Betamethasone dipropionate_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0265998
FAM3C family with sequence similarity 3, member C 0.0227341
FTH1 ferritin, heavy polypeptide 1 0.0218468
RAD21 RAD21 homolog (S. pombe) 0.0209018
NCKAP1 NCK-associated protein 1 0.0208402
BCL2L1 BCL2-like 1 0.01823
CUL3 cullin 3 0.0178867
KRT8 keratin 8, type II 0.0177295
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0177028
ESYT2 extended synaptotagmin-like protein 2 0.0171163
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0163249
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0157948
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.015682
RBM27 RNA binding motif protein 27 0.0155487
PTEN phosphatase and tensin homolog 0.0154403
RBM39 RNA binding motif protein 39 0.0151824
ATAD2B ATPase family, AAA domain containing 2B 0.0149113
PRPF6 pre-mRNA processing factor 6 0.0146541
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.014546
DIDO1 death inducer-obliterator 1 0.0144617
XPO1 exportin 1 0.014421
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0143412
ZNRF3 zinc and ring finger 3 0.0141985
LMO7 LIM domain 7 0.0137883
PDS5B PDS5 cohesin associated factor B 0.0136851
HMGB2 high mobility group box 2 0.0135361
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0134278
CTNND1 catenin (cadherin-associated protein), delta 1 0.0132591
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0132299
ZYX zyxin 0.0131571
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0130659
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.013034
SNX9 sorting nexin 9 0.0129716
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.01271
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0127037
NCOA6 nuclear receptor coactivator 6 0.0126477
OSBPL3 oxysterol binding protein-like 3 0.0126394
RABGAP1 RAB GTPase activating protein 1 0.012601
DSCAM Down syndrome cell adhesion molecule 0.0124753
CENPF centromere protein F, 350/400kDa 0.0123791
CD46 CD46 molecule, complement regulatory protein 0.0122894
EPN2 epsin 2 0.0122125
MARCHF6 membrane associated ring-CH-type finger 6 0.0120983
PDE4B phosphodiesterase 4B, cAMP-specific 0.0120965
AFDN afadin, adherens junction formation factor 0.0120668
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0120019
TMSB4X thymosin beta 4, X-linked 0.0119241
EVI5 ecotropic viral integration site 5 0.011912
SETD2 SET domain containing 2 0.0118938
MYH9 myosin, heavy chain 9, non-muscle 0.0117058
PIAS1 protein inhibitor of activated STAT, 1 0.0116932
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0116577
NEMF nuclear export mediator factor 0.0115618
SRSF11 serine/arginine-rich splicing factor 11 0.0115028
AREG amphiregulin 0.0114541
MYO5B myosin VB 0.0114322
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0112821
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0111475
SRRM2 serine/arginine repetitive matrix 2 0.0111313
ITGB4 integrin, beta 4 0.0110994
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.010951
KMT2C lysine (K)-specific methyltransferase 2C 0.0109336
HEATR5B HEAT repeat containing 5B 0.0108866
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0107751
USP24 ubiquitin specific peptidase 24 0.0107102
OSBPL9 oxysterol binding protein-like 9 0.0106932
KDM7A lysine (K)-specific demethylase 7A 0.0106861
IWS1 IWS1 homolog (S. cerevisiae) 0.0106469
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.0106386
PUM2 pumilio RNA-binding family member 2 0.01053
BTBD10 BTB (POZ) domain containing 10 0.0104948
AMBRA1 autophagy/beclin-1 regulator 1 0.0104839
CAMKMT calmodulin-lysine N-methyltransferase 0.0104337
N4BP1 NEDD4 binding protein 1 0.0103272
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0103234
STK24 serine/threonine kinase 24 0.0103089
ICE1 interactor of little elongation complex ELL subunit 1 0.0102399
NT5DC3 5'-nucleotidase domain containing 3 0.0102156
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0100304
MYO6 myosin VI 0.01002
CDYL chromodomain protein, Y-like 0.00997424
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00997105
MED13L mediator complex subunit 13-like 0.00996663
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.00992168
UBE3A ubiquitin protein ligase E3A 0.00990918
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.00988926
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.00988043
TUFT1 tuftelin 1 0.00987051
RLIM ring finger protein, LIM domain interacting 0.00983624
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.00978224
KDM3B lysine (K)-specific demethylase 3B 0.00970263
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 0.00966541
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.00963179
GARS1 glycyl-tRNA synthetase 1 0.00961262
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0095792
THOC2 THO complex 2 0.00948857
KDM6A lysine (K)-specific demethylase 6A 0.00945906
ATAD2 ATPase family, AAA domain containing 2 0.00939035
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.00938615
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0093813

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.146147
PTMA prothymosin, alpha -0.0979173
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0926352
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0880428
TMSB10 thymosin beta 10 -0.0768989
ANXA2 annexin A2 -0.0450352
NDRG1 N-myc downstream regulated 1 -0.0417502
RPL37A ribosomal protein L37a -0.0416413
RPS25 ribosomal protein S25 -0.0404298
EZR ezrin -0.0389454
RPS12 ribosomal protein S12 -0.0385128
RPS19 ribosomal protein S19 -0.0380175
LDHA lactate dehydrogenase A -0.0378073
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0358159
RPS3 ribosomal protein S3 -0.0354673
RPL12 ribosomal protein L12 -0.0352525
RPL28 ribosomal protein L28 -0.0350189
RPL18 ribosomal protein L18 -0.0339601
B2M beta-2-microglobulin -0.033416
RPS13 ribosomal protein S13 -0.0333391
RPS6 ribosomal protein S6 -0.0325852
RPLP1 ribosomal protein, large, P1 -0.0320252
RPL23 ribosomal protein L23 -0.0314912
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0313513
RPL19 ribosomal protein L19 -0.031308
LOC102724023 ES1 protein homolog, mitochondrial -0.0309309
RPL13A ribosomal protein L13a -0.0301541
RPL35A ribosomal protein L35a -0.0295661
RPLP2 ribosomal protein, large, P2 -0.0294221
NEBL nebulette -0.0285312
PKM pyruvate kinase, muscle -0.0275956
CANX calnexin -0.0271132
RPL31 ribosomal protein L31 -0.0269446
AKAP12 A kinase (PRKA) anchor protein 12 -0.0256228
PRRC2C proline-rich coiled-coil 2C -0.0255703
CDK13 cyclin-dependent kinase 13 -0.0254863
RPS11 ribosomal protein S11 -0.0253311
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0252452
STAU1 staufen double-stranded RNA binding protein 1 -0.0252124
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0248177
RPL36 ribosomal protein L36 -0.0247822
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0246993
PDIA3 protein disulfide isomerase family A, member 3 -0.0245327
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0244262
EGR1 early growth response 1 -0.0239547
GNAS GNAS complex locus -0.0239267
COG5 component of oligomeric golgi complex 5 -0.0232612
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0229728
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0223255
RYBP RING1 and YY1 binding protein -0.0222532
TPT1 tumor protein, translationally-controlled 1 -0.0221743
RPL27A ribosomal protein L27a -0.0219571
PGK1 phosphoglycerate kinase 1 -0.0218709
RPS5 ribosomal protein S5 -0.0213763
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0213712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0212208
RPS14 ribosomal protein S14 -0.0211275
JMJD1C jumonji domain containing 1C -0.0210402
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0209302
RPS21 ribosomal protein S21 -0.0207907
IFRD1 interferon-related developmental regulator 1 -0.0206912
RACK1 receptor for activated C kinase 1 -0.0206189
RPL8 ribosomal protein L8 -0.0204838
CLDN4 claudin 4 -0.0204149
RTN3 reticulon 3 -0.0203145
EIF5B eukaryotic translation initiation factor 5B -0.0199489
INTS6 integrator complex subunit 6 -0.0199242
TMEM123 transmembrane protein 123 -0.0199017
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0198936
RCOR1 REST corepressor 1 -0.0198854
RPLP0 ribosomal protein, large, P0 -0.0198549
RPS17 ribosomal protein S17 -0.0198243
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0196422
MYO1E myosin IE -0.0195918
RPL37 ribosomal protein L37 -0.0195904
RAB5A RAB5A, member RAS oncogene family -0.0192375
RPS15 ribosomal protein S15 -0.0191848
BRD2 bromodomain containing 2 -0.0191785
FOXO1 forkhead box O1 -0.019149
ANKRD12 ankyrin repeat domain 12 -0.0185845
RPS27 ribosomal protein S27 -0.0185505
KRT18 keratin 18, type I -0.0184985
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0184812
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0184568
EIF1 eukaryotic translation initiation factor 1 -0.018452
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0183331
ZNF207 zinc finger protein 207 -0.0181397
SPAG9 sperm associated antigen 9 -0.0180962
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0180929
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.017856
EEF1G eukaryotic translation elongation factor 1 gamma -0.0178136
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0178127
CEP350 centrosomal protein 350kDa -0.0177998
RAB10 RAB10, member RAS oncogene family -0.0175466
RPL32 ribosomal protein L32 -0.0174767
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0174272
RPL30 ribosomal protein L30 -0.0172722
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0171896
RPS8 ribosomal protein S8 -0.0170571
RPS27A ribosomal protein S27a -0.0170319