Betamethasone dipropionate_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0837065
PPME1 protein phosphatase methylesterase 1 0.0421895
SLC12A8 solute carrier family 12, member 8 0.0409762
SET SET nuclear proto-oncogene 0.0292594
SAA2 serum amyloid A2 0.0255867
MYH9 myosin, heavy chain 9, non-muscle 0.0247919
HMGB2 high mobility group box 2 0.0221417
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0221096
CCBE1 collagen and calcium binding EGF domains 1 0.0220407
ZEB2 zinc finger E-box binding homeobox 2 0.0204832
MT2A metallothionein 2A 0.0199919
FTH1 ferritin, heavy polypeptide 1 0.0199146
RUNX2 runt-related transcription factor 2 0.0184824
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.018234
TENM3 teneurin transmembrane protein 3 0.0181473
POTEF POTE ankyrin domain family, member F 0.0180777
NCOR2 nuclear receptor corepressor 2 0.0179925
CEP250 centrosomal protein 250kDa 0.0173954
ZMYND8 zinc finger, MYND-type containing 8 0.0173442
GMPS guanine monphosphate synthase 0.0168566
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016623
RBM26 RNA binding motif protein 26 0.0162442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0157221
COL5A1 collagen, type V, alpha 1 0.015673
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0152899
CTIF CBP80/20-dependent translation initiation factor 0.0150466
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0142983
FN1 fibronectin 1 0.014029
PTPRM protein tyrosine phosphatase, receptor type, M 0.0140148
MMP12 matrix metallopeptidase 12 0.0138805
FLNA filamin A, alpha 0.0138235
ANKRD36 ankyrin repeat domain 36 0.0137282
WWOX WW domain containing oxidoreductase 0.0134415
RBMS1 RNA binding motif, single stranded interacting protein 1 0.013382
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0132543
ABLIM3 actin binding LIM protein family, member 3 0.0132072
ECPAS Ecm29 proteasome adaptor and scaffold 0.0128537
HIPK2 homeodomain interacting protein kinase 2 0.0127077
PLPP3 phospholipid phosphatase 3 0.0126417
BCL2L1 BCL2-like 1 0.0125305
SFPQ splicing factor proline/glutamine-rich 0.0123922
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0121876
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.012173
TGFB2 transforming growth factor, beta 2 0.0121524
NAP1L1 nucleosome assembly protein 1-like 1 0.0117565
EGFR epidermal growth factor receptor 0.0116359
PCLO piccolo presynaptic cytomatrix protein 0.0114444
RAD51B RAD51 paralog B 0.0114321
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0113177
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0113057
DSCAM Down syndrome cell adhesion molecule 0.0112893
PHRF1 PHD and ring finger domains 1 0.010987
TPM3 tropomyosin 3 0.0109362
PRRC2A proline-rich coiled-coil 2A 0.0106949
DST dystonin 0.0105888
USP9X ubiquitin specific peptidase 9, X-linked 0.0104322
HLA-C major histocompatibility complex, class I, C 0.0103284
SRRM2 serine/arginine repetitive matrix 2 0.0102906
COL27A1 collagen, type XXVII, alpha 1 0.0102418
RPL29 ribosomal protein L29 0.010159
HELLS helicase, lymphoid-specific 0.0101121
PRELID2 PRELI domain containing 2 0.0101058
C2CD3 C2 calcium-dependent domain containing 3 0.00998505
BRD4 bromodomain containing 4 0.00989073
NASP nuclear autoantigenic sperm protein (histone-binding) 0.00982561
PABPN1 poly(A) binding protein, nuclear 1 0.00981563
SAA2-SAA4 SAA2-SAA4 readthrough 0.00974004
VEGFA vascular endothelial growth factor A 0.00972795
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 0.00970194
EFNA5 ephrin-A5 0.00967237
KRT8 keratin 8, type II 0.00953946
NEBL nebulette 0.00953102
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.00950957
ANGPTL4 angiopoietin-like 4 0.00950509
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.00949903
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.00945878
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00945462
CENPF centromere protein F, 350/400kDa 0.00939027
PNN pinin, desmosome associated protein 0.00928681
CEP192 centrosomal protein 192kDa 0.00924086
RABGAP1 RAB GTPase activating protein 1 0.00921454
RGS7 regulator of G-protein signaling 7 0.00916524
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00908923
YEATS2 YEATS domain containing 2 0.00908467
RBBP6 retinoblastoma binding protein 6 0.00899878
ICE1 interactor of little elongation complex ELL subunit 1 0.00899826
PANX1 pannexin 1 0.00899342
WDR75 WD repeat domain 75 0.00897879
INVS inversin 0.00894273
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00885687
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.00881977
ZNF462 zinc finger protein 462 0.00880255
UBE3C ubiquitin protein ligase E3C 0.00879938
PCBP3 poly(rC) binding protein 3 0.00875678
SSRP1 structure specific recognition protein 1 0.00862378
TRA2B transformer 2 beta homolog (Drosophila) 0.00860715
PDS5A PDS5 cohesin associated factor A 0.00859159
NRCAM neuronal cell adhesion molecule 0.00855755
TNRC6A trinucleotide repeat containing 6A 0.00852723
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00847716

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.241551
FTL ferritin, light polypeptide -0.138809
IGFBP3 insulin-like growth factor binding protein 3 -0.128284
HLA-B major histocompatibility complex, class I, B -0.127186
EXT1 exostosin glycosyltransferase 1 -0.115048
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0865628
CD44 CD44 molecule (Indian blood group) -0.0849851
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0770003
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.071313
ANXA2 annexin A2 -0.0682971
NDRG1 N-myc downstream regulated 1 -0.0675228
NALF1 NALCN channel auxiliary factor 1 -0.0671887
VIM vimentin -0.0623973
ABI3BP ABI family, member 3 (NESH) binding protein -0.0581889
B2M beta-2-microglobulin -0.0555309
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0535652
TPT1 tumor protein, translationally-controlled 1 -0.0507206
F3 coagulation factor III (thromboplastin, tissue factor) -0.0506017
ERBIN erbb2 interacting protein -0.0475214
PDIA3 protein disulfide isomerase family A, member 3 -0.0474826
HLA-A major histocompatibility complex, class I, A -0.047303
CANX calnexin -0.0463767
TRIO trio Rho guanine nucleotide exchange factor -0.0433099
TMSB10 thymosin beta 10 -0.0430486
PGK1 phosphoglycerate kinase 1 -0.0405143
CALR calreticulin -0.0405111
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0393863
DLG1 discs, large homolog 1 (Drosophila) -0.0368978
RAI14 retinoic acid induced 14 -0.0362681
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0355619
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0353349
UBC ubiquitin C -0.0351791
ENO1 enolase 1, (alpha) -0.0349472
P4HB prolyl 4-hydroxylase, beta polypeptide -0.034244
PHACTR1 phosphatase and actin regulator 1 -0.0337837
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0334587
ADM adrenomedullin -0.0326955
IFI6 interferon, alpha-inducible protein 6 -0.0316255
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0314811
RAP1B RAP1B, member of RAS oncogene family -0.0314745
RPL35A ribosomal protein L35a -0.0310275
ACTG1 actin gamma 1 -0.0309436
GOLGA4 golgin A4 -0.0308159
SOD2 superoxide dismutase 2, mitochondrial -0.030371
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0301872
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0300707
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0297421
IL6ST interleukin 6 signal transducer -0.029579
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0295513
PICALM phosphatidylinositol binding clathrin assembly protein -0.0293179
CAVIN1 caveolae associated protein 1 -0.028993
HLA-E major histocompatibility complex, class I, E -0.0288325
RPS6 ribosomal protein S6 -0.0284367
ANXA1 annexin A1 -0.0284146
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0281694
RND3 Rho family GTPase 3 -0.0280816
CCND1 cyclin D1 -0.0279781
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0275601
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0273959
IGFBP5 insulin-like growth factor binding protein 5 -0.0273002
MAP1B microtubule-associated protein 1B -0.0271335
CLIC4 chloride intracellular channel 4 -0.0266471
STAU1 staufen double-stranded RNA binding protein 1 -0.0265589
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0263914
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0261217
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0259066
S100A6 S100 calcium binding protein A6 -0.0256664
RPL12 ribosomal protein L12 -0.0256106
GNAS GNAS complex locus -0.0254439
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0250579
TMSB4X thymosin beta 4, X-linked -0.024868
NOP58 NOP58 ribonucleoprotein -0.0242357
EIF1 eukaryotic translation initiation factor 1 -0.0241332
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.024078
DEK DEK proto-oncogene -0.0238596
S100A10 S100 calcium binding protein A10 -0.0237564
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0234861
POSTN periostin, osteoblast specific factor -0.0232317
JUN jun proto-oncogene -0.0231954
LOX lysyl oxidase -0.0228172
IFITM1 interferon induced transmembrane protein 1 -0.0226735
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0226575
ATP13A3 ATPase type 13A3 -0.0226374
VDAC1 voltage-dependent anion channel 1 -0.0226043
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0224685
PRRC2C proline-rich coiled-coil 2C -0.0224497
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0223366
PTK2 protein tyrosine kinase 2 -0.0221674
BZW1 basic leucine zipper and W2 domains 1 -0.0221123
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220721
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0219324
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0218502
RPLP2 ribosomal protein, large, P2 -0.0214931
TPM4 tropomyosin 4 -0.0212725
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0211206
UGCG UDP-glucose ceramide glucosyltransferase -0.0209731
STK4 serine/threonine kinase 4 -0.0209655
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0208509
ELL2 elongation factor, RNA polymerase II, 2 -0.0208388
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0205708