Bexarotene_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bexarotene_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.173147
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.104366
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0874985
IGFBP3 insulin-like growth factor binding protein 3 0.0826169
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.071722
PSD3 pleckstrin and Sec7 domain containing 3 0.0704567
LIMCH1 LIM and calponin homology domains 1 0.06992
DST dystonin 0.0686135
FLNB filamin B, beta 0.0532528
FNDC3B fibronectin type III domain containing 3B 0.0525512
PM20D1 peptidase M20 domain containing 1 0.0509319
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0489147
COL8A1 collagen, type VIII, alpha 1 0.0473868
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0442501
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0434956
VMP1 vacuole membrane protein 1 0.0420145
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0360146
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0348798
MCL1 myeloid cell leukemia 1 0.0346659
MARCHF1 membrane associated ring-CH-type finger 1 0.0341123
FAM13A family with sequence similarity 13, member A 0.0331912
PDE4D phosphodiesterase 4D, cAMP-specific 0.0309475
GPRIN3 GPRIN family member 3 0.0306299
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0301605
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0292321
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0289769
AGFG1 ArfGAP with FG repeats 1 0.0278935
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0278096
BMP6 bone morphogenetic protein 6 0.0273654
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0271229
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0265133
GRAMD1B GRAM domain containing 1B 0.0262851
DOCK5 dedicator of cytokinesis 5 0.0261186
ZBTB38 zinc finger and BTB domain containing 38 0.0243086
PRELID2 PRELI domain containing 2 0.0237927
NRG1 neuregulin 1 0.0235828
GPC6 glypican 6 0.0228248
RARB retinoic acid receptor, beta 0.022651
OGA O-GlcNAcase 0.022079
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0214594
PTEN phosphatase and tensin homolog 0.0214326
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0211934
ARHGAP5 Rho GTPase activating protein 5 0.0211324
ARHGAP29 Rho GTPase activating protein 29 0.0207953
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0206616
USP34 ubiquitin specific peptidase 34 0.0204747
MFF mitochondrial fission factor 0.0201175
NBAS neuroblastoma amplified sequence 0.019926
FNIP1 folliculin interacting protein 1 0.0195276
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0191971
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.019163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0189213
RNF145 ring finger protein 145 0.0187739
CD46 CD46 molecule, complement regulatory protein 0.0179691
BCAR3 breast cancer anti-estrogen resistance 3 0.0179688
KYNU kynureninase 0.0176033
VCL vinculin 0.0175261
WDFY2 WD repeat and FYVE domain containing 2 0.0175188
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0175184
FAM107B family with sequence similarity 107, member B 0.0172864
RAD51B RAD51 paralog B 0.0171361
ITGB5 integrin, beta 5 0.0170507
MON2 MON2 homolog (S. cerevisiae) 0.0168953
RTN4 reticulon 4 0.0167016
NRIP1 nuclear receptor interacting protein 1 0.0167012
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0166169
CSNK1A1 casein kinase 1, alpha 1 0.0162267
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0161667
AVL9 AVL9 homolog (S. cerevisiase) 0.0161645
METTL15 methyltransferase like 15 0.01607
AKAP12 A kinase (PRKA) anchor protein 12 0.0160308
ANKRD12 ankyrin repeat domain 12 0.015907
PBX1 pre-B-cell leukemia homeobox 1 0.0157945
APLP2 amyloid beta (A4) precursor-like protein 2 0.0157446
UBA6 ubiquitin-like modifier activating enzyme 6 0.0156817
TGFBR1 transforming growth factor, beta receptor 1 0.0154578
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0152389
NHSL1 NHS-like 1 0.0151318
NGLY1 N-glycanase 1 0.0149514
ZFC3H1 zinc finger, C3H1-type containing 0.0148802
ZNF292 zinc finger protein 292 0.0147661
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0146057
ZSWIM6 zinc finger, SWIM-type containing 6 0.0141617
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0141557
COL4A6 collagen, type IV, alpha 6 0.0141517
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0138298
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0138176
ANKRD36 ankyrin repeat domain 36 0.0137414
AKAP13 A kinase (PRKA) anchor protein 13 0.0136673
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0135382
YEATS2 YEATS domain containing 2 0.0133733
FAM219A family with sequence similarity 219, member A 0.0132517
CDC73 cell division cycle 73 0.0131661
SDK1 sidekick cell adhesion molecule 1 0.0130896
CREB5 cAMP responsive element binding protein 5 0.0130234
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0129724
MCTP1 multiple C2 domains, transmembrane 1 0.0128912
MOSMO modulator of smoothened 0.0128489
THSD4 thrombospondin, type I, domain containing 4 0.0127709
ERRFI1 ERBB receptor feedback inhibitor 1 0.0127234

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.129075
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11179
FN1 fibronectin 1 -0.110545
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0931657
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0921343
TMSB10 thymosin beta 10 -0.0878777
VIM vimentin -0.082937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.080643
GDA guanine deaminase -0.078998
TPT1 tumor protein, translationally-controlled 1 -0.078925
PTMA prothymosin, alpha -0.0751382
FTL ferritin, light polypeptide -0.0734824
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0731848
RPLP1 ribosomal protein, large, P1 -0.0621909
SMYD3 SET and MYND domain containing 3 -0.0595613
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0589511
PCBP3 poly(rC) binding protein 3 -0.0577111
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0548518
RPS6 ribosomal protein S6 -0.0520164
PDE10A phosphodiesterase 10A -0.0470919
COL5A2 collagen, type V, alpha 2 -0.0446484
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0440887
RPL26 ribosomal protein L26 -0.0427686
RPS3 ribosomal protein S3 -0.04137
PDLIM5 PDZ and LIM domain 5 -0.0404559
B2M beta-2-microglobulin -0.0402586
RPL31 ribosomal protein L31 -0.0401875
DGKD diacylglycerol kinase, delta 130kDa -0.0400112
SOX4 SRY (sex determining region Y)-box 4 -0.0395878
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0386437
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.038254
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0378073
BASP1 brain abundant, membrane attached signal protein 1 -0.0376851
S100A6 S100 calcium binding protein A6 -0.037026
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0369189
RPL37A ribosomal protein L37a -0.0367863
ADGRD1 adhesion G protein-coupled receptor D1 -0.0366642
RPL35A ribosomal protein L35a -0.035901
RPLP0 ribosomal protein, large, P0 -0.0353233
RPS19 ribosomal protein S19 -0.0349441
TENM3 teneurin transmembrane protein 3 -0.0346134
GNAS GNAS complex locus -0.0342286
RPS12 ribosomal protein S12 -0.0339664
RPL12 ribosomal protein L12 -0.0337436
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0335686
RPS8 ribosomal protein S8 -0.0335682
NAMPT nicotinamide phosphoribosyltransferase -0.0333141
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0318321
RPS24 ribosomal protein S24 -0.0316835
CD109 CD109 molecule -0.0311238
EZR ezrin -0.0299283
RPS27A ribosomal protein S27a -0.0298549
CTSL cathepsin L -0.0295987
IGF1R insulin-like growth factor 1 receptor -0.0294963
RPL37 ribosomal protein L37 -0.028871
AUTS2 autism susceptibility candidate 2 -0.0287989
HLA-B major histocompatibility complex, class I, B -0.0286313
TBXT T-box transcription factor T -0.0285501
RPL19 ribosomal protein L19 -0.0285121
AGTPBP1 ATP/GTP binding protein 1 -0.0283321
PALLD palladin, cytoskeletal associated protein -0.0280895
RPLP2 ribosomal protein, large, P2 -0.0280435
RPL23 ribosomal protein L23 -0.0280347
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0279228
P3H2 prolyl 3-hydroxylase 2 -0.0277342
S100A10 S100 calcium binding protein A10 -0.0275619
AKR1C1 aldo-keto reductase family 1, member C1 -0.0272223
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0272099
PTGR1 prostaglandin reductase 1 -0.0268499
PRKN parkin RBR E3 ubiquitin protein ligase -0.0265929
LMNA lamin A/C -0.0265489
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0262499
RPL9 ribosomal protein L9 -0.026024
LOC112694756 uncharaterized LOC112694756 -0.0259117
RPL36A ribosomal protein L36a -0.0254777
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0254248
RPL38 ribosomal protein L38 -0.0251342
RPS4X ribosomal protein S4, X-linked -0.0251313
RPL13A ribosomal protein L13a -0.0250233
RPL11 ribosomal protein L11 -0.0248289
RPS29 ribosomal protein S29 -0.0243596
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0243426
HLA-A major histocompatibility complex, class I, A -0.0242678
ASPH aspartate beta-hydroxylase -0.0237267
RPS27 ribosomal protein S27 -0.0235735
CDH13 cadherin 13 -0.0234026
NAP1L1 nucleosome assembly protein 1-like 1 -0.023299
RPL36 ribosomal protein L36 -0.0232267
RPS23 ribosomal protein S23 -0.0230918
IER3 immediate early response 3 -0.0226957
NALF1 NALCN channel auxiliary factor 1 -0.0226432
FTH1 ferritin, heavy polypeptide 1 -0.0226375
YBX3 Y box binding protein 3 -0.0226016
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0225152
RPL34 ribosomal protein L34 -0.0224962
RPS16 ribosomal protein S16 -0.0224938
EIF1 eukaryotic translation initiation factor 1 -0.0224883
RACK1 receptor for activated C kinase 1 -0.0224742
ENO1 enolase 1, (alpha) -0.0224742
RPL7A ribosomal protein L7a -0.0222951