Betamethasone dipropionate_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TNS3 tensin 3 0.121864
HIPK2 homeodomain interacting protein kinase 2 0.104203
COL6A3 collagen, type VI, alpha 3 0.101131
FNDC3B fibronectin type III domain containing 3B 0.100826
FTH1 ferritin, heavy polypeptide 1 0.0973344
NAMPT nicotinamide phosphoribosyltransferase 0.089085
GLIS3 GLIS family zinc finger 3 0.0807195
LOX lysyl oxidase 0.0786843
RTN4 reticulon 4 0.078516
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0785013
FN1 fibronectin 1 0.0704644
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0681165
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0654094
ERRFI1 ERBB receptor feedback inhibitor 1 0.0647454
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0611156
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0610887
AKAP12 A kinase (PRKA) anchor protein 12 0.0596754
TSC22D3 TSC22 domain family, member 3 0.058485
TXNIP thioredoxin interacting protein 0.058113
MSN moesin 0.057451
FAM13A family with sequence similarity 13, member A 0.0551795
PCNX1 pecanex 1 0.0537223
LAMB1 laminin, beta 1 0.0525929
ANKRD11 ankyrin repeat domain 11 0.0516933
MBNL1 muscleblind-like splicing regulator 1 0.0514119
PHF21A PHD finger protein 21A 0.0500136
TUT4 terminal uridylyl transferase 4 0.0486413
ZMYND8 zinc finger, MYND-type containing 8 0.0481358
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.045622
AVL9 AVL9 homolog (S. cerevisiase) 0.0451658
DNER delta/notch-like EGF repeat containing 0.0448553
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0445746
ANKRD17 ankyrin repeat domain 17 0.0418148
JAK1 Janus kinase 1 0.0407484
SBF2 SET binding factor 2 0.0406339
SOD2 superoxide dismutase 2, mitochondrial 0.0397457
MAML2 mastermind-like 2 (Drosophila) 0.0384042
MT2A metallothionein 2A 0.0380731
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0378314
FKBP5 FK506 binding protein 5 0.0370856
NAV2 neuron navigator 2 0.0365275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0363826
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0351925
HIP1 huntingtin interacting protein 1 0.034467
LPP LIM domain containing preferred translocation partner in lipoma 0.0342914
LDHA lactate dehydrogenase A 0.0340685
USP47 ubiquitin specific peptidase 47 0.0340472
ABLIM3 actin binding LIM protein family, member 3 0.0339675
SLC38A1 solute carrier family 38, member 1 0.0331363
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0330103
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0329053
OGA O-GlcNAcase 0.0327717
SSBP2 single-stranded DNA binding protein 2 0.0326355
SNX13 sorting nexin 13 0.0326033
ZBTB38 zinc finger and BTB domain containing 38 0.0323225
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0319425
SETD5 SET domain containing 5 0.031891
STK17B serine/threonine kinase 17b 0.0315568
SH3RF3 SH3 domain containing ring finger 3 0.0314548
COG5 component of oligomeric golgi complex 5 0.0313246
TMEM87A transmembrane protein 87A 0.0305367
PRELID2 PRELI domain containing 2 0.0304591
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0304353
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0302017
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0300382
ZFHX3 zinc finger homeobox 3 0.0300302
AHNAK AHNAK nucleoprotein 0.0299643
ANKRD28 ankyrin repeat domain 28 0.0295972
TOP1 topoisomerase (DNA) I 0.0291774
CLASP1 cytoplasmic linker associated protein 1 0.0291611
RUNX2 runt-related transcription factor 2 0.0291361
PKM pyruvate kinase, muscle 0.0286149
PDZD2 PDZ domain containing 2 0.0285944
UGP2 UDP-glucose pyrophosphorylase 2 0.0284838
RASA2 RAS p21 protein activator 2 0.0282999
TPM3 tropomyosin 3 0.0280871
MYOF myoferlin 0.0279015
AKAP13 A kinase (PRKA) anchor protein 13 0.0274694
ZFP36L1 ZFP36 ring finger protein-like 1 0.0269753
TNIP1 TNFAIP3 interacting protein 1 0.0269394
ANKRD12 ankyrin repeat domain 12 0.0267087
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0266858
CCNL1 cyclin L1 0.0265995
ALCAM activated leukocyte cell adhesion molecule 0.0265873
TM9SF3 transmembrane 9 superfamily member 3 0.0263388
SPRED1 sprouty-related, EVH1 domain containing 1 0.0262932
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0262189
ANXA2 annexin A2 0.0260709
FOXJ3 forkhead box J3 0.025928
CD109 CD109 molecule 0.0259192
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0256395
NNMT nicotinamide N-methyltransferase 0.0256053
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0255678
RNF220 ring finger protein 220 0.0255131
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0255068
ELL2 elongation factor, RNA polymerase II, 2 0.025388
HSPA8 heat shock 70kDa protein 8 0.0250998
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.024593
BIRC3 baculoviral IAP repeat containing 3 0.0245363
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0244805

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.263824
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.189267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168614
FTL ferritin, light polypeptide -0.159767
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.119955
TMSB10 thymosin beta 10 -0.112459
NALF1 NALCN channel auxiliary factor 1 -0.107861
EXT1 exostosin glycosyltransferase 1 -0.0990339
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0735153
IGFBP5 insulin-like growth factor binding protein 5 -0.072581
PDE4D phosphodiesterase 4D, cAMP-specific -0.05879
PTMA prothymosin, alpha -0.0577491
GRB10 growth factor receptor-bound protein 10 -0.0574978
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0543578
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.052786
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0527813
DST dystonin -0.0496167
ASPH aspartate beta-hydroxylase -0.0492908
HDAC9 histone deacetylase 9 -0.0458895
DTNA dystrobrevin, alpha -0.0447638
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0444959
B2M beta-2-microglobulin -0.0437202
RPLP1 ribosomal protein, large, P1 -0.043292
RPL37A ribosomal protein L37a -0.0418336
RPL35A ribosomal protein L35a -0.0414146
NDRG1 N-myc downstream regulated 1 -0.0407891
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0405664
HLA-B major histocompatibility complex, class I, B -0.0391223
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0378121
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0363655
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0360151
BACE2 beta-site APP-cleaving enzyme 2 -0.0347985
RPS19 ribosomal protein S19 -0.0339611
TENT5A terminal nucleotidyltransferase 5A -0.0338003
MACF1 microtubule-actin crosslinking factor 1 -0.0336985
KYNU kynureninase -0.0334638
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0326212
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0323924
COL5A1 collagen, type V, alpha 1 -0.0323021
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0319157
VIM vimentin -0.0317512
TPT1 tumor protein, translationally-controlled 1 -0.0310247
PRSS23 protease, serine, 23 -0.0299843
RPL28 ribosomal protein L28 -0.0299558
RIGI RNA sensor RIG-I -0.0296286
LYPD6B LY6/PLAUR domain containing 6B -0.0290826
SQSTM1 sequestosome 1 -0.0286134
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0282864
GLCCI1 glucocorticoid induced 1 -0.0280298
STC1 stanniocalcin 1 -0.0280212
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0277482
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0275055
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.027339
OXR1 oxidation resistance 1 -0.0268423
RPS3 ribosomal protein S3 -0.0268242
RPL18 ribosomal protein L18 -0.0262697
RPLP2 ribosomal protein, large, P2 -0.0261123
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0244326
CADM1 cell adhesion molecule 1 -0.0242246
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0237429
FSTL1 follistatin-like 1 -0.0234756
HILPDA hypoxia inducible lipid droplet-associated -0.0234151
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0232206
RPL34 ribosomal protein L34 -0.0231963
RPL27A ribosomal protein L27a -0.0229281
RPS25 ribosomal protein S25 -0.0225595
IFIH1 interferon induced with helicase C domain 1 -0.0223448
PSD3 pleckstrin and Sec7 domain containing 3 -0.0221996
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0214967
MORF4L2 mortality factor 4 like 2 -0.0213624
SEC61G Sec61 gamma subunit -0.0211902
EIF1 eukaryotic translation initiation factor 1 -0.0211025
IER3 immediate early response 3 -0.0207585
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0207375
SYT1 synaptotagmin I -0.0205887
WSB1 WD repeat and SOCS box containing 1 -0.0205756
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0204231
RPL36 ribosomal protein L36 -0.0203429
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0202944
RPL37 ribosomal protein L37 -0.0201606
INTS6 integrator complex subunit 6 -0.0201154
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0200937
GNAS GNAS complex locus -0.0198828
ANTXR2 anthrax toxin receptor 2 -0.0196036
JUN jun proto-oncogene -0.0194973
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0192946
MRPS6 mitochondrial ribosomal protein S6 -0.0190633
PTCHD4 patched domain containing 4 -0.0189858
RUNX1 runt-related transcription factor 1 -0.0189783
RPS8 ribosomal protein S8 -0.018949
ZNF804A zinc finger protein 804A -0.0188768
FGFR1 fibroblast growth factor receptor 1 -0.0188081
KCTD16 potassium channel tetramerization domain containing 16 -0.0187404
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.018679
ZNF432 zinc finger protein 432 -0.0186698
FNIP1 folliculin interacting protein 1 -0.0185628
ADM adrenomedullin -0.0184654
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0183384
INHBA inhibin, beta A -0.0182419
AHRR aryl-hydrocarbon receptor repressor -0.0181758