Betamethasone dipropionate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0876834
TXNRD1 thioredoxin reductase 1 0.078561
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0731019
RPS6 ribosomal protein S6 0.0685255
FAT1 FAT atypical cadherin 1 0.0660052
LOC112694756 uncharaterized LOC112694756 0.0652417
GOLGA4 golgin A4 0.058081
KRT18 keratin 18, type I 0.0559476
EIF1 eukaryotic translation initiation factor 1 0.0551975
ENO1 enolase 1, (alpha) 0.0537629
CANX calnexin 0.0509496
ANKRD12 ankyrin repeat domain 12 0.0494938
LDHA lactate dehydrogenase A 0.0487528
TMEM41B transmembrane protein 41B 0.0477146
GPHN gephyrin 0.0475463
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0465223
RPLP1 ribosomal protein, large, P1 0.046282
MKI67 marker of proliferation Ki-67 0.0451635
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0444725
MYH9 myosin, heavy chain 9, non-muscle 0.0442847
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0438819
AKAP9 A kinase (PRKA) anchor protein 9 0.0434848
NF1 neurofibromin 1 0.0432349
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0431597
EEF2 eukaryotic translation elongation factor 2 0.0426445
CSDE1 cold shock domain containing E1, RNA-binding 0.0423645
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0422061
KRT8 keratin 8, type II 0.0419441
SON SON DNA binding protein 0.0408538
ZNF292 zinc finger protein 292 0.0405609
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0403191
SET SET nuclear proto-oncogene 0.0395294
SHROOM3 shroom family member 3 0.0388616
SEC31A SEC31 homolog A (S. cerevisiae) 0.0386843
SEPTIN7 septin 7 0.0383693
MATR3 matrin 3 0.0383541
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0380826
ILF3 interleukin enhancer binding factor 3, 90kDa 0.037861
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0375819
EPCAM epithelial cell adhesion molecule 0.0373655
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0373514
RPS3 ribosomal protein S3 0.0370167
DSCAM Down syndrome cell adhesion molecule 0.0363554
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0359873
MED13L mediator complex subunit 13-like 0.0358739
UBE3A ubiquitin protein ligase E3A 0.0358476
TRA2B transformer 2 beta homolog (Drosophila) 0.0357531
RPLP0 ribosomal protein, large, P0 0.0352705
ACIN1 apoptotic chromatin condensation inducer 1 0.0352585
TMF1 TATA element modulatory factor 1 0.0351951
NCOR1 nuclear receptor corepressor 1 0.0348289
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0343622
PDIA3 protein disulfide isomerase family A, member 3 0.0338687
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0338495
SSR1 signal sequence receptor, alpha 0.0336051
P4HB prolyl 4-hydroxylase, beta polypeptide 0.033459
PNISR PNN-interacting serine/arginine-rich protein 0.0331764
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0330077
RACK1 receptor for activated C kinase 1 0.0330069
PERP PERP, TP53 apoptosis effector 0.0328989
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0328687
IPO7 importin 7 0.0328031
PCM1 pericentriolar material 1 0.0321841
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0321316
SMC5 structural maintenance of chromosomes 5 0.0317867
OGA O-GlcNAcase 0.0312821
HMGA1 high mobility group AT-hook 1 0.0310416
CEP350 centrosomal protein 350kDa 0.0309777
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0308952
CLTC clathrin, heavy chain (Hc) 0.0306879
THOC2 THO complex 2 0.0303065
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0302094
NSD1 nuclear receptor binding SET domain protein 1 0.0302087
KTN1 kinectin 1 (kinesin receptor) 0.0300538
ANXA2 annexin A2 0.02947
RSRC2 arginine/serine-rich coiled-coil 2 0.0294419
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0294078
PTEN phosphatase and tensin homolog 0.0293232
TENM3 teneurin transmembrane protein 3 0.0290278
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0288796
NIPBL Nipped-B homolog (Drosophila) 0.028583
SCAF11 SR-related CTD-associated factor 11 0.0284638
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0284562
RPL30 ribosomal protein L30 0.0284222
WDR45B WD repeat domain 45B 0.0283927
NSRP1 nuclear speckle splicing regulatory protein 1 0.0283116
CEP95 centrosomal protein 95kDa 0.0281499
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0280667
XPO1 exportin 1 0.028063
SFPQ splicing factor proline/glutamine-rich 0.0280118
PTBP3 polypyrimidine tract binding protein 3 0.0277552
PDS5A PDS5 cohesin associated factor A 0.0273669
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0273241
CTNND1 catenin (cadherin-associated protein), delta 1 0.0273111
FAF1 Fas (TNFRSF6) associated factor 1 0.0272487
GCC2 GRIP and coiled-coil domain containing 2 0.0272294
ZFR zinc finger RNA binding protein 0.0271894
CSNK1A1 casein kinase 1, alpha 1 0.0271543
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0268102
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0268059

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.090669
INTS6 integrator complex subunit 6 -0.0510241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0494116
CTBP2 C-terminal binding protein 2 -0.0432048
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0388111
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0331
SCARB1 scavenger receptor class B, member 1 -0.0312091
SPDYA speedy/RINGO cell cycle regulator family member A -0.0293992
ENO2 enolase 2 (gamma, neuronal) -0.028783
FUS FUS RNA binding protein -0.0287116
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0279434
ANGPTL4 angiopoietin-like 4 -0.0275215
EGFR epidermal growth factor receptor -0.027212
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0271031
RPL37A ribosomal protein L37a -0.0256704
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0243116
MCL1 myeloid cell leukemia 1 -0.0242975
PTPRK protein tyrosine phosphatase, receptor type, K -0.0236146
RIGI RNA sensor RIG-I -0.023426
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0232116
LRRC23 leucine rich repeat containing 23 -0.0230704
WWC2 WW and C2 domain containing 2 -0.0229204
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0227518
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0223078
KLHL29 kelch-like family member 29 -0.0222162
PTMA prothymosin, alpha -0.0220434
NABP1 nucleic acid binding protein 1 -0.0218277
TTC3 tetratricopeptide repeat domain 3 -0.0213296
DIAPH2 diaphanous-related formin 2 -0.0209551
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0206464
MRPS6 mitochondrial ribosomal protein S6 -0.0205492
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0203084
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0200075
ABLIM1 actin binding LIM protein 1 -0.0197523
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0195614
WWOX WW domain containing oxidoreductase -0.0194153
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0192002
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0190619
CHSY1 chondroitin sulfate synthase 1 -0.0185751
ADAM20 ADAM metallopeptidase domain 20 -0.0184801
SERINC5 serine incorporator 5 -0.0180454
SNX14 sorting nexin 14 -0.0180171
PCNT pericentrin -0.0179289
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0178392
ARF4 ADP-ribosylation factor 4 -0.0177384
CELF2 CUGBP, Elav-like family member 2 -0.0177215
LMO7 LIM domain 7 -0.0177017
FBXL2 F-box and leucine-rich repeat protein 2 -0.0176072
FOXO3 forkhead box O3 -0.0176024
FNDC3B fibronectin type III domain containing 3B -0.0174128
RALY RALY heterogeneous nuclear ribonucleoprotein -0.017356
ATM ATM serine/threonine kinase -0.0173294
PLAUR plasminogen activator, urokinase receptor -0.0173037
SPATS2 spermatogenesis associated, serine-rich 2 -0.017294
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0171408
DENND4C DENN/MADD domain containing 4C -0.0169188
ASXL1 additional sex combs like transcriptional regulator 1 -0.0166863
TASOR transcription activation suppressor -0.0166317
HPCAL1 hippocalcin-like 1 -0.0165876
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0164264
ASXL2 additional sex combs like transcriptional regulator 2 -0.0163645
TMEM263 transmembrane protein 263 -0.0162971
PARD3B par-3 family cell polarity regulator beta -0.0162416
WSB1 WD repeat and SOCS box containing 1 -0.0162318
COMMD10 COMM domain containing 10 -0.0160992
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0159472
CCNYL1 cyclin Y-like 1 -0.0159289
PAQR5 progestin and adipoQ receptor family member V -0.0156164
ESYT2 extended synaptotagmin-like protein 2 -0.015541
MAP7 microtubule-associated protein 7 -0.0155322
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0154558
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0154388
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0154234
SKP1 S-phase kinase-associated protein 1 -0.0153694
POLN polymerase (DNA directed) nu -0.0153304
EIF4A3 eukaryotic translation initiation factor 4A3 -0.0152175
HDAC4 histone deacetylase 4 -0.0151927
FUBP3 far upstream element (FUSE) binding protein 3 -0.0151789
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0150868
CFAP44 cilia and flagella associated protein 44 -0.0150598
FAM193A family with sequence similarity 193, member A -0.0149977
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0148418
GLS2 glutaminase 2 (liver, mitochondrial) -0.0148286
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0147793
CEMIP2 cell migration inducing hyaluronidase 2 -0.0146194
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0145618
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.01456
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0144894
MYOF myoferlin -0.0144548
NXF1 nuclear RNA export factor 1 -0.0144326
SKI SKI proto-oncogene -0.0142771
WDR13 WD repeat domain 13 -0.0139543
TUT7 terminal uridylyl transferase 7 -0.0139355
SEC24A SEC24 family member A -0.0139174
PDE4D phosphodiesterase 4D, cAMP-specific -0.0137672
TMC6 transmembrane channel-like 6 -0.0137611
RCC1 regulator of chromosome condensation 1 -0.0137218
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0136918
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0136589
RPS24 ribosomal protein S24 -0.0135667