Betamethasone dipropionate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IRAK3 interleukin-1 receptor-associated kinase 3 0.113443
FTH1 ferritin, heavy polypeptide 1 0.111845
NAMPT nicotinamide phosphoribosyltransferase 0.111592
TMEM156 transmembrane protein 156 0.105148
MT2A metallothionein 2A 0.0892348
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0809405
FKBP5 FK506 binding protein 5 0.080476
AKAP12 A kinase (PRKA) anchor protein 12 0.0787922
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0754524
TXNIP thioredoxin interacting protein 0.0671505
HOMER2 homer scaffolding protein 2 0.0650016
S100A6 S100 calcium binding protein A6 0.0639474
SAMD4A sterile alpha motif domain containing 4A 0.062306
CENPF centromere protein F, 350/400kDa 0.062224
GLUL glutamate-ammonia ligase 0.0618967
IFI27 interferon, alpha-inducible protein 27 0.0582693
POTEF POTE ankyrin domain family, member F 0.056021
TOP1 topoisomerase (DNA) I 0.0551597
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0530741
EPS8 epidermal growth factor receptor pathway substrate 8 0.0497965
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0496106
MKI67 marker of proliferation Ki-67 0.0495221
KLHL5 kelch-like family member 5 0.047292
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0469764
ETV1 ets variant 1 0.046414
NRP1 neuropilin 1 0.0425273
LOC102724023 ES1 protein homolog, mitochondrial 0.0412317
MYH9 myosin, heavy chain 9, non-muscle 0.0387181
RNF145 ring finger protein 145 0.0384139
KTN1 kinectin 1 (kinesin receptor) 0.0381997
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0381034
IL6ST interleukin 6 signal transducer 0.0375174
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0362242
TMEM165 transmembrane protein 165 0.0361958
JAK2 Janus kinase 2 0.0358503
VIM vimentin 0.0358322
MT1X metallothionein 1X 0.0352331
HIPK2 homeodomain interacting protein kinase 2 0.034878
OSMR oncostatin M receptor 0.0348032
KPNB1 karyopherin (importin) beta 1 0.0341808
IRS2 insulin receptor substrate 2 0.0339213
ZMYND8 zinc finger, MYND-type containing 8 0.0339007
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0332725
TMSB10 thymosin beta 10 0.0331828
MT1E metallothionein 1E 0.032759
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0317076
EGR1 early growth response 1 0.0315419
RUNX2 runt-related transcription factor 2 0.0307646
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0306652
RBM25 RNA binding motif protein 25 0.0301456
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0299919
PCBP2 poly(rC) binding protein 2 0.0293085
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0289516
CCNL1 cyclin L1 0.0287935
B2M beta-2-microglobulin 0.0285121
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0282038
PTBP2 polypyrimidine tract binding protein 2 0.0277784
LAMB1 laminin, beta 1 0.0275526
PDS5A PDS5 cohesin associated factor A 0.0268271
RSRC2 arginine/serine-rich coiled-coil 2 0.0263668
TPM4 tropomyosin 4 0.0258521
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0257439
MATR3 matrin 3 0.0255559
ANLN anillin, actin binding protein 0.0255179
SPRED2 sprouty-related, EVH1 domain containing 2 0.0250495
PKM pyruvate kinase, muscle 0.0249519
HDGF hepatoma-derived growth factor 0.0249442
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0247736
TNS3 tensin 3 0.0247474
PCNX1 pecanex 1 0.0245788
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0244728
ARHGAP9 Rho GTPase activating protein 9 0.0244555
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0243831
NAV2 neuron navigator 2 0.0243749
BIRC3 baculoviral IAP repeat containing 3 0.0242873
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0242786
TLK2 tousled-like kinase 2 0.0241135
CCDC6 coiled-coil domain containing 6 0.0240887
HPCAL1 hippocalcin-like 1 0.0240831
IFITM1 interferon induced transmembrane protein 1 0.0237755
RBMS3 RNA binding motif, single stranded interacting protein 3 0.023475
NTN4 netrin 4 0.0234346
SVIL supervillin 0.0233218
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0233059
DPYD dihydropyrimidine dehydrogenase 0.0232557
TMEM245 transmembrane protein 245 0.0230988
SP3 Sp3 transcription factor 0.0230949
PNISR PNN-interacting serine/arginine-rich protein 0.0229411
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0228737
SRRM2 serine/arginine repetitive matrix 2 0.022757
TPI1 triosephosphate isomerase 1 0.0227214
ANKRD11 ankyrin repeat domain 11 0.0225684
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0225065
FTL ferritin, light polypeptide 0.0224474
STK39 serine threonine kinase 39 0.0222164
CBX3 chromobox homolog 3 0.0221514
KIF5B kinesin family member 5B 0.0220365
SLC38A1 solute carrier family 38, member 1 0.0220141
S100A9 S100 calcium binding protein A9 0.0218612
RIPOR2 RHO family interacting cell polarization regulator 2 0.0217676

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.152262
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139416
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123031
TRIO trio Rho guanine nucleotide exchange factor -0.118648
NRG1 neuregulin 1 -0.105985
CANX calnexin -0.0974247
NDRG1 N-myc downstream regulated 1 -0.0915366
EXT1 exostosin glycosyltransferase 1 -0.0790257
SQSTM1 sequestosome 1 -0.0778476
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0770616
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0768977
CXCL8 chemokine (C-X-C motif) ligand 8 -0.069157
INTS6 integrator complex subunit 6 -0.0684803
AHR aryl hydrocarbon receptor -0.0653039
LOXL2 lysyl oxidase-like 2 -0.0607224
CADM1 cell adhesion molecule 1 -0.0586748
LIMCH1 LIM and calponin homology domains 1 -0.0567238
AEBP2 AE binding protein 2 -0.0565972
HDLBP high density lipoprotein binding protein -0.0548588
RAI14 retinoic acid induced 14 -0.0527759
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0499695
GRB10 growth factor receptor-bound protein 10 -0.0491394
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.045848
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0442787
LRRC23 leucine rich repeat containing 23 -0.0432655
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0424851
MBD5 methyl-CpG binding domain protein 5 -0.0412518
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0407951
MRPS6 mitochondrial ribosomal protein S6 -0.0398826
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.039492
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0394471
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0391757
CTBP2 C-terminal binding protein 2 -0.0372278
EFNA5 ephrin-A5 -0.0362081
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0361681
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0359477
RASAL2 RAS protein activator like 2 -0.03521
GLIS3 GLIS family zinc finger 3 -0.0349502
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0344768
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0338673
FNDC3B fibronectin type III domain containing 3B -0.0331346
HMGA2 high mobility group AT-hook 2 -0.0331143
TGFA transforming growth factor, alpha -0.032431
PARD3 par-3 family cell polarity regulator -0.0319529
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0316246
ARHGAP35 Rho GTPase activating protein 35 -0.0307296
MYOF myoferlin -0.0304713
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0304344
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0295247
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0294631
BZW1 basic leucine zipper and W2 domains 1 -0.0293961
STC2 stanniocalcin 2 -0.029185
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0291619
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0287261
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0285051
IGFBP3 insulin-like growth factor binding protein 3 -0.0284959
CD109 CD109 molecule -0.0282256
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -0.0279536
ASPH aspartate beta-hydroxylase -0.0278888
TUFT1 tuftelin 1 -0.0278243
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0276649
VEGFC vascular endothelial growth factor C -0.0276204
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0274271
RUNX1 runt-related transcription factor 1 -0.027332
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0269304
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0262132
AHI1 Abelson helper integration site 1 -0.0260191
CEMIP2 cell migration inducing hyaluronidase 2 -0.0259977
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0257924
FAT1 FAT atypical cadherin 1 -0.0257621
AHRR aryl-hydrocarbon receptor repressor -0.0255951
MORF4L2 mortality factor 4 like 2 -0.0255772
TRA2A transformer 2 alpha homolog (Drosophila) -0.0253513
SPAG9 sperm associated antigen 9 -0.0251589
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0247476
UGDH UDP-glucose 6-dehydrogenase -0.0247362
SLC35F3 solute carrier family 35, member F3 -0.0245925
MAP1B microtubule-associated protein 1B -0.0245919
AGO2 argonaute RISC catalytic component 2 -0.024472
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0243391
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0240272
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0239707
ETV6 ets variant 6 -0.0238611
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0238078
TFRC transferrin receptor -0.0237882
NBEAL1 neurobeachin-like 1 -0.0237677
RAB10 RAB10, member RAS oncogene family -0.0237508
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0236373
SOD2 superoxide dismutase 2, mitochondrial -0.023428
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0232872
WNK1 WNK lysine deficient protein kinase 1 -0.0231979
RPL12 ribosomal protein L12 -0.0228404
OSBPL8 oxysterol binding protein-like 8 -0.022838
SDCBP syndecan binding protein (syntenin) -0.0225794
FERMT2 fermitin family member 2 -0.0224685
NAV1 neuron navigator 1 -0.0224661
IFRD1 interferon-related developmental regulator 1 -0.0217392
TBC1D22A TBC1 domain family, member 22A -0.0217116
GOLGB1 golgin B1 -0.0216484
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0215527