Bexarotene_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRA2A transformer 2 alpha homolog (Drosophila) 0.0367244
PDE4D phosphodiesterase 4D, cAMP-specific 0.0342539
NKD1 naked cuticle homolog 1 (Drosophila) 0.0321854
ESYT2 extended synaptotagmin-like protein 2 0.0316547
ELL2 elongation factor, RNA polymerase II, 2 0.0295518
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0295279
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0285056
ERRFI1 ERBB receptor feedback inhibitor 1 0.0284458
AREG amphiregulin 0.0282294
PRELID2 PRELI domain containing 2 0.0282075
SETD5 SET domain containing 5 0.0281024
AKAP12 A kinase (PRKA) anchor protein 12 0.0275834
WDFY2 WD repeat and FYVE domain containing 2 0.025645
AKAP9 A kinase (PRKA) anchor protein 9 0.0253964
RAB1A RAB1A, member RAS oncogene family 0.0246287
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0246215
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.022899
TM4SF1 transmembrane 4 L six family member 1 0.022876
COG6 component of oligomeric golgi complex 6 0.0224904
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0222416
TPD52 tumor protein D52 0.0220201
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0217891
NOP58 NOP58 ribonucleoprotein 0.0208856
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0208531
COPA coatomer protein complex, subunit alpha 0.0203374
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0200982
SBF2 SET binding factor 2 0.0200486
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0197415
SOS1 son of sevenless homolog 1 (Drosophila) 0.0194845
FOXO3 forkhead box O3 0.0193317
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0192896
FAM13A family with sequence similarity 13, member A 0.0192641
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0192485
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0192125
SDC4 syndecan 4 0.019171
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.0190781
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0190317
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0188367
SLC35F5 solute carrier family 35, member F5 0.0186623
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.018426
EIF4B eukaryotic translation initiation factor 4B 0.0180972
AVL9 AVL9 homolog (S. cerevisiase) 0.0180333
STK4 serine/threonine kinase 4 0.0179109
UBA6 ubiquitin-like modifier activating enzyme 6 0.0175336
YTHDC1 YTH domain containing 1 0.0174769
FAM107B family with sequence similarity 107, member B 0.0174371
GPHN gephyrin 0.0172857
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0170283
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0168357
ELP2 elongator acetyltransferase complex subunit 2 0.0166826
GPR107 G protein-coupled receptor 107 0.0166342
OSBPL9 oxysterol binding protein-like 9 0.0166083
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0161723
THOC1 THO complex 1 0.0160991
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0160594
PDIA5 protein disulfide isomerase family A, member 5 0.0160377
RNF121 ring finger protein 121 0.0158319
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0158064
DSCAM Down syndrome cell adhesion molecule 0.0156492
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0156184
TBC1D23 TBC1 domain family, member 23 0.0156084
TFG TRK-fused gene 0.0155816
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0155276
RAP1B RAP1B, member of RAS oncogene family 0.0153628
POM121C POM121 transmembrane nucleoporin C 0.0153251
ARRDC3 arrestin domain containing 3 0.0153091
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0152569
RORA RAR-related orphan receptor A 0.0152145
ZCCHC7 zinc finger, CCHC domain containing 7 0.0150005
KDM1A lysine (K)-specific demethylase 1A 0.0149242
USP53 ubiquitin specific peptidase 53 0.0149084
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.014905
CKAP5 cytoskeleton associated protein 5 0.014893
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0147956
GCC2 GRIP and coiled-coil domain containing 2 0.0146648
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0145615
TBC1D22A TBC1 domain family, member 22A 0.0145103
LCMT1 leucine carboxyl methyltransferase 1 0.0144527
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0143371
COLEC11 collectin sub-family member 11 0.0143046
SUCO SUN domain containing ossification factor 0.014217
SNX27 sorting nexin family member 27 0.0140989
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.014
U2SURP U2 snRNP-associated SURP domain containing 0.0139987
NGLY1 N-glycanase 1 0.0139963
TMEM39A transmembrane protein 39A 0.0139782
PCM1 pericentriolar material 1 0.0139696
BACE2 beta-site APP-cleaving enzyme 2 0.0139508
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0139351
ARHGAP26 Rho GTPase activating protein 26 0.013923
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0138498
SRP54 signal recognition particle 54kDa 0.0137572
ZNHIT6 zinc finger, HIT-type containing 6 0.0137549
CCNL1 cyclin L1 0.0137134
PTBP2 polypyrimidine tract binding protein 2 0.0137008
NUP54 nucleoporin 54kDa 0.0136594
AKAP13 A kinase (PRKA) anchor protein 13 0.0136367
FNIP1 folliculin interacting protein 1 0.0136327
MATR3 matrin 3 0.0136114
SMC5 structural maintenance of chromosomes 5 0.0135907

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.190917
IGFBP3 insulin-like growth factor binding protein 3 -0.189472
FN1 fibronectin 1 -0.155763
TGFBI transforming growth factor, beta-induced, 68kDa -0.144255
TIMP3 TIMP metallopeptidase inhibitor 3 -0.122293
HLA-B major histocompatibility complex, class I, B -0.11761
TMSB10 thymosin beta 10 -0.114419
COL1A1 collagen, type I, alpha 1 -0.109816
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0985882
COL1A2 collagen, type I, alpha 2 -0.0937278
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0826292
VIM vimentin -0.0824054
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.080014
CD44 CD44 molecule (Indian blood group) -0.0795035
POTEF POTE ankyrin domain family, member F -0.0702561
B2M beta-2-microglobulin -0.0659656
MAP1B microtubule-associated protein 1B -0.0659652
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0630019
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0610165
PRSS23 protease, serine, 23 -0.0606211
CDH13 cadherin 13 -0.0605551
ENO1 enolase 1, (alpha) -0.0594779
LOX lysyl oxidase -0.058543
MT2A metallothionein 2A -0.0585211
F3 coagulation factor III (thromboplastin, tissue factor) -0.0581373
COL5A1 collagen, type V, alpha 1 -0.0574946
PSD3 pleckstrin and Sec7 domain containing 3 -0.055731
COL6A1 collagen, type VI, alpha 1 -0.055711
HLA-C major histocompatibility complex, class I, C -0.0545588
GLIS3 GLIS family zinc finger 3 -0.0522113
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0517039
CALD1 caldesmon 1 -0.0506353
ANXA2 annexin A2 -0.0496563
CALU calumenin -0.0491867
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0490425
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0487414
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0466322
EGFR epidermal growth factor receptor -0.0440144
TPM4 tropomyosin 4 -0.0411413
COL6A2 collagen, type VI, alpha 2 -0.0407916
CDK6 cyclin-dependent kinase 6 -0.0402986
EXT1 exostosin glycosyltransferase 1 -0.0400288
IGFBP7 insulin-like growth factor binding protein 7 -0.0392925
ACTG1 actin gamma 1 -0.0377726
TPM1 tropomyosin 1 (alpha) -0.0371311
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0357962
VCL vinculin -0.035181
PGK1 phosphoglycerate kinase 1 -0.0347805
TNS3 tensin 3 -0.0338717
LOXL2 lysyl oxidase-like 2 -0.0336542
GLG1 golgi glycoprotein 1 -0.0336227
VEGFC vascular endothelial growth factor C -0.0333846
HLA-A major histocompatibility complex, class I, A -0.0330046
HMGA2 high mobility group AT-hook 2 -0.0325782
LDHA lactate dehydrogenase A -0.0319995
HIPK2 homeodomain interacting protein kinase 2 -0.0315715
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0313966
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0310702
TPT1 tumor protein, translationally-controlled 1 -0.030519
MYH9 myosin, heavy chain 9, non-muscle -0.0290101
CALR calreticulin -0.0289326
CAVIN1 caveolae associated protein 1 -0.028923
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0285754
SEPTIN7 septin 7 -0.028182
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281688
DPYD dihydropyrimidine dehydrogenase -0.0277978
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0277695
NAV1 neuron navigator 1 -0.0275676
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0274709
ANKRD11 ankyrin repeat domain 11 -0.0269491
S100A10 S100 calcium binding protein A10 -0.0267438
COL5A2 collagen, type V, alpha 2 -0.0267171
AHNAK AHNAK nucleoprotein -0.0266127
FBXL7 F-box and leucine-rich repeat protein 7 -0.0265146
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0263584
PDIA4 protein disulfide isomerase family A, member 4 -0.0260242
PDIA3 protein disulfide isomerase family A, member 3 -0.0259089
GRB10 growth factor receptor-bound protein 10 -0.0253175
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0252939
TNNC1 troponin C type 1 (slow) -0.0251471
ASPH aspartate beta-hydroxylase -0.0250872
RRBP1 ribosome binding protein 1 -0.0249751
HIP1 huntingtin interacting protein 1 -0.0238533
DLG1 discs, large homolog 1 (Drosophila) -0.0237696
FTL ferritin, light polypeptide -0.0236499
EXOC4 exocyst complex component 4 -0.0236287
MYOF myoferlin -0.0229179
CA12 carbonic anhydrase XII -0.0226381
COL3A1 collagen, type III, alpha 1 -0.0223057
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.021981
RASAL2 RAS protein activator like 2 -0.0217819
CAV1 caveolin 1, caveolae protein, 22kDa -0.0217712
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0216886
LPP LIM domain containing preferred translocation partner in lipoma -0.0213721
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0213334
SPAG9 sperm associated antigen 9 -0.021115
ZNF395 zinc finger protein 395 -0.020935
EGR1 early growth response 1 -0.020913
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.020813
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0207877