Betamethasone dipropionate_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.235624
AKAP12 A kinase (PRKA) anchor protein 12 0.124253
FTH1 ferritin, heavy polypeptide 1 0.0664511
EFNA5 ephrin-A5 0.0621964
BIRC3 baculoviral IAP repeat containing 3 0.051115
IRAK3 interleukin-1 receptor-associated kinase 3 0.0481397
ERRFI1 ERBB receptor feedback inhibitor 1 0.0426067
POTEF POTE ankyrin domain family, member F 0.0413356
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0377091
CP ceruloplasmin (ferroxidase) 0.0360769
TNS4 tensin 4 0.0326795
MT1E metallothionein 1E 0.0295704
FKBP5 FK506 binding protein 5 0.0286388
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0278418
C3 complement component 3 0.026362
AHNAK2 AHNAK nucleoprotein 2 0.024874
RAD51B RAD51 paralog B 0.0244226
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0231753
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0230566
ESYT2 extended synaptotagmin-like protein 2 0.0207832
KIF13B kinesin family member 13B 0.0203404
PYGB phosphorylase, glycogen; brain 0.0197973
ZMYND8 zinc finger, MYND-type containing 8 0.0188062
NRG1 neuregulin 1 0.0177909
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0175909
EGFR epidermal growth factor receptor 0.0173802
MUC1 mucin 1, cell surface associated 0.0171049
CEP70 centrosomal protein 70kDa 0.0162725
IRS2 insulin receptor substrate 2 0.0159862
PLAC8 placenta-specific 8 0.0159245
S100P S100 calcium binding protein P 0.0157511
TSC22D3 TSC22 domain family, member 3 0.0156028
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0155543
HMGA2 high mobility group AT-hook 2 0.0152522
CCND3 cyclin D3 0.015114
MUC4 mucin 4, cell surface associated 0.0144411
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0143989
ANGPTL4 angiopoietin-like 4 0.0142852
BCL2L1 BCL2-like 1 0.0141109
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0139259
BCAR3 breast cancer anti-estrogen resistance 3 0.0137889
HOMER2 homer scaffolding protein 2 0.0132054
AREG amphiregulin 0.0130861
EHBP1 EH domain binding protein 1 0.0130347
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0128664
SQOR sulfide quinone oxidoreductase 0.0124659
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0122257
FAT1 FAT atypical cadherin 1 0.0120957
ITGB4 integrin, beta 4 0.0120752
FGB fibrinogen beta chain 0.0119327
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0118189
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0117934
PDE4D phosphodiesterase 4D, cAMP-specific 0.0117146
LOX lysyl oxidase 0.0116067
VSTM2L V-set and transmembrane domain containing 2 like 0.0112441
DSPP dentin sialophosphoprotein 0.0111102
CYBA cytochrome b-245, alpha polypeptide 0.0108331
DGKH diacylglycerol kinase, eta 0.0106536
TMSB10 thymosin beta 10 0.0105495
LAMA4 laminin, alpha 4 0.0104837
RPS4X ribosomal protein S4, X-linked 0.0101922
AKAP9 A kinase (PRKA) anchor protein 9 0.0101911
FMN1 formin 1 0.010103
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0100475
PPL periplakin 0.00981562
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.00979079
EGR1 early growth response 1 0.00972484
C6ORF132 chromosome 6 open reading frame 132 0.00969592
NNMT nicotinamide N-methyltransferase 0.00966733
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.00962556
SH3TC1 SH3 domain and tetratricopeptide repeats 1 0.00934048
EDN1 endothelin 1 0.00931996
DPYD dihydropyrimidine dehydrogenase 0.00918684
PHF21A PHD finger protein 21A 0.00916303
RRBP1 ribosome binding protein 1 0.00909699
RAB2A RAB2A, member RAS oncogene family 0.00887735
RPL35A ribosomal protein L35a 0.00886269
NCOR2 nuclear receptor corepressor 2 0.00884923
ANXA4 annexin A4 0.00877903
TLR2 toll-like receptor 2 0.00871055
CCDC6 coiled-coil domain containing 6 0.00845513
TGFB2 transforming growth factor, beta 2 0.0083645
RPL3 ribosomal protein L3 0.00832027
PHACTR3 phosphatase and actin regulator 3 0.00830992
PRSS8 protease, serine, 8 0.00826369
RHEX regulator of hemoglobinization and erythroid cell expansion 0.00808059
GLIS3 GLIS family zinc finger 3 0.00807693
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0080418
SLK STE20-like kinase 0.00801502
LAMA5 laminin, alpha 5 0.00799961
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.00797883
MYO9A myosin IXA 0.00795884
MLKL mixed lineage kinase domain-like 0.00788906
SGPP2 sphingosine-1-phosphate phosphatase 2 0.00778266
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.00773235
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.00772214
MTSS1 metastasis suppressor 1 0.00769807
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.00766863
RPS7 ribosomal protein S7 0.0076467
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.00764341

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.203537
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175614
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.15739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107071
PTMA prothymosin, alpha -0.09681
ASPH aspartate beta-hydroxylase -0.0673956
FNDC3B fibronectin type III domain containing 3B -0.0663935
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0651276
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0606602
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0594973
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0580068
SAMD4A sterile alpha motif domain containing 4A -0.0533372
SMAD3 SMAD family member 3 -0.0524669
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.05061
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0495784
PLAU plasminogen activator, urokinase -0.0485798
SPAG9 sperm associated antigen 9 -0.048044
RPS27A ribosomal protein S27a -0.0467729
EIF1 eukaryotic translation initiation factor 1 -0.0454176
VIM vimentin -0.0445724
APP amyloid beta (A4) precursor protein -0.0433006
TM4SF1 transmembrane 4 L six family member 1 -0.0428527
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0423954
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0421145
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0418459
PCBP2 poly(rC) binding protein 2 -0.0414996
JUN jun proto-oncogene -0.0410211
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0403936
ACTG1 actin gamma 1 -0.0397634
AHNAK AHNAK nucleoprotein -0.0393759
ARHGAP26 Rho GTPase activating protein 26 -0.0390872
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0388368
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.038691
PDIA3 protein disulfide isomerase family A, member 3 -0.0380027
ELL2 elongation factor, RNA polymerase II, 2 -0.0379741
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0377123
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0371055
TSC22D2 TSC22 domain family, member 2 -0.0367142
C15ORF48 chromosome 15 open reading frame 48 -0.0352491
OGA O-GlcNAcase -0.0351104
CANX calnexin -0.035017
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0344556
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0338254
RBM39 RNA binding motif protein 39 -0.0335855
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0326582
WWTR1 WW domain containing transcription regulator 1 -0.0319689
DTNA dystrobrevin, alpha -0.0318263
PDIA4 protein disulfide isomerase family A, member 4 -0.0308816
MYO1E myosin IE -0.0307517
HLA-B major histocompatibility complex, class I, B -0.0303944
SLC38A1 solute carrier family 38, member 1 -0.030004
TMSB4X thymosin beta 4, X-linked -0.0299683
ADAM9 ADAM metallopeptidase domain 9 -0.0295828
ENO1 enolase 1, (alpha) -0.029213
RAB1A RAB1A, member RAS oncogene family -0.0289862
RPL23 ribosomal protein L23 -0.0289082
B2M beta-2-microglobulin -0.0284358
NDRG1 N-myc downstream regulated 1 -0.0279263
ANXA2 annexin A2 -0.0277799
CD2AP CD2-associated protein -0.0276309
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0274787
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.026956
PLAUR plasminogen activator, urokinase receptor -0.026941
DSCAM Down syndrome cell adhesion molecule -0.0269173
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0267417
CALR calreticulin -0.0265861
KMT2E lysine (K)-specific methyltransferase 2E -0.0260727
MYOF myoferlin -0.0257601
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0257336
DST dystonin -0.0253503
UBE2H ubiquitin-conjugating enzyme E2H -0.025342
EMP1 epithelial membrane protein 1 -0.0250963
CDCP1 CUB domain containing protein 1 -0.0250876
NPEPPS aminopeptidase puromycin sensitive -0.0250368
AKAP13 A kinase (PRKA) anchor protein 13 -0.0248146
KDM3A lysine (K)-specific demethylase 3A -0.0246688
RLF rearranged L-myc fusion -0.0244896
CD47 CD47 molecule -0.0243772
PDIA6 protein disulfide isomerase family A, member 6 -0.0241027
MCTP1 multiple C2 domains, transmembrane 1 -0.0238794
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0238037
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0237112
WAC WW domain containing adaptor with coiled-coil -0.0234819
FAM107B family with sequence similarity 107, member B -0.0232801
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0228271
WSB1 WD repeat and SOCS box containing 1 -0.0223377
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0222663
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0222018
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0221616
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0220959
SQSTM1 sequestosome 1 -0.0220305
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0219982
PPARD peroxisome proliferator-activated receptor delta -0.021995
HELZ helicase with zinc finger -0.0218171
IER3 immediate early response 3 -0.021604
JAK1 Janus kinase 1 -0.0212308
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0211352
FUS FUS RNA binding protein -0.0211183
USP3 ubiquitin specific peptidase 3 -0.0211043
MACF1 microtubule-actin crosslinking factor 1 -0.0210098