Bexarotene_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
WDR43 WD repeat domain 43 0.0294232
PTK2 protein tyrosine kinase 2 0.0290233
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0271169
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0265648
DENND4A DENN/MADD domain containing 4A 0.0251864
ERBIN erbb2 interacting protein 0.0246573
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0237129
ERRFI1 ERBB receptor feedback inhibitor 1 0.022165
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0218999
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0209422
USP3 ubiquitin specific peptidase 3 0.0207542
RNF145 ring finger protein 145 0.0202962
KMT2E lysine (K)-specific methyltransferase 2E 0.0200553
TRA2A transformer 2 alpha homolog (Drosophila) 0.0197075
TFG TRK-fused gene 0.0193989
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0187788
FAM168A family with sequence similarity 168, member A 0.0186958
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0179505
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0179151
ELOVL5 ELOVL fatty acid elongase 5 0.0175611
SBF2 SET binding factor 2 0.0175139
COPA coatomer protein complex, subunit alpha 0.0171719
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0165701
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.016308
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0153824
RBM39 RNA binding motif protein 39 0.0152582
JAK1 Janus kinase 1 0.0152421
WAC WW domain containing adaptor with coiled-coil 0.0150358
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0146138
FNBP1L formin binding protein 1-like 0.0143282
OSBPL9 oxysterol binding protein-like 9 0.0143165
RICTOR RPTOR independent companion of MTOR, complex 2 0.0142368
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0140851
BTBD7 BTB (POZ) domain containing 7 0.0138952
MACF1 microtubule-actin crosslinking factor 1 0.0138409
SDC4 syndecan 4 0.0136031
ACACA acetyl-CoA carboxylase alpha 0.013374
BHLHE40 basic helix-loop-helix family, member e40 0.0130999
VMP1 vacuole membrane protein 1 0.012986
SPOPL speckle-type POZ protein-like 0.0128738
WBP11 WW domain binding protein 11 0.0128293
ANXA1 annexin A1 0.0127967
PTGES2 prostaglandin E synthase 2 0.0127429
CLINT1 clathrin interactor 1 0.0127341
DSCAM Down syndrome cell adhesion molecule 0.012476
TMEM39A transmembrane protein 39A 0.0124379
CYRIB CYFIP related Rac1 interactor B 0.0122408
PARD3 par-3 family cell polarity regulator 0.0121549
SUCO SUN domain containing ossification factor 0.0121428
NAMPT nicotinamide phosphoribosyltransferase 0.0121418
ZNF292 zinc finger protein 292 0.0120935
CRY1 cryptochrome circadian clock 1 0.0120487
SIK3 SIK family kinase 3 0.0120022
ABI1 abl-interactor 1 0.0119003
BIRC2 baculoviral IAP repeat containing 2 0.0117927
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0116588
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0114686
FXR1 fragile X mental retardation, autosomal homolog 1 0.0112543
RAB1A RAB1A, member RAS oncogene family 0.0112363
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0112254
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0111752
SCAF4 SR-related CTD-associated factor 4 0.0111116
CDC73 cell division cycle 73 0.0110744
SRRM1 serine/arginine repetitive matrix 1 0.0109972
HBS1L HBS1-like translational GTPase 0.0109878
PUM2 pumilio RNA-binding family member 2 0.0109876
PUM1 pumilio RNA-binding family member 1 0.0108706
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0107612
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0107504
BCLAF1 BCL2-associated transcription factor 1 0.0107155
SAMD8 sterile alpha motif domain containing 8 0.010627
MTMR3 myotubularin related protein 3 0.0105365
GOLGA4 golgin A4 0.0104421
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0104014
PPHLN1 periphilin 1 0.0102289
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0102273
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0100641
YTHDC1 YTH domain containing 1 0.0100203
SETD5 SET domain containing 5 0.01
DCAF5 DDB1 and CUL4 associated factor 5 0.00997683
MSMO1 methylsterol monooxygenase 1 0.00991961
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.00989292
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00981714
GOLT1B golgi transport 1B 0.00979485
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00974542
RPS7 ribosomal protein S7 0.00964789
NUP58 nucleoporin 58 0.00956149
DMXL1 Dmx-like 1 0.00943787
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.00936043
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00925448
UGCG UDP-glucose ceramide glucosyltransferase 0.00924702
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0090973
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00909112
ITCH itchy E3 ubiquitin protein ligase 0.00905054
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.00904121
RIOK3 RIO kinase 3 0.00882678
OXSR1 oxidative stress responsive 1 0.00880297
MRTFA myocardin related transcription factor A 0.00875932
CCL5 chemokine (C-C motif) ligand 5 0.00871707
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0086833

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.213843
MT2A metallothionein 2A -0.198585
TMSB10 thymosin beta 10 -0.181949
VIM vimentin -0.169643
GRAMD1B GRAM domain containing 1B -0.12334
FTL ferritin, light polypeptide -0.109476
PM20D1 peptidase M20 domain containing 1 -0.0923451
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0902484
PDE4D phosphodiesterase 4D, cAMP-specific -0.0895671
RPL23 ribosomal protein L23 -0.0867251
TM4SF1 transmembrane 4 L six family member 1 -0.0777176
RPS27A ribosomal protein S27a -0.0765285
POTEF POTE ankyrin domain family, member F -0.0669846
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0649299
UBC ubiquitin C -0.0585612
PTMA prothymosin, alpha -0.0546206
ASPH aspartate beta-hydroxylase -0.0489063
ACTG1 actin gamma 1 -0.0486133
ENO1 enolase 1, (alpha) -0.0460172
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0441075
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0440542
PKM pyruvate kinase, muscle -0.0428328
RPL19 ribosomal protein L19 -0.0417532
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.041515
EEF2 eukaryotic translation elongation factor 2 -0.040878
IER3 immediate early response 3 -0.0389451
S100A6 S100 calcium binding protein A6 -0.0385047
RPLP1 ribosomal protein, large, P1 -0.0383616
AHNAK AHNAK nucleoprotein -0.03816
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0379396
RPS8 ribosomal protein S8 -0.0370854
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0358679
WWOX WW domain containing oxidoreductase -0.0355672
FGB fibrinogen beta chain -0.0327423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0318496
FTH1 ferritin, heavy polypeptide 1 -0.0300904
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0297741
THSD4 thrombospondin, type I, domain containing 4 -0.0296253
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0295544
PFN1 profilin 1 -0.0294003
RPL8 ribosomal protein L8 -0.0279884
RPS19 ribosomal protein S19 -0.0268985
MCL1 myeloid cell leukemia 1 -0.0266325
SLC38A2 solute carrier family 38, member 2 -0.025382
RPL31 ribosomal protein L31 -0.0253007
RPS29 ribosomal protein S29 -0.0252067
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0245234
S100A10 S100 calcium binding protein A10 -0.0242098
RPS3 ribosomal protein S3 -0.0238314
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0237602
ACTN1 actinin, alpha 1 -0.0228638
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0228039
C15ORF48 chromosome 15 open reading frame 48 -0.0224208
LOC112694756 uncharaterized LOC112694756 -0.0222559
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0221226
RPL26 ribosomal protein L26 -0.022085
PCBP2 poly(rC) binding protein 2 -0.0220822
RPS16 ribosomal protein S16 -0.0219599
RPL30 ribosomal protein L30 -0.0218737
RPLP0 ribosomal protein, large, P0 -0.0217652
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0216033
RACK1 receptor for activated C kinase 1 -0.0215392
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0214413
TFPI2 tissue factor pathway inhibitor 2 -0.0213394
STC1 stanniocalcin 1 -0.0212745
RPL9 ribosomal protein L9 -0.0212373
RPS21 ribosomal protein S21 -0.0212322
RPS23 ribosomal protein S23 -0.0210566
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0209656
TXNRD1 thioredoxin reductase 1 -0.020949
TNPO1 transportin 1 -0.0209151
MKI67 marker of proliferation Ki-67 -0.0205507
RPS12 ribosomal protein S12 -0.0204993
TAGLN2 transgelin 2 -0.0204196
TPT1 tumor protein, translationally-controlled 1 -0.0202183
GNAS GNAS complex locus -0.0202139
NNMT nicotinamide N-methyltransferase -0.0199956
RPS20 ribosomal protein S20 -0.0199561
RPS6 ribosomal protein S6 -0.0196981
RPL37A ribosomal protein L37a -0.0196208
RPS25 ribosomal protein S25 -0.0195553
RPS5 ribosomal protein S5 -0.0195259
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0194668
CFLAR CASP8 and FADD-like apoptosis regulator -0.0194409
ATP5F1E ATP synthase F1 subunit epsilon -0.0193024
LDHA lactate dehydrogenase A -0.0192859
LDHB lactate dehydrogenase B -0.0192078
BASP1 brain abundant, membrane attached signal protein 1 -0.0191658
RPL35A ribosomal protein L35a -0.0191507
RPS15 ribosomal protein S15 -0.0191033
SFPQ splicing factor proline/glutamine-rich -0.0190758
PDIA6 protein disulfide isomerase family A, member 6 -0.0190559
RPL36 ribosomal protein L36 -0.0190424
CMIP c-Maf inducing protein -0.0188945
TPI1 triosephosphate isomerase 1 -0.018841
RPL12 ribosomal protein L12 -0.0187992
VDAC1 voltage-dependent anion channel 1 -0.0187153
FGG fibrinogen gamma chain -0.0186417
OSMR oncostatin M receptor -0.0186017
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0184961