Bexarotene_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.146956
NAMPT nicotinamide phosphoribosyltransferase 0.12363
RB1CC1 RB1-inducible coiled-coil 1 0.0853655
ELL2 elongation factor, RNA polymerase II, 2 0.0788683
AKAP12 A kinase (PRKA) anchor protein 12 0.0736249
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0573778
FNIP1 folliculin interacting protein 1 0.0535209
TENT5A terminal nucleotidyltransferase 5A 0.0501883
ARRDC3 arrestin domain containing 3 0.050128
JMJD1C jumonji domain containing 1C 0.0479436
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0467073
IL1RAP interleukin 1 receptor accessory protein 0.0446093
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0427364
DSCAM Down syndrome cell adhesion molecule 0.0411859
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0395484
SOD2 superoxide dismutase 2, mitochondrial 0.0393181
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0376306
PPARD peroxisome proliferator-activated receptor delta 0.0365496
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364648
NRIP1 nuclear receptor interacting protein 1 0.0355092
SDC4 syndecan 4 0.0344317
MKI67 marker of proliferation Ki-67 0.0343356
OGA O-GlcNAcase 0.033695
CDK19 cyclin-dependent kinase 19 0.033398
ESYT2 extended synaptotagmin-like protein 2 0.0332734
CENPF centromere protein F, 350/400kDa 0.0328508
GOLGA4 golgin A4 0.0324694
NPEPPS aminopeptidase puromycin sensitive 0.032286
MXI1 MAX interactor 1, dimerization protein 0.0322849
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0313203
UGCG UDP-glucose ceramide glucosyltransferase 0.031251
VMP1 vacuole membrane protein 1 0.0301011
BRWD3 bromodomain and WD repeat domain containing 3 0.0290202
UBE2H ubiquitin-conjugating enzyme E2H 0.0287719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0283971
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0283429
STC1 stanniocalcin 1 0.0276403
NGLY1 N-glycanase 1 0.0275134
ANLN anillin, actin binding protein 0.0272874
LOXL2 lysyl oxidase-like 2 0.0270526
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0267688
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0266304
ANKHD1 ankyrin repeat and KH domain containing 1 0.0264696
DUSP5 dual specificity phosphatase 5 0.0263438
RTN4 reticulon 4 0.02531
NAV2 neuron navigator 2 0.0248407
USP47 ubiquitin specific peptidase 47 0.0246658
DIAPH3 diaphanous-related formin 3 0.0246558
CDCP1 CUB domain containing protein 1 0.0240152
ZNF654 zinc finger protein 654 0.0238102
MBNL2 muscleblind-like splicing regulator 2 0.023451
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0232706
NKTR natural killer cell triggering receptor 0.0232684
FAM3C family with sequence similarity 3, member C 0.0230769
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0229268
SNX3 sorting nexin 3 0.0227272
SMC5 structural maintenance of chromosomes 5 0.0226274
TM4SF1 transmembrane 4 L six family member 1 0.0221778
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0218244
USP9X ubiquitin specific peptidase 9, X-linked 0.0211089
KIF4A kinesin family member 4A 0.0210645
MIS18BP1 MIS18 binding protein 1 0.0210421
FLNB filamin B, beta 0.020941
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0208366
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0207539
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0207029
ARFGEF3 ARFGEF family member 3 0.0206584
ZBTB38 zinc finger and BTB domain containing 38 0.0205501
CEP95 centrosomal protein 95kDa 0.0203837
DOCK5 dedicator of cytokinesis 5 0.0200955
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0200048
KIF18A kinesin family member 18A 0.0198721
RSF1 remodeling and spacing factor 1 0.0198284
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0194294
FNDC3B fibronectin type III domain containing 3B 0.0193211
SMC4 structural maintenance of chromosomes 4 0.0191159
ADM adrenomedullin 0.0190926
UBA6 ubiquitin-like modifier activating enzyme 6 0.0188231
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.0188113
YTHDC1 YTH domain containing 1 0.0186424
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0186061
CDC27 cell division cycle 27 0.0186017
MAPK14 mitogen-activated protein kinase 14 0.0185795
KDM2A lysine (K)-specific demethylase 2A 0.0185785
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0185262
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0184855
SMAD3 SMAD family member 3 0.018247
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0181904
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0181072
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0180241
TMEM41B transmembrane protein 41B 0.0178692
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0177417
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0177388
TPX2 TPX2, microtubule-associated 0.0176086
AKAP9 A kinase (PRKA) anchor protein 9 0.0175382
FOXO3 forkhead box O3 0.0174071
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0172566
DENND4C DENN/MADD domain containing 4C 0.0170783
HDAC8 histone deacetylase 8 0.0169587
CACUL1 CDK2-associated, cullin domain 1 0.0169508

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.165933
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.149488
FRMD4A FERM domain containing 4A -0.14159
GLIS3 GLIS family zinc finger 3 -0.133667
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0949872
HMGA2 high mobility group AT-hook 2 -0.09196
COL6A3 collagen, type VI, alpha 3 -0.0893635
IGFBP3 insulin-like growth factor binding protein 3 -0.0861033
CDH13 cadherin 13 -0.0850473
HLA-B major histocompatibility complex, class I, B -0.0849421
RPS6 ribosomal protein S6 -0.0793282
TMSB10 thymosin beta 10 -0.0780086
FTL ferritin, light polypeptide -0.0755721
IER3 immediate early response 3 -0.0745456
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0709149
BICC1 BicC family RNA binding protein 1 -0.0676093
DST dystonin -0.0603399
EXT1 exostosin glycosyltransferase 1 -0.0587555
TPT1 tumor protein, translationally-controlled 1 -0.0557116
QKI QKI, KH domain containing, RNA binding -0.0531824
VCAN versican -0.0522448
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.049265
RPS12 ribosomal protein S12 -0.0471913
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0467671
TPM1 tropomyosin 1 (alpha) -0.0459521
NAV1 neuron navigator 1 -0.0444328
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0431029
RPS3 ribosomal protein S3 -0.0430216
TMEM132D transmembrane protein 132D -0.0429237
PLIN2 perilipin 2 -0.042677
RPS8 ribosomal protein S8 -0.0426543
RPL37A ribosomal protein L37a -0.0410189
ADAM12 ADAM metallopeptidase domain 12 -0.0409375
RPL23 ribosomal protein L23 -0.0409305
DIAPH2 diaphanous-related formin 2 -0.0395114
RNF213 ring finger protein 213 -0.0390857
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0388302
NAP1L1 nucleosome assembly protein 1-like 1 -0.0380895
FN1 fibronectin 1 -0.0379948
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0379019
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0377565
HLA-A major histocompatibility complex, class I, A -0.0373692
SFRP1 secreted frizzled-related protein 1 -0.0369158
COL5A1 collagen, type V, alpha 1 -0.0368201
TGFBI transforming growth factor, beta-induced, 68kDa -0.0362992
ACTG1 actin gamma 1 -0.0357796
PTPRK protein tyrosine phosphatase, receptor type, K -0.0352542
SLC35F3 solute carrier family 35, member F3 -0.0349469
CALR calreticulin -0.0345466
PDE10A phosphodiesterase 10A -0.0343352
FBXL7 F-box and leucine-rich repeat protein 7 -0.0340507
ASPH aspartate beta-hydroxylase -0.0339686
RRBP1 ribosome binding protein 1 -0.0337481
SOX5 SRY (sex determining region Y)-box 5 -0.0337273
B2M beta-2-microglobulin -0.0333463
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0331854
ENO1 enolase 1, (alpha) -0.0325994
RPLP2 ribosomal protein, large, P2 -0.0321557
CTSD cathepsin D -0.0319417
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0318637
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0315539
THBS1 thrombospondin 1 -0.0314245
RPL26 ribosomal protein L26 -0.031117
FLNA filamin A, alpha -0.0303584
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0298875
SLC38A1 solute carrier family 38, member 1 -0.0295326
GNAS GNAS complex locus -0.0292681
C3 complement component 3 -0.0286996
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0286701
ZMYND8 zinc finger, MYND-type containing 8 -0.0285089
TPM4 tropomyosin 4 -0.0284028
RPL35A ribosomal protein L35a -0.0282343
HMGA1 high mobility group AT-hook 1 -0.028046
CD44 CD44 molecule (Indian blood group) -0.027905
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0275779
EGFR epidermal growth factor receptor -0.0275441
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0275386
LDHA lactate dehydrogenase A -0.0275023
BNC2 basonuclin 2 -0.0269114
POTEF POTE ankyrin domain family, member F -0.0268536
SAMD3 sterile alpha motif domain containing 3 -0.0264007
RPLP1 ribosomal protein, large, P1 -0.0260947
RPS4X ribosomal protein S4, X-linked -0.0257886
PRKCA protein kinase C, alpha -0.025742
FTH1 ferritin, heavy polypeptide 1 -0.0254909
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0254813
COL6A2 collagen, type VI, alpha 2 -0.0254776
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.02538
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0253785
AHNAK AHNAK nucleoprotein -0.0250843
RACK1 receptor for activated C kinase 1 -0.0250616
RPL5 ribosomal protein L5 -0.0245572
SYNJ2 synaptojanin 2 -0.0243018
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0242198
RAD51B RAD51 paralog B -0.0241706
ZFAND3 zinc finger, AN1-type domain 3 -0.0241272
PTMA prothymosin, alpha -0.0238871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0237303
FRMPD4 FERM and PDZ domain containing 4 -0.0236574
RPL32 ribosomal protein L32 -0.0235642