Betamethasone dipropionate_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Betamethasone dipropionate perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Betamethasone dipropionate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.180968
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.10298
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0417856
SYT1 synaptotagmin I 0.035227
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0351832
MKI67 marker of proliferation Ki-67 0.0332729
TNS3 tensin 3 0.0286564
HDAC4 histone deacetylase 4 0.0266894
CD46 CD46 molecule, complement regulatory protein 0.0261907
DSPP dentin sialophosphoprotein 0.0256415
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0249524
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0243587
CENPF centromere protein F, 350/400kDa 0.0242795
ENO1 enolase 1, (alpha) 0.023747
PDE4D phosphodiesterase 4D, cAMP-specific 0.0236868
WWOX WW domain containing oxidoreductase 0.0235511
NAV2 neuron navigator 2 0.0226648
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0217155
CDH13 cadherin 13 0.0216926
MAML2 mastermind-like 2 (Drosophila) 0.0213712
ZBTB20 zinc finger and BTB domain containing 20 0.0211997
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0207374
PROX1 prospero homeobox 1 0.0206848
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196992
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0187166
MYH9 myosin, heavy chain 9, non-muscle 0.0185951
SET SET nuclear proto-oncogene 0.0183503
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0181231
DST dystonin 0.0167532
HMGB2 high mobility group box 2 0.0164796
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0159327
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0153905
MACC1 metastasis associated in colon cancer 1 0.0141442
AKAP12 A kinase (PRKA) anchor protein 12 0.0140725
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0139759
ZNRF3 zinc and ring finger 3 0.0138892
PGK1 phosphoglycerate kinase 1 0.0137526
HSPA8 heat shock 70kDa protein 8 0.0135888
RBM26 RNA binding motif protein 26 0.0135642
ADGRL2 adhesion G protein-coupled receptor L2 0.0132388
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0131254
VGLL4 vestigial-like family member 4 0.0131091
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0123457
NONO non-POU domain containing, octamer-binding 0.0123124
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0122744
TAS2R14 taste receptor, type 2, member 14 0.0121874
RPL3 ribosomal protein L3 0.0121711
TCF12 transcription factor 12 0.0121067
RAD21 RAD21 homolog (S. pombe) 0.0119716
CDK6 cyclin-dependent kinase 6 0.0119476
RBM25 RNA binding motif protein 25 0.0118186
KIZ kizuna centrosomal protein 0.011744
AOPEP aminopeptidase O (putative) 0.0116398
ILF3 interleukin enhancer binding factor 3, 90kDa 0.011637
BMP5 bone morphogenetic protein 5 0.011617
EXOC4 exocyst complex component 4 0.0113922
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0112514
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0107212
C2CD5 C2 calcium-dependent domain containing 5 0.0106675
PEAK1 pseudopodium-enriched atypical kinase 1 0.0106091
SOX4 SRY (sex determining region Y)-box 4 0.0105221
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0104779
BCAS3 breast carcinoma amplified sequence 3 0.0103528
RPS4X ribosomal protein S4, X-linked 0.0102614
HDAC2 histone deacetylase 2 0.0102567
EIF4B eukaryotic translation initiation factor 4B 0.00997905
ARHGAP9 Rho GTPase activating protein 9 0.00981741
TMSB4X thymosin beta 4, X-linked 0.0095703
ARL15 ADP-ribosylation factor-like 15 0.0095592
ARID1B AT rich interactive domain 1B (SWI1-like) 0.00951383
CEMIP cell migration inducing protein, hyaluronan binding 0.00946003
RNF43 ring finger protein 43 0.00931875
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00927307
LMO7 LIM domain 7 0.00922945
EEF2 eukaryotic translation elongation factor 2 0.00922752
PRELID2 PRELI domain containing 2 0.00915288
PLEC plectin 0.00907203
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.00905038
PHF14 PHD finger protein 14 0.00896758
PCDH9 protocadherin 9 0.00883048
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00876773
MTCL1 microtubule crosslinking factor 1 0.00872625
MAN1A1 mannosidase, alpha, class 1A, member 1 0.00871956
PTEN phosphatase and tensin homolog 0.00862432
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.00854308
SFPQ splicing factor proline/glutamine-rich 0.00851927
KRT8 keratin 8, type II 0.00844751
CCDC6 coiled-coil domain containing 6 0.00840996
SRSF10 serine/arginine-rich splicing factor 10 0.00833389
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00828082
ATXN1 ataxin 1 0.00814092
TMEM163 transmembrane protein 163 0.0078678
ANKRD36 ankyrin repeat domain 36 0.00776244
SPATA13 spermatogenesis associated 13 0.00772111
CNTRL centriolin 0.0077174
CMIP c-Maf inducing protein 0.00764986
THADA thyroid adenoma associated 0.0076336
NIPBL Nipped-B homolog (Drosophila) 0.00757986
IGF2R insulin-like growth factor 2 receptor 0.00756707
MATR3 matrin 3 0.00753354

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113391
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0773555
TPT1 tumor protein, translationally-controlled 1 -0.0653862
RPL35A ribosomal protein L35a -0.0568798
ANXA2 annexin A2 -0.0536056
TMSB10 thymosin beta 10 -0.0477943
FTL ferritin, light polypeptide -0.042057
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383657
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.038288
EZR ezrin -0.0381393
RPS19 ribosomal protein S19 -0.0363675
MT2A metallothionein 2A -0.0362951
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.036144
RPS13 ribosomal protein S13 -0.0342183
NDRG1 N-myc downstream regulated 1 -0.0338459
RPL37A ribosomal protein L37a -0.032651
RPLP1 ribosomal protein, large, P1 -0.0318637
EIF1 eukaryotic translation initiation factor 1 -0.0307883
EGR1 early growth response 1 -0.0304409
RPS25 ribosomal protein S25 -0.0301207
RPL12 ribosomal protein L12 -0.0297067
RPS8 ribosomal protein S8 -0.0296401
ESYT2 extended synaptotagmin-like protein 2 -0.0291661
RPL31 ribosomal protein L31 -0.0288846
PTMA prothymosin, alpha -0.0270164
RPLP2 ribosomal protein, large, P2 -0.0264159
LOC102724023 ES1 protein homolog, mitochondrial -0.0260662
RPL23 ribosomal protein L23 -0.0258671
EMP1 epithelial membrane protein 1 -0.0258637
RPS6 ribosomal protein S6 -0.0258272
RPS23 ribosomal protein S23 -0.0251728
S100A10 S100 calcium binding protein A10 -0.0247286
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0244458
RPS24 ribosomal protein S24 -0.0233734
GOLGA4 golgin A4 -0.0225675
RPS5 ribosomal protein S5 -0.0223811
RPL19 ribosomal protein L19 -0.0221314
VMP1 vacuole membrane protein 1 -0.0220297
RPS11 ribosomal protein S11 -0.0219189
ACTG1 actin gamma 1 -0.0218516
RPL28 ribosomal protein L28 -0.0216188
RBP1 retinol binding protein 1, cellular -0.0212704
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0205606
SEC31A SEC31 homolog A (S. cerevisiae) -0.0205503
ARF4 ADP-ribosylation factor 4 -0.0197653
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0193038
RPS14 ribosomal protein S14 -0.0192141
FLNB filamin B, beta -0.0191857
KMT2E lysine (K)-specific methyltransferase 2E -0.0191111
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0190153
CCND1 cyclin D1 -0.0189414
COG5 component of oligomeric golgi complex 5 -0.0189407
RPLP0 ribosomal protein, large, P0 -0.0186882
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0185275
RPS29 ribosomal protein S29 -0.0183241
DDIT4 DNA-damage-inducible transcript 4 -0.0182864
ZCCHC7 zinc finger, CCHC domain containing 7 -0.018139
RPS16 ribosomal protein S16 -0.0180831
RPL36 ribosomal protein L36 -0.0178668
RPL7A ribosomal protein L7a -0.0178601
INTS6 integrator complex subunit 6 -0.0178318
RPL11 ribosomal protein L11 -0.0177864
RPL5 ribosomal protein L5 -0.0172047
RPS21 ribosomal protein S21 -0.0171936
SQSTM1 sequestosome 1 -0.0170933
PFN1 profilin 1 -0.0169839
VDAC1 voltage-dependent anion channel 1 -0.0162922
RPS27A ribosomal protein S27a -0.0160946
RPL9 ribosomal protein L9 -0.0159807
SDK1 sidekick cell adhesion molecule 1 -0.0158838
RPL34 ribosomal protein L34 -0.0158806
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.015806
RPS12 ribosomal protein S12 -0.0154701
VCL vinculin -0.015356
VIM vimentin -0.0150118
CD9 CD9 molecule -0.0148842
RPL36A ribosomal protein L36a -0.0146292
SLC38A2 solute carrier family 38, member 2 -0.0141292
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0140807
RPL38 ribosomal protein L38 -0.0140512
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0140011
HM13 histocompatibility (minor) 13 -0.0139662
GNAS GNAS complex locus -0.0139469
RPS15 ribosomal protein S15 -0.0138863
RAB1A RAB1A, member RAS oncogene family -0.0138646
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0138535
FOSL1 FOS-like antigen 1 -0.013782
UBC ubiquitin C -0.0135824
RACK1 receptor for activated C kinase 1 -0.0134116
SLC38A1 solute carrier family 38, member 1 -0.0134112
ATP5F1B ATP synthase F1 subunit beta -0.0133671
DLG1 discs, large homolog 1 (Drosophila) -0.0133568
IER3 immediate early response 3 -0.0130799
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0130472
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0129022
PCBP2 poly(rC) binding protein 2 -0.0128895
FNIP1 folliculin interacting protein 1 -0.0128641
RPS17 ribosomal protein S17 -0.0128599
RAB7A RAB7A, member RAS oncogene family -0.0127809
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0126941