Betamethasone dipropionate_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.0874125
NPSR1 neuropeptide S receptor 1 0.0870429
VEGFA vascular endothelial growth factor A 0.0569826
POTEF POTE ankyrin domain family, member F 0.0513781
CEMIP cell migration inducing protein, hyaluronan binding 0.0472644
MAML2 mastermind-like 2 (Drosophila) 0.0451282
FTH1 ferritin, heavy polypeptide 1 0.0383395
FAT1 FAT atypical cadherin 1 0.0364906
MYH9 myosin, heavy chain 9, non-muscle 0.0337193
ITGB4 integrin, beta 4 0.0312603
SET SET nuclear proto-oncogene 0.0297252
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0293315
EHBP1 EH domain binding protein 1 0.0277639
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0276696
NCOR2 nuclear receptor corepressor 2 0.0261574
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0253324
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0249585
HYOU1 hypoxia up-regulated 1 0.0240624
ANO1 anoctamin 1, calcium activated chloride channel 0.0237004
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.023271
SLK STE20-like kinase 0.0232087
RPS7 ribosomal protein S7 0.0215234
HSPA8 heat shock 70kDa protein 8 0.0211499
GOLGA4 golgin A4 0.0203543
HMGB2 high mobility group box 2 0.0202653
CD46 CD46 molecule, complement regulatory protein 0.019555
FLNB filamin B, beta 0.0192519
ENO1 enolase 1, (alpha) 0.0190043
NFE2L1 nuclear factor, erythroid 2-like 1 0.0188628
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0184247
EIF4H eukaryotic translation initiation factor 4H 0.0174558
RPL3 ribosomal protein L3 0.0174291
AUTS2 autism susceptibility candidate 2 0.0170325
RPS18 ribosomal protein S18 0.0152078
SSR1 signal sequence receptor, alpha 0.0145804
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0145241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0144423
KRT18 keratin 18, type I 0.0143754
ASPH aspartate beta-hydroxylase 0.014078
YBX1 Y box binding protein 1 0.0134556
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0133309
GTF2I general transcription factor IIi 0.0133249
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0131874
SMC1A structural maintenance of chromosomes 1A 0.0131819
TPM3 tropomyosin 3 0.0130809
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0128685
EIF4B eukaryotic translation initiation factor 4B 0.0127409
KIF16B kinesin family member 16B 0.0127049
NEK6 NIMA-related kinase 6 0.0125904
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0125139
ANXA3 annexin A3 0.0125001
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0124975
RNF43 ring finger protein 43 0.0123399
TSC22D1 TSC22 domain family, member 1 0.0122952
TNIK TRAF2 and NCK interacting kinase 0.0122696
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0121818
KLHL29 kelch-like family member 29 0.0120913
DSPP dentin sialophosphoprotein 0.0120895
ARHGAP6 Rho GTPase activating protein 6 0.0119282
MYO5B myosin VB 0.0119101
MKI67 marker of proliferation Ki-67 0.0117893
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0117348
MYO18A myosin XVIIIA 0.0116551
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.0115319
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0114143
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.011384
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0112618
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0111957
ESYT2 extended synaptotagmin-like protein 2 0.0110413
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0110068
ZCCHC7 zinc finger, CCHC domain containing 7 0.0107026
EGFR epidermal growth factor receptor 0.0106814
CXCL5 chemokine (C-X-C motif) ligand 5 0.0105689
FAM120A family with sequence similarity 120A 0.010549
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0105435
FAM13A family with sequence similarity 13, member A 0.0104726
AHNAK2 AHNAK nucleoprotein 2 0.0104558
CTSE cathepsin E 0.0104444
TMF1 TATA element modulatory factor 1 0.0102648
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.010212
SRRM2 serine/arginine repetitive matrix 2 0.0102108
RBM26 RNA binding motif protein 26 0.0101611
XYLT1 xylosyltransferase I 0.0101048
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.00991208
NUDCD3 NudC domain containing 3 0.00988622
PRDM16 PR domain containing 16 0.00985511
EGLN3 egl-9 family hypoxia-inducible factor 3 0.00981297
LAMA5 laminin, alpha 5 0.00981047
SCFD1 sec1 family domain containing 1 0.00976953
SAMD12 sterile alpha motif domain containing 12 0.00968221
MGAM2 maltase-glucoamylase 2 (putative) 0.00968039
ADAP1 ArfGAP with dual PH domains 1 0.00962912
RPS3 ribosomal protein S3 0.00962378
MSI2 musashi RNA-binding protein 2 0.00957235
DYNC2I1 dynein 2 intermediate chain 1 0.00956895
FNBP4 formin binding protein 4 0.00956191
CNOT1 CCR4-NOT transcription complex, subunit 1 0.00953629
ADD3 adducin 3 (gamma) 0.00952709
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.00952626
SHB Src homology 2 domain containing adaptor protein B 0.00952384

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228401
TMSB10 thymosin beta 10 -0.154713
TPT1 tumor protein, translationally-controlled 1 -0.12218
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.109624
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107368
S100A10 S100 calcium binding protein A10 -0.0914915
EIF1 eukaryotic translation initiation factor 1 -0.082107
EMP1 epithelial membrane protein 1 -0.0778373
RPS21 ribosomal protein S21 -0.0744305
PTMA prothymosin, alpha -0.0743906
RPL35A ribosomal protein L35a -0.0710352
RPL23 ribosomal protein L23 -0.0702894
S100A9 S100 calcium binding protein A9 -0.0702892
B2M beta-2-microglobulin -0.0669968
RPS19 ribosomal protein S19 -0.0643625
IFI27 interferon, alpha-inducible protein 27 -0.0564039
RPS25 ribosomal protein S25 -0.0555404
RPS24 ribosomal protein S24 -0.0510386
ANXA2 annexin A2 -0.0486089
HLA-E major histocompatibility complex, class I, E -0.04721
TM4SF1 transmembrane 4 L six family member 1 -0.0467485
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0467305
ACTG1 actin gamma 1 -0.0464843
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0461497
AREG amphiregulin -0.0450561
RPL28 ribosomal protein L28 -0.0446021
RPL19 ribosomal protein L19 -0.0438912
RPLP1 ribosomal protein, large, P1 -0.0433222
FTL ferritin, light polypeptide -0.0430422
RPS6 ribosomal protein S6 -0.0425862
RPL8 ribosomal protein L8 -0.0413511
RPS11 ribosomal protein S11 -0.0411452
RAB1A RAB1A, member RAS oncogene family -0.0410612
PDIA4 protein disulfide isomerase family A, member 4 -0.0410033
ACTN4 actinin, alpha 4 -0.041
CALR calreticulin -0.0395012
H3-3B H3.3 histone B -0.0394874
HLA-B major histocompatibility complex, class I, B -0.0391605
AGR2 anterior gradient 2 -0.0389708
IFI6 interferon, alpha-inducible protein 6 -0.0389443
RPL32 ribosomal protein L32 -0.0382606
RPL38 ribosomal protein L38 -0.0382565
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0379915
ATF5 activating transcription factor 5 -0.0375405
RPS8 ribosomal protein S8 -0.0370565
LOC102724023 ES1 protein homolog, mitochondrial -0.0366965
RPL36A ribosomal protein L36a -0.0364126
RPLP2 ribosomal protein, large, P2 -0.0362829
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0357137
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0356943
RPL34 ribosomal protein L34 -0.0346588
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0344995
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0342814
EPCAM epithelial cell adhesion molecule -0.0338266
TMEM123 transmembrane protein 123 -0.0326632
HLA-A major histocompatibility complex, class I, A -0.0325473
RRBP1 ribosome binding protein 1 -0.0324408
UBE2H ubiquitin-conjugating enzyme E2H -0.0322901
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0318481
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0317874
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0316554
UBC ubiquitin C -0.0315983
TXNRD1 thioredoxin reductase 1 -0.0315068
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0308578
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0306103
RAB7A RAB7A, member RAS oncogene family -0.0305524
ASTN2 astrotactin 2 -0.030515
RPS23 ribosomal protein S23 -0.0300127
RPS29 ribosomal protein S29 -0.029726
MYL12B myosin, light chain 12B, regulatory -0.0295876
SLC38A2 solute carrier family 38, member 2 -0.0294496
MYOF myoferlin -0.0292884
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0291023
RPS16 ribosomal protein S16 -0.0288671
RPL12 ribosomal protein L12 -0.0287827
RPS15 ribosomal protein S15 -0.0276771
TJP1 tight junction protein 1 -0.0276224
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0276077
GSTP1 glutathione S-transferase pi 1 -0.0272609
LY6E lymphocyte antigen 6 complex, locus E -0.0270205
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0269856
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.026817
GNAS GNAS complex locus -0.0263018
MDK midkine (neurite growth-promoting factor 2) -0.0260785
NDUFA4 NDUFA4, mitochondrial complex associated -0.026044
RPS27A ribosomal protein S27a -0.0255992
RB1CC1 RB1-inducible coiled-coil 1 -0.0255173
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0254044
KLF6 Kruppel-like factor 6 -0.0253773
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0253589
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0253553
TES testin LIM domain protein -0.0253543
ZC3H12B zinc finger CCCH-type containing 12B -0.0249484
SNX9 sorting nexin 9 -0.0245692
RPLP0 ribosomal protein, large, P0 -0.0245479
GARS1 glycyl-tRNA synthetase 1 -0.0245301
NCOA7 nuclear receptor coactivator 7 -0.0241562
INSIG1 insulin induced gene 1 -0.0241071
IER3 immediate early response 3 -0.0239354
PRRC2C proline-rich coiled-coil 2C -0.0238908