Bexarotene_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.319969
DPH6 diphthamine biosynthesis 6 0.0841705
PLAT plasminogen activator, tissue 0.0825157
VMP1 vacuole membrane protein 1 0.0818372
FAM13A family with sequence similarity 13, member A 0.0762482
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0749641
FNDC3B fibronectin type III domain containing 3B 0.058788
ITPRID2 ITPR interacting domain containing 2 0.0532945
STC1 stanniocalcin 1 0.0503687
MEF2A myocyte enhancer factor 2A 0.0458366
ZBTB20 zinc finger and BTB domain containing 20 0.0452548
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0421968
PSD3 pleckstrin and Sec7 domain containing 3 0.0409105
TENT5A terminal nucleotidyltransferase 5A 0.0353361
DST dystonin 0.0351797
PRKD1 protein kinase D1 0.0349625
GPC5 glypican 5 0.0344376
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0338132
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0331725
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0306265
IGFBP3 insulin-like growth factor binding protein 3 0.0296325
NGLY1 N-glycanase 1 0.0287376
IGFBP5 insulin-like growth factor binding protein 5 0.0287019
ADARB1 adenosine deaminase, RNA-specific, B1 0.0286085
CADM1 cell adhesion molecule 1 0.028486
SMAD3 SMAD family member 3 0.0283602
LIMCH1 LIM and calponin homology domains 1 0.0282651
ATRNL1 attractin-like 1 0.0279464
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0276405
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.027624
ATM ATM serine/threonine kinase 0.0271112
VEGFA vascular endothelial growth factor A 0.0266694
AHR aryl hydrocarbon receptor 0.026539
CEMIP cell migration inducing protein, hyaluronan binding 0.026273
CRYBG3 beta-gamma crystallin domain containing 3 0.026194
ZCCHC7 zinc finger, CCHC domain containing 7 0.0256357
MACF1 microtubule-actin crosslinking factor 1 0.0255621
MBD5 methyl-CpG binding domain protein 5 0.0255136
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0250042
CALD1 caldesmon 1 0.0248089
PTPRD protein tyrosine phosphatase, receptor type, D 0.0247972
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0246108
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0244253
ERRFI1 ERBB receptor feedback inhibitor 1 0.024314
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0242755
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.0237395
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0236593
RAD51B RAD51 paralog B 0.0233648
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.023071
RUNX1 runt-related transcription factor 1 0.0229969
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0229179
FNDC3A fibronectin type III domain containing 3A 0.0229019
HILPDA hypoxia inducible lipid droplet-associated 0.0228513
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0228482
ANTXR1 anthrax toxin receptor 1 0.022606
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0225474
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0224517
ELL2 elongation factor, RNA polymerase II, 2 0.0224045
KIAA1217 KIAA1217 0.0219198
RAB1A RAB1A, member RAS oncogene family 0.0217087
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0215432
N4BP2L2 NEDD4 binding protein 2-like 2 0.021414
CAMKMT calmodulin-lysine N-methyltransferase 0.0212756
KCTD16 potassium channel tetramerization domain containing 16 0.0212287
AKAP9 A kinase (PRKA) anchor protein 9 0.0211262
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0210423
SNX13 sorting nexin 13 0.020959
SBF2 SET binding factor 2 0.0209551
SDCCAG8 serologically defined colon cancer antigen 8 0.0208971
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.020634
GNPDA1 glucosamine-6-phosphate deaminase 1 0.020577
RAB6A RAB6A, member RAS oncogene family 0.0204024
EXT1 exostosin glycosyltransferase 1 0.0202929
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0202744
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0201473
SMYD3 SET and MYND domain containing 3 0.0200437
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0199933
ZXDC ZXD family zinc finger C 0.0199152
CPED1 cadherin-like and PC-esterase domain containing 1 0.0199105
BPTF bromodomain PHD finger transcription factor 0.0198518
MBTD1 mbt domain containing 1 0.0197785
NPAS2 neuronal PAS domain protein 2 0.0197344
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0197149
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0196342
PGK1 phosphoglycerate kinase 1 0.0195529
LINGO2 leucine rich repeat and Ig domain containing 2 0.019514
ZMIZ1 zinc finger, MIZ-type containing 1 0.0193651
TIMP3 TIMP metallopeptidase inhibitor 3 0.0191447
RPL34 ribosomal protein L34 0.0190914
SMC5 structural maintenance of chromosomes 5 0.0189626
SKIC3 SKI3 subunit of superkiller complex 0.0189606
ANGPTL4 angiopoietin-like 4 0.0189516
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0188936
NES nestin 0.0188573
NBPF15 neuroblastoma breakpoint family, member 15 0.0187296
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.01862
GCC2 GRIP and coiled-coil domain containing 2 0.0185266
FLT1 fms-related tyrosine kinase 1 0.018392
HDAC8 histone deacetylase 8 0.0182393
EEA1 early endosome antigen 1 0.0182374

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.26058
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0899832
LPIN1 lipin 1 -0.0856312
SYT1 synaptotagmin I -0.085026
PTMA prothymosin, alpha -0.0805255
COL1A1 collagen, type I, alpha 1 -0.071565
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0660761
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0616199
VIM vimentin -0.0612119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0597308
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0595411
AHNAK AHNAK nucleoprotein -0.0576928
LSAMP limbic system-associated membrane protein -0.0562783
SSBP2 single-stranded DNA binding protein 2 -0.0551101
NCAM2 neural cell adhesion molecule 2 -0.0517851
CADM2 cell adhesion molecule 2 -0.0506844
COL3A1 collagen, type III, alpha 1 -0.0492189
LMNA lamin A/C -0.0476939
CENPF centromere protein F, 350/400kDa -0.0461969
NALF1 NALCN channel auxiliary factor 1 -0.0461637
HELZ helicase with zinc finger -0.0455476
GNAS GNAS complex locus -0.0451104
POTEF POTE ankyrin domain family, member F -0.0445235
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0430561
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0424138
NRG1 neuregulin 1 -0.0405045
MAP1B microtubule-associated protein 1B -0.0395151
AOPEP aminopeptidase O (putative) -0.0394226
HMGB2 high mobility group box 2 -0.0390177
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0368821
PCBP2 poly(rC) binding protein 2 -0.0366579
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0355598
USP3 ubiquitin specific peptidase 3 -0.0355012
UNC5C unc-5 homolog C (C. elegans) -0.0340846
ACTG1 actin gamma 1 -0.0338356
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0337773
RPS27A ribosomal protein S27a -0.0333934
NAMPT nicotinamide phosphoribosyltransferase -0.0329707
ENAH enabled homolog (Drosophila) -0.0324612
KMT2C lysine (K)-specific methyltransferase 2C -0.0323343
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.031424
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0305503
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0304815
PDIA3 protein disulfide isomerase family A, member 3 -0.0304378
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0302911
SEPTIN7 septin 7 -0.030008
TRIB2 tribbles pseudokinase 2 -0.0297525
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0296752
MEIS2 Meis homeobox 2 -0.029665
FMN1 formin 1 -0.0296091
TPST1 tyrosylprotein sulfotransferase 1 -0.0294539
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0291788
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0290778
QKI QKI, KH domain containing, RNA binding -0.0289946
PLPP1 phospholipid phosphatase 1 -0.0278487
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0275856
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0273345
SPAG9 sperm associated antigen 9 -0.0272587
FOXK2 forkhead box K2 -0.0266856
RPL23 ribosomal protein L23 -0.026667
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0263263
PTK2 protein tyrosine kinase 2 -0.0255619
NRP1 neuropilin 1 -0.0255587
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0255026
PTPRK protein tyrosine phosphatase, receptor type, K -0.0253685
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0253496
UBC ubiquitin C -0.0251458
AUTS2 autism susceptibility candidate 2 -0.0250885
WAC WW domain containing adaptor with coiled-coil -0.0249479
PRKCA protein kinase C, alpha -0.024733
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0245524
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0243629
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0242126
TMSB10 thymosin beta 10 -0.0241726
RNF213 ring finger protein 213 -0.0240177
KMT2E lysine (K)-specific methyltransferase 2E -0.0239135
EEF2 eukaryotic translation elongation factor 2 -0.0237506
RYBP RING1 and YY1 binding protein -0.023414
MMP2 matrix metallopeptidase 2 -0.0234071
MATR3 matrin 3 -0.0233899
CCND1 cyclin D1 -0.0233761
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0233074
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.023124
JPT1 Jupiter microtubule associated homolog 1 -0.0227389
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0227091
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0225665
ADAM9 ADAM metallopeptidase domain 9 -0.022551
USP9X ubiquitin specific peptidase 9, X-linked -0.02234
TPT1 tumor protein, translationally-controlled 1 -0.0222027
SLC38A2 solute carrier family 38, member 2 -0.0221829
TLK2 tousled-like kinase 2 -0.0221241
MAPK6 mitogen-activated protein kinase 6 -0.0220238
NOP58 NOP58 ribonucleoprotein -0.0219102
ADAR adenosine deaminase, RNA-specific -0.0217705
CHD4 chromodomain helicase DNA binding protein 4 -0.0216292
HAND2 heart and neural crest derivatives expressed 2 -0.0216177
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0215775
ZMYM2 zinc finger, MYM-type 2 -0.0215531
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0215422
MAP4 microtubule-associated protein 4 -0.0214539