Betamethasone dipropionate_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.122138
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0625758
DTNA dystrobrevin, alpha 0.0479226
EFNA5 ephrin-A5 0.0476778
AKAP12 A kinase (PRKA) anchor protein 12 0.0469437
HMGA2 high mobility group AT-hook 2 0.0331908
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0320333
FKBP5 FK506 binding protein 5 0.0277199
IRS2 insulin receptor substrate 2 0.0255595
HIPK2 homeodomain interacting protein kinase 2 0.0237509
POTEF POTE ankyrin domain family, member F 0.0233131
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0209581
HSPA8 heat shock 70kDa protein 8 0.0206211
FNDC3B fibronectin type III domain containing 3B 0.0203075
AKAP13 A kinase (PRKA) anchor protein 13 0.0185708
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0183573
MYH9 myosin, heavy chain 9, non-muscle 0.0181672
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.017032
MSN moesin 0.0168976
NALF1 NALCN channel auxiliary factor 1 0.016607
MT1E metallothionein 1E 0.0164413
MYOF myoferlin 0.0158656
ASPH aspartate beta-hydroxylase 0.0154882
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0151604
KDM4C lysine (K)-specific demethylase 4C 0.0149834
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0145726
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0144652
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.014425
NAV1 neuron navigator 1 0.0143645
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0142849
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0141459
PRKCE protein kinase C, epsilon 0.0140017
ZMYND8 zinc finger, MYND-type containing 8 0.0137659
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0131143
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0129112
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0127701
JARID2 jumonji, AT rich interactive domain 2 0.0127336
RPL3 ribosomal protein L3 0.012723
NBAS neuroblastoma amplified sequence 0.0123923
MT1X metallothionein 1X 0.0118732
NPAS2 neuronal PAS domain protein 2 0.0115813
PTPRD protein tyrosine phosphatase, receptor type, D 0.0115351
PTK2 protein tyrosine kinase 2 0.0114157
FLNA filamin A, alpha 0.0113892
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0112863
LPP LIM domain containing preferred translocation partner in lipoma 0.0112741
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0111578
ADAM32 ADAM metallopeptidase domain 32 0.0110391
INTS6 integrator complex subunit 6 0.0106245
SAMD4A sterile alpha motif domain containing 4A 0.0106228
CAST calpastatin 0.0104939
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0104079
UGP2 UDP-glucose pyrophosphorylase 2 0.0103402
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0103246
FTH1 ferritin, heavy polypeptide 1 0.010242
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0100993
NUP58 nucleoporin 58 0.00984105
RYBP RING1 and YY1 binding protein 0.00957513
GLS2 glutaminase 2 (liver, mitochondrial) 0.0094458
PRELID2 PRELI domain containing 2 0.0093812
RBM39 RNA binding motif protein 39 0.00926899
NCOR2 nuclear receptor corepressor 2 0.00923179
RPS18 ribosomal protein S18 0.00921027
SFPQ splicing factor proline/glutamine-rich 0.00919059
RERE arginine-glutamic acid dipeptide (RE) repeats 0.00914679
BCL6 B-cell CLL/lymphoma 6 0.00895557
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.00881698
ESYT2 extended synaptotagmin-like protein 2 0.00864863
DIAPH1 diaphanous-related formin 1 0.00862994
VEGFA vascular endothelial growth factor A 0.0085653
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00852975
RCC1 regulator of chromosome condensation 1 0.00825619
ZFHX3 zinc finger homeobox 3 0.00824413
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00823877
RNF144A ring finger protein 144A 0.00790219
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.00783387
SH3PXD2A SH3 and PX domains 2A 0.00778206
ANKRD36 ankyrin repeat domain 36 0.00773981
MAML3 mastermind-like 3 (Drosophila) 0.00766042
TSC22D3 TSC22 domain family, member 3 0.00758897
TRA2B transformer 2 beta homolog (Drosophila) 0.00757459
SND1 staphylococcal nuclease and tudor domain containing 1 0.00752909
ARMC8 armadillo repeat containing 8 0.00748109
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.00744208
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00734822
CD109 CD109 molecule 0.00732367
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00725475
PLEC plectin 0.00711043
PRKCA protein kinase C, alpha 0.00702299
CEP250 centrosomal protein 250kDa 0.00700069
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00700037
PFKP phosphofructokinase, platelet 0.0069374
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.00690535
SKI SKI proto-oncogene 0.00688193
NFE2L1 nuclear factor, erythroid 2-like 1 0.00685695
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0068237
TPM3 tropomyosin 3 0.00677704
YAP1 Yes-associated protein 1 0.00662905
EP400 E1A binding protein p400 0.00662354
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00661526

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.290992
VIM vimentin -0.245872
TMSB10 thymosin beta 10 -0.0822163
MMP12 matrix metallopeptidase 12 -0.0800882
RPS6 ribosomal protein S6 -0.0621267
PTMA prothymosin, alpha -0.0603721
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0575639
FTL ferritin, light polypeptide -0.0565349
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0527388
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0513956
ENKUR enkurin, TRPC channel interacting protein -0.0473389
ACTG1 actin gamma 1 -0.0460449
EIF1 eukaryotic translation initiation factor 1 -0.0456357
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0450777
DST dystonin -0.0447384
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0414635
PRKG1 protein kinase, cGMP-dependent, type I -0.0389199
CTSB cathepsin B -0.0383089
LSAMP limbic system-associated membrane protein -0.0377186
JMJD1C jumonji domain containing 1C -0.0367869
BTG1 B-cell translocation gene 1, anti-proliferative -0.0359234
CD44 CD44 molecule (Indian blood group) -0.0358804
RPL19 ribosomal protein L19 -0.034172
AHNAK AHNAK nucleoprotein -0.033674
YBX3 Y box binding protein 3 -0.0335061
PTCHD4 patched domain containing 4 -0.0327416
RPL12 ribosomal protein L12 -0.0322028
SAMD3 sterile alpha motif domain containing 3 -0.0320668
TPT1 tumor protein, translationally-controlled 1 -0.031503
VCL vinculin -0.0313016
KYNU kynureninase -0.0312718
ADAM19 ADAM metallopeptidase domain 19 -0.0309248
TM4SF1 transmembrane 4 L six family member 1 -0.0308755
RPS19 ribosomal protein S19 -0.0307975
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0307407
HDAC9 histone deacetylase 9 -0.0292859
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0289418
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0288057
RPS13 ribosomal protein S13 -0.0286893
RPL35A ribosomal protein L35a -0.0286187
RPLP1 ribosomal protein, large, P1 -0.0283038
KIAA1217 KIAA1217 -0.0282876
IFI16 interferon, gamma-inducible protein 16 -0.0281393
NTM neurotrimin -0.0279387
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0274878
RPS27A ribosomal protein S27a -0.027226
EMP1 epithelial membrane protein 1 -0.0270876
RPL8 ribosomal protein L8 -0.0269497
RPLP0 ribosomal protein, large, P0 -0.0269163
ERBIN erbb2 interacting protein -0.0266706
ALCAM activated leukocyte cell adhesion molecule -0.0266468
CDK17 cyclin-dependent kinase 17 -0.026506
RPS8 ribosomal protein S8 -0.0259402
TPM4 tropomyosin 4 -0.0258691
RPL11 ribosomal protein L11 -0.025706
EXT1 exostosin glycosyltransferase 1 -0.0253657
RPS3 ribosomal protein S3 -0.0251603
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0250316
VDAC1 voltage-dependent anion channel 1 -0.0247787
RPLP2 ribosomal protein, large, P2 -0.0247238
HAS2 hyaluronan synthase 2 -0.0245336
NF1 neurofibromin 1 -0.0239311
TXNRD1 thioredoxin reductase 1 -0.0238524
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0234215
RPL32 ribosomal protein L32 -0.0232801
TNNC1 troponin C type 1 (slow) -0.0231388
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0230167
GNAS GNAS complex locus -0.0221597
FOXP1 forkhead box P1 -0.0221044
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.02208
RPL23 ribosomal protein L23 -0.0219343
ANXA2 annexin A2 -0.0217674
CFAP251 cilia and flagella associated protein 251 -0.021483
FRMD6 FERM domain containing 6 -0.0213764
BMAL2 basic helix-loop-helix ARNT like 2 -0.0208095
RPS25 ribosomal protein S25 -0.020738
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0205525
RAD21 RAD21 homolog (S. pombe) -0.020456
BPTF bromodomain PHD finger transcription factor -0.0204214
ANTXR2 anthrax toxin receptor 2 -0.0203933
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0203584
RPL30 ribosomal protein L30 -0.0203233
RPL13A ribosomal protein L13a -0.020242
CAVIN1 caveolae associated protein 1 -0.020238
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0201888
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0197832
WSB1 WD repeat and SOCS box containing 1 -0.0197781
PGK1 phosphoglycerate kinase 1 -0.0196839
PBX3 pre-B-cell leukemia homeobox 3 -0.0194252
RPL34 ribosomal protein L34 -0.0193245
RPL37A ribosomal protein L37a -0.0193192
UGCG UDP-glucose ceramide glucosyltransferase -0.0191269
CALD1 caldesmon 1 -0.019072
SLC38A2 solute carrier family 38, member 2 -0.0187893
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0187373
RPL31 ribosomal protein L31 -0.018708
RPL36A ribosomal protein L36a -0.0186479
NAV3 neuron navigator 3 -0.018576
RAI14 retinoic acid induced 14 -0.018525
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0183355