Bexarotene Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/82146
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Genes

198 proteins with high or low expression in Bexarotene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PLIN2 perilipin 2 1.52
TINAGL1 tubulointerstitial nephritis antigen-like 1 1.11
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 1.01
KLK6 kallikrein-related peptidase 6 0.88
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.87
HMCN1 hemicentin 1 0.77
SMIM26 small integral membrane protein 26 0.73
GID8 GID complex subunit 8 0.72
MID1IP1 MID1 interacting protein 1 0.71
C5ORF34 chromosome 5 open reading frame 34 0.65
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.65
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.64
CLTA clathrin, light chain A 0.62
TOX2 TOX high mobility group box family member 2 0.62
TMEM135 transmembrane protein 135 0.61
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.6
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.59
GEMIN7 gem (nuclear organelle) associated protein 7 0.57
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.57
PRELID1 PRELI domain containing 1 0.56
PRELID3B PRELI domain containing 3B 0.55
FYN FYN proto-oncogene, Src family tyrosine kinase 0.53
XTBD1 XRN2 binding domain containing 1 0.52
CCDC57 coiled-coil domain containing 57 0.52
UBL7 ubiquitin-like 7 0.51
POMP proteasome maturation protein 0.51
HYPK huntingtin interacting protein K 0.51
C9ORF40 chromosome 9 open reading frame 40 0.5
COL6A3 collagen, type VI, alpha 3 0.5
S100A14 S100 calcium binding protein A14 0.5
HAS3 hyaluronan synthase 3 0.49
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.49
ATP5PF ATP synthase peripheral stalk subunit F6 0.49
ERH enhancer of rudimentary homolog (Drosophila) 0.49
C12ORF57 chromosome 12 open reading frame 57 0.49
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.49
FAM89A family with sequence similarity 89, member A 0.48
ABHD5 abhydrolase domain containing 5 0.48
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.46
F13A1 coagulation factor XIII, A1 polypeptide 0.46
ZNF114 zinc finger protein 114 0.45
PFDN5 prefoldin subunit 5 0.45
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.44
COX5A cytochrome c oxidase subunit Va 0.44
UBE2C ubiquitin-conjugating enzyme E2C 0.44
NKAPD1 NKAP domain containing 1 0.44
TMSB10 thymosin beta 10 0.44
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.43
ERVK3-1 endogenous retrovirus group K3, member 1 0.43
FGG fibrinogen gamma chain 0.43
C7 complement component 7 0.42
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.42
GLRX glutaredoxin (thioltransferase) 0.42
MCFD2 multiple coagulation factor deficiency 2 0.42
VCAN versican 0.42
PFDN1 prefoldin subunit 1 0.41
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.41
ZNF296 zinc finger protein 296 0.41
RPLP2 ribosomal protein, large, P2 0.41
COQ4 coenzyme Q4 0.41
ANAPC16 anaphase promoting complex subunit 16 0.4
CCDC43 coiled-coil domain containing 43 0.4
TACSTD2 tumor-associated calcium signal transducer 2 0.39
DLEC1 deleted in lung and esophageal cancer 1 0.39
PABPC1 poly(A) binding protein, cytoplasmic 1 0.39
KIAA0586 KIAA0586 0.39
STMN3 stathmin-like 3 0.39
SHB Src homology 2 domain containing adaptor protein B 0.38
SPC24 SPC24, NDC80 kinetochore complex component 0.38
COX19 COX19 cytochrome c oxidase assembly factor 0.38
ANKRD36C ankyrin repeat domain 36C 0.38
ALAS1 5'-aminolevulinate synthase 1 0.38
DCTPP1 dCTP pyrophosphatase 1 0.38
TNNC2 troponin C type 2 (fast) 0.38
JPT1 Jupiter microtubule associated homolog 1 0.37
BANF1 barrier to autointegration factor 1 0.37
XIRP2 xin actin binding repeat containing 2 0.37
PPCDC phosphopantothenoylcysteine decarboxylase 0.37
LOXL2 lysyl oxidase-like 2 0.37
MTPN myotrophin 0.37
HINT2 histidine triad nucleotide binding protein 2 0.37
FAM136A family with sequence similarity 136, member A 0.37
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.36
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.36
DOHH deoxyhypusine hydroxylase/monooxygenase 0.36
PKM pyruvate kinase, muscle 0.36
METTL9 methyltransferase like 9 0.36
MRPL12 mitochondrial ribosomal protein L12 0.36
BID BH3 interacting domain death agonist 0.36
MXRA7 matrix-remodelling associated 7 0.36
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.36
LYPLA2 lysophospholipase II 0.36
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.35
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.35
ACSL3 acyl-CoA synthetase long-chain family member 3 0.35
BPTF bromodomain PHD finger transcription factor 0.35
RPL36A ribosomal protein L36a 0.35
PRKCH protein kinase C, eta 0.35

low expression

Symbol Name Standardized Value
KMT2B lysine (K)-specific methyltransferase 2B -2.4
ZSCAN32 zinc finger and SCAN domain containing 32 -2.27
DMD dystrophin -1.42
TAZ tafazzin -1.42
NPHP3 nephronophthisis 3 (adolescent) -1.4
KSR2 kinase suppressor of ras 2 -1.34
ADCY10 adenylate cyclase 10 (soluble) -1.29
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.19
COL17A1 collagen, type XVII, alpha 1 -1.16
TTLL4 tubulin tyrosine ligase-like family member 4 -1.15
SLC30A6 solute carrier family 30 (zinc transporter), member 6 -0.97
BAIAP2 BAI1-associated protein 2 -0.89
RXRG retinoid X receptor, gamma -0.89
DSTYK dual serine/threonine and tyrosine protein kinase -0.87
GJC1 gap junction protein, gamma 1, 45kDa -0.85
COL11A1 collagen, type XI, alpha 1 -0.8
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.75
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.74
MYH13 myosin, heavy chain 13, skeletal muscle -0.7
SUSD2 sushi domain containing 2 -0.69
ARG2 arginase 2 -0.69
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -0.69
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.68
RARG retinoic acid receptor, gamma -0.67
RXRB retinoid X receptor, beta -0.67
PPP1R26 protein phosphatase 1, regulatory subunit 26 -0.66
WDR25 WD repeat domain 25 -0.66
ZNF780A zinc finger protein 780A -0.63
PCLO piccolo presynaptic cytomatrix protein -0.62
SNRPC small nuclear ribonucleoprotein polypeptide C -0.62
WASF3 WAS protein family, member 3 -0.61
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.61
PPARD peroxisome proliferator-activated receptor delta -0.6
VIM vimentin -0.59
DNASE1L1 deoxyribonuclease I-like 1 -0.58
CRELD1 cysteine-rich with EGF-like domains 1 -0.57
RXRA retinoid X receptor, alpha -0.57
DUSP4 dual specificity phosphatase 4 -0.57
SLC16A6 solute carrier family 16, member 6 -0.55
PRKCQ protein kinase C, theta -0.54
IRF9 interferon regulatory factor 9 -0.54
PIAS3 protein inhibitor of activated STAT, 3 -0.54
RGN regucalcin -0.53
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.53
KLHL24 kelch-like family member 24 -0.53
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 -0.52
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.52
MNT MAX network transcriptional repressor -0.52
RYK receptor-like tyrosine kinase -0.52
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.51
RBL2 retinoblastoma-like 2 -0.51
BMPR1A bone morphogenetic protein receptor, type IA -0.49
ENO1 enolase 1, (alpha) -0.49
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.49
INPP5J inositol polyphosphate-5-phosphatase J -0.49
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -0.49
BAHCC1 BAH domain and coiled-coil containing 1 -0.48
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.47
FGF2 fibroblast growth factor 2 (basic) -0.47
PLAUR plasminogen activator, urokinase receptor -0.47
TRIM8 tripartite motif containing 8 -0.47
CPE carboxypeptidase E -0.47
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -0.46
NLGN2 neuroligin 2 -0.46
SIX5 SIX homeobox 5 -0.46
TMEM120A transmembrane protein 120A -0.45
AASS aminoadipate-semialdehyde synthase -0.45
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) -0.45
PXK PX domain containing serine/threonine kinase -0.45
FAM122B family with sequence similarity 122B -0.44
TP53I3 tumor protein p53 inducible protein 3 -0.44
PYGO2 pygopus family PHD finger 2 -0.44
TMEM173 transmembrane protein 173 -0.43
FAM102B family with sequence similarity 102, member B -0.43
PLPP3 phospholipid phosphatase 3 -0.42
CD63 CD63 molecule -0.42
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 -0.41
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.41
ZNF428 zinc finger protein 428 -0.41
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.41
TPM4 tropomyosin 4 -0.4
TMEM200A transmembrane protein 200A -0.4
PRMT6 protein arginine methyltransferase 6 -0.4
TMEM41B transmembrane protein 41B -0.39
PTPRB protein tyrosine phosphatase, receptor type, B -0.39
FAM171A1 family with sequence similarity 171, member A1 -0.39
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -0.39
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -0.38
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.37
CERS4 ceramide synthase 4 -0.37
ALG12 ALG12, alpha-1,6-mannosyltransferase -0.37
TFCP2L1 transcription factor CP2-like 1 -0.37
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.37
ARSK arylsulfatase family, member K -0.37
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.36
JPT2 Jupiter microtubule associated homolog 2 -0.36
FBXL14 F-box and leucine-rich repeat protein 14 -0.36
RAB27B RAB27B, member RAS oncogene family -0.36
PEBP1 phosphatidylethanolamine binding protein 1 -0.36
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -0.35