Betamethasone dipropionate_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.1346
BIRC3 baculoviral IAP repeat containing 3 0.116696
POTEF POTE ankyrin domain family, member F 0.0849851
RPS6 ribosomal protein S6 0.0758768
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702417
RPS3 ribosomal protein S3 0.0679378
RPL23 ribosomal protein L23 0.0596254
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0568007
KRT7 keratin 7, type II 0.0548927
RPS12 ribosomal protein S12 0.0501544
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0487496
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0486291
C3 complement component 3 0.0481334
RPS19 ribosomal protein S19 0.0440588
FTH1 ferritin, heavy polypeptide 1 0.043957
VEGFA vascular endothelial growth factor A 0.0438276
IRS2 insulin receptor substrate 2 0.0433531
RPS8 ribosomal protein S8 0.0426713
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0415327
FKBP5 FK506 binding protein 5 0.0414422
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0395153
RACK1 receptor for activated C kinase 1 0.0395036
EEF2 eukaryotic translation elongation factor 2 0.0390543
TMSB10 thymosin beta 10 0.0384893
RPLP1 ribosomal protein, large, P1 0.0379934
PLEC plectin 0.0375005
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0370939
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0368066
HMGB2 high mobility group box 2 0.034948
BRD2 bromodomain containing 2 0.0343753
RPL35A ribosomal protein L35a 0.0339544
RPL37A ribosomal protein L37a 0.0337533
YBX1 Y box binding protein 1 0.0326796
ERRFI1 ERBB receptor feedback inhibitor 1 0.0319764
RPS4X ribosomal protein S4, X-linked 0.0317918
RPS17 ribosomal protein S17 0.031597
RPL26 ribosomal protein L26 0.031537
EEF1G eukaryotic translation elongation factor 1 gamma 0.029983
RPL12 ribosomal protein L12 0.0295456
AKAP12 A kinase (PRKA) anchor protein 12 0.0289787
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0284874
LOC112694756 uncharaterized LOC112694756 0.0280128
FOSL1 FOS-like antigen 1 0.0278884
TGM2 transglutaminase 2 0.0278522
RPL28 ribosomal protein L28 0.0273265
RPL3 ribosomal protein L3 0.0270922
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0268046
KRT19 keratin 19, type I 0.0267985
DDIT4 DNA-damage-inducible transcript 4 0.0263499
KTN1 kinectin 1 (kinesin receptor) 0.0261458
SET SET nuclear proto-oncogene 0.026127
RPL37 ribosomal protein L37 0.0254358
RPL9 ribosomal protein L9 0.0253529
PELI1 pellino E3 ubiquitin protein ligase 1 0.0253292
SRRM2 serine/arginine repetitive matrix 2 0.0249903
RPL27 ribosomal protein L27 0.0249163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246211
RPL30 ribosomal protein L30 0.0241246
MYH9 myosin, heavy chain 9, non-muscle 0.0236484
PCBP2 poly(rC) binding protein 2 0.023616
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233873
TNS4 tensin 4 0.0231793
RPL11 ribosomal protein L11 0.0230321
RBM25 RNA binding motif protein 25 0.0230028
TFCP2L1 transcription factor CP2-like 1 0.0228344
RPL5 ribosomal protein L5 0.022522
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224125
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0223537
HSPA8 heat shock 70kDa protein 8 0.0221717
RDX radixin 0.0220862
MCL1 myeloid cell leukemia 1 0.0220839
KLF6 Kruppel-like factor 6 0.0220146
KRT17 keratin 17, type I 0.0220112
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.021781
PCDH1 protocadherin 1 0.021664
KRT8 keratin 8, type II 0.0216548
RPL13A ribosomal protein L13a 0.021615
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0213607
SAA2 serum amyloid A2 0.0211778
TNIP1 TNFAIP3 interacting protein 1 0.0211732
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0210905
JUP junction plakoglobin 0.0209724
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0207079
DSPP dentin sialophosphoprotein 0.0206257
CCND3 cyclin D3 0.0205678
RPS2 ribosomal protein S2 0.0205475
RPS18 ribosomal protein S18 0.0204045
TPM3 tropomyosin 3 0.0202068
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0201466
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0198258
EFNA5 ephrin-A5 0.0196651
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0194624
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.019368
RPL21 ribosomal protein L21 0.0193495
NACA nascent polypeptide-associated complex alpha subunit 0.0192837
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0192286
AKAP13 A kinase (PRKA) anchor protein 13 0.0189822
TSC22D2 TSC22 domain family, member 2 0.0188576
RTN4 reticulon 4 0.0187859
RPS27 ribosomal protein S27 0.0185589

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.1132
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.112631
DLG1 discs, large homolog 1 (Drosophila) -0.107055
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0974327
EMP1 epithelial membrane protein 1 -0.0953816
F3 coagulation factor III (thromboplastin, tissue factor) -0.0898572
CD2AP CD2-associated protein -0.0817504
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0799551
LAMA4 laminin, alpha 4 -0.0775816
MAML2 mastermind-like 2 (Drosophila) -0.0706576
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0703663
TM4SF1 transmembrane 4 L six family member 1 -0.0686961
TMSB4X thymosin beta 4, X-linked -0.0670224
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0654701
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0636686
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0631504
LAMC2 laminin, gamma 2 -0.0599577
DSG2 desmoglein 2 -0.0570542
MYO6 myosin VI -0.0566281
ASPH aspartate beta-hydroxylase -0.0556766
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0551122
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0529265
ANLN anillin, actin binding protein -0.0526826
ZFAND3 zinc finger, AN1-type domain 3 -0.0522972
VCL vinculin -0.0509166
ANXA2 annexin A2 -0.0505426
TMEM123 transmembrane protein 123 -0.0472058
FRMD5 FERM domain containing 5 -0.0469282
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0457575
CANX calnexin -0.0454811
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0454441
RUNX1 runt-related transcription factor 1 -0.0454276
ZBTB20 zinc finger and BTB domain containing 20 -0.0453335
PTMA prothymosin, alpha -0.045189
NF1 neurofibromin 1 -0.0447713
UBE2H ubiquitin-conjugating enzyme E2H -0.0446808
IGFBP3 insulin-like growth factor binding protein 3 -0.044235
MBNL2 muscleblind-like splicing regulator 2 -0.0435394
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.041857
OSBPL3 oxysterol binding protein-like 3 -0.0412315
FN1 fibronectin 1 -0.0401576
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0396437
JMJD1C jumonji domain containing 1C -0.039542
MYOF myoferlin -0.0394738
RNF213 ring finger protein 213 -0.0390934
NPEPPS aminopeptidase puromycin sensitive -0.0390011
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.038267
PLAT plasminogen activator, tissue -0.037762
PATJ PATJ crumbs cell polarity complex component -0.0368481
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.036812
PDLIM5 PDZ and LIM domain 5 -0.0360303
AHNAK AHNAK nucleoprotein -0.0351649
ETV6 ets variant 6 -0.0345851
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0345309
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0344849
MUC4 mucin 4, cell surface associated -0.0343332
RASAL2 RAS protein activator like 2 -0.0341824
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0339535
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0338969
UBC ubiquitin C -0.0338487
LY6E lymphocyte antigen 6 complex, locus E -0.033512
MEF2A myocyte enhancer factor 2A -0.0334793
PLSCR1 phospholipid scramblase 1 -0.0334074
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0329354
ITPRID2 ITPR interacting domain containing 2 -0.0326446
PARD3 par-3 family cell polarity regulator -0.0324762
CDK6 cyclin-dependent kinase 6 -0.0324673
ACTG1 actin gamma 1 -0.0323986
PLAU plasminogen activator, urokinase -0.0322766
INHBA inhibin, beta A -0.0321709
DSCAM Down syndrome cell adhesion molecule -0.0321357
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0320842
EHF ets homologous factor -0.0314265
EPCAM epithelial cell adhesion molecule -0.0312787
EHBP1 EH domain binding protein 1 -0.0310599
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0310369
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0309812
OSMR oncostatin M receptor -0.0306324
MACC1 metastasis associated in colon cancer 1 -0.0306124
UGCG UDP-glucose ceramide glucosyltransferase -0.0305668
MTAP methylthioadenosine phosphorylase -0.0299006
ARHGAP29 Rho GTPase activating protein 29 -0.0298501
FCHSD2 FCH and double SH3 domains 2 -0.0298393
SVIL supervillin -0.029739
HLA-B major histocompatibility complex, class I, B -0.0294121
TRIO trio Rho guanine nucleotide exchange factor -0.0293091
BMAL2 basic helix-loop-helix ARNT like 2 -0.029028
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0288387
SKAP2 src kinase associated phosphoprotein 2 -0.0287998
KDM3A lysine (K)-specific demethylase 3A -0.0287086
ADGRF1 adhesion G protein-coupled receptor F1 -0.0287077
SAMD12 sterile alpha motif domain containing 12 -0.0284901
ADGRG6 adhesion G protein-coupled receptor G6 -0.0284385
IL1RAP interleukin 1 receptor accessory protein -0.0284267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0281818
HLA-E major histocompatibility complex, class I, E -0.0278368
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0277731
ERBIN erbb2 interacting protein -0.027448
MECOM MDS1 and EVI1 complex locus -0.0272663
DIAPH3 diaphanous-related formin 3 -0.0272259