Betamethasone dipropionate_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.120199
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.085465
LOC112694756 uncharaterized LOC112694756 0.0829837
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0768918
PKM pyruvate kinase, muscle 0.0731815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.072927
EGFR epidermal growth factor receptor 0.0661642
FLNB filamin B, beta 0.0610182
ANK2 ankyrin 2, neuronal 0.0536073
LDHA lactate dehydrogenase A 0.0520067
GOLGA4 golgin A4 0.0519183
TMSB4X thymosin beta 4, X-linked 0.051871
EZR ezrin 0.0484957
RPL3 ribosomal protein L3 0.0430804
ADAM10 ADAM metallopeptidase domain 10 0.0419942
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0417232
SMYD3 SET and MYND domain containing 3 0.0395373
ZBTB20 zinc finger and BTB domain containing 20 0.039151
EEF2 eukaryotic translation elongation factor 2 0.0385361
EFNA5 ephrin-A5 0.0383243
POTEF POTE ankyrin domain family, member F 0.0380008
TMEM65 transmembrane protein 65 0.0374665
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0371965
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0370833
PYGB phosphorylase, glycogen; brain 0.0369347
TXNRD1 thioredoxin reductase 1 0.0364607
CAMTA1 calmodulin binding transcription activator 1 0.0347396
NBAS neuroblastoma amplified sequence 0.0332563
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0311541
RHBDD1 rhomboid domain containing 1 0.0311019
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0308886
RTN4 reticulon 4 0.0302542
MAP4 microtubule-associated protein 4 0.0302426
S100A6 S100 calcium binding protein A6 0.0296807
EIF4A2 eukaryotic translation initiation factor 4A2 0.0293489
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0287386
ENO1 enolase 1, (alpha) 0.0282435
SET SET nuclear proto-oncogene 0.026988
METTL15 methyltransferase like 15 0.0264337
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259462
HDAC9 histone deacetylase 9 0.0256707
SSR1 signal sequence receptor, alpha 0.0256057
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0251972
AKAP9 A kinase (PRKA) anchor protein 9 0.0249506
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0249342
LPP LIM domain containing preferred translocation partner in lipoma 0.024141
RPL4 ribosomal protein L4 0.0240504
SREBF2 sterol regulatory element binding transcription factor 2 0.0238813
CD47 CD47 molecule 0.0231738
SRRM2 serine/arginine repetitive matrix 2 0.0224369
FAM114A1 family with sequence similarity 114, member A1 0.0219348
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0218734
TBC1D5 TBC1 domain family, member 5 0.0217425
ZFAND3 zinc finger, AN1-type domain 3 0.0217236
CALR calreticulin 0.0216709
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0216515
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0215724
LMAN1 lectin, mannose-binding, 1 0.0214965
HSPA8 heat shock 70kDa protein 8 0.021454
DSTN destrin (actin depolymerizing factor) 0.0212904
PLK2 polo-like kinase 2 0.0211201
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0210917
EPB41 erythrocyte membrane protein band 4.1 0.0208631
ANKRD36 ankyrin repeat domain 36 0.0206847
FKBP10 FK506 binding protein 10, 65 kDa 0.0202406
WDPCP WD repeat containing planar cell polarity effector 0.0199237
PTPRG protein tyrosine phosphatase, receptor type, G 0.0197715
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0197029
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0196678
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0195846
PGK1 phosphoglycerate kinase 1 0.0192922
PSAT1 phosphoserine aminotransferase 1 0.0191196
SAMD4A sterile alpha motif domain containing 4A 0.0190057
PICALM phosphatidylinositol binding clathrin assembly protein 0.0187878
TMEM135 transmembrane protein 135 0.0185496
SQSTM1 sequestosome 1 0.0185447
CEP83 centrosomal protein 83kDa 0.0185318
AOPEP aminopeptidase O (putative) 0.0183283
RB1CC1 RB1-inducible coiled-coil 1 0.018309
CLIC4 chloride intracellular channel 4 0.0182407
NCEH1 neutral cholesterol ester hydrolase 1 0.0181609
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0179288
GOLGB1 golgin B1 0.0178054
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.017802
ARB2A ARB2 cotranscriptional regulator A 0.017794
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0177356
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177008
COG5 component of oligomeric golgi complex 5 0.0176596
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.017638
CEP250 centrosomal protein 250kDa 0.0174589
RPL13A ribosomal protein L13a 0.017272
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0172586
KMT2D lysine (K)-specific methyltransferase 2D 0.0170967
HDAC8 histone deacetylase 8 0.0170851
TTC3 tetratricopeptide repeat domain 3 0.0170279
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.0169696
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0169288
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0168604
FBXL4 F-box and leucine-rich repeat protein 4 0.0167963
CTIF CBP80/20-dependent translation initiation factor 0.0167395

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.245112
PTMA prothymosin, alpha -0.209631
TPT1 tumor protein, translationally-controlled 1 -0.132142
BMP10 bone morphogenetic protein 10 -0.0998997
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0811259
RPL35A ribosomal protein L35a -0.062901
ECT2 epithelial cell transforming 2 -0.0603569
RPS8 ribosomal protein S8 -0.0600384
DIAPH3 diaphanous-related formin 3 -0.0600093
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.059316
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0581511
SSBP2 single-stranded DNA binding protein 2 -0.057661
SMC4 structural maintenance of chromosomes 4 -0.0552186
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0551968
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0513711
NAV2 neuron navigator 2 -0.051298
VCL vinculin -0.050238
HSPB1 heat shock 27kDa protein 1 -0.0493549
RPS6 ribosomal protein S6 -0.048519
RPS13 ribosomal protein S13 -0.0465598
MKI67 marker of proliferation Ki-67 -0.0464382
RPL34 ribosomal protein L34 -0.0456356
RPS21 ribosomal protein S21 -0.0447256
RPS25 ribosomal protein S25 -0.0438316
RPLP2 ribosomal protein, large, P2 -0.0430678
KPNB1 karyopherin (importin) beta 1 -0.0428437
RPLP0 ribosomal protein, large, P0 -0.039712
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0394746
RPS23 ribosomal protein S23 -0.039264
FUS FUS RNA binding protein -0.0388985
NAP1L1 nucleosome assembly protein 1-like 1 -0.0382524
RPL19 ribosomal protein L19 -0.0369818
CENPF centromere protein F, 350/400kDa -0.0366385
RFC3 replication factor C (activator 1) 3, 38kDa -0.0364284
RRM2 ribonucleotide reductase M2 -0.0363779
TPX2 TPX2, microtubule-associated -0.0354089
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0349041
PUM2 pumilio RNA-binding family member 2 -0.0348773
ANLN anillin, actin binding protein -0.0342989
TRA2A transformer 2 alpha homolog (Drosophila) -0.0340338
TM4SF1 transmembrane 4 L six family member 1 -0.0336577
ACTG1 actin gamma 1 -0.0335153
MACROD2 MACRO domain containing 2 -0.0333901
RPL27A ribosomal protein L27a -0.0315579
QKI QKI, KH domain containing, RNA binding -0.0313328
TUBA1B tubulin, alpha 1b -0.0307303
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0306613
RPLP1 ribosomal protein, large, P1 -0.0306264
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0305741
ATAD2 ATPase family, AAA domain containing 2 -0.030537
RPS11 ribosomal protein S11 -0.0305205
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0302523
RPS27A ribosomal protein S27a -0.0301288
ZEB1 zinc finger E-box binding homeobox 1 -0.0300044
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0291592
LOC102724023 ES1 protein homolog, mitochondrial -0.0288694
S100A9 S100 calcium binding protein A9 -0.0284292
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0282397
RPS24 ribosomal protein S24 -0.0280232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0276058
ASTN2 astrotactin 2 -0.0274569
DLG1 discs, large homolog 1 (Drosophila) -0.0274081
ANXA1 annexin A1 -0.0273233
PDE4D phosphodiesterase 4D, cAMP-specific -0.0271567
DEK DEK proto-oncogene -0.0269492
RPS17 ribosomal protein S17 -0.0269255
GPHN gephyrin -0.0269002
NAMPT nicotinamide phosphoribosyltransferase -0.0263039
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0260983
WAC WW domain containing adaptor with coiled-coil -0.0257941
RAB7A RAB7A, member RAS oncogene family -0.0257823
HJURP Holliday junction recognition protein -0.0257219
RPL23 ribosomal protein L23 -0.0256163
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0255403
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0254596
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.025452
SLC38A2 solute carrier family 38, member 2 -0.0251486
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0250718
CCND1 cyclin D1 -0.0248827
FOXP1 forkhead box P1 -0.0246117
GSE1 Gse1 coiled-coil protein -0.0244541
TAOK1 TAO kinase 1 -0.0242614
TUBB tubulin, beta class I -0.0240851
SCLT1 sodium channel and clathrin linker 1 -0.0238349
PRUNE2 prune homolog 2 (Drosophila) -0.0236629
CAMKMT calmodulin-lysine N-methyltransferase -0.0233688
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0233408
TUBB4B tubulin, beta 4B class IVb -0.0232552
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0232076
SOX6 SRY (sex determining region Y)-box 6 -0.0231196
RPL18 ribosomal protein L18 -0.022984
NOP56 NOP56 ribonucleoprotein -0.0227078
GNAS GNAS complex locus -0.0225811
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0224468
CENPE centromere protein E, 312kDa -0.0223544
RPL11 ribosomal protein L11 -0.0222079
NOP58 NOP58 ribonucleoprotein -0.0220041
RSL1D1 ribosomal L1 domain containing 1 -0.0219939
PDS5A PDS5 cohesin associated factor A -0.0219575
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0219335