Betamethasone dipropionate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Betamethasone dipropionate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.118502
GDA guanine deaminase 0.103815
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.103142
NALF1 NALCN channel auxiliary factor 1 0.0639614
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0612278
TMSB10 thymosin beta 10 0.0595552
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0561699
RBMS3 RNA binding motif, single stranded interacting protein 3 0.055608
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0537528
SORBS2 sorbin and SH3 domain containing 2 0.0460261
POTEF POTE ankyrin domain family, member F 0.0437847
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.042908
CENPF centromere protein F, 350/400kDa 0.0427098
PDE4D phosphodiesterase 4D, cAMP-specific 0.0422751
MGST1 microsomal glutathione S-transferase 1 0.0379988
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0348563
WDFY2 WD repeat and FYVE domain containing 2 0.0343404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0330123
DNER delta/notch-like EGF repeat containing 0.0303131
SRGN serglycin 0.0300488
COL5A2 collagen, type V, alpha 2 0.0299968
SLF1 SMC5-SMC6 complex localization factor 1 0.0290536
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0288968
SMYD3 SET and MYND domain containing 3 0.0287933
CAVIN2 caveolae associated protein 2 0.0286489
PDE10A phosphodiesterase 10A 0.0282676
MFF mitochondrial fission factor 0.0281424
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.027483
FTH1 ferritin, heavy polypeptide 1 0.0270097
MT2A metallothionein 2A 0.0264485
HIPK2 homeodomain interacting protein kinase 2 0.0256713
AKAP12 A kinase (PRKA) anchor protein 12 0.0255942
DST dystonin 0.0244315
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0237695
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0227009
RTN1 reticulon 1 0.022432
TXNRD1 thioredoxin reductase 1 0.0224
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0223066
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0222626
PKM pyruvate kinase, muscle 0.0221477
RPS4X ribosomal protein S4, X-linked 0.022071
VCL vinculin 0.0217985
RPS6 ribosomal protein S6 0.0216936
RPL3 ribosomal protein L3 0.021655
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0215264
FKBP5 FK506 binding protein 5 0.021056
MKI67 marker of proliferation Ki-67 0.0210438
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.020384
SET SET nuclear proto-oncogene 0.0201276
ATP5F1B ATP synthase F1 subunit beta 0.0199903
ADGRG6 adhesion G protein-coupled receptor G6 0.0198266
RPS12 ribosomal protein S12 0.0196922
NFIA nuclear factor I/A 0.0194584
RPGR retinitis pigmentosa GTPase regulator 0.0186766
TXNIP thioredoxin interacting protein 0.0184795
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.018319
LDHA lactate dehydrogenase A 0.0178938
ENO1 enolase 1, (alpha) 0.0178587
STXBP5 syntaxin binding protein 5 (tomosyn) 0.017854
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0177241
SFPQ splicing factor proline/glutamine-rich 0.0175787
GPC6 glypican 6 0.0175629
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0174488
ARHGAP29 Rho GTPase activating protein 29 0.0174137
PCBP2 poly(rC) binding protein 2 0.0172861
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0171265
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0168848
PFN1 profilin 1 0.0162972
DPYD dihydropyrimidine dehydrogenase 0.0161327
PRRC2C proline-rich coiled-coil 2C 0.0160689
ATP5F1E ATP synthase F1 subunit epsilon 0.0160554
SCARA5 scavenger receptor class A, member 5 0.0160392
RTN4 reticulon 4 0.0159746
PHF20 PHD finger protein 20 0.0158484
TPI1 triosephosphate isomerase 1 0.0157951
COL8A1 collagen, type VIII, alpha 1 0.0156407
RPS19 ribosomal protein S19 0.01558
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0155654
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0153557
PA2G4 proliferation-associated 2G4, 38kDa 0.0151662
LDHB lactate dehydrogenase B 0.0151137
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0149667
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.014945
FBXL5 F-box and leucine-rich repeat protein 5 0.0147837
MSN moesin 0.0147182
RPL23 ribosomal protein L23 0.0146707
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0146447
EIF5B eukaryotic translation initiation factor 5B 0.0145645
CBX3 chromobox homolog 3 0.0144029
RPL9 ribosomal protein L9 0.0143766
KIAA0825 KIAA0825 0.0140802
RRM2 ribonucleotide reductase M2 0.0140188
DIAPH3 diaphanous-related formin 3 0.013928
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0139118
EPHA5 EPH receptor A5 0.0138126
CTSC cathepsin C 0.0136578
PRKD3 protein kinase D3 0.0136137
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0136096
DOCK5 dedicator of cytokinesis 5 0.0129567
SDC2 syndecan 2 0.0129364

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.278029
FN1 fibronectin 1 -0.173014
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.140891
PSD3 pleckstrin and Sec7 domain containing 3 -0.117959
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0946404
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0923188
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0783066
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0760457
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0677397
ELL2 elongation factor, RNA polymerase II, 2 -0.0619812
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0603505
CDH13 cadherin 13 -0.0599992
CANX calnexin -0.0544706
TM4SF1 transmembrane 4 L six family member 1 -0.0518449
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0481122
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0457452
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0451661
STC1 stanniocalcin 1 -0.0447519
DOCK4 dedicator of cytokinesis 4 -0.0442547
MAP7 microtubule-associated protein 7 -0.0434799
SPAG9 sperm associated antigen 9 -0.0425563
TFPI2 tissue factor pathway inhibitor 2 -0.0406035
TPT1 tumor protein, translationally-controlled 1 -0.0404541
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0381659
PCBP3 poly(rC) binding protein 3 -0.0381285
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0368005
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0365786
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0365481
SOD2 superoxide dismutase 2, mitochondrial -0.0362067
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0357129
DGKD diacylglycerol kinase, delta 130kDa -0.03548
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0353845
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0350031
INHBA inhibin, beta A -0.0344387
ADGRD1 adhesion G protein-coupled receptor D1 -0.0343944
FNDC3A fibronectin type III domain containing 3A -0.0333744
BMERB1 bMERB domain containing 1 -0.0333436
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0333149
FMNL2 formin-like 2 -0.0332611
P3H2 prolyl 3-hydroxylase 2 -0.033171
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0328292
NCKAP5 NCK-associated protein 5 -0.0327264
PYGL phosphorylase, glycogen, liver -0.0325286
SH3KBP1 SH3-domain kinase binding protein 1 -0.0315192
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0312063
SMOC1 SPARC related modular calcium binding 1 -0.0311642
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0309755
MYOF myoferlin -0.030471
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0303535
DENND1A DENN/MADD domain containing 1A -0.0299331
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0296603
NDRG1 N-myc downstream regulated 1 -0.0296016
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0291667
LIMCH1 LIM and calponin homology domains 1 -0.0284252
IGFBP3 insulin-like growth factor binding protein 3 -0.0282186
TGFBR1 transforming growth factor, beta receptor 1 -0.0278898
SOX4 SRY (sex determining region Y)-box 4 -0.0278861
KDM3A lysine (K)-specific demethylase 3A -0.0274715
IER3 immediate early response 3 -0.0272798
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0269938
SQSTM1 sequestosome 1 -0.0269316
NPAS2 neuronal PAS domain protein 2 -0.0269205
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0268212
ESM1 endothelial cell-specific molecule 1 -0.0268021
NBEAL1 neurobeachin-like 1 -0.0264018
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0258988
SLC16A6 solute carrier family 16, member 6 -0.0256859
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0256542
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0250928
WARS1 tryptophanyl-tRNA synthetase 1 -0.0250119
CD44 CD44 molecule (Indian blood group) -0.0249595
CREB5 cAMP responsive element binding protein 5 -0.0240266
IGF1R insulin-like growth factor 1 receptor -0.0233637
ESYT2 extended synaptotagmin-like protein 2 -0.0233614
CTBP2 C-terminal binding protein 2 -0.0233254
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0230201
RORA RAR-related orphan receptor A -0.0228526
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.022791
NCOA7 nuclear receptor coactivator 7 -0.0227004
COL4A5 collagen, type IV, alpha 5 -0.0225289
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0225249
TENM3 teneurin transmembrane protein 3 -0.0224662
GRB10 growth factor receptor-bound protein 10 -0.0224243
XYLT1 xylosyltransferase I -0.0222269
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0221594
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0220126
NAMPT nicotinamide phosphoribosyltransferase -0.021814
FNIP1 folliculin interacting protein 1 -0.0217147
BZW1 basic leucine zipper and W2 domains 1 -0.0212319
KMT2E lysine (K)-specific methyltransferase 2E -0.021096
ASPH aspartate beta-hydroxylase -0.0209128
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0208895
RIGI RNA sensor RIG-I -0.0207828
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.020603
UNC5D unc-5 homolog D (C. elegans) -0.0205517
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0205146
OXSR1 oxidative stress responsive 1 -0.0203461
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0202971
EZR ezrin -0.0202214
ABLIM1 actin binding LIM protein 1 -0.0202194