Betamethasone dipropionate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0792288
NALF1 NALCN channel auxiliary factor 1 0.0596462
NPSR1 neuropeptide S receptor 1 0.0581446
KRT8 keratin 8, type II 0.0541566
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0513886
GMDS GDP-mannose 4,6-dehydratase 0.0504046
ALCAM activated leukocyte cell adhesion molecule 0.0487436
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.047573
CEMIP cell migration inducing protein, hyaluronan binding 0.0444807
ONECUT3 one cut homeobox 3 0.0418412
PTPRK protein tyrosine phosphatase, receptor type, K 0.0390439
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0384005
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0382799
LMO7 LIM domain 7 0.0382339
AHNAK AHNAK nucleoprotein 0.036728
TTC3 tetratricopeptide repeat domain 3 0.0348015
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0345553
ASPH aspartate beta-hydroxylase 0.0336773
EXT1 exostosin glycosyltransferase 1 0.0332086
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0329747
HSPA8 heat shock 70kDa protein 8 0.032364
ANTXR2 anthrax toxin receptor 2 0.0313836
ZFAND3 zinc finger, AN1-type domain 3 0.0307628
GPHN gephyrin 0.0301329
RPL3 ribosomal protein L3 0.0281947
BTBD9 BTB (POZ) domain containing 9 0.0276184
PDE4D phosphodiesterase 4D, cAMP-specific 0.0275255
APP amyloid beta (A4) precursor protein 0.0274463
MYH9 myosin, heavy chain 9, non-muscle 0.027363
GREB1L growth regulation by estrogen in breast cancer-like 0.0270784
DSCAM Down syndrome cell adhesion molecule 0.0268205
SLC35F3 solute carrier family 35, member F3 0.0253941
EHBP1 EH domain binding protein 1 0.0252681
MON2 MON2 homolog (S. cerevisiae) 0.0251512
LPP LIM domain containing preferred translocation partner in lipoma 0.0248515
FRMD5 FERM domain containing 5 0.0247877
DSPP dentin sialophosphoprotein 0.0245977
POF1B premature ovarian failure, 1B 0.0240051
EEF2 eukaryotic translation elongation factor 2 0.0234845
KMT2C lysine (K)-specific methyltransferase 2C 0.0234081
CADPS Ca++-dependent secretion activator 0.0233752
CANX calnexin 0.0231974
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0230178
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0228141
BACE2 beta-site APP-cleaving enzyme 2 0.0228032
TAS2R14 taste receptor, type 2, member 14 0.0227754
PARD3B par-3 family cell polarity regulator beta 0.0227016
CCSER1 coiled-coil serine-rich protein 1 0.0220546
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0213941
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0212343
FAF1 Fas (TNFRSF6) associated factor 1 0.0212029
KDM3A lysine (K)-specific demethylase 3A 0.0208508
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0208448
CUX1 cut-like homeobox 1 0.0207002
SAMD4A sterile alpha motif domain containing 4A 0.020497
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0202617
PATJ PATJ crumbs cell polarity complex component 0.02021
TRAPPC9 trafficking protein particle complex 9 0.0201614
RAD51B RAD51 paralog B 0.0200996
SSR1 signal sequence receptor, alpha 0.0199051
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.019747
ANKRD17 ankyrin repeat domain 17 0.0197059
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.019645
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0196141
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0195346
MSI2 musashi RNA-binding protein 2 0.0194615
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0192251
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0191147
EIF4B eukaryotic translation initiation factor 4B 0.0190025
RBM25 RNA binding motif protein 25 0.0189576
KLF5 Kruppel-like factor 5 (intestinal) 0.0186979
NEBL nebulette 0.0184902
BZW1 basic leucine zipper and W2 domains 1 0.0183833
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0181793
MPRIP myosin phosphatase Rho interacting protein 0.0181494
EXOC4 exocyst complex component 4 0.0181259
KANK1 KN motif and ankyrin repeat domains 1 0.0180475
VCL vinculin 0.0179296
TTC17 tetratricopeptide repeat domain 17 0.017782
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.017693
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0174792
UBE3C ubiquitin protein ligase E3C 0.0174657
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0173438
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0172805
MBD5 methyl-CpG binding domain protein 5 0.0171987
NRXN3 neurexin 3 0.0170046
MBNL2 muscleblind-like splicing regulator 2 0.016981
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.016979
MAML3 mastermind-like 3 (Drosophila) 0.0168643
OSBPL10 oxysterol binding protein-like 10 0.0167722
MYOF myoferlin 0.0167541
PHF3 PHD finger protein 3 0.016605
EIF4A2 eukaryotic translation initiation factor 4A2 0.0165855
IGF1R insulin-like growth factor 1 receptor 0.0165429
HDLBP high density lipoprotein binding protein 0.0165394
SMYD3 SET and MYND domain containing 3 0.0164207
CTBP2 C-terminal binding protein 2 0.0163319
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0161883
MTAP methylthioadenosine phosphorylase 0.0160547
TMSB4X thymosin beta 4, X-linked 0.0160537

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.360778
NDRG1 N-myc downstream regulated 1 -0.127132
RPS6 ribosomal protein S6 -0.099138
TXNIP thioredoxin interacting protein -0.0976788
MUC6 mucin 6, oligomeric mucus/gel-forming -0.095382
PTMA prothymosin, alpha -0.0845996
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0706786
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0654425
RPL35A ribosomal protein L35a -0.0642916
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0617748
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0596573
RPLP1 ribosomal protein, large, P1 -0.0557149
FTL ferritin, light polypeptide -0.0549566
RPS19 ribosomal protein S19 -0.0532299
RPS8 ribosomal protein S8 -0.0500827
FTH1 ferritin, heavy polypeptide 1 -0.0497209
RPLP0 ribosomal protein, large, P0 -0.0470474
TMSB10 thymosin beta 10 -0.0461307
RPL34 ribosomal protein L34 -0.0426161
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0416004
TPT1 tumor protein, translationally-controlled 1 -0.0408691
RPS13 ribosomal protein S13 -0.0392132
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0380765
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0375717
ANXA2 annexin A2 -0.0364272
S100A9 S100 calcium binding protein A9 -0.0362243
S100A10 S100 calcium binding protein A10 -0.0361464
RPL12 ribosomal protein L12 -0.0352838
EZR ezrin -0.0349105
RPL8 ribosomal protein L8 -0.0345272
KRT19 keratin 19, type I -0.0334226
PDIA3 protein disulfide isomerase family A, member 3 -0.0332502
TNS4 tensin 4 -0.0331584
HMGA1 high mobility group AT-hook 1 -0.0317791
RPLP2 ribosomal protein, large, P2 -0.0315277
PTBP3 polypyrimidine tract binding protein 3 -0.0304752
PFN1 profilin 1 -0.029974
S100A6 S100 calcium binding protein A6 -0.0298223
RPL32 ribosomal protein L32 -0.0297944
RPL9 ribosomal protein L9 -0.0296729
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0292688
RPL23 ribosomal protein L23 -0.0291606
RPL36 ribosomal protein L36 -0.0287945
RPL11 ribosomal protein L11 -0.0282554
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.028077
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0275687
RPL19 ribosomal protein L19 -0.0273642
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027354
RPS25 ribosomal protein S25 -0.0272406
HILPDA hypoxia inducible lipid droplet-associated -0.027209
KMT2E lysine (K)-specific methyltransferase 2E -0.0264477
RPL31 ribosomal protein L31 -0.0258566
ESYT2 extended synaptotagmin-like protein 2 -0.02561
MT1X metallothionein 1X -0.02549
LOC102724023 ES1 protein homolog, mitochondrial -0.0254744
AREG amphiregulin -0.0254468
FAM13A family with sequence similarity 13, member A -0.025144
MT2A metallothionein 2A -0.0250508
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0248256
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0246322
RPS29 ribosomal protein S29 -0.0243978
RPS21 ribosomal protein S21 -0.0243747
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0243455
RPS23 ribosomal protein S23 -0.0241797
RPS11 ribosomal protein S11 -0.0239398
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0239033
DDIT4 DNA-damage-inducible transcript 4 -0.0223421
PERP PERP, TP53 apoptosis effector -0.0221062
RPL28 ribosomal protein L28 -0.0221004
GSTP1 glutathione S-transferase pi 1 -0.0220489
TSC22D2 TSC22 domain family, member 2 -0.0219025
RPS14 ribosomal protein S14 -0.0213002
EGR1 early growth response 1 -0.0212954
RPL37A ribosomal protein L37a -0.021191
RPL27A ribosomal protein L27a -0.0209971
WDR45B WD repeat domain 45B -0.0206661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0206299
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0199532
RPL7A ribosomal protein L7a -0.0199378
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0199172
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0198082
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0197391
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0197063
RPL21 ribosomal protein L21 -0.0193739
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0191445
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0189717
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0187656
ZNF292 zinc finger protein 292 -0.0187487
FAM162A family with sequence similarity 162, member A -0.0186161
ACTG1 actin gamma 1 -0.0184794
RPS10 ribosomal protein S10 -0.0183457
EEF1G eukaryotic translation elongation factor 1 gamma -0.018327
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0182974
CCNI cyclin I -0.0180886
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.017915
SETD5 SET domain containing 5 -0.0178915
FOSL1 FOS-like antigen 1 -0.0178504
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.017836
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0177561
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0176524