Betamethasone dipropionate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ARHGAP26 Rho GTPase activating protein 26 0.045942
EPSTI1 epithelial stromal interaction 1 (breast) 0.0450874
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0439038
STS steroid sulfatase (microsomal), isozyme S 0.0420363
BTBD9 BTB (POZ) domain containing 9 0.0377044
RABGAP1L RAB GTPase activating protein 1-like 0.0365707
TSHZ2 teashirt zinc finger homeobox 2 0.0291191
RAD51B RAD51 paralog B 0.0271366
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263786
EPHB2 EPH receptor B2 0.0248092
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0243932
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0243089
ZMYND8 zinc finger, MYND-type containing 8 0.0238695
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.023217
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0231166
SORBS1 sorbin and SH3 domain containing 1 0.0230826
FMN1 formin 1 0.0230062
TRIO trio Rho guanine nucleotide exchange factor 0.0228599
FAT1 FAT atypical cadherin 1 0.0228191
ATP10B ATPase, class V, type 10B 0.021192
MSI2 musashi RNA-binding protein 2 0.0204434
SSH2 slingshot protein phosphatase 2 0.0204007
GMDS GDP-mannose 4,6-dehydratase 0.0198875
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0194641
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0190338
MX1 MX dynamin-like GTPase 1 0.0189955
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0189174
NCKAP5 NCK-associated protein 5 0.0187007
PCED1B PC-esterase domain containing 1B 0.0184913
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0178562
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0178552
ATP11A ATPase, class VI, type 11A 0.0175793
NRIP1 nuclear receptor interacting protein 1 0.0175047
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0173541
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0169868
TRERF1 transcriptional regulating factor 1 0.0167253
ETV6 ets variant 6 0.0166394
ASPH aspartate beta-hydroxylase 0.0166007
NPSR1 neuropeptide S receptor 1 0.0163811
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0162535
RBM26 RNA binding motif protein 26 0.0160706
ZBTB20 zinc finger and BTB domain containing 20 0.0160133
HDAC4 histone deacetylase 4 0.0159379
MAML2 mastermind-like 2 (Drosophila) 0.0155788
CTNND1 catenin (cadherin-associated protein), delta 1 0.0151104
SPATS2L spermatogenesis associated, serine-rich 2-like 0.015033
DGKH diacylglycerol kinase, eta 0.0148332
MEIS2 Meis homeobox 2 0.0146924
UTRN utrophin 0.0146434
MYH9 myosin, heavy chain 9, non-muscle 0.0145044
SH3PXD2A SH3 and PX domains 2A 0.0142065
RNF43 ring finger protein 43 0.0141966
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0141635
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0141453
SAMD9 sterile alpha motif domain containing 9 0.0140219
RNF213 ring finger protein 213 0.0139454
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0138872
MX2 MX dynamin-like GTPase 2 0.0137882
FOXP1 forkhead box P1 0.013768
EHBP1 EH domain binding protein 1 0.0136089
CD46 CD46 molecule, complement regulatory protein 0.0135399
IFNGR1 interferon gamma receptor 1 0.0132902
RIGI RNA sensor RIG-I 0.0132216
YAP1 Yes-associated protein 1 0.0130827
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0130311
PRKCA protein kinase C, alpha 0.0130003
BICRAL BICRA like chromatin remodeling complex associated protein 0.0129884
CARD16 caspase recruitment domain family, member 16 0.0128957
ALCAM activated leukocyte cell adhesion molecule 0.0127453
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0122888
MAP2K6 mitogen-activated protein kinase kinase 6 0.012226
CYRIB CYFIP related Rac1 interactor B 0.0122096
C6ORF132 chromosome 6 open reading frame 132 0.0121715
SPATA6L spermatogenesis associated 6-like 0.0121663
ADAM10 ADAM metallopeptidase domain 10 0.0121576
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0121215
TBC1D22A TBC1 domain family, member 22A 0.0120096
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0119104
NKD1 naked cuticle homolog 1 (Drosophila) 0.0118897
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0118825
SPIDR scaffolding protein involved in DNA repair 0.0118528
METTL15 methyltransferase like 15 0.0117511
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.01174
ERBIN erbb2 interacting protein 0.0116974
PTGR1 prostaglandin reductase 1 0.0116409
PRSS3 protease, serine, 3 0.011556
APP amyloid beta (A4) precursor protein 0.0114214
BCL2L1 BCL2-like 1 0.0114149
XPO1 exportin 1 0.0114
TRIM22 tripartite motif containing 22 0.0113931
LYZ lysozyme 0.0113814
ANXA4 annexin A4 0.0112853
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0112744
IGF1R insulin-like growth factor 1 receptor 0.0112463
CD2AP CD2-associated protein 0.0112354
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0109534
MICU2 mitochondrial calcium uptake 2 0.0107262
CAB39 calcium binding protein 39 0.0106777
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0106393
ATXN1 ataxin 1 0.010607

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.101894
TPT1 tumor protein, translationally-controlled 1 -0.0991974
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0930931
LMO7 LIM domain 7 -0.0751687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0656051
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0626498
EGR1 early growth response 1 -0.0579534
ANXA2 annexin A2 -0.0535732
EZR ezrin -0.0510334
LCN2 lipocalin 2 -0.0509817
NDRG1 N-myc downstream regulated 1 -0.0486106
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0448871
EIF1 eukaryotic translation initiation factor 1 -0.0428268
PTMA prothymosin, alpha -0.0413084
FTL ferritin, light polypeptide -0.0399659
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0390809
MBNL2 muscleblind-like splicing regulator 2 -0.0387819
IRF1 interferon regulatory factor 1 -0.038517
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0382317
SQSTM1 sequestosome 1 -0.0374851
PDIA3 protein disulfide isomerase family A, member 3 -0.0372164
MYO1E myosin IE -0.034711
HLA-B major histocompatibility complex, class I, B -0.0345784
UBC ubiquitin C -0.0344334
AHI1 Abelson helper integration site 1 -0.0337657
RPS6 ribosomal protein S6 -0.033416
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329931
RPL19 ribosomal protein L19 -0.030482
RPL23 ribosomal protein L23 -0.0301597
RPL34 ribosomal protein L34 -0.0299129
RPL35A ribosomal protein L35a -0.0297157
JUN jun proto-oncogene -0.0287476
GOLGB1 golgin B1 -0.0286965
LOC102724023 ES1 protein homolog, mitochondrial -0.0279941
TMSB10 thymosin beta 10 -0.0271746
RPLP1 ribosomal protein, large, P1 -0.0271053
HM13 histocompatibility (minor) 13 -0.0267817
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0255099
SEC31A SEC31 homolog A (S. cerevisiae) -0.0254054
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0253247
CCNL1 cyclin L1 -0.0246609
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0245554
NAMPT nicotinamide phosphoribosyltransferase -0.0245506
UBE2B ubiquitin-conjugating enzyme E2B -0.0244917
CALR calreticulin -0.0244809
UGDH UDP-glucose 6-dehydrogenase -0.0236983
CXCL8 chemokine (C-X-C motif) ligand 8 -0.023106
IFI6 interferon, alpha-inducible protein 6 -0.0226786
RPL11 ribosomal protein L11 -0.0221311
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0220256
S100A10 S100 calcium binding protein A10 -0.021694
CANX calnexin -0.0216903
ANXA1 annexin A1 -0.0216694
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0213779
MORF4L2 mortality factor 4 like 2 -0.0211795
RAB7A RAB7A, member RAS oncogene family -0.0210676
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0206542
RPS8 ribosomal protein S8 -0.0206476
DSTN destrin (actin depolymerizing factor) -0.0205485
HLA-C major histocompatibility complex, class I, C -0.0205255
INTS6 integrator complex subunit 6 -0.0202849
ITPKC inositol-trisphosphate 3-kinase C -0.0200319
RPL37 ribosomal protein L37 -0.0199755
AREG amphiregulin -0.0198498
HLA-A major histocompatibility complex, class I, A -0.0198352
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0197941
PERP PERP, TP53 apoptosis effector -0.0194977
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.019393
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0192999
MCL1 myeloid cell leukemia 1 -0.0192443
DDIT3 DNA-damage-inducible transcript 3 -0.0191957
RPS19 ribosomal protein S19 -0.019052
AGR2 anterior gradient 2 -0.0189863
WDR45B WD repeat domain 45B -0.0188977
TMC5 transmembrane channel-like 5 -0.0185994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0185583
SEC24D SEC24 family member D -0.0185216
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0184692
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0184141
FTH1 ferritin, heavy polypeptide 1 -0.0183393
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0183369
RPS27 ribosomal protein S27 -0.0182916
ACBD3 acyl-CoA binding domain containing 3 -0.0179915
IFI27 interferon, alpha-inducible protein 27 -0.0179075
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0177774
PDIA4 protein disulfide isomerase family A, member 4 -0.0177161
DSCAM Down syndrome cell adhesion molecule -0.0177071
TPI1 triosephosphate isomerase 1 -0.0175683
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0175484
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0174347
GCC2 GRIP and coiled-coil domain containing 2 -0.0174224
ARF4 ADP-ribosylation factor 4 -0.0171297
RAB1A RAB1A, member RAS oncogene family -0.0169131
RPL31 ribosomal protein L31 -0.0168754
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0168715
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0167631
SDC4 syndecan 4 -0.0166944
RPL12 ribosomal protein L12 -0.0165081
BLZF1 basic leucine zipper nuclear factor 1 -0.0163754
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0162932