Bexarotene_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bexarotene_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.190626
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.170549
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.140338
NDRG1 N-myc downstream regulated 1 0.135256
FNDC3B fibronectin type III domain containing 3B 0.12552
ELL2 elongation factor, RNA polymerase II, 2 0.0927314
FAM13A family with sequence similarity 13, member A 0.0925929
RNF145 ring finger protein 145 0.0923673
NPEPPS aminopeptidase puromycin sensitive 0.0873244
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0853848
TFG TRK-fused gene 0.0821225
KMT2E lysine (K)-specific methyltransferase 2E 0.0748161
FXR1 fragile X mental retardation, autosomal homolog 1 0.0723557
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0697889
NAMPT nicotinamide phosphoribosyltransferase 0.0666715
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0648406
UBA6 ubiquitin-like modifier activating enzyme 6 0.0644965
MARCHF6 membrane associated ring-CH-type finger 6 0.0621963
FAM3C family with sequence similarity 3, member C 0.0595894
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0586478
TRIO trio Rho guanine nucleotide exchange factor 0.0582096
ADAM9 ADAM metallopeptidase domain 9 0.0579982
EPS8 epidermal growth factor receptor pathway substrate 8 0.0564929
DSCAM Down syndrome cell adhesion molecule 0.0555333
GPBP1 GC-rich promoter binding protein 1 0.0554366
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0550845
CCNL1 cyclin L1 0.0545864
TOP1 topoisomerase (DNA) I 0.0523221
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0506151
CDC73 cell division cycle 73 0.0500517
SPAG9 sperm associated antigen 9 0.0494926
QKI QKI, KH domain containing, RNA binding 0.0482667
PGK1 phosphoglycerate kinase 1 0.0479892
ANXA5 annexin A5 0.0478251
AKAP13 A kinase (PRKA) anchor protein 13 0.0474821
RYBP RING1 and YY1 binding protein 0.0472875
SLMAP sarcolemma associated protein 0.0467124
ERRFI1 ERBB receptor feedback inhibitor 1 0.046101
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0453996
MYO6 myosin VI 0.045189
WAC WW domain containing adaptor with coiled-coil 0.0446323
NUP58 nucleoporin 58 0.0444501
UGCG UDP-glucose ceramide glucosyltransferase 0.0438918
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0432031
COPA coatomer protein complex, subunit alpha 0.0427328
RHEB Ras homolog enriched in brain 0.0420882
USP3 ubiquitin specific peptidase 3 0.0420747
NCKAP1 NCK-associated protein 1 0.0420594
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0419683
ZNF292 zinc finger protein 292 0.0419039
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0417692
SSBP2 single-stranded DNA binding protein 2 0.0414152
MEF2A myocyte enhancer factor 2A 0.0408009
PRRC1 proline-rich coiled-coil 1 0.0398872
GOLGA4 golgin A4 0.0397299
PAPOLA poly(A) polymerase alpha 0.0395792
KDM3A lysine (K)-specific demethylase 3A 0.0393215
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0388885
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0388737
PTK2 protein tyrosine kinase 2 0.0388274
TRA2A transformer 2 alpha homolog (Drosophila) 0.0385428
RAD21 RAD21 homolog (S. pombe) 0.0384839
NRIP1 nuclear receptor interacting protein 1 0.0382407
YTHDC1 YTH domain containing 1 0.0377838
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0376925
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0376568
ATP11B ATPase, class VI, type 11B 0.0376089
MATR3 matrin 3 0.0372744
RASA2 RAS p21 protein activator 2 0.0371054
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0370819
STRN3 striatin, calmodulin binding protein 3 0.0370596
PUM1 pumilio RNA-binding family member 1 0.0368161
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0365111
KDM6A lysine (K)-specific demethylase 6A 0.0362139
ATP13A3 ATPase type 13A3 0.0361024
RAB1A RAB1A, member RAS oncogene family 0.0360262
SDC4 syndecan 4 0.0357546
RIOK3 RIO kinase 3 0.0350157
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0349514
PUM2 pumilio RNA-binding family member 2 0.0349154
CPNE8 copine VIII 0.0346719
RBM25 RNA binding motif protein 25 0.0346004
PELI1 pellino E3 ubiquitin protein ligase 1 0.0345495
ASPH aspartate beta-hydroxylase 0.0344262
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0332271
RAD23B RAD23 homolog B (S. cerevisiae) 0.0330288
ECT2 epithelial cell transforming 2 0.0328331
DUSP10 dual specificity phosphatase 10 0.0326176
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0322481
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.032213
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0319555
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.031795
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0316599
SEC23A Sec23 homolog A (S. cerevisiae) 0.0313782
FAM162A family with sequence similarity 162, member A 0.0313418
NDFIP1 Nedd4 family interacting protein 1 0.0312697
UPP1 uridine phosphorylase 1 0.0311449
HOMER2 homer scaffolding protein 2 0.0311255
TENT2 terminal nucleotidyltransferase 2 0.0307555
RTN4 reticulon 4 0.0304313

decreased expression

Symbol Name Standardized Value
LPP LIM domain containing preferred translocation partner in lipoma -0.12016
SAMD4A sterile alpha motif domain containing 4A -0.116587
EXT1 exostosin glycosyltransferase 1 -0.0967935
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0941378
ACTG1 actin gamma 1 -0.0848649
TMSB10 thymosin beta 10 -0.0821989
EFNA5 ephrin-A5 -0.0767629
ZSWIM6 zinc finger, SWIM-type containing 6 -0.066972
LIMCH1 LIM and calponin homology domains 1 -0.065034
CCND1 cyclin D1 -0.0626403
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0563215
RPS3 ribosomal protein S3 -0.0551005
FBXO32 F-box protein 32 -0.0550166
KRT7 keratin 7, type II -0.0543166
TPT1 tumor protein, translationally-controlled 1 -0.0514915
RPS8 ribosomal protein S8 -0.0458234
S100A10 S100 calcium binding protein A10 -0.0457348
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0451277
VCL vinculin -0.0446215
ISG15 ISG15 ubiquitin-like modifier -0.044596
RNF213 ring finger protein 213 -0.0436967
LMO7 LIM domain 7 -0.0430216
LAMC2 laminin, gamma 2 -0.0427996
TPM4 tropomyosin 4 -0.0418611
RPL34 ribosomal protein L34 -0.0416106
IFI6 interferon, alpha-inducible protein 6 -0.0414675
PTMA prothymosin, alpha -0.0407723
RPL23 ribosomal protein L23 -0.0406909
LMNA lamin A/C -0.0400401
RPL19 ribosomal protein L19 -0.0390259
RPLP1 ribosomal protein, large, P1 -0.0382927
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0382311
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0380626
RACK1 receptor for activated C kinase 1 -0.0374537
ZBTB20 zinc finger and BTB domain containing 20 -0.0374215
GOLGB1 golgin B1 -0.0374021
AHNAK AHNAK nucleoprotein -0.0373473
IFI16 interferon, gamma-inducible protein 16 -0.0359792
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0358548
ENO1 enolase 1, (alpha) -0.0357092
ALCAM activated leukocyte cell adhesion molecule -0.0356956
ATXN1 ataxin 1 -0.0356486
RPS29 ribosomal protein S29 -0.0355461
RIGI RNA sensor RIG-I -0.0352147
IFI27 interferon, alpha-inducible protein 27 -0.0350927
ATP11A ATPase, class VI, type 11A -0.0347745
RPL37A ribosomal protein L37a -0.0344769
MAP1B microtubule-associated protein 1B -0.0339091
KRT18 keratin 18, type I -0.0337689
MYO1E myosin IE -0.0331923
NAV2 neuron navigator 2 -0.0329435
RPS17 ribosomal protein S17 -0.0329318
RBM47 RNA binding motif protein 47 -0.0327242
ETV6 ets variant 6 -0.0325453
MX1 MX dynamin-like GTPase 1 -0.0324015
RRBP1 ribosome binding protein 1 -0.0322165
PALLD palladin, cytoskeletal associated protein -0.0322028
MX2 MX dynamin-like GTPase 2 -0.032083
INTS6 integrator complex subunit 6 -0.0319296
PGBD5 piggyBac transposable element derived 5 -0.0317951
MYOF myoferlin -0.0316221
RPL8 ribosomal protein L8 -0.03156
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0311436
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0305606
CSTB cystatin B (stefin B) -0.0303572
LAMB3 laminin, beta 3 -0.0295789
RPS12 ribosomal protein S12 -0.0294166
PLSCR1 phospholipid scramblase 1 -0.0293191
SEC31A SEC31 homolog A (S. cerevisiae) -0.0292733
RPL37 ribosomal protein L37 -0.0281817
RPL32 ribosomal protein L32 -0.0280847
MAML2 mastermind-like 2 (Drosophila) -0.0280373
SP100 SP100 nuclear antigen -0.0278402
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0274643
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.02737
KRT8 keratin 8, type II -0.02731
SVIL supervillin -0.027182
RPL36 ribosomal protein L36 -0.0267632
AHNAK2 AHNAK nucleoprotein 2 -0.0266864
SOX4 SRY (sex determining region Y)-box 4 -0.0264479
BLZF1 basic leucine zipper nuclear factor 1 -0.0264078
TPI1 triosephosphate isomerase 1 -0.0262207
IFIH1 interferon induced with helicase C domain 1 -0.0261808
TMSB4X thymosin beta 4, X-linked -0.0258237
WARS1 tryptophanyl-tRNA synthetase 1 -0.0252354
RAB7A RAB7A, member RAS oncogene family -0.0251685
TBCA tubulin folding cofactor A -0.0251553
KRT19 keratin 19, type I -0.0249055
ARHGAP20 Rho GTPase activating protein 20 -0.0248126
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0246491
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0246192
RPS27A ribosomal protein S27a -0.0244838
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0244461
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0244186
GNAS GNAS complex locus -0.0244097
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0243851
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0242655
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0242326
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0239669
SQSTM1 sequestosome 1 -0.023933