Betamethasone dipropionate_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.27752
FN1 fibronectin 1 0.195347
AKAP12 A kinase (PRKA) anchor protein 12 0.165621
ENO1 enolase 1, (alpha) 0.0976865
NRCAM neuronal cell adhesion molecule 0.0751573
TMSB10 thymosin beta 10 0.0746983
VGF VGF nerve growth factor inducible 0.0734792
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.066446
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.062297
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0593501
CD109 CD109 molecule 0.0585914
POTEF POTE ankyrin domain family, member F 0.0564952
FKBP5 FK506 binding protein 5 0.0560909
MT1X metallothionein 1X 0.0537983
EGR1 early growth response 1 0.0536344
TAGLN2 transgelin 2 0.0490043
LDHA lactate dehydrogenase A 0.0484275
IGFBP5 insulin-like growth factor binding protein 5 0.0478252
NPAS2 neuronal PAS domain protein 2 0.0477215
HILPDA hypoxia inducible lipid droplet-associated 0.0441992
PLIN2 perilipin 2 0.0433233
RBMS3 RNA binding motif, single stranded interacting protein 3 0.039193
NLGN1 neuroligin 1 0.0383598
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0370177
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0363807
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0360408
GHR growth hormone receptor 0.0351155
PKM pyruvate kinase, muscle 0.0349019
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0346207
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0344919
FTH1 ferritin, heavy polypeptide 1 0.0340203
EEF2 eukaryotic translation elongation factor 2 0.0322927
IRS2 insulin receptor substrate 2 0.0318999
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0316326
HIPK2 homeodomain interacting protein kinase 2 0.0295447
NAV3 neuron navigator 3 0.0295444
PDE10A phosphodiesterase 10A 0.0295094
DDIT4 DNA-damage-inducible transcript 4 0.0294472
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.02909
CALR calreticulin 0.0288232
ESYT2 extended synaptotagmin-like protein 2 0.0280224
HMGA2 high mobility group AT-hook 2 0.0270399
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0264464
ZMYND8 zinc finger, MYND-type containing 8 0.0256313
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0255244
LIFR leukemia inhibitory factor receptor alpha 0.0254258
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0252172
LOC112694756 uncharaterized LOC112694756 0.0249142
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0242972
VIM vimentin 0.024217
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0242079
C1ORF21 chromosome 1 open reading frame 21 0.0236652
TPI1 triosephosphate isomerase 1 0.0233532
IGFBP3 insulin-like growth factor binding protein 3 0.0232775
RPGR retinitis pigmentosa GTPase regulator 0.02227
NPR2 natriuretic peptide receptor 2 0.0220987
RPS4X ribosomal protein S4, X-linked 0.0216235
RPS3 ribosomal protein S3 0.0210737
PTPRG protein tyrosine phosphatase, receptor type, G 0.0208369
DYNC2I1 dynein 2 intermediate chain 1 0.0204726
IFI16 interferon, gamma-inducible protein 16 0.0198723
DIAPH2 diaphanous-related formin 2 0.0196914
TRIM2 tripartite motif containing 2 0.0194523
BCAS3 breast carcinoma amplified sequence 3 0.0191314
CALD1 caldesmon 1 0.0190855
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0189576
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0187601
PDIA4 protein disulfide isomerase family A, member 4 0.0185599
PTCHD4 patched domain containing 4 0.0184002
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0178242
IFITM3 interferon induced transmembrane protein 3 0.0175926
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0174353
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0173063
JUN jun proto-oncogene 0.016924
RPL3 ribosomal protein L3 0.0169179
ENO2 enolase 2 (gamma, neuronal) 0.0167575
HMGB2 high mobility group box 2 0.0166162
LMCD1 LIM and cysteine-rich domains 1 0.0165646
ITGA10 integrin, alpha 10 0.0165165
MRPS6 mitochondrial ribosomal protein S6 0.0164204
SRPX sushi-repeat containing protein, X-linked 0.0163623
RNF144A ring finger protein 144A 0.0160628
STRIP2 striatin interacting protein 2 0.0159489
ABLIM3 actin binding LIM protein family, member 3 0.0159459
OPHN1 oligophrenin 1 0.0159201
ZYX zyxin 0.0158529
PYGB phosphorylase, glycogen; brain 0.0158466
YBX1 Y box binding protein 1 0.0158457
NCOR2 nuclear receptor corepressor 2 0.0153415
CSPG4 chondroitin sulfate proteoglycan 4 0.0152421
GPNMB glycoprotein (transmembrane) nmb 0.0151623
CADM1 cell adhesion molecule 1 0.0151096
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.015066
SON SON DNA binding protein 0.0150347
CDK16 cyclin-dependent kinase 16 0.0148776
EVA1C eva-1 homolog C (C. elegans) 0.0147054
EHBP1 EH domain binding protein 1 0.0143369
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0142907
SSR1 signal sequence receptor, alpha 0.0142561
EIF4H eukaryotic translation initiation factor 4H 0.0142291

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291233
NAMPT nicotinamide phosphoribosyltransferase -0.112838
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0949614
FMN1 formin 1 -0.0902921
NDRG1 N-myc downstream regulated 1 -0.0795969
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0758601
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0715486
ASPH aspartate beta-hydroxylase -0.0669783
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0661592
KMT2E lysine (K)-specific methyltransferase 2E -0.0577137
ICAM1 intercellular adhesion molecule 1 -0.0574143
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.053031
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0480182
MTPN myotrophin -0.0479427
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0469557
GPC6 glypican 6 -0.0456215
SRPK2 SRSF protein kinase 2 -0.0453145
PI15 peptidase inhibitor 15 -0.0447054
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0445661
CDC73 cell division cycle 73 -0.0445017
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0444498
FRMD4A FERM domain containing 4A -0.0433041
COG5 component of oligomeric golgi complex 5 -0.0426995
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0426651
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0420902
MRTFA myocardin related transcription factor A -0.0418149
WWTR1 WW domain containing transcription regulator 1 -0.0409213
NEK7 NIMA-related kinase 7 -0.0401292
MYO10 myosin X -0.0369209
FOXJ3 forkhead box J3 -0.0362847
CHSY1 chondroitin sulfate synthase 1 -0.0357128
FNDC3B fibronectin type III domain containing 3B -0.0354042
PTK2 protein tyrosine kinase 2 -0.0353096
TM4SF1 transmembrane 4 L six family member 1 -0.0351073
PHF21A PHD finger protein 21A -0.0345503
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0340294
IER3 immediate early response 3 -0.031723
TNNC1 troponin C type 1 (slow) -0.0316718
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0316561
A2M alpha-2-macroglobulin -0.0314742
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0314329
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0314047
SMAD3 SMAD family member 3 -0.0308111
APP amyloid beta (A4) precursor protein -0.0304105
RTN4 reticulon 4 -0.0301218
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0300203
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0300003
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0295731
RO60 Ro60, Y RNA binding protein -0.0294521
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0294394
SPAG9 sperm associated antigen 9 -0.0291321
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0289762
ATXN1 ataxin 1 -0.0288603
XPO1 exportin 1 -0.0288387
FRMD6 FERM domain containing 6 -0.0288385
NAV1 neuron navigator 1 -0.0286641
RHEB Ras homolog enriched in brain -0.0285523
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0282452
VGLL4 vestigial-like family member 4 -0.0280892
PTPRM protein tyrosine phosphatase, receptor type, M -0.0279927
RPS2 ribosomal protein S2 -0.0278298
FMNL2 formin-like 2 -0.0275229
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0273319
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0271775
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0270938
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0267294
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0257314
EXT1 exostosin glycosyltransferase 1 -0.0255751
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0255136
DSTYK dual serine/threonine and tyrosine protein kinase -0.0249349
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0247805
ACTN4 actinin, alpha 4 -0.0243492
BIRC2 baculoviral IAP repeat containing 2 -0.0242722
UBC ubiquitin C -0.0238449
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0238327
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0236346
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0236177
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0235122
UBE2H ubiquitin-conjugating enzyme E2H -0.0234819
ZFAND3 zinc finger, AN1-type domain 3 -0.0234246
TMEM178B transmembrane protein 178B -0.0230035
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0229449
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0229358
GLS2 glutaminase 2 (liver, mitochondrial) -0.0229226
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0228761
RAB1A RAB1A, member RAS oncogene family -0.0228024
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0226315
IGFBP7 insulin-like growth factor binding protein 7 -0.0225844
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0224525
ANO6 anoctamin 6 -0.022437
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0223511
HBP1 HMG-box transcription factor 1 -0.0220384
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0218932
DSCAM Down syndrome cell adhesion molecule -0.0218047
RASA3 RAS p21 protein activator 3 -0.0216982
RYBP RING1 and YY1 binding protein -0.021532
PUM2 pumilio RNA-binding family member 2 -0.0215161
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0214104
ZNF292 zinc finger protein 292 -0.0212606
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0212018