Betamethasone dipropionate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT6A keratin 6A, type II 0.109039
FKBP5 FK506 binding protein 5 0.0902122
HMGA2 high mobility group AT-hook 2 0.0736604
MT2A metallothionein 2A 0.0709896
TXNIP thioredoxin interacting protein 0.0670572
POTEF POTE ankyrin domain family, member F 0.0620421
ITGB4 integrin, beta 4 0.0553211
EFNA5 ephrin-A5 0.0530744
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0498869
NIBAN2 niban apoptosis regulator 2 0.0455672
LAMB1 laminin, beta 1 0.0450278
IRS2 insulin receptor substrate 2 0.0449453
CAPRIN2 caprin family member 2 0.0426065
ABLIM3 actin binding LIM protein family, member 3 0.0415984
BCL2L1 BCL2-like 1 0.03939
AHNAK AHNAK nucleoprotein 0.0380155
AKAP13 A kinase (PRKA) anchor protein 13 0.0354491
ABLIM2 actin binding LIM protein family, member 2 0.0354397
ZMYND8 zinc finger, MYND-type containing 8 0.0354141
NAV2 neuron navigator 2 0.0353281
DOCK5 dedicator of cytokinesis 5 0.0351466
BIRC3 baculoviral IAP repeat containing 3 0.0347216
PLXNA2 plexin A2 0.03459
VCL vinculin 0.0324789
THSD4 thrombospondin, type I, domain containing 4 0.0307746
TNS4 tensin 4 0.0305856
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0298142
ZHX3 zinc fingers and homeoboxes 3 0.0283325
BCAR3 breast cancer anti-estrogen resistance 3 0.0275563
ZFHX3 zinc finger homeobox 3 0.0267871
MSN moesin 0.0262669
PLEC plectin 0.0252305
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0245467
CLMB calcimembrin 0.0243387
MCL1 myeloid cell leukemia 1 0.0242979
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0240192
TPM4 tropomyosin 4 0.0229451
GLUL glutamate-ammonia ligase 0.022832
TNS3 tensin 3 0.0225042
OSMR oncostatin M receptor 0.0223437
NRCAM neuronal cell adhesion molecule 0.0218965
SASH1 SAM and SH3 domain containing 1 0.0217105
DOCK9 dedicator of cytokinesis 9 0.0212528
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0207658
ALCAM activated leukocyte cell adhesion molecule 0.0204753
UTRN utrophin 0.0204726
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.020116
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0198924
LUZP1 leucine zipper protein 1 0.0198685
INTS6 integrator complex subunit 6 0.0197642
HSPA8 heat shock 70kDa protein 8 0.0196812
EGR1 early growth response 1 0.019299
TBC1D2 TBC1 domain family, member 2 0.019198
RASAL2 RAS protein activator like 2 0.0189856
LAMA5 laminin, alpha 5 0.0187976
DNAH5 dynein, axonemal, heavy chain 5 0.0185722
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0182667
ZC3H12C zinc finger CCCH-type containing 12C 0.0181987
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.01819
MLKL mixed lineage kinase domain-like 0.0181509
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0180064
JPH2 junctophilin 2 0.0178476
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0177968
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0175119
AFAP1L1 actin filament associated protein 1-like 1 0.0172915
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0172628
RIPOR2 RHO family interacting cell polarization regulator 2 0.0172072
BCL9L B-cell CLL/lymphoma 9-like 0.0171743
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0168486
RPL3 ribosomal protein L3 0.0167181
SETX senataxin 0.0165487
KLF9 Kruppel-like factor 9 0.0163165
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0162708
FRMD4B FERM domain containing 4B 0.0162357
SACK1A scaffolding CK1 anchoring protein A 0.0162223
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0161747
MOSMO modulator of smoothened 0.0161007
TEK TEK tyrosine kinase, endothelial 0.0160421
FTH1 ferritin, heavy polypeptide 1 0.0159197
HIPK2 homeodomain interacting protein kinase 2 0.0158899
CLMP CXADR-like membrane protein 0.0158794
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.015828
SKI SKI proto-oncogene 0.0156916
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.015621
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0156108
NPC1 Niemann-Pick disease, type C1 0.0155941
ADRB2 adrenoceptor beta 2, surface 0.0155501
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0154064
FMNL2 formin-like 2 0.0153631
RNF217 ring finger protein 217 0.0151743
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.014673
LAMC2 laminin, gamma 2 0.0145614
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.0144845
TSC22D1 TSC22 domain family, member 1 0.0144768
ITGA10 integrin, alpha 10 0.0144571
CALB1 calbindin 1, 28kDa 0.0143171
THBS1 thrombospondin 1 0.0140655
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0134909
S100P S100 calcium binding protein P 0.0134907
MYH9 myosin, heavy chain 9, non-muscle 0.0134385

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216272
TIMP3 TIMP metallopeptidase inhibitor 3 -0.106545
B2M beta-2-microglobulin -0.100079
S100A10 S100 calcium binding protein A10 -0.0845295
CLU clusterin -0.0829784
TPT1 tumor protein, translationally-controlled 1 -0.0828183
NDRG1 N-myc downstream regulated 1 -0.077889
CD44 CD44 molecule (Indian blood group) -0.0750849
RPS21 ribosomal protein S21 -0.0722124
PTMA prothymosin, alpha -0.0710363
ANXA1 annexin A1 -0.0678566
ITGA6 integrin, alpha 6 -0.0656694
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0605446
PGK1 phosphoglycerate kinase 1 -0.0604315
MEF2A myocyte enhancer factor 2A -0.0598957
HLA-B major histocompatibility complex, class I, B -0.0585266
EMP1 epithelial membrane protein 1 -0.0578842
RPS6 ribosomal protein S6 -0.0533126
STC1 stanniocalcin 1 -0.0523277
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0520324
RPLP2 ribosomal protein, large, P2 -0.0519176
GNAS GNAS complex locus -0.0517578
RPS8 ribosomal protein S8 -0.0506433
RPS24 ribosomal protein S24 -0.050076
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0489109
RPS13 ribosomal protein S13 -0.0487617
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0485994
LMNA lamin A/C -0.0436593
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0432706
UBC ubiquitin C -0.0428964
IFITM1 interferon induced transmembrane protein 1 -0.0423382
ESYT2 extended synaptotagmin-like protein 2 -0.0413541
TMSB4X thymosin beta 4, X-linked -0.0410896
IFITM3 interferon induced transmembrane protein 3 -0.0409097
RPS25 ribosomal protein S25 -0.0395504
MYOF myoferlin -0.039356
FTL ferritin, light polypeptide -0.0389968
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0385297
LDHA lactate dehydrogenase A -0.0383295
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0380241
RPL11 ribosomal protein L11 -0.0378795
RPS23 ribosomal protein S23 -0.0373446
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0366689
KMT2E lysine (K)-specific methyltransferase 2E -0.0366215
RBM39 RNA binding motif protein 39 -0.0365397
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0353069
MBNL2 muscleblind-like splicing regulator 2 -0.0349432
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0349331
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0340892
IFI6 interferon, alpha-inducible protein 6 -0.0340478
KIAA1217 KIAA1217 -0.0337904
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333794
RPL8 ribosomal protein L8 -0.0332959
GOLGA4 golgin A4 -0.0331313
SPAG9 sperm associated antigen 9 -0.0328412
MARCHF6 membrane associated ring-CH-type finger 6 -0.0327616
OGA O-GlcNAcase -0.0325809
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0324737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0323765
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0322735
RPLP1 ribosomal protein, large, P1 -0.0320063
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0319278
FNDC3B fibronectin type III domain containing 3B -0.0317748
MORF4L2 mortality factor 4 like 2 -0.0316868
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0310395
RPL34 ribosomal protein L34 -0.0309716
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0306537
S100A6 S100 calcium binding protein A6 -0.0304579
MDK midkine (neurite growth-promoting factor 2) -0.0304022
RPL23 ribosomal protein L23 -0.0303952
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0302424
RPL12 ribosomal protein L12 -0.030084
RPL32 ribosomal protein L32 -0.030064
KDM6A lysine (K)-specific demethylase 6A -0.0298172
DSTN destrin (actin depolymerizing factor) -0.0295348
S100A9 S100 calcium binding protein A9 -0.0295037
RPL19 ribosomal protein L19 -0.029392
RPL27A ribosomal protein L27a -0.0293758
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0292829
EXT1 exostosin glycosyltransferase 1 -0.029078
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0284813
RPL35A ribosomal protein L35a -0.0277217
IFI27 interferon, alpha-inducible protein 27 -0.0275348
RPL31 ribosomal protein L31 -0.027334
RAB1A RAB1A, member RAS oncogene family -0.027257
RPS11 ribosomal protein S11 -0.0270794
CD99 CD99 molecule -0.0270632
RLF rearranged L-myc fusion -0.0270295
TRA2A transformer 2 alpha homolog (Drosophila) -0.0267937
JMJD1C jumonji domain containing 1C -0.0267483
COPB1 coatomer protein complex, subunit beta 1 -0.0266472
CAV1 caveolin 1, caveolae protein, 22kDa -0.0264498
SUCO SUN domain containing ossification factor -0.0263588
KDM3A lysine (K)-specific demethylase 3A -0.0263289
SEC31A SEC31 homolog A (S. cerevisiae) -0.0260761
S100A11 S100 calcium binding protein A11 -0.0260716
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0260318
NAP1L1 nucleosome assembly protein 1-like 1 -0.0257467
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0256778
GLG1 golgi glycoprotein 1 -0.0256735