Betamethasone dipropionate_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0587179
ZNF292 zinc finger protein 292 0.0341762
NAMPT nicotinamide phosphoribosyltransferase 0.0304825
NUP58 nucleoporin 58 0.0303973
KMT2C lysine (K)-specific methyltransferase 2C 0.0293282
CDC73 cell division cycle 73 0.0271563
PTK2 protein tyrosine kinase 2 0.0270633
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0269507
TSC22D2 TSC22 domain family, member 2 0.0267325
KMT2E lysine (K)-specific methyltransferase 2E 0.0243265
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.02391
WAC WW domain containing adaptor with coiled-coil 0.023025
KDM6A lysine (K)-specific demethylase 6A 0.022832
ADAM9 ADAM metallopeptidase domain 9 0.0227732
ATP13A3 ATPase type 13A3 0.0224399
RBM39 RNA binding motif protein 39 0.0219687
USP3 ubiquitin specific peptidase 3 0.0217481
CAMTA1 calmodulin binding transcription activator 1 0.021207
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0209304
HELZ helicase with zinc finger 0.0202048
ABI1 abl-interactor 1 0.0201362
ADAM17 ADAM metallopeptidase domain 17 0.019468
FXR1 fragile X mental retardation, autosomal homolog 1 0.0189487
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0182772
FNDC3B fibronectin type III domain containing 3B 0.0181107
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0171369
CCNL1 cyclin L1 0.0167189
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0165952
RSRC2 arginine/serine-rich coiled-coil 2 0.0165571
ZFAND3 zinc finger, AN1-type domain 3 0.0164439
RLF rearranged L-myc fusion 0.0163822
TPM3 tropomyosin 3 0.0162997
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0157255
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0157254
MTMR3 myotubularin related protein 3 0.015709
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0156236
RTN4 reticulon 4 0.0155118
FAM91A1 family with sequence similarity 91, member A1 0.0150929
TRA2A transformer 2 alpha homolog (Drosophila) 0.0150908
CHD1 chromodomain helicase DNA binding protein 1 0.0150166
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0145852
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.014487
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0144519
ZMYM2 zinc finger, MYM-type 2 0.014302
EPS8 epidermal growth factor receptor pathway substrate 8 0.0142822
PUM1 pumilio RNA-binding family member 1 0.0142643
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0142262
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0142118
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0141028
TFG TRK-fused gene 0.0139237
ZNF451 zinc finger protein 451 0.0139101
UBA6 ubiquitin-like modifier activating enzyme 6 0.013812
TPD52 tumor protein D52 0.0136807
PCBP2 poly(rC) binding protein 2 0.0136768
MARCHF6 membrane associated ring-CH-type finger 6 0.0136428
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0133733
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0131283
CDK17 cyclin-dependent kinase 17 0.013098
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0130862
NEK7 NIMA-related kinase 7 0.0129774
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0129211
MATR3 matrin 3 0.0128368
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0128298
PICALM phosphatidylinositol binding clathrin assembly protein 0.0126144
RAB18 RAB18, member RAS oncogene family 0.012589
RASA2 RAS p21 protein activator 2 0.0125516
USP9X ubiquitin specific peptidase 9, X-linked 0.0123678
PTBP2 polypyrimidine tract binding protein 2 0.0121044
RUNX1 runt-related transcription factor 1 0.0120802
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0120729
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0119768
TFRC transferrin receptor 0.0119523
FKBP15 FK506 binding protein 15, 133kDa 0.0119246
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0119166
CUL3 cullin 3 0.0118308
MYH9 myosin, heavy chain 9, non-muscle 0.0118042
SUCO SUN domain containing ossification factor 0.0117917
PTEN phosphatase and tensin homolog 0.0117454
BBX bobby sox homolog (Drosophila) 0.0117084
LCORL ligand dependent nuclear receptor corepressor-like 0.0117008
RPL3 ribosomal protein L3 0.0116755
TBC1D23 TBC1 domain family, member 23 0.0116714
POTEF POTE ankyrin domain family, member F 0.0115549
CREB5 cAMP responsive element binding protein 5 0.0113894
DENND4A DENN/MADD domain containing 4A 0.0113603
RBM33 RNA binding motif protein 33 0.0113591
VMP1 vacuole membrane protein 1 0.0113535
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0113271
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0112157
YME1L1 YME1-like 1 ATPase 0.0112038
ANKRD11 ankyrin repeat domain 11 0.0111749
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0111324
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0110927
KIF1B kinesin family member 1B 0.0110436
CERT1 ceramide transporter 1 0.0109971
PIAS2 protein inhibitor of activated STAT, 2 0.0109749
RNMT RNA (guanine-7-) methyltransferase 0.0109588
ELP2 elongator acetyltransferase complex subunit 2 0.0109505
ANXA5 annexin A5 0.0109083
CCNY cyclin Y 0.0107878

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.172055
MT2A metallothionein 2A -0.122108
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0922224
FRMD6 FERM domain containing 6 -0.0761945
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0761025
ZNF438 zinc finger protein 438 -0.0672263
FLNB filamin B, beta -0.0615867
IFI16 interferon, gamma-inducible protein 16 -0.0548581
HMGA2 high mobility group AT-hook 2 -0.0537286
ARHGAP22 Rho GTPase activating protein 22 -0.0517407
RPL12 ribosomal protein L12 -0.0516117
RPS6 ribosomal protein S6 -0.0505725
NAV3 neuron navigator 3 -0.0478188
LAMB3 laminin, beta 3 -0.0467699
RPLP1 ribosomal protein, large, P1 -0.0458646
TMSB10 thymosin beta 10 -0.0445965
RPL7A ribosomal protein L7a -0.0443944
TTR transthyretin -0.0440749
RPL30 ribosomal protein L30 -0.0440163
FRMD4A FERM domain containing 4A -0.0408015
RPL35A ribosomal protein L35a -0.0392862
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0355896
SLC38A2 solute carrier family 38, member 2 -0.0353884
CALD1 caldesmon 1 -0.0340446
RPL19 ribosomal protein L19 -0.0335534
RPS19 ribosomal protein S19 -0.0334535
RPS3 ribosomal protein S3 -0.0329906
PTMA prothymosin, alpha -0.0329729
NABP1 nucleic acid binding protein 1 -0.0323006
RPL8 ribosomal protein L8 -0.0320697
RPL35 ribosomal protein L35 -0.0320669
BNC2 basonuclin 2 -0.0318121
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0317415
RPL26 ribosomal protein L26 -0.0311502
RPL7 ribosomal protein L7 -0.0311461
C2CD2 C2 calcium-dependent domain containing 2 -0.0307355
RPL13A ribosomal protein L13a -0.030116
TPM4 tropomyosin 4 -0.0296782
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0296073
RPL11 ribosomal protein L11 -0.0295971
PBX3 pre-B-cell leukemia homeobox 3 -0.0295148
ANTXR2 anthrax toxin receptor 2 -0.0295096
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0292218
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0289178
FTL ferritin, light polypeptide -0.0288053
MTAP methylthioadenosine phosphorylase -0.0287777
NAP1L1 nucleosome assembly protein 1-like 1 -0.0286085
RACK1 receptor for activated C kinase 1 -0.0284081
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0279865
ENO1 enolase 1, (alpha) -0.0279809
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0275208
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274572
RPS27A ribosomal protein S27a -0.026904
TPT1 tumor protein, translationally-controlled 1 -0.0259346
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0258517
RPS8 ribosomal protein S8 -0.0258081
RPL9 ribosomal protein L9 -0.0256585
RPS12 ribosomal protein S12 -0.0255856
RPL31 ribosomal protein L31 -0.0249823
PTPRG protein tyrosine phosphatase, receptor type, G -0.0247157
PGK1 phosphoglycerate kinase 1 -0.0241502
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.02392
RPL34 ribosomal protein L34 -0.023446
RPS16 ribosomal protein S16 -0.0231237
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0230882
TCF12 transcription factor 12 -0.0230607
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0229832
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.022857
PCNX4 pecanex 4 -0.0227462
ALCAM activated leukocyte cell adhesion molecule -0.0227168
RPL18 ribosomal protein L18 -0.0225824
RPL37A ribosomal protein L37a -0.021875
RPL23 ribosomal protein L23 -0.0217674
RPLP2 ribosomal protein, large, P2 -0.0217419
RPLP0 ribosomal protein, large, P0 -0.0216761
SAMD12 sterile alpha motif domain containing 12 -0.021501
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0214259
MKI67 marker of proliferation Ki-67 -0.0211876
RPS29 ribosomal protein S29 -0.0210354
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0209965
HDAC9 histone deacetylase 9 -0.0208609
G0S2 G0/G1 switch 2 -0.0206375
RPL37 ribosomal protein L37 -0.0205308
RPL36 ribosomal protein L36 -0.0200391
STC1 stanniocalcin 1 -0.0199884
RIGI RNA sensor RIG-I -0.0198114
RPL27 ribosomal protein L27 -0.0197385
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0194949
SP100 SP100 nuclear antigen -0.0190144
RPS25 ribosomal protein S25 -0.0189658
RPS24 ribosomal protein S24 -0.0189418
CD274 CD274 molecule -0.0188659
SAMD4A sterile alpha motif domain containing 4A -0.0188399
CAST calpastatin -0.0188116
RPL32 ribosomal protein L32 -0.0185594
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0180883
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0180521
S100A9 S100 calcium binding protein A9 -0.018035
EFNB2 ephrin-B2 -0.0177699
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0176856