Bexarotene_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.0876786
SLC35F3 solute carrier family 35, member F3 0.0812519
FLNB filamin B, beta 0.0812274
TRIO trio Rho guanine nucleotide exchange factor 0.0676258
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0664154
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0644509
PDLIM5 PDZ and LIM domain 5 0.0626397
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0597286
PSD3 pleckstrin and Sec7 domain containing 3 0.0597166
TIMP3 TIMP metallopeptidase inhibitor 3 0.0590828
RAI14 retinoic acid induced 14 0.0545668
LMO7 LIM domain 7 0.0522802
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0495306
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0472398
AKAP13 A kinase (PRKA) anchor protein 13 0.0468697
MEF2A myocyte enhancer factor 2A 0.0409223
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.040064
PDE4D phosphodiesterase 4D, cAMP-specific 0.0396215
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0389589
PICALM phosphatidylinositol binding clathrin assembly protein 0.037561
LAMC2 laminin, gamma 2 0.0353095
FNIP1 folliculin interacting protein 1 0.0351108
PLS3 plastin 3 0.0340079
FNDC3B fibronectin type III domain containing 3B 0.0337933
MSN moesin 0.0337897
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0320536
NAV2 neuron navigator 2 0.0308317
GRB10 growth factor receptor-bound protein 10 0.0305087
RNF217 ring finger protein 217 0.0301751
RASAL2 RAS protein activator like 2 0.0299132
PODXL podocalyxin-like 0.0289839
NRIP1 nuclear receptor interacting protein 1 0.0279287
DPYD dihydropyrimidine dehydrogenase 0.0278084
DOCK5 dedicator of cytokinesis 5 0.0264759
ZEB1 zinc finger E-box binding homeobox 1 0.0263376
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.026076
RABGAP1L RAB GTPase activating protein 1-like 0.0259476
CALB1 calbindin 1, 28kDa 0.025797
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0257527
CAPRIN2 caprin family member 2 0.0252767
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0251558
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0246748
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0245472
ALCAM activated leukocyte cell adhesion molecule 0.0238794
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.023676
HMGA2 high mobility group AT-hook 2 0.023313
UTRN utrophin 0.0229382
RCOR1 REST corepressor 1 0.0228857
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0226107
BCAR3 breast cancer anti-estrogen resistance 3 0.0224943
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0218517
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0211064
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0208396
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0204512
MACF1 microtubule-actin crosslinking factor 1 0.0204251
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0194759
ZSWIM6 zinc finger, SWIM-type containing 6 0.0191659
ESYT2 extended synaptotagmin-like protein 2 0.0191012
NCOR2 nuclear receptor corepressor 2 0.0189588
PTK2 protein tyrosine kinase 2 0.0182754
FRMD6 FERM domain containing 6 0.0182248
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0181433
TNS3 tensin 3 0.0178748
MYH9 myosin, heavy chain 9, non-muscle 0.0176935
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0176367
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0174969
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0174468
THSD4 thrombospondin, type I, domain containing 4 0.0173705
ITCH itchy E3 ubiquitin protein ligase 0.0173376
ABI3BP ABI family, member 3 (NESH) binding protein 0.0172801
INTS6 integrator complex subunit 6 0.0172765
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0172448
TSC22D1 TSC22 domain family, member 1 0.0172173
DOCK9 dedicator of cytokinesis 9 0.0170961
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0167963
KIAA1671 KIAA1671 0.0167588
EXOC4 exocyst complex component 4 0.016724
MECOM MDS1 and EVI1 complex locus 0.0167171
ANO1 anoctamin 1, calcium activated chloride channel 0.0166795
VMP1 vacuole membrane protein 1 0.0166285
PALLD palladin, cytoskeletal associated protein 0.0162779
ZMIZ1 zinc finger, MIZ-type containing 1 0.0162551
PPARG peroxisome proliferator-activated receptor gamma 0.0158023
GLS2 glutaminase 2 (liver, mitochondrial) 0.0155933
ITPRID2 ITPR interacting domain containing 2 0.0155301
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0154554
SULF1 sulfatase 1 0.0153388
DOCK4 dedicator of cytokinesis 4 0.0152498
DIAPH1 diaphanous-related formin 1 0.0151905
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0151431
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0150634
CDK6 cyclin-dependent kinase 6 0.0149809
SQLE squalene epoxidase 0.0149691
CDK17 cyclin-dependent kinase 17 0.0149543
EFNA5 ephrin-A5 0.0146021
EGFR epidermal growth factor receptor 0.0145524
SPIRE1 spire-type actin nucleation factor 1 0.0145205
ZC3H12C zinc finger CCCH-type containing 12C 0.0144313
YOD1 YOD1 deubiquitinase 0.0143206
SLK STE20-like kinase 0.0141784

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204186
TMSB10 thymosin beta 10 -0.134109
MT2A metallothionein 2A -0.133287
B2M beta-2-microglobulin -0.0975484
TPT1 tumor protein, translationally-controlled 1 -0.0911773
RPS21 ribosomal protein S21 -0.0882788
PTMA prothymosin, alpha -0.085763
RPS6 ribosomal protein S6 -0.085055
RPLP1 ribosomal protein, large, P1 -0.0822303
RPLP2 ribosomal protein, large, P2 -0.0815926
IFITM3 interferon induced transmembrane protein 3 -0.0793843
RPS8 ribosomal protein S8 -0.0741559
LMNA lamin A/C -0.0733462
RPL11 ribosomal protein L11 -0.0698137
S100A10 S100 calcium binding protein A10 -0.0686813
HLA-B major histocompatibility complex, class I, B -0.066613
RPS19 ribosomal protein S19 -0.0655965
RPS13 ribosomal protein S13 -0.0605482
IFITM1 interferon induced transmembrane protein 1 -0.0590677
LOC112694756 uncharaterized LOC112694756 -0.0587727
ENO1 enolase 1, (alpha) -0.0586341
GNAS GNAS complex locus -0.056622
TMSB4X thymosin beta 4, X-linked -0.0539575
NDRG1 N-myc downstream regulated 1 -0.0536944
RPL12 ribosomal protein L12 -0.053388
RPL35A ribosomal protein L35a -0.051029
S100A6 S100 calcium binding protein A6 -0.0503657
RPS3 ribosomal protein S3 -0.0503485
FTL ferritin, light polypeptide -0.0502758
RPL23 ribosomal protein L23 -0.0488206
RPL8 ribosomal protein L8 -0.047646
RPL37 ribosomal protein L37 -0.0475785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.047038
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.045785
KRT17 keratin 17, type I -0.0449609
RPS24 ribosomal protein S24 -0.0447484
S100A9 S100 calcium binding protein A9 -0.0442187
RPL37A ribosomal protein L37a -0.0441005
S100A2 S100 calcium binding protein A2 -0.0430872
RPL34 ribosomal protein L34 -0.0429327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0425891
CLU clusterin -0.0421592
RPL19 ribosomal protein L19 -0.0417398
RPS25 ribosomal protein S25 -0.0405796
RPS12 ribosomal protein S12 -0.0401139
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0393099
RPL36 ribosomal protein L36 -0.0388996
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384467
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0382059
RPL30 ribosomal protein L30 -0.0376976
RPL32 ribosomal protein L32 -0.0375958
EIF1 eukaryotic translation initiation factor 1 -0.0375172
RACK1 receptor for activated C kinase 1 -0.0364585
RPS29 ribosomal protein S29 -0.036344
RPL31 ribosomal protein L31 -0.0359541
RPL7A ribosomal protein L7a -0.0358554
RPL5 ribosomal protein L5 -0.0358289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0356274
CNRIP1 cannabinoid receptor interacting protein 1 -0.035392
RPS23 ribosomal protein S23 -0.0352472
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0349576
IGF2 insulin-like growth factor 2 -0.0346533
RPS27A ribosomal protein S27a -0.0342362
RPS27 ribosomal protein S27 -0.0341218
RPS4X ribosomal protein S4, X-linked -0.0339589
RPL26 ribosomal protein L26 -0.0338648
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333992
LDHA lactate dehydrogenase A -0.0327455
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0323843
RPL28 ribosomal protein L28 -0.0321626
MT1X metallothionein 1X -0.0321523
RPS14 ribosomal protein S14 -0.0320278
IFI6 interferon, alpha-inducible protein 6 -0.0318968
RPLP0 ribosomal protein, large, P0 -0.0315871
RPL35 ribosomal protein L35 -0.0315736
YBX3 Y box binding protein 3 -0.0311559
ATP5F1E ATP synthase F1 subunit epsilon -0.031124
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.030911
RPL27A ribosomal protein L27a -0.0308669
RPS16 ribosomal protein S16 -0.0307333
PLAT plasminogen activator, tissue -0.0305709
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0304709
RPS11 ribosomal protein S11 -0.0302588
RPS20 ribosomal protein S20 -0.0298001
VDAC1 voltage-dependent anion channel 1 -0.0293565
DSTN destrin (actin depolymerizing factor) -0.0292969
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0287995
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0283738
S100A4 S100 calcium binding protein A4 -0.0281511
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0280786
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0276834
IER3 immediate early response 3 -0.0275032
CAV1 caveolin 1, caveolae protein, 22kDa -0.0273618
RPL36A ribosomal protein L36a -0.0271899
PKM pyruvate kinase, muscle -0.0270881
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0269383
S100A11 S100 calcium binding protein A11 -0.0267014
FSCN1 fascin actin-bundling protein 1 -0.0266205
GUK1 guanylate kinase 1 -0.0265265
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0263496