Bexarotene_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.109639
GOLGA4 golgin A4 0.0890602
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0833823
TXNRD1 thioredoxin reductase 1 0.0744365
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0734856
ADAM10 ADAM metallopeptidase domain 10 0.063769
ZNF292 zinc finger protein 292 0.0592387
ECT2 epithelial cell transforming 2 0.0542318
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0526704
NUP58 nucleoporin 58 0.0496185
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0476916
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0421772
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0420736
ANK2 ankyrin 2, neuronal 0.0412843
NBAS neuroblastoma amplified sequence 0.0408139
RNF145 ring finger protein 145 0.03968
GARS1 glycyl-tRNA synthetase 1 0.0394783
BRWD1 bromodomain and WD repeat domain containing 1 0.0391625
SOX6 SRY (sex determining region Y)-box 6 0.0390563
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.03883
TMEM65 transmembrane protein 65 0.0387707
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0376408
TMSB4X thymosin beta 4, X-linked 0.0371211
CDC73 cell division cycle 73 0.0367081
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0364147
FAM13A family with sequence similarity 13, member A 0.0363542
QKI QKI, KH domain containing, RNA binding 0.0358918
BMP2K BMP2 inducible kinase 0.0354766
ZBTB20 zinc finger and BTB domain containing 20 0.035306
FLNB filamin B, beta 0.0350681
PTBP2 polypyrimidine tract binding protein 2 0.0344717
PICALM phosphatidylinositol binding clathrin assembly protein 0.0344481
RTN4 reticulon 4 0.0341644
NCKAP1 NCK-associated protein 1 0.0331988
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0331964
ZMYM2 zinc finger, MYM-type 2 0.0323411
CCNL1 cyclin L1 0.0317654
UBA6 ubiquitin-like modifier activating enzyme 6 0.0317337
TTC3 tetratricopeptide repeat domain 3 0.0317083
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0313748
PRELID2 PRELI domain containing 2 0.0312556
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0308936
TMEM41B transmembrane protein 41B 0.0307733
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0297425
PNISR PNN-interacting serine/arginine-rich protein 0.0295484
ADAM9 ADAM metallopeptidase domain 9 0.0291572
TXNIP thioredoxin interacting protein 0.0289697
ZCCHC7 zinc finger, CCHC domain containing 7 0.0287046
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0286355
RBM39 RNA binding motif protein 39 0.0282494
IARS1 isoleucyl-tRNA synthetase 1 0.0280982
ACACA acetyl-CoA carboxylase alpha 0.0278824
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0273969
KDM3A lysine (K)-specific demethylase 3A 0.0272631
PUM2 pumilio RNA-binding family member 2 0.0270244
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0269536
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0266567
ELOVL5 ELOVL fatty acid elongase 5 0.0266359
GSK3B glycogen synthase kinase 3 beta 0.0265536
MON2 MON2 homolog (S. cerevisiae) 0.0263351
YEATS2 YEATS domain containing 2 0.0261838
TFG TRK-fused gene 0.0258803
TMEM135 transmembrane protein 135 0.0258737
PARD3 par-3 family cell polarity regulator 0.0257523
COG6 component of oligomeric golgi complex 6 0.0255686
COPA coatomer protein complex, subunit alpha 0.025181
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0251597
SBF2 SET binding factor 2 0.0250066
AHI1 Abelson helper integration site 1 0.0249522
PLK2 polo-like kinase 2 0.0248555
ZNF638 zinc finger protein 638 0.024738
USP3 ubiquitin specific peptidase 3 0.024655
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0244641
MATR3 matrin 3 0.0244539
COPB1 coatomer protein complex, subunit beta 1 0.0243222
TBC1D5 TBC1 domain family, member 5 0.0241911
AKAP9 A kinase (PRKA) anchor protein 9 0.0240632
RAB6A RAB6A, member RAS oncogene family 0.0239596
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0239583
GLS2 glutaminase 2 (liver, mitochondrial) 0.0237403
BIRC6 baculoviral IAP repeat containing 6 0.0232793
TOP2B topoisomerase (DNA) II beta 180kDa 0.0232379
SREBF2 sterol regulatory element binding transcription factor 2 0.0231737
USP24 ubiquitin specific peptidase 24 0.0230895
EVI5 ecotropic viral integration site 5 0.0230771
SSBP2 single-stranded DNA binding protein 2 0.0230699
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0229727
DSCAM Down syndrome cell adhesion molecule 0.02281
HELZ helicase with zinc finger 0.022736
TNRC6B trinucleotide repeat containing 6B 0.022721
ZFC3H1 zinc finger, C3H1-type containing 0.0227177
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0227092
LDHA lactate dehydrogenase A 0.0226482
LPP LIM domain containing preferred translocation partner in lipoma 0.0225804
SUCO SUN domain containing ossification factor 0.0225547
METTL15 methyltransferase like 15 0.0224395
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0224077
ZNF608 zinc finger protein 608 0.0223383
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222549
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0220418

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.34471
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20094
TPT1 tumor protein, translationally-controlled 1 -0.148926
RPS6 ribosomal protein S6 -0.139951
RPL35A ribosomal protein L35a -0.113709
RPS8 ribosomal protein S8 -0.106419
RPL31 ribosomal protein L31 -0.0941001
RPLP1 ribosomal protein, large, P1 -0.0886865
RPL34 ribosomal protein L34 -0.0798419
BMP10 bone morphogenetic protein 10 -0.0797179
FOXP1 forkhead box P1 -0.0731408
RPS13 ribosomal protein S13 -0.0725253
RPL9 ribosomal protein L9 -0.0705454
RPS3 ribosomal protein S3 -0.0701009
RPS23 ribosomal protein S23 -0.0694465
RPL26 ribosomal protein L26 -0.068895
RPL37A ribosomal protein L37a -0.0685754
RPLP2 ribosomal protein, large, P2 -0.0660685
RPS25 ribosomal protein S25 -0.0648139
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0640651
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0635201
RPL19 ribosomal protein L19 -0.0623773
PKM pyruvate kinase, muscle -0.0619912
RPL23 ribosomal protein L23 -0.0618173
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0609104
ACTG1 actin gamma 1 -0.0589845
RPS19 ribosomal protein S19 -0.0589728
RPS27A ribosomal protein S27a -0.0573822
RPS12 ribosomal protein S12 -0.052134
RPS29 ribosomal protein S29 -0.0499197
RPS24 ribosomal protein S24 -0.0464038
RPL36 ribosomal protein L36 -0.0462942
HSPB1 heat shock 27kDa protein 1 -0.0453762
RPL38 ribosomal protein L38 -0.0452903
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0437056
RPL7A ribosomal protein L7a -0.0435883
S100A9 S100 calcium binding protein A9 -0.0434412
RPL30 ribosomal protein L30 -0.0412364
RPL11 ribosomal protein L11 -0.040673
ZMYND8 zinc finger, MYND-type containing 8 -0.0404367
RPL8 ribosomal protein L8 -0.039508
KPNB1 karyopherin (importin) beta 1 -0.0392289
RPS27 ribosomal protein S27 -0.0392048
VCL vinculin -0.038843
FTL ferritin, light polypeptide -0.0387197
TUBB4B tubulin, beta 4B class IVb -0.0386197
RPS21 ribosomal protein S21 -0.0384447
RPL12 ribosomal protein L12 -0.0383616
MYL12B myosin, light chain 12B, regulatory -0.0383024
S100A10 S100 calcium binding protein A10 -0.0378776
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0377118
RPL37 ribosomal protein L37 -0.0368192
RPL13A ribosomal protein L13a -0.0367136
PDE4B phosphodiesterase 4B, cAMP-specific -0.0340571
CCND1 cyclin D1 -0.0340352
RPLP0 ribosomal protein, large, P0 -0.0339171
RPS11 ribosomal protein S11 -0.0327252
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0321225
RPS17 ribosomal protein S17 -0.0318328
RPS15 ribosomal protein S15 -0.0315457
TMSB10 thymosin beta 10 -0.0315233
RPS16 ribosomal protein S16 -0.0315099
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0314876
RPS14 ribosomal protein S14 -0.0313354
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.031042
RPL28 ribosomal protein L28 -0.0308708
RACK1 receptor for activated C kinase 1 -0.030521
RPL10A ribosomal protein L10a -0.0303802
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0303567
LOC102724023 ES1 protein homolog, mitochondrial -0.0302317
HLA-B major histocompatibility complex, class I, B -0.0299033
RPS10 ribosomal protein S10 -0.0293057
EBNA1BP2 EBNA1 binding protein 2 -0.0290304
ENO2 enolase 2 (gamma, neuronal) -0.0289288
IFI16 interferon, gamma-inducible protein 16 -0.0287477
RPS5 ribosomal protein S5 -0.0287212
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0287197
RPL5 ribosomal protein L5 -0.0287118
RPL15 ribosomal protein L15 -0.0284616
IFITM3 interferon induced transmembrane protein 3 -0.0281851
RPL27A ribosomal protein L27a -0.0280286
RPL32 ribosomal protein L32 -0.0278557
RPL36A ribosomal protein L36a -0.0274422
S100A4 S100 calcium binding protein A4 -0.0272489
RPL35 ribosomal protein L35 -0.0271176
EIF1 eukaryotic translation initiation factor 1 -0.0271124
NOP56 NOP56 ribonucleoprotein -0.0270722
EMP3 epithelial membrane protein 3 -0.0268667
NAP1L1 nucleosome assembly protein 1-like 1 -0.0267986
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0266945
GLI3 GLI family zinc finger 3 -0.026465
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0264136
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0262186
PRDX2 peroxiredoxin 2 -0.0260509
SEPTIN9 septin 9 -0.0259729
HMGB1 high mobility group box 1 -0.0259282
RPS4X ribosomal protein S4, X-linked -0.0258382
RPS20 ribosomal protein S20 -0.0253575
TUBA1B tubulin, alpha 1b -0.025145
VIM vimentin -0.0248246