Bexarotene_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.138367
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.125479
ACSL3 acyl-CoA synthetase long-chain family member 3 0.102014
FNDC3B fibronectin type III domain containing 3B 0.0815708
PLIN2 perilipin 2 0.05834
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0445112
ERBIN erbb2 interacting protein 0.0444073
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0442487
SSH2 slingshot protein phosphatase 2 0.0407587
PTGR1 prostaglandin reductase 1 0.0397254
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.03863
ZMYND8 zinc finger, MYND-type containing 8 0.0384317
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.0366926
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0333772
ATP10B ATPase, class V, type 10B 0.0324112
DSCAM Down syndrome cell adhesion molecule 0.0309781
STK39 serine threonine kinase 39 0.030709
DENND4C DENN/MADD domain containing 4C 0.0305068
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.027565
RNF149 ring finger protein 149 0.0266526
ACACA acetyl-CoA carboxylase alpha 0.0241007
SPATA13 spermatogenesis associated 13 0.0237312
RAD51B RAD51 paralog B 0.0236025
TMPRSS4 transmembrane protease, serine 4 0.0229925
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0227198
KIF16B kinesin family member 16B 0.0204714
ERMP1 endoplasmic reticulum metallopeptidase 1 0.0197423
ZNF292 zinc finger protein 292 0.0196969
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0194276
PCED1B PC-esterase domain containing 1B 0.0189864
PADI1 peptidyl arginine deiminase, type I 0.018964
FNIP1 folliculin interacting protein 1 0.0178637
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.017403
MYZAP myocardial zonula adherens protein 0.0171388
TMEM135 transmembrane protein 135 0.0170356
DAPK2 death-associated protein kinase 2 0.016393
PTBP3 polypyrimidine tract binding protein 3 0.0156143
ZBTB20 zinc finger and BTB domain containing 20 0.0155342
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0154126
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0154066
PRELID2 PRELI domain containing 2 0.0149819
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0149543
SPATA6L spermatogenesis associated 6-like 0.014781
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0146733
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0141857
LIMA1 LIM domain and actin binding 1 0.014028
ALPK1 alpha-kinase 1 0.0138769
BRWD3 bromodomain and WD repeat domain containing 3 0.0137682
FAM13A family with sequence similarity 13, member A 0.0137182
TAOK3 TAO kinase 3 0.0135245
SLK STE20-like kinase 0.0134421
AKAP13 A kinase (PRKA) anchor protein 13 0.013333
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0132388
SREBF1 sterol regulatory element binding transcription factor 1 0.0131427
MINDY2 MINDY lysine 48 deubiquitinase 2 0.013041
MAML2 mastermind-like 2 (Drosophila) 0.0127438
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0126077
CD46 CD46 molecule, complement regulatory protein 0.0125297
SAMD4A sterile alpha motif domain containing 4A 0.0124873
ZDHHC20 zinc finger, DHHC-type containing 20 0.0124069
SAMD12 sterile alpha motif domain containing 12 0.0123744
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0123237
NPEPPS aminopeptidase puromycin sensitive 0.0122723
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0122574
ITGB6 integrin, beta 6 0.0122115
FOXO1 forkhead box O1 0.0121461
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0120991
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0120684
IFNGR1 interferon gamma receptor 1 0.012044
TSC22D2 TSC22 domain family, member 2 0.0119749
NT5C2 5'-nucleotidase, cytosolic II 0.0119724
PTK2 protein tyrosine kinase 2 0.0119327
SREBF2 sterol regulatory element binding transcription factor 2 0.0119163
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0117102
CAB39 calcium binding protein 39 0.0116814
PIAS1 protein inhibitor of activated STAT, 1 0.0116703
ERRFI1 ERBB receptor feedback inhibitor 1 0.0116584
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0116528
HOOK3 hook microtubule-tethering protein 3 0.0115195
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0114436
CCDC146 coiled-coil domain containing 146 0.0113893
DGKH diacylglycerol kinase, eta 0.0113485
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0112958
SCARB1 scavenger receptor class B, member 1 0.0112237
ARRDC3 arrestin domain containing 3 0.0111497
CTTNBP2NL CTTNBP2 N-terminal like 0.0110366
STAMBPL1 STAM binding protein-like 1 0.0109476
BIRC3 baculoviral IAP repeat containing 3 0.0109015
ESYT2 extended synaptotagmin-like protein 2 0.0108555
TJP2 tight junction protein 2 0.0107936
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0107844
CCDC14 coiled-coil domain containing 14 0.0107733
OARD1 O-acyl-ADP-ribose deacylase 1 0.0106883
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0106711
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0106113
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0105807
PBX4 pre-B-cell leukemia homeobox 4 0.0103172
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0102715
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0102627
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0102578

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129875
TPT1 tumor protein, translationally-controlled 1 -0.121703
UBC ubiquitin C -0.114435
LMO7 LIM domain 7 -0.105659
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0997659
B2M beta-2-microglobulin -0.0979093
LCN2 lipocalin 2 -0.0826764
PKM pyruvate kinase, muscle -0.0777994
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0755657
RUNX1 runt-related transcription factor 1 -0.0745298
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0741164
PTMA prothymosin, alpha -0.0718239
ANXA2 annexin A2 -0.0711212
RNF213 ring finger protein 213 -0.0706176
EZR ezrin -0.0662839
IFI6 interferon, alpha-inducible protein 6 -0.0643601
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0620485
MX1 MX dynamin-like GTPase 1 -0.0619119
RRBP1 ribosome binding protein 1 -0.0598597
CALR calreticulin -0.0550429
JUN jun proto-oncogene -0.0544997
PERP PERP, TP53 apoptosis effector -0.0527897
ACTN4 actinin, alpha 4 -0.0521029
AHNAK AHNAK nucleoprotein -0.051887
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0517721
HLA-B major histocompatibility complex, class I, B -0.0511878
PDIA3 protein disulfide isomerase family A, member 3 -0.050513
C6ORF132 chromosome 6 open reading frame 132 -0.0485509
IRF1 interferon regulatory factor 1 -0.0476003
MYO1E myosin IE -0.0469139
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0468754
GCLC glutamate-cysteine ligase, catalytic subunit -0.0467221
ENO1 enolase 1, (alpha) -0.0455104
MX2 MX dynamin-like GTPase 2 -0.0453778
RIGI RNA sensor RIG-I -0.0450037
GMDS GDP-mannose 4,6-dehydratase -0.0440918
EPHB2 EPH receptor B2 -0.043404
RPL23 ribosomal protein L23 -0.0428541
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0421974
TMSB10 thymosin beta 10 -0.0399971
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0398007
RPS6 ribosomal protein S6 -0.0395201
ATP11A ATPase, class VI, type 11A -0.03854
LOC112694756 uncharaterized LOC112694756 -0.0384839
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038186
ACTG1 actin gamma 1 -0.0360982
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0359514
IFI27 interferon, alpha-inducible protein 27 -0.0352991
VCL vinculin -0.034403
HLA-C major histocompatibility complex, class I, C -0.0342319
EPSTI1 epithelial stromal interaction 1 (breast) -0.0338857
PDIA4 protein disulfide isomerase family A, member 4 -0.0332912
EGR1 early growth response 1 -0.0328218
CANX calnexin -0.0322646
DSPP dentin sialophosphoprotein -0.0321394
SP100 SP100 nuclear antigen -0.032005
RPS8 ribosomal protein S8 -0.0315373
LOC102724023 ES1 protein homolog, mitochondrial -0.0312759
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0311803
IRS2 insulin receptor substrate 2 -0.0310653
EFNB2 ephrin-B2 -0.0309434
MORF4L2 mortality factor 4 like 2 -0.0306992
EPCAM epithelial cell adhesion molecule -0.0306659
CALU calumenin -0.030581
S100A10 S100 calcium binding protein A10 -0.0304019
HLA-E major histocompatibility complex, class I, E -0.0302337
HDAC4 histone deacetylase 4 -0.0295946
POTEF POTE ankyrin domain family, member F -0.0290014
TJP1 tight junction protein 1 -0.0287735
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0287565
PLSCR1 phospholipid scramblase 1 -0.0283416
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0282708
RNF43 ring finger protein 43 -0.0282526
RHOBTB3 Rho-related BTB domain containing 3 -0.0280901
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0275508
MSI2 musashi RNA-binding protein 2 -0.0273147
TXNIP thioredoxin interacting protein -0.0271393
NDRG1 N-myc downstream regulated 1 -0.0271233
NCKAP5 NCK-associated protein 5 -0.0269713
MUC13 mucin 13, cell surface associated -0.0269669
ZNRF3 zinc and ring finger 3 -0.0268579
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0268381
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0266474
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0265598
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0260859
RPL7L1 ribosomal protein L7-like 1 -0.0260031
RPL35A ribosomal protein L35a -0.0257516
PCBP2 poly(rC) binding protein 2 -0.0257228
EIF1 eukaryotic translation initiation factor 1 -0.0256282
RPS27A ribosomal protein S27a -0.0254856
FTL ferritin, light polypeptide -0.0254046
RPLP1 ribosomal protein, large, P1 -0.02521
EXT1 exostosin glycosyltransferase 1 -0.0251162
RPL34 ribosomal protein L34 -0.0249728
AHI1 Abelson helper integration site 1 -0.0247935
MACF1 microtubule-actin crosslinking factor 1 -0.024769
TPM4 tropomyosin 4 -0.0246504
FOXP1 forkhead box P1 -0.0245859
ITGA6 integrin, alpha 6 -0.024447