Betamethasone dipropionate_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Betamethasone dipropionate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.20907
TMSB10 thymosin beta 10 0.112113
TOP1 topoisomerase (DNA) I 0.0962069
EEF2 eukaryotic translation elongation factor 2 0.0941375
FTH1 ferritin, heavy polypeptide 1 0.0733263
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0721895
MT1E metallothionein 1E 0.065842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0652823
VIM vimentin 0.0645825
RPS4X ribosomal protein S4, X-linked 0.0614903
LDHA lactate dehydrogenase A 0.0544346
RPS3 ribosomal protein S3 0.0500729
RPL23 ribosomal protein L23 0.0483393
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0481626
FKBP5 FK506 binding protein 5 0.0455694
ENO1 enolase 1, (alpha) 0.0450519
LOC112694756 uncharaterized LOC112694756 0.04217
POTEF POTE ankyrin domain family, member F 0.0402895
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0400842
YBX1 Y box binding protein 1 0.0369249
DLG1 discs, large homolog 1 (Drosophila) 0.0362463
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0345438
RPL26 ribosomal protein L26 0.0306475
RACK1 receptor for activated C kinase 1 0.0300747
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0286842
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0274186
AHNAK AHNAK nucleoprotein 0.0272838
RPL3 ribosomal protein L3 0.0261881
ITGB4 integrin, beta 4 0.0250025
ESYT2 extended synaptotagmin-like protein 2 0.0248924
RPL35A ribosomal protein L35a 0.0241944
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0241689
SET SET nuclear proto-oncogene 0.0240375
RBM25 RNA binding motif protein 25 0.0237722
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0233466
ZFP36L1 ZFP36 ring finger protein-like 1 0.0233139
PKM pyruvate kinase, muscle 0.0232079
KLF6 Kruppel-like factor 6 0.0230545
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0223459
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0218194
PTPRF protein tyrosine phosphatase, receptor type, F 0.0211287
GARS1 glycyl-tRNA synthetase 1 0.0208229
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0205327
DDIT4 DNA-damage-inducible transcript 4 0.0198143
ENO2 enolase 2 (gamma, neuronal) 0.0195546
EIF5B eukaryotic translation initiation factor 5B 0.0192707
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0191623
RPL5 ribosomal protein L5 0.0191217
FTL ferritin, light polypeptide 0.0190836
RPL13A ribosomal protein L13a 0.0189662
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0185102
TXNIP thioredoxin interacting protein 0.018484
SSR1 signal sequence receptor, alpha 0.0180982
CALR calreticulin 0.0180582
EIF4H eukaryotic translation initiation factor 4H 0.0177735
EEF1G eukaryotic translation elongation factor 1 gamma 0.0176287
HMGB2 high mobility group box 2 0.0172087
LMAN1 lectin, mannose-binding, 1 0.016605
RPL12 ribosomal protein L12 0.0163497
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.016149
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.016101
RPS7 ribosomal protein S7 0.0160177
RPL18 ribosomal protein L18 0.0158505
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0153628
TMEM123 transmembrane protein 123 0.0153113
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0146376
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0146083
SRRM2 serine/arginine repetitive matrix 2 0.0144134
KLF9 Kruppel-like factor 9 0.0143621
RPL35 ribosomal protein L35 0.0143206
EGR1 early growth response 1 0.0141202
RPS19 ribosomal protein S19 0.0140283
EPHA4 EPH receptor A4 0.0138405
AKAP9 A kinase (PRKA) anchor protein 9 0.0134655
FNBP4 formin binding protein 4 0.0134631
ANXA2 annexin A2 0.0131528
DNER delta/notch-like EGF repeat containing 0.0131313
AKAP12 A kinase (PRKA) anchor protein 12 0.0129835
PLIN2 perilipin 2 0.01297
CD46 CD46 molecule, complement regulatory protein 0.012885
SSB Sjogren syndrome antigen B (autoantigen La) 0.0128695
CD109 CD109 molecule 0.0127768
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0127345
EGFR epidermal growth factor receptor 0.0125524
RPL37A ribosomal protein L37a 0.012453
GOLGA4 golgin A4 0.0123675
MATR3 matrin 3 0.0122724
CSDE1 cold shock domain containing E1, RNA-binding 0.0121085
EIF3D eukaryotic translation initiation factor 3, subunit D 0.012099
ZBTB38 zinc finger and BTB domain containing 38 0.011996
ARHGAP12 Rho GTPase activating protein 12 0.0119199
NAP1L1 nucleosome assembly protein 1-like 1 0.0119126
UBAP2L ubiquitin associated protein 2-like 0.0118511
WDR43 WD repeat domain 43 0.0116956
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0114426
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0114217
HDGF hepatoma-derived growth factor 0.0114215
HYOU1 hypoxia up-regulated 1 0.0113928
RPLP1 ribosomal protein, large, P1 0.01134
CLIC1 chloride intracellular channel 1 0.011329

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.296205
TM4SF1 transmembrane 4 L six family member 1 -0.190281
PSD3 pleckstrin and Sec7 domain containing 3 -0.112536
TXNRD1 thioredoxin reductase 1 -0.109241
KMT2E lysine (K)-specific methyltransferase 2E -0.10325
DST dystonin -0.0897205
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0874475
SPAG9 sperm associated antigen 9 -0.0791221
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0785728
TP63 tumor protein p63 -0.0689929
USP34 ubiquitin specific peptidase 34 -0.0674474
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0669334
ARHGAP5 Rho GTPase activating protein 5 -0.0628212
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0625121
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0584634
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0574371
WWTR1 WW domain containing transcription regulator 1 -0.0568888
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.055126
MACF1 microtubule-actin crosslinking factor 1 -0.0543177
FMNL2 formin-like 2 -0.0539973
HLA-B major histocompatibility complex, class I, B -0.0524293
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0509051
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0488722
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0446558
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0445639
JMJD1C jumonji domain containing 1C -0.0430998
CAPRIN2 caprin family member 2 -0.0420206
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0417254
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0415268
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0414991
CD44 CD44 molecule (Indian blood group) -0.0414423
UBC ubiquitin C -0.0411563
TPT1 tumor protein, translationally-controlled 1 -0.0407171
ADAM17 ADAM metallopeptidase domain 17 -0.0400948
ZEB1 zinc finger E-box binding homeobox 1 -0.0397872
WARS1 tryptophanyl-tRNA synthetase 1 -0.0387662
CDCP1 CUB domain containing protein 1 -0.0386809
RAI1 retinoic acid induced 1 -0.0380888
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0377198
BCAR3 breast cancer anti-estrogen resistance 3 -0.0375432
RAB27B RAB27B, member RAS oncogene family -0.0374127
GCLM glutamate-cysteine ligase, modifier subunit -0.0362127
PDE10A phosphodiesterase 10A -0.0358739
EREG epiregulin -0.034838
BIRC2 baculoviral IAP repeat containing 2 -0.0348294
TMEM41B transmembrane protein 41B -0.0346691
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0345683
CLTC clathrin, heavy chain (Hc) -0.0344959
TRIO trio Rho guanine nucleotide exchange factor -0.0333879
CMIP c-Maf inducing protein -0.0333704
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0332251
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0331269
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0324256
ZFAND3 zinc finger, AN1-type domain 3 -0.0320764
TMSB4X thymosin beta 4, X-linked -0.0319606
LOXL2 lysyl oxidase-like 2 -0.0315664
SDC4 syndecan 4 -0.0312038
FBXO11 F-box protein 11 -0.0309304
UPP1 uridine phosphorylase 1 -0.0307774
RPL38 ribosomal protein L38 -0.0306513
FERMT1 fermitin family member 1 -0.0300624
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0300176
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0296662
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0291938
RPS2 ribosomal protein S2 -0.0286884
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0281301
VMP1 vacuole membrane protein 1 -0.0278964
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0274277
ZNF217 zinc finger protein 217 -0.0273901
TRIP12 thyroid hormone receptor interactor 12 -0.0273768
BMERB1 bMERB domain containing 1 -0.0271708
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0268898
RRM2 ribonucleotide reductase M2 -0.026761
XPO1 exportin 1 -0.0267058
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0266914
USP12 ubiquitin specific peptidase 12 -0.0266458
SRPK2 SRSF protein kinase 2 -0.0265978
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0265633
PYGL phosphorylase, glycogen, liver -0.0265358
RCOR1 REST corepressor 1 -0.0264037
CEP170 centrosomal protein 170kDa -0.0263262
EMP1 epithelial membrane protein 1 -0.0263041
SDK1 sidekick cell adhesion molecule 1 -0.0262457
SQSTM1 sequestosome 1 -0.0262412
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0256249
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0256208
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0253938
GSK3B glycogen synthase kinase 3 beta -0.0250304
PTK2 protein tyrosine kinase 2 -0.0250165
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.024898
CSNK1A1 casein kinase 1, alpha 1 -0.0245844
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0243822
RTN4 reticulon 4 -0.0243277
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0240049
PRDX1 peroxiredoxin 1 -0.023864
PLAUR plasminogen activator, urokinase receptor -0.0238363
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0237764
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase -0.0236446
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0234242
SNX14 sorting nexin 14 -0.0233217