIM domain containing preferred translocation partner in lipoma -0.0252215
MSRB3 methionine sulfoxide reductase B3 -0.0251668
ANKRD12 ankyrin repeat domain 12 -0.0248287
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0248267
MYPN myopalladin -0.0246605
NF1 neurofibromin 1 -0.0244896
MARCHF4 membrane associated ring-CH-type finger 4 -0.0243379
CUX1 cut-like homeobox 1 -0.0241941
ANXA1 annexin A1 -0.0239489
ELP4 elongator acetyltransferase complex subunit 4 -0.0237936
CDK6 cyclin-dependent kinase 6 -0.0236933
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0236013
USP34 ubiquitin specific peptidase 34 -0.0235346
ZFAND3 zinc finger, AN1-type domain 3 -0.0230299
DTNA dystrobrevin, alpha -0.0230216
TRIO trio Rho guanine nucleotide exchange factor -0.0227614
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.022536
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0223907
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0222158
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0219309
EXOC4 exocyst complex component 4 -0.021714
DOCK1 dedicator of cytokinesis 1 -0.0214807
FSTL5 follistatin-like 5 -0.0211827
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0210856
P3H2 prolyl 3-hydroxylase 2 -0.0209746
SMYD3 SET and MYND domain containing 3 -0.0208487
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0208189
EGFR epidermal growth factor receptor -0.0207945
SBF2 SET binding factor 2 -0.0207727
TMCC1 transmembrane and coiled-coil domain family 1 -0.020725
AFF4 AF4/FMR2 family, member 4 -0.0206631
RAD51B RAD51 paralog B -0.0205783
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.020409
MACF1 microtubule-actin crosslinking factor 1 -0.0199369
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0196948
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0196835
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0193897
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0193537
SPATS2 spermatogenesis associated, serine-rich 2 -0.0191421
CANX calnexin -0.0190869
CEP112 centrosomal protein 112kDa -0.0186753
MAP1B microtubule-associated protein 1B -0.0186177
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0185376
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0184417
ASPH aspartate beta-hydroxylase -0.0184212
RIMKLB ribosomal modification protein rimK-like family member B -0.0179067
AK1 adenylate kinase 1 -0.0178949