Bexarotene_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.452836
AKAP12 A kinase (PRKA) anchor protein 12 0.306753
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.146303
DLG1 discs, large homolog 1 (Drosophila) 0.10204
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.100185
IGFBP3 insulin-like growth factor binding protein 3 0.0945211
TRIO trio Rho guanine nucleotide exchange factor 0.086578
FLNB filamin B, beta 0.0717716
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0655553
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0639261
SLC39A11 solute carrier family 39, member 11 0.058945
NAV2 neuron navigator 2 0.0589316
ZEB1 zinc finger E-box binding homeobox 1 0.0562123
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.055331
PBX3 pre-B-cell leukemia homeobox 3 0.0533623
LOXL2 lysyl oxidase-like 2 0.0517052
CDH13 cadherin 13 0.0515026
PLAT plasminogen activator, tissue 0.0490992
EGFR epidermal growth factor receptor 0.0483718
SEPTIN9 septin 9 0.0419032
FNIP1 folliculin interacting protein 1 0.0412738
ZFP36L1 ZFP36 ring finger protein-like 1 0.041071
MBNL2 muscleblind-like splicing regulator 2 0.0403757
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0392617
GOLGA4 golgin A4 0.0390357
HDAC9 histone deacetylase 9 0.0384726
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0384586
OPTN optineurin 0.0378859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.037859
PODXL podocalyxin-like 0.0373168
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0370878
ELL2 elongation factor, RNA polymerase II, 2 0.0365629
MYADM myeloid-associated differentiation marker 0.036503
CD109 CD109 molecule 0.0351561
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0349424
MSI2 musashi RNA-binding protein 2 0.0347064
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0342351
MACF1 microtubule-actin crosslinking factor 1 0.0336297
MSN moesin 0.0335889
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328391
FNDC3B fibronectin type III domain containing 3B 0.0324963
HELZ helicase with zinc finger 0.0324501
ABI3BP ABI family, member 3 (NESH) binding protein 0.0321633
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0299931
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0298969
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0294242
DSPP dentin sialophosphoprotein 0.0293432
SPIRE1 spire-type actin nucleation factor 1 0.0282743
AFF3 AF4/FMR2 family, member 3 0.0281194
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0281138
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.027882
ESYT2 extended synaptotagmin-like protein 2 0.0276688
FAM107B family with sequence similarity 107, member B 0.0276358
CANX calnexin 0.0275407
MYOF myoferlin 0.0275218
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0268802
VEGFA vascular endothelial growth factor A 0.0267589
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0262968
UBA6 ubiquitin-like modifier activating enzyme 6 0.0253668
DST dystonin 0.0252732
ANO6 anoctamin 6 0.0252543
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0251777
SOX9 SRY (sex determining region Y)-box 9 0.0251511
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.024143
DCAF6 DDB1 and CUL4 associated factor 6 0.023966
MYH9 myosin, heavy chain 9, non-muscle 0.0239409
BACE2 beta-site APP-cleaving enzyme 2 0.0239049
TPM3 tropomyosin 3 0.0238675
SBF2 SET binding factor 2 0.0238275
ZMIZ1 zinc finger, MIZ-type containing 1 0.0235885
ANXA1 annexin A1 0.0235103
BHLHE40 basic helix-loop-helix family, member e40 0.0232648
EFNA5 ephrin-A5 0.0232212
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0229184
RND3 Rho family GTPase 3 0.0226449
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0225294
SETD5 SET domain containing 5 0.0225137
FN1 fibronectin 1 0.0223272
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0221815
AFDN afadin, adherens junction formation factor 0.0221252
SP3 Sp3 transcription factor 0.0220098
RASA2 RAS p21 protein activator 2 0.0219034
SUCO SUN domain containing ossification factor 0.0217762
COPA coatomer protein complex, subunit alpha 0.0217521
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0214928
CENPF centromere protein F, 350/400kDa 0.0214043
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0212115
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0211732
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0210606
MMP12 matrix metallopeptidase 12 0.0209495
TSC22D2 TSC22 domain family, member 2 0.0201574
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0201227
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0201049
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0200269
TIMP2 TIMP metallopeptidase inhibitor 2 0.019993
CALR calreticulin 0.0199871
FAM219A family with sequence similarity 219, member A 0.0199202
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0199041
C1ORF21 chromosome 1 open reading frame 21 0.0196132
FRMD5 FERM domain containing 5 0.019518

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.185401
TMSB10 thymosin beta 10 -0.150223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14449
FBN1 fibrillin 1 -0.112903
LOX lysyl oxidase -0.0980174
VIM vimentin -0.0952028
MT2A metallothionein 2A -0.0904382
HLA-B major histocompatibility complex, class I, B -0.0886247
THBS2 thrombospondin 2 -0.0703515
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0688399
S100A10 S100 calcium binding protein A10 -0.0687755
CD44 CD44 molecule (Indian blood group) -0.0638207
MEIS2 Meis homeobox 2 -0.060931
GLIS3 GLIS family zinc finger 3 -0.0573002
COL1A2 collagen, type I, alpha 2 -0.0572232
IFITM3 interferon induced transmembrane protein 3 -0.052021
B2M beta-2-microglobulin -0.047926
MX2 MX dynamin-like GTPase 2 -0.0479246
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0465736
HLA-C major histocompatibility complex, class I, C -0.0457242
IFITM1 interferon induced transmembrane protein 1 -0.0442422
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0414412
COL3A1 collagen, type III, alpha 1 -0.0405497
RIGI RNA sensor RIG-I -0.038658
LOC112694756 uncharaterized LOC112694756 -0.0384223
CAVIN1 caveolae associated protein 1 -0.0382728
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0375343
LMNA lamin A/C -0.0363477
WWTR1 WW domain containing transcription regulator 1 -0.034739
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0340893
PRSS23 protease, serine, 23 -0.0320966
IFI16 interferon, gamma-inducible protein 16 -0.0310107
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0309197
NPR2 natriuretic peptide receptor 2 -0.0305024
COL5A2 collagen, type V, alpha 2 -0.0304037
IFIH1 interferon induced with helicase C domain 1 -0.0303435
MARCKS myristoylated alanine-rich protein kinase C substrate -0.028754
HLA-E major histocompatibility complex, class I, E -0.0285898
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0284961
ACTG1 actin gamma 1 -0.0283268
TPT1 tumor protein, translationally-controlled 1 -0.0283104
RRBP1 ribosome binding protein 1 -0.0275543
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.027077
PTMA prothymosin, alpha -0.0270601
RPL23 ribosomal protein L23 -0.0269498
HSPB1 heat shock 27kDa protein 1 -0.0263068
SAMD9 sterile alpha motif domain containing 9 -0.0247628
FTH1 ferritin, heavy polypeptide 1 -0.0239631
EXT1 exostosin glycosyltransferase 1 -0.0238368
RPL35A ribosomal protein L35a -0.0232269
ANXA2 annexin A2 -0.0231216
ARF1 ADP-ribosylation factor 1 -0.0229514
TUBB4B tubulin, beta 4B class IVb -0.0228743
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0228731
S100A6 S100 calcium binding protein A6 -0.0226959
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0224901
CCL5 chemokine (C-C motif) ligand 5 -0.0222697
SP100 SP100 nuclear antigen -0.0220962
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0220784
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0217517
ZNFX1 zinc finger, NFX1-type containing 1 -0.0216248
TXNIP thioredoxin interacting protein -0.021553
NAP1L1 nucleosome assembly protein 1-like 1 -0.0212206
MT1X metallothionein 1X -0.0208782
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0207812
RNF213 ring finger protein 213 -0.0204311
PXDN peroxidasin -0.0204111
RPS24 ribosomal protein S24 -0.0203939
SAMD9L sterile alpha motif domain containing 9-like -0.0203851
GNAS GNAS complex locus -0.0201009
CKAP4 cytoskeleton-associated protein 4 -0.0200279
ISG15 ISG15 ubiquitin-like modifier -0.0199767
CDK6 cyclin-dependent kinase 6 -0.0198937
FTL ferritin, light polypeptide -0.0196763
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0194177
IFI6 interferon, alpha-inducible protein 6 -0.0192411
RPS6 ribosomal protein S6 -0.0192122
SMC4 structural maintenance of chromosomes 4 -0.019204
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0191791
DPYSL3 dihydropyrimidinase-like 3 -0.0191679
RPLP2 ribosomal protein, large, P2 -0.0187593
OSMR oncostatin M receptor -0.0185951
GSE1 Gse1 coiled-coil protein -0.0184523
RPL36 ribosomal protein L36 -0.0184109
H3-3B H3.3 histone B -0.0183145
KIFAP3 kinesin-associated protein 3 -0.018191
RFTN1 raftlin, lipid raft linker 1 -0.0180978
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.01768
ADAR adenosine deaminase, RNA-specific -0.0176298
RPL28 ribosomal protein L28 -0.0175792
VEGFC vascular endothelial growth factor C -0.0173777
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0171754
SUCNR1 succinate receptor 1 -0.0168282
ANKRD10 ankyrin repeat domain 10 -0.016792
PLSCR1 phospholipid scramblase 1 -0.0167085
TUBB tubulin, beta class I -0.0164191
HMGB1 high mobility group box 1 -0.0163941
COL4A2 collagen, type IV, alpha 2 -0.0162451
ZNF217 zinc finger protein 217 -0.0160234
PMP22 peripheral myelin protein 22 -0.0158868