Betamethasone dipropionate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM3 teneurin transmembrane protein 3 0.0726916
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0700138
ADGRG6 adhesion G protein-coupled receptor G6 0.0554017
ZNF608 zinc finger protein 608 0.0544895
BCAS3 breast carcinoma amplified sequence 3 0.0508915
COL5A2 collagen, type V, alpha 2 0.0486562
EXT1 exostosin glycosyltransferase 1 0.0463738
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0457824
FER fer (fps/fes related) tyrosine kinase 0.0452261
ATP11A ATPase, class VI, type 11A 0.0430828
VCL vinculin 0.0426897
MLIP muscular LMNA-interacting protein 0.0403933
TTC28 tetratricopeptide repeat domain 28 0.0399452
JMJD1C jumonji domain containing 1C 0.0396296
SBF2 SET binding factor 2 0.0388082
SMYD3 SET and MYND domain containing 3 0.037444
CDH18 cadherin 18, type 2 0.0350538
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.034168
USP9X ubiquitin specific peptidase 9, X-linked 0.0336569
HELZ helicase with zinc finger 0.0332026
TOX thymocyte selection-associated high mobility group box 0.0331622
DST dystonin 0.0319849
SOX4 SRY (sex determining region Y)-box 4 0.0314632
PDE4D phosphodiesterase 4D, cAMP-specific 0.0310601
HDAC8 histone deacetylase 8 0.0309426
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0309256
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0304062
COL11A1 collagen, type XI, alpha 1 0.0301276
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0299446
MKI67 marker of proliferation Ki-67 0.0297067
WDPCP WD repeat containing planar cell polarity effector 0.029607
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0294182
ANKRD12 ankyrin repeat domain 12 0.0290083
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0289358
KIF1B kinesin family member 1B 0.02889
AUTS2 autism susceptibility candidate 2 0.0286062
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.028493
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0284248
PHF3 PHD finger protein 3 0.0281741
CEP192 centrosomal protein 192kDa 0.0279693
NALF1 NALCN channel auxiliary factor 1 0.0276461
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0276366
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0276093
KTN1 kinectin 1 (kinesin receptor) 0.0272304
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0271829
DOCK3 dedicator of cytokinesis 3 0.0267368
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0266337
PARD3 par-3 family cell polarity regulator 0.0264681
KMT2C lysine (K)-specific methyltransferase 2C 0.0261718
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0261558
CADM2 cell adhesion molecule 2 0.0261505
SHROOM3 shroom family member 3 0.0256293
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0255253
ZBTB20 zinc finger and BTB domain containing 20 0.0255205
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0251374
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0250883
GRID2 glutamate receptor, ionotropic, delta 2 0.0248871
ANKRD11 ankyrin repeat domain 11 0.0248392
SRSF4 serine/arginine-rich splicing factor 4 0.0247247
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0245336
ZC3H12B zinc finger CCCH-type containing 12B 0.024531
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0243889
EXOC6B exocyst complex component 6B 0.0243509
VMP1 vacuole membrane protein 1 0.0242269
PRRC2A proline-rich coiled-coil 2A 0.0241205
RIGI RNA sensor RIG-I 0.0240231
EEF2 eukaryotic translation elongation factor 2 0.0237149
WDFY3 WD repeat and FYVE domain containing 3 0.0236368
PRRC2B proline-rich coiled-coil 2B 0.0235257
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0235049
BRD4 bromodomain containing 4 0.0233206
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0232899
BBX bobby sox homolog (Drosophila) 0.023158
ARFGEF3 ARFGEF family member 3 0.0226617
TNPO3 transportin 3 0.0226047
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0225103
ACBD6 acyl-CoA binding domain containing 6 0.0224767
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224725
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0221202
RSRP1 arginine/serine-rich protein 1 0.0220724
USP34 ubiquitin specific peptidase 34 0.0219507
HIP1 huntingtin interacting protein 1 0.0218667
ARHGAP5 Rho GTPase activating protein 5 0.0218636
SEPTIN10 septin 10 0.0218433
ZSWIM5 zinc finger, SWIM-type containing 5 0.0218237
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0216371
MACF1 microtubule-actin crosslinking factor 1 0.0214902
NFIB nuclear factor I/B 0.0214581
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.021413
MAP1B microtubule-associated protein 1B 0.0210967
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0210775
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0209316
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0207269
QKI QKI, KH domain containing, RNA binding 0.0206681
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0206281
FMNL2 formin-like 2 0.0205647
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0204902
KIAA1958 KIAA1958 0.0204549
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0203658
STRBP spermatid perinuclear RNA binding protein 0.0203477

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0656865
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0532783
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0532384
RPS12 ribosomal protein S12 -0.0404545
TMSB10 thymosin beta 10 -0.0382027
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0304663
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0303797
RPL23 ribosomal protein L23 -0.0296717
RPL7 ribosomal protein L7 -0.0284878
RPL12 ribosomal protein L12 -0.0284686
RPS3 ribosomal protein S3 -0.028212
SLF1 SMC5-SMC6 complex localization factor 1 -0.0275417
RPL35A ribosomal protein L35a -0.0269707
RPS17 ribosomal protein S17 -0.025425
RPL34 ribosomal protein L34 -0.0252871
PGAP1 post-GPI attachment to proteins 1 -0.0236112
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0225695
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0223103
PYGL phosphorylase, glycogen, liver -0.0221008
FTL ferritin, light polypeptide -0.0219393
FN1 fibronectin 1 -0.0213145
RPL9 ribosomal protein L9 -0.0212611
RPS25 ribosomal protein S25 -0.0211291
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0210311
TTC17 tetratricopeptide repeat domain 17 -0.0206525
SCAF11 SR-related CTD-associated factor 11 -0.0200976
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0191572
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0191493
LDHB lactate dehydrogenase B -0.0187185
NKD1 naked cuticle homolog 1 (Drosophila) -0.0186922
WDR45B WD repeat domain 45B -0.0184981
RPL35 ribosomal protein L35 -0.018477
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0184593
RPS13 ribosomal protein S13 -0.0183753
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0180472
NUDC nudC nuclear distribution protein -0.0179273
ACTG1 actin gamma 1 -0.0177992
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0175912
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0175446
AFG2A AFG2 AAA ATPase homolog A -0.0172367
OSBPL10 oxysterol binding protein-like 10 -0.0169925
SERBP1 SERPINE1 mRNA binding protein 1 -0.0169577
ANKRD17 ankyrin repeat domain 17 -0.016922
HMGA2 high mobility group AT-hook 2 -0.0168538
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0168501
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0168359
KDM5B lysine (K)-specific demethylase 5B -0.0167788
RPS28 ribosomal protein S28 -0.0167434
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0166299
TUBB tubulin, beta class I -0.016549
RPL11 ribosomal protein L11 -0.0164296
ANAPC5 anaphase promoting complex subunit 5 -0.015707
RPLP0 ribosomal protein, large, P0 -0.0156921
RAB6A RAB6A, member RAS oncogene family -0.0156606
RPL7A ribosomal protein L7a -0.0153322
RPS29 ribosomal protein S29 -0.0153228
PKM pyruvate kinase, muscle -0.0152597
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0152201
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0151115
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0149753
EXOC4 exocyst complex component 4 -0.014972
SOD1 superoxide dismutase 1, soluble -0.014956
PA2G4 proliferation-associated 2G4, 38kDa -0.0149415
RPS11 ribosomal protein S11 -0.0146698
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0146087
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0144515
CCDC88A coiled-coil domain containing 88A -0.0143292
RPS14 ribosomal protein S14 -0.0142719
RUNX1 runt-related transcription factor 1 -0.0142357
MTAP methylthioadenosine phosphorylase -0.0141415
RPL32 ribosomal protein L32 -0.0141013
PDCD10 programmed cell death 10 -0.0139182
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0138755
ZNF160 zinc finger protein 160 -0.0138342
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0137914
PRPF4B pre-mRNA processing factor 4B -0.0137142
RPL18 ribosomal protein L18 -0.0136842
EMP1 epithelial membrane protein 1 -0.0136336
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0135859
AKAP12 A kinase (PRKA) anchor protein 12 -0.0135769
ATRN attractin -0.0135309
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0133996
NCAPD3 non-SMC condensin II complex, subunit D3 -0.0133477
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0133329
NELFCD negative elongation factor complex member C/D -0.0131687
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0131662
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0130787
FNBP1 formin binding protein 1 -0.0130624
GPC6 glypican 6 -0.0130222
RPL37 ribosomal protein L37 -0.0129874
RSL1D1 ribosomal L1 domain containing 1 -0.0129648
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0129627
EIF4A3 eukaryotic translation initiation factor 4A3 -0.0129174
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0128675
YBX3 Y box binding protein 3 -0.0128234
WRN Werner syndrome, RecQ helicase-like -0.0127667
RPL13A ribosomal protein L13a -0.0127489
CSTB cystatin B (stefin B) -0.0127384
H1-0 H1.0 linker histone -0.0125539
PFN1 profilin 1 -0.0125019