Betamethasone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
Description A glucocorticoid that has formula C22H29FO5. (Chemical Entities of Biological Interest Ontology, CHEBI_3077)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9782
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Genes

199 proteins with high or low expression in Betamethasone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DMD dystrophin 5.04
DNAH6 dynein, axonemal, heavy chain 6 2.58
NCAM1 neural cell adhesion molecule 1 2.36
CCDC91 coiled-coil domain containing 91 1.61
UBE2C ubiquitin-conjugating enzyme E2C 1.23
PSRC1 proline/serine-rich coiled-coil 1 1.19
CREG1 cellular repressor of E1A-stimulated genes 1 1.17
HOXA10 homeobox A10 1.17
ENKD1 enkurin domain containing 1 1.15
PCLAF PCNA clamp associated factor 1.1
MAGEF1 melanoma antigen family F1 1.1
CCNB1 cyclin B1 1.09
CDC20 cell division cycle 20 1.08
LMLN leishmanolysin-like (metallopeptidase M8 family) 1.06
PLK1 polo-like kinase 1 1.05
ZFYVE9 zinc finger, FYVE domain containing 9 1.02
RRM2 ribonucleotide reductase M2 1.02
PTTG1 pituitary tumor-transforming 1 0.98
CCNA1 cyclin A1 0.98
TK1 thymidine kinase 1, soluble 0.96
KMT2B lysine (K)-specific methyltransferase 2B 0.96
CCNA2 cyclin A2 0.95
MYO15A myosin XVA 0.95
CLSPN claspin 0.93
TOP2A topoisomerase (DNA) II alpha 170kDa 0.92
CCNB2 cyclin B2 0.92
ANLN anillin, actin binding protein 0.91
FBXO5 F-box protein 5 0.9
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.89
NAF1 nuclear assembly factor 1 ribonucleoprotein 0.89
UBE2T ubiquitin-conjugating enzyme E2T 0.88
CDKN3 cyclin-dependent kinase inhibitor 3 0.88
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.87
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.87
CDCA2 cell division cycle associated 2 0.87
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.86
CDC6 cell division cycle 6 0.86
PBK PDZ binding kinase 0.86
RAD51AP1 RAD51 associated protein 1 0.86
AURKA aurora kinase A 0.84
NEK2 NIMA-related kinase 2 0.84
PRR11 proline rich 11 0.83
SHCBP1 SHC SH2-domain binding protein 1 0.83
DONSON downstream neighbor of SON 0.82
LRR1 leucine rich repeat protein 1 0.82
ZNF445 zinc finger protein 445 0.82
KIF20A kinesin family member 20A 0.82
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.82
SACK1D scaffolding CK1 anchoring protein D 0.81
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 0.81
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.8
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.8
FAM111B family with sequence similarity 111, member B 0.79
CDCA8 cell division cycle associated 8 0.78
TTK TTK protein kinase 0.77
RAD51 RAD51 recombinase 0.77
TYRO3 TYRO3 protein tyrosine kinase 0.76
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.74
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.73
AURKB aurora kinase B 0.73
KIF22 kinesin family member 22 0.73
GTSE1 G-2 and S-phase expressed 1 0.72
CCDC138 coiled-coil domain containing 138 0.72
DNA2 DNA replication helicase/nuclease 2 0.72
GMNN geminin, DNA replication inhibitor 0.72
CDCA5 cell division cycle associated 5 0.72
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.72
CTNND2 catenin (cadherin-associated protein), delta 2 0.71
SPDL1 spindle apparatus coiled-coil protein 1 0.71
DEPDC1B DEP domain containing 1B 0.71
TPX2 TPX2, microtubule-associated 0.7
SGO2 shugoshin 2 0.7
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.69
SAPCD2 suppressor APC domain containing 2 0.69
RAD54B RAD54 homolog B (S. cerevisiae) 0.69
C6ORF89 chromosome 6 open reading frame 89 0.69
RAD54L RAD54-like (S. cerevisiae) 0.68
KIF20B kinesin family member 20B 0.67
ARHGAP19 Rho GTPase activating protein 19 0.67
CENPE centromere protein E, 312kDa 0.67
WDR20 WD repeat domain 20 0.67
TRIM29 tripartite motif containing 29 0.67
MCM10 minichromosome maintenance complex component 10 0.66
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.66
EXO1 exonuclease 1 0.66
KNL1 kinetochore scaffold 1 0.66
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.65
BIRC5 baculoviral IAP repeat containing 5 0.65
C5ORF34 chromosome 5 open reading frame 34 0.65
MIS18BP1 MIS18 binding protein 1 0.65
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.65
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.65
UBE2S ubiquitin-conjugating enzyme E2S 0.64
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.64
B2M beta-2-microglobulin 0.63
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.62
WDR76 WD repeat domain 76 0.62
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.62
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.62

low expression

Symbol Name Standardized Value
LRRC49 leucine rich repeat containing 49 -2.74
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -1.09
GDF15 growth differentiation factor 15 -1.04
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.89
VGF VGF nerve growth factor inducible -0.8
SLC16A6 solute carrier family 16, member 6 -0.8
FTL ferritin, light polypeptide -0.74
BAIAP2 BAI1-associated protein 2 -0.71
FTH1 ferritin, heavy polypeptide 1 -0.71
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.7
HMOX1 heme oxygenase 1 -0.7
FBXL20 F-box and leucine-rich repeat protein 20 -0.66
ZBED8 zinc finger, BED-type containing 8 -0.65
ZNF483 zinc finger protein 483 -0.65
FAM110A family with sequence similarity 110, member A -0.64
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.62
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.62
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -0.59
SERINC1 serine incorporator 1 -0.58
ADIRF adipogenesis regulatory factor -0.58
CCDC28A coiled-coil domain containing 28A -0.58
RNASE4 ribonuclease, RNase A family, 4 -0.58
C12ORF66 chromosome 12 open reading frame 66 -0.57
MEGF8 multiple EGF-like-domains 8 -0.57
PGPEP1 pyroglutamyl-peptidase I -0.57
TBC1D25 TBC1 domain family, member 25 -0.56
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.56
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 -0.56
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.55
CES2 carboxylesterase 2 -0.55
MYH13 myosin, heavy chain 13, skeletal muscle -0.54
PLCD1 phospholipase C, delta 1 -0.54
SLC22A18 solute carrier family 22, member 18 -0.54
ADGRE2 adhesion G protein-coupled receptor E2 -0.54
MAP1B microtubule-associated protein 1B -0.53
C18ORF32 chromosome 18 open reading frame 32 -0.53
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.52
KIAA1324L KIAA1324-like -0.52
YIPF1 Yip1 domain family, member 1 -0.52
NDRG1 N-myc downstream regulated 1 -0.51
LRP10 low density lipoprotein receptor-related protein 10 -0.51
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.5
COL6A6 collagen, type VI, alpha 6 -0.5
PLEK pleckstrin -0.5
IRF9 interferon regulatory factor 9 -0.5
GLRX glutaredoxin (thioltransferase) -0.5
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -0.49
PSAP prosaposin -0.49
PLD6 phospholipase D family, member 6 -0.49
SERINC5 serine incorporator 5 -0.49
TIMP3 TIMP metallopeptidase inhibitor 3 -0.49
FHIT fragile histidine triad -0.49
AAMDC adipogenesis associated, Mth938 domain containing -0.48
RNF126 ring finger protein 126 -0.48
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.48
OAF OAF homolog (Drosophila) -0.48
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.47
SDHAF4 succinate dehydrogenase complex assembly factor 4 -0.47
SYTL1 synaptotagmin-like 1 -0.47
RGPD8 RANBP2-like and GRIP domain containing 8 -0.47
DIPK1A divergent protein kinase domain 1A -0.46
COL14A1 collagen, type XIV, alpha 1 -0.46
TP53I3 tumor protein p53 inducible protein 3 -0.46
UQCRB ubiquinol-cytochrome c reductase binding protein -0.46
ICAM5 intercellular adhesion molecule 5, telencephalin -0.46
ABRACL ABRA C-terminal like -0.46
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -0.45
TSKU tsukushi, small leucine rich proteoglycan -0.45
MID2 midline 2 -0.44
WTAP Wilms tumor 1 associated protein -0.44
SYK spleen tyrosine kinase -0.44
ZFP64 ZFP64 zinc finger protein -0.44
ZSWIM7 zinc finger, SWIM-type containing 7 -0.44
F13A1 coagulation factor XIII, A1 polypeptide -0.43
ZYX zyxin -0.43
FBXO44 F-box protein 44 -0.43
PSEN2 presenilin 2 -0.43
SF3B4 splicing factor 3b, subunit 4, 49kDa -0.43
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.43
FBF1 Fas (TNFRSF6) binding factor 1 -0.43
PLSCR3 phospholipid scramblase 3 -0.43
INHBA inhibin, beta A -0.42
CERS4 ceramide synthase 4 -0.42
PDGFC platelet derived growth factor C -0.42
ABHD4 abhydrolase domain containing 4 -0.42
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -0.42
FCHSD1 FCH and double SH3 domains 1 -0.42
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.42
TECPR1 tectonin beta-propeller repeat containing 1 -0.42
PLA2G12A phospholipase A2, group XIIA -0.41
RABAC1 Rab acceptor 1 (prenylated) -0.41
SNRPF small nuclear ribonucleoprotein polypeptide F -0.41
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.41
SDSL serine dehydratase-like -0.41
AKR1C2 aldo-keto reductase family 1, member C2 -0.41
NRBF2 nuclear receptor binding factor 2 -0.41
ATG4A autophagy related 4A, cysteine peptidase -0.41
EML2 echinoderm microtubule associated protein like 2 -0.41
L1RE1 LINE1 retrotransposable element 1 -0.41