Bexarotene_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bexarotene_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.212392
C3 complement component 3 0.132916
FNDC3B fibronectin type III domain containing 3B 0.12311
APOB apolipoprotein B 0.114347
ERRFI1 ERBB receptor feedback inhibitor 1 0.101717
AFDN afadin, adherens junction formation factor 0.0581123
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0571559
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.055325
IGFBP1 insulin-like growth factor binding protein 1 0.053401
VMP1 vacuole membrane protein 1 0.0508374
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0506265
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0483971
JMJD1C jumonji domain containing 1C 0.0437541
RBM25 RNA binding motif protein 25 0.043293
ELL2 elongation factor, RNA polymerase II, 2 0.0426229
NRIP1 nuclear receptor interacting protein 1 0.0419222
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0414257
WAC WW domain containing adaptor with coiled-coil 0.0398581
DLC1 DLC1 Rho GTPase activating protein 0.0382984
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0380567
RBM39 RNA binding motif protein 39 0.0378879
SMAD3 SMAD family member 3 0.037692
VEGFA vascular endothelial growth factor A 0.0376203
SESTD1 SEC14 and spectrin domains 1 0.0371323
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0368418
ITGAV integrin, alpha V 0.0367137
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0360589
PCBP2 poly(rC) binding protein 2 0.0357206
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0357035
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0356944
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0342928
YAP1 Yes-associated protein 1 0.0339118
ITCH itchy E3 ubiquitin protein ligase 0.0332986
MED13L mediator complex subunit 13-like 0.0329629
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0323642
ADAM9 ADAM metallopeptidase domain 9 0.0319748
CCL20 chemokine (C-C motif) ligand 20 0.0319606
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0318425
PUM2 pumilio RNA-binding family member 2 0.0316132
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0310039
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0308865
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0308654
ARHGAP9 Rho GTPase activating protein 9 0.0301687
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0299331
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0295203
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0291797
SNX9 sorting nexin 9 0.0287707
STRN3 striatin, calmodulin binding protein 3 0.0284043
MRTFA myocardin related transcription factor A 0.0281907
TRIO trio Rho guanine nucleotide exchange factor 0.0275492
BCL2L1 BCL2-like 1 0.0274046
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0273244
KTN1 kinectin 1 (kinesin receptor) 0.027208
KIF5B kinesin family member 5B 0.0264016
OLA1 Obg-like ATPase 1 0.0263909
LCOR ligand dependent nuclear receptor corepressor 0.0261104
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0258005
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0256116
EPS8 epidermal growth factor receptor pathway substrate 8 0.0255479
PICALM phosphatidylinositol binding clathrin assembly protein 0.0255192
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0252436
MSI2 musashi RNA-binding protein 2 0.0252306
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0251176
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0251161
FOXO1 forkhead box O1 0.02477
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0244986
TOP1 topoisomerase (DNA) I 0.0240267
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0238221
MATR3 matrin 3 0.0235583
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0234276
RPL3 ribosomal protein L3 0.0232208
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0232198
SOD2 superoxide dismutase 2, mitochondrial 0.0230295
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0230111
CCNL1 cyclin L1 0.0229399
TM9SF3 transmembrane 9 superfamily member 3 0.0229294
APLP2 amyloid beta (A4) precursor-like protein 2 0.0228832
EEF2 eukaryotic translation elongation factor 2 0.0227753
KCMF1 potassium channel modulatory factor 1 0.0227522
IGF1R insulin-like growth factor 1 receptor 0.0226746
EIF4B eukaryotic translation initiation factor 4B 0.0225815
TNS1 tensin 1 0.0225679
JAK1 Janus kinase 1 0.0224895
TMEM51 transmembrane protein 51 0.0224159
PTK2 protein tyrosine kinase 2 0.0223656
WDFY3 WD repeat and FYVE domain containing 3 0.0223652
DOCK5 dedicator of cytokinesis 5 0.0222279
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0221411
PCM1 pericentriolar material 1 0.0220211
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 0.021973
PTBP3 polypyrimidine tract binding protein 3 0.0218983
EML4 echinoderm microtubule associated protein like 4 0.0218207
GK glycerol kinase 0.0217539
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0217154
ANKRD10 ankyrin repeat domain 10 0.0215673
TNS3 tensin 3 0.0214075
DOCK4 dedicator of cytokinesis 4 0.0211346
TRIP12 thyroid hormone receptor interactor 12 0.0210796
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0209798
PAWR PRKC, apoptosis, WT1, regulator 0.0208025

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.499724
TPT1 tumor protein, translationally-controlled 1 -0.144867
APOA2 apolipoprotein A-II -0.109113
AKAP12 A kinase (PRKA) anchor protein 12 -0.104709
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104562
ASPH aspartate beta-hydroxylase -0.100541
ENO1 enolase 1, (alpha) -0.0938899
MT2A metallothionein 2A -0.0883277
TMSB10 thymosin beta 10 -0.081651
GPC3 glypican 3 -0.0810106
TM4SF1 transmembrane 4 L six family member 1 -0.0735025
RPS24 ribosomal protein S24 -0.0667803
HMGA1 high mobility group AT-hook 1 -0.0612185
FN1 fibronectin 1 -0.0564824
RPS8 ribosomal protein S8 -0.0521739
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0515786
RPL35A ribosomal protein L35a -0.0463193
FTL ferritin, light polypeptide -0.0432709
ACTG1 actin gamma 1 -0.0428487
PLIN2 perilipin 2 -0.0416143
NDRG1 N-myc downstream regulated 1 -0.0409971
CP ceruloplasmin (ferroxidase) -0.0385848
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0375477
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.037004
ZBTB20 zinc finger and BTB domain containing 20 -0.0366267
INTS6 integrator complex subunit 6 -0.0355568
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0351003
FAM107B family with sequence similarity 107, member B -0.0348984
RPL12 ribosomal protein L12 -0.0347544
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.033939
RPLP0 ribosomal protein, large, P0 -0.0335413
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0335255
RPL26 ribosomal protein L26 -0.0334784
RPL37A ribosomal protein L37a -0.0333302
RPS21 ribosomal protein S21 -0.0321618
RPL11 ribosomal protein L11 -0.0318224
GMDS GDP-mannose 4,6-dehydratase -0.0315415
RPLP1 ribosomal protein, large, P1 -0.0312724
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0308519
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0306811
RPL9 ribosomal protein L9 -0.0295773
IFITM1 interferon induced transmembrane protein 1 -0.0281804
GNAS GNAS complex locus -0.0280216
PTPRF protein tyrosine phosphatase, receptor type, F -0.0280151
STK17A serine/threonine kinase 17a -0.0277445
RPS27A ribosomal protein S27a -0.0266895
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0265598
AHSG alpha-2-HS-glycoprotein -0.0265201
LDHA lactate dehydrogenase A -0.0257916
KRT18 keratin 18, type I -0.0257738
EHBP1 EH domain binding protein 1 -0.0256171
RPL34 ribosomal protein L34 -0.0251042
LOC112694756 uncharaterized LOC112694756 -0.0249488
RPL37 ribosomal protein L37 -0.0248379
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0246682
RPL32 ribosomal protein L32 -0.0245732
KIF21A kinesin family member 21A -0.0245292
KDM3A lysine (K)-specific demethylase 3A -0.0237031
RPS5 ribosomal protein S5 -0.0235836
GRB10 growth factor receptor-bound protein 10 -0.023394
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0232744
PTMA prothymosin, alpha -0.0230418
RPL31 ribosomal protein L31 -0.0226971
EIF1 eukaryotic translation initiation factor 1 -0.0225953
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0225741
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0225547
RIGI RNA sensor RIG-I -0.0222588
IFIH1 interferon induced with helicase C domain 1 -0.022119
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0218361
KRT23 keratin 23, type I -0.0215882
RPLP2 ribosomal protein, large, P2 -0.0213116
TPM4 tropomyosin 4 -0.0212089
RPS12 ribosomal protein S12 -0.0210432
RPS13 ribosomal protein S13 -0.0209885
APOE apolipoprotein E -0.0209246
NABP1 nucleic acid binding protein 1 -0.0209022
RPS3 ribosomal protein S3 -0.0207915
RACK1 receptor for activated C kinase 1 -0.0205615
DST dystonin -0.020276
BTG1 B-cell translocation gene 1, anti-proliferative -0.0202618
NPR2 natriuretic peptide receptor 2 -0.0201837
DUSP6 dual specificity phosphatase 6 -0.0199862
EGR1 early growth response 1 -0.0199826
TMEM263 transmembrane protein 263 -0.0194491
S100A6 S100 calcium binding protein A6 -0.0193022
AHNAK AHNAK nucleoprotein -0.0192887
H1-0 H1.0 linker histone -0.0189792
FOXP1 forkhead box P1 -0.0189608
DSG2 desmoglein 2 -0.0189545
AMBP alpha-1-microglobulin/bikunin precursor -0.0188012
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0187733
NACA nascent polypeptide-associated complex alpha subunit -0.0187415
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0186183
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0186068
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0183972
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0183231
RPL10A ribosomal protein L10a -0.0180447
IFI6 interferon, alpha-inducible protein 6 -0.0178414
RPL38 ribosomal protein L38 -0.017833
SEC31A SEC31 homolog A (S. cerevisiae) -0.0177024