Betamethasone dipropionate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.264608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0618601
FNDC3B fibronectin type III domain containing 3B 0.0596934
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0584763
ZFP36 ZFP36 ring finger protein 0.0570492
ERRFI1 ERBB receptor feedback inhibitor 1 0.0456177
BIRC3 baculoviral IAP repeat containing 3 0.0404801
EGFR epidermal growth factor receptor 0.0386316
TRIO trio Rho guanine nucleotide exchange factor 0.0315011
AKAP13 A kinase (PRKA) anchor protein 13 0.029652
FKBP5 FK506 binding protein 5 0.0275699
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0257508
MYH9 myosin, heavy chain 9, non-muscle 0.0253084
KTN1 kinectin 1 (kinesin receptor) 0.0241749
MSN moesin 0.0240565
UTRN utrophin 0.0235766
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0231368
SRRM2 serine/arginine repetitive matrix 2 0.0227677
HPCAL1 hippocalcin-like 1 0.0227097
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0220023
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0213602
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0212751
TPM3 tropomyosin 3 0.0212337
HMGA2 high mobility group AT-hook 2 0.020881
DST dystonin 0.0207166
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0196813
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0193444
MACF1 microtubule-actin crosslinking factor 1 0.0192403
EPAS1 endothelial PAS domain protein 1 0.0192204
VEGFA vascular endothelial growth factor A 0.0191674
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0187628
ANGPTL4 angiopoietin-like 4 0.0185746
MT2A metallothionein 2A 0.0184707
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0178795
MED13L mediator complex subunit 13-like 0.0176343
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0175703
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0175644
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0168669
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0166815
SET SET nuclear proto-oncogene 0.016503
WNK1 WNK lysine deficient protein kinase 1 0.0162231
KRT8 keratin 8, type II 0.0158317
BCL2L1 BCL2-like 1 0.015206
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0150492
POTEF POTE ankyrin domain family, member F 0.0150259
PDIA3 protein disulfide isomerase family A, member 3 0.014971
MAP1B microtubule-associated protein 1B 0.014846
SEPTIN9 septin 9 0.0146215
NCOR2 nuclear receptor corepressor 2 0.0146062
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0144665
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.014421
RPL3 ribosomal protein L3 0.0143536
FMNL2 formin-like 2 0.0142231
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0141915
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.013703
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0136797
HYOU1 hypoxia up-regulated 1 0.0136141
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0134001
MYOF myoferlin 0.0133026
PKM pyruvate kinase, muscle 0.0132722
ANKRD11 ankyrin repeat domain 11 0.013228
CENPF centromere protein F, 350/400kDa 0.0129934
YAP1 Yes-associated protein 1 0.0129127
FTH1 ferritin, heavy polypeptide 1 0.0127079
SOD2 superoxide dismutase 2, mitochondrial 0.0126484
GOLGA4 golgin A4 0.0126442
PDIA6 protein disulfide isomerase family A, member 6 0.0126117
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0121637
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0120352
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0117493
HSPA8 heat shock 70kDa protein 8 0.0117082
HIPK2 homeodomain interacting protein kinase 2 0.0116834
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0116784
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0115623
KRT18 keratin 18, type I 0.0113912
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0113704
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0113037
GOLT1A golgi transport 1A 0.0113002
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0112479
WDR43 WD repeat domain 43 0.0111394
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0111079
NAV2 neuron navigator 2 0.0109854
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0107518
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.010702
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0106759
NEBL nebulette 0.0106358
SDK1 sidekick cell adhesion molecule 1 0.0106298
NFE2L1 nuclear factor, erythroid 2-like 1 0.0103128
FOSL1 FOS-like antigen 1 0.0102173
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0101485
ZMYND8 zinc finger, MYND-type containing 8 0.0101481
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0100692
CTBP2 C-terminal binding protein 2 0.00988935
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0097487
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00972907
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.00967592
ESYT2 extended synaptotagmin-like protein 2 0.00963893
RNF220 ring finger protein 220 0.00961081
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.00958814
DNAH5 dynein, axonemal, heavy chain 5 0.00956871

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.319262
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.29422
VIM vimentin -0.286678
PTMA prothymosin, alpha -0.0933432
TMSB10 thymosin beta 10 -0.0749296
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0720755
FBL fibrillarin -0.0665138
S100A6 S100 calcium binding protein A6 -0.0652884
ACTG1 actin gamma 1 -0.060998
ACTN4 actinin, alpha 4 -0.0593151
RPLP0 ribosomal protein, large, P0 -0.0572793
RPLP1 ribosomal protein, large, P1 -0.0572482
ANXA2 annexin A2 -0.0535661
TM4SF1 transmembrane 4 L six family member 1 -0.0493324
RPLP2 ribosomal protein, large, P2 -0.0483021
RPL35A ribosomal protein L35a -0.0466502
RPS24 ribosomal protein S24 -0.0454268
VCL vinculin -0.0432977
FTL ferritin, light polypeptide -0.0432316
SAMD4B sterile alpha motif domain containing 4B -0.0412464
RPS25 ribosomal protein S25 -0.0387225
CD44 CD44 molecule (Indian blood group) -0.0377206
EIF1 eukaryotic translation initiation factor 1 -0.0370277
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0362788
RPS8 ribosomal protein S8 -0.0355887
RPL28 ribosomal protein L28 -0.0344139
TPT1 tumor protein, translationally-controlled 1 -0.033735
RPL27A ribosomal protein L27a -0.0336805
RPS5 ribosomal protein S5 -0.0335323
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0333612
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0320894
SFTPA2 surfactant protein A2 -0.0319002
RPL12 ribosomal protein L12 -0.0311721
LOC112694756 uncharaterized LOC112694756 -0.0298999
S100A10 S100 calcium binding protein A10 -0.0284712
RPL8 ribosomal protein L8 -0.0284106
ZNF780B zinc finger protein 780B -0.0282088
RPL34 ribosomal protein L34 -0.0280062
RPS21 ribosomal protein S21 -0.0273177
JMJD1C jumonji domain containing 1C -0.0270128
RPL11 ribosomal protein L11 -0.0264105
RPS14 ribosomal protein S14 -0.0246132
UBC ubiquitin C -0.0240854
RPS13 ribosomal protein S13 -0.0238966
RPL36A ribosomal protein L36a -0.0230479
RPL38 ribosomal protein L38 -0.0229376
CARD18 caspase recruitment domain family, member 18 -0.0214076
B2M beta-2-microglobulin -0.0207861
LMNA lamin A/C -0.020526
CAVIN1 caveolae associated protein 1 -0.0203087
SMYD3 SET and MYND domain containing 3 -0.0202423
RPL32 ribosomal protein L32 -0.0202294
RPL31 ribosomal protein L31 -0.0202183
SQSTM1 sequestosome 1 -0.0200766
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0200616
RPS27A ribosomal protein S27a -0.0199114
NAP1L1 nucleosome assembly protein 1-like 1 -0.0197224
RPS19 ribosomal protein S19 -0.0195433
TUBB tubulin, beta class I -0.0189769
RPS23 ribosomal protein S23 -0.0188233
MORF4L2 mortality factor 4 like 2 -0.0186161
CD59 CD59 molecule, complement regulatory protein -0.0185624
RPL23 ribosomal protein L23 -0.0184217
SNX14 sorting nexin 14 -0.0184076
PGK1 phosphoglycerate kinase 1 -0.0181882
MED29 mediator complex subunit 29 -0.0181737
RACK1 receptor for activated C kinase 1 -0.0180851
OGA O-GlcNAcase -0.0180126
TXNRD1 thioredoxin reductase 1 -0.0179116
ASTN2 astrotactin 2 -0.0176853
FRMD5 FERM domain containing 5 -0.0175508
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0175354
IFITM3 interferon induced transmembrane protein 3 -0.0174444
RAP1B RAP1B, member of RAS oncogene family -0.0174333
WWTR1 WW domain containing transcription regulator 1 -0.0170268
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0166477
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0166205
RPL19 ribosomal protein L19 -0.0165544
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0164257
SLC35F3 solute carrier family 35, member F3 -0.0163409
RPS3 ribosomal protein S3 -0.0161768
RPS15 ribosomal protein S15 -0.0161588
FHL2 four and a half LIM domains 2 -0.0161548
C15ORF48 chromosome 15 open reading frame 48 -0.0160697
RPL37 ribosomal protein L37 -0.0160662
SERF2 small EDRK-rich factor 2 -0.0159558
WDR45B WD repeat domain 45B -0.0159276
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0158156
HLA-B major histocompatibility complex, class I, B -0.0157963
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.015723
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0156582
TMEM41B transmembrane protein 41B -0.0155675
IER3 immediate early response 3 -0.0155443
ASPH aspartate beta-hydroxylase -0.015509
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0154793
S100A9 S100 calcium binding protein A9 -0.0154769
KDM3A lysine (K)-specific demethylase 3A -0.0154247
ANLN anillin, actin binding protein -0.0153935
TMEM123 transmembrane protein 123 -0.0153768
RPS6 ribosomal protein S6 -0.0153666