Betamethasone dipropionate_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.257327
FN1 fibronectin 1 0.121743
FKBP5 FK506 binding protein 5 0.109477
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.102229
PCBP2 poly(rC) binding protein 2 0.095907
VIM vimentin 0.0896403
AHNAK AHNAK nucleoprotein 0.0749502
HMGA2 high mobility group AT-hook 2 0.0730552
HIPK2 homeodomain interacting protein kinase 2 0.0714928
IRAK3 interleukin-1 receptor-associated kinase 3 0.0712586
TOP1 topoisomerase (DNA) I 0.0691479
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.068634
FTH1 ferritin, heavy polypeptide 1 0.0665138
EEF2 eukaryotic translation elongation factor 2 0.0651323
UBC ubiquitin C 0.0623013
NRCAM neuronal cell adhesion molecule 0.0594222
PID1 phosphotyrosine interaction domain containing 1 0.0530827
SOD2 superoxide dismutase 2, mitochondrial 0.050993
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0509472
STXBP5 syntaxin binding protein 5 (tomosyn) 0.049437
DNER delta/notch-like EGF repeat containing 0.0485285
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.048407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0471414
ANKRD28 ankyrin repeat domain 28 0.0464192
LOX lysyl oxidase 0.0461227
TMSB10 thymosin beta 10 0.0458913
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.043136
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0431284
EPS8 epidermal growth factor receptor pathway substrate 8 0.042407
SH3RF3 SH3 domain containing ring finger 3 0.0419013
SORBS2 sorbin and SH3 domain containing 2 0.0416497
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0400806
TSC22D3 TSC22 domain family, member 3 0.0396522
BIRC3 baculoviral IAP repeat containing 3 0.0388016
UGP2 UDP-glucose pyrophosphorylase 2 0.0345222
LDHA lactate dehydrogenase A 0.0342568
POTEF POTE ankyrin domain family, member F 0.032421
ZBTB16 zinc finger and BTB domain containing 16 0.031861
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0310944
ABLIM3 actin binding LIM protein family, member 3 0.0310305
MBNL1 muscleblind-like splicing regulator 1 0.0307989
PKM pyruvate kinase, muscle 0.0306259
ZFP36L1 ZFP36 ring finger protein-like 1 0.0304053
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.028745
MT1X metallothionein 1X 0.0286952
RUNX2 runt-related transcription factor 2 0.0286173
CALR calreticulin 0.0285429
ZMYND8 zinc finger, MYND-type containing 8 0.0280988
NRG1 neuregulin 1 0.0280352
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0276805
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0274441
IRS2 insulin receptor substrate 2 0.0273
CLMP CXADR-like membrane protein 0.0272661
NEBL nebulette 0.0267073
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0259392
ZFHX3 zinc finger homeobox 3 0.0257758
DCN decorin 0.0256348
PDIA4 protein disulfide isomerase family A, member 4 0.0244704
RTN4 reticulon 4 0.0243317
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.024178
MCL1 myeloid cell leukemia 1 0.0232752
ENO1 enolase 1, (alpha) 0.0227243
DPYD dihydropyrimidine dehydrogenase 0.0226107
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0219679
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0219025
TNS3 tensin 3 0.0218191
ZHX3 zinc fingers and homeoboxes 3 0.0215161
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211508
IL18R1 interleukin 18 receptor 1 0.0208211
GPC6 glypican 6 0.0206034
THSD4 thrombospondin, type I, domain containing 4 0.0204667
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0203613
RPGR retinitis pigmentosa GTPase regulator 0.0202295
TXNIP thioredoxin interacting protein 0.0202276
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0201876
RPL23 ribosomal protein L23 0.0200922
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0200779
EIF4A1 eukaryotic translation initiation factor 4A1 0.0200258
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 0.019433
FGD4 FYVE, RhoGEF and PH domain containing 4 0.019409
HMGB2 high mobility group box 2 0.0188766
MYOF myoferlin 0.0188381
EZR ezrin 0.0184697
LOC112694756 uncharaterized LOC112694756 0.0181979
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0180608
MYO1B myosin IB 0.0179908
TOX2 TOX high mobility group box family member 2 0.0179682
IPO7 importin 7 0.0176906
METAP2 methionyl aminopeptidase 2 0.0176887
PDIA6 protein disulfide isomerase family A, member 6 0.0175645
SRGN serglycin 0.0175145
COL7A1 collagen, type VII, alpha 1 0.017491
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0172117
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0171836
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0171489
MARS1 methionyl-tRNA synthetase 1 0.0170025
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0168768
SP100 SP100 nuclear antigen 0.0168361
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0167828
PLIN2 perilipin 2 0.0165678

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.163928
SMAD3 SMAD family member 3 -0.124915
FNDC3B fibronectin type III domain containing 3B -0.109658
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0998532
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0980401
NDRG1 N-myc downstream regulated 1 -0.0918534
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0904775
CD44 CD44 molecule (Indian blood group) -0.0899298
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0840931
ELL2 elongation factor, RNA polymerase II, 2 -0.0800768
STC1 stanniocalcin 1 -0.0780398
CDCP1 CUB domain containing protein 1 -0.0747003
NAMPT nicotinamide phosphoribosyltransferase -0.0725309
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0654713
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0647226
GOLGA4 golgin A4 -0.0596672
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0588938
EFNA5 ephrin-A5 -0.057762
KDM2A lysine (K)-specific demethylase 2A -0.0556142
JMJD1C jumonji domain containing 1C -0.053242
SDK1 sidekick cell adhesion molecule 1 -0.051687
RUNX1 runt-related transcription factor 1 -0.0515486
RPS2 ribosomal protein S2 -0.0512885
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0500528
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0495643
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0485004
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0484492
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0471497
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.04695
FAM107B family with sequence similarity 107, member B -0.0469107
ATXN1 ataxin 1 -0.0466766
LRRC49 leucine rich repeat containing 49 -0.0465726
ETV6 ets variant 6 -0.0463558
NPC1 Niemann-Pick disease, type C1 -0.0445394
KYNU kynureninase -0.0444162
AKAP9 A kinase (PRKA) anchor protein 9 -0.0434994
EGFR epidermal growth factor receptor -0.0432589
OSMR oncostatin M receptor -0.0430509
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0429246
EXT1 exostosin glycosyltransferase 1 -0.0428595
ANTXR2 anthrax toxin receptor 2 -0.0425226
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0416563
FNBP1 formin binding protein 1 -0.0412303
BASP1 brain abundant, membrane attached signal protein 1 -0.0392636
TFPI2 tissue factor pathway inhibitor 2 -0.0386272
GRB10 growth factor receptor-bound protein 10 -0.0370312
HDAC9 histone deacetylase 9 -0.0368935
ARHGAP5 Rho GTPase activating protein 5 -0.0364815
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0364483
KTN1 kinectin 1 (kinesin receptor) -0.0355034
NAV2 neuron navigator 2 -0.0351459
AHR aryl hydrocarbon receptor -0.0345146
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0343182
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0338037
MYO10 myosin X -0.0337695
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0332627
BACE2 beta-site APP-cleaving enzyme 2 -0.0331415
BMAL2 basic helix-loop-helix ARNT like 2 -0.0328879
DSCAM Down syndrome cell adhesion molecule -0.0328195
FBXL13 F-box and leucine-rich repeat protein 13 -0.0328088
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0327841
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.032555
ZBTB20 zinc finger and BTB domain containing 20 -0.0323846
RNF24 ring finger protein 24 -0.0323587
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0322426
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0320943
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0319995
VEGFC vascular endothelial growth factor C -0.0319488
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0313703
RAP1B RAP1B, member of RAS oncogene family -0.0311745
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0311339
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0301503
DUSP5 dual specificity phosphatase 5 -0.0299447
CHD1L chromodomain helicase DNA binding protein 1-like -0.0297082
NCOA7 nuclear receptor coactivator 7 -0.0296561
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0295232
PRRC2C proline-rich coiled-coil 2C -0.0294543
STK38L serine/threonine kinase 38 like -0.0291579
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0290149
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0288189
ECE1 endothelin converting enzyme 1 -0.028798
B2M beta-2-microglobulin -0.0285476
EIF1 eukaryotic translation initiation factor 1 -0.0284452
DAAM1 dishevelled associated activator of morphogenesis 1 -0.028419
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0282715
LOXL2 lysyl oxidase-like 2 -0.0281661
RPS6 ribosomal protein S6 -0.027934
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0275991
RARB retinoic acid receptor, beta -0.0275714
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0275336
UGCG UDP-glucose ceramide glucosyltransferase -0.0272946
PDE8A phosphodiesterase 8A -0.0272486
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0272374
WWTR1 WW domain containing transcription regulator 1 -0.027207
FAM3C family with sequence similarity 3, member C -0.0271077
MEF2A myocyte enhancer factor 2A -0.0270864
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0267805
USP34 ubiquitin specific peptidase 34 -0.0265843
DENND4A DENN/MADD domain containing 4A -0.0265361
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.02647