Bexarotene_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bexarotene perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bexarotene_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HILPDA hypoxia inducible lipid droplet-associated 0.0681228
BIRC3 baculoviral IAP repeat containing 3 0.0676004
GOLGA4 golgin A4 0.0649705
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0584432
TPX2 TPX2, microtubule-associated 0.0565158
YBX3 Y box binding protein 3 0.0561521
WAC WW domain containing adaptor with coiled-coil 0.0557474
CHD1 chromodomain helicase DNA binding protein 1 0.053229
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0515995
AKAP13 A kinase (PRKA) anchor protein 13 0.0515861
PNISR PNN-interacting serine/arginine-rich protein 0.0491102
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0463558
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0462623
SPAG9 sperm associated antigen 9 0.0443326
RSRC2 arginine/serine-rich coiled-coil 2 0.0437856
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0435641
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0430213
YBX1 Y box binding protein 1 0.0428364
ZNF292 zinc finger protein 292 0.0419911
CXCL8 chemokine (C-X-C motif) ligand 8 0.0418845
FXR1 fragile X mental retardation, autosomal homolog 1 0.0418467
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0415592
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0414945
ECT2 epithelial cell transforming 2 0.0407596
BIRC2 baculoviral IAP repeat containing 2 0.0404627
APLP2 amyloid beta (A4) precursor-like protein 2 0.0402564
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0391195
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.038123
XPO1 exportin 1 0.0375202
WBP11 WW domain binding protein 11 0.0374331
B2M beta-2-microglobulin 0.0371154
PUM2 pumilio RNA-binding family member 2 0.0369782
CENPF centromere protein F, 350/400kDa 0.036852
ATXN2 ataxin 2 0.0363199
CKAP5 cytoskeleton associated protein 5 0.0359962
TMEM135 transmembrane protein 135 0.0356544
NUP58 nucleoporin 58 0.0355638
RBM39 RNA binding motif protein 39 0.0352358
SDC4 syndecan 4 0.0351062
DSCAM Down syndrome cell adhesion molecule 0.0347481
FAM13A family with sequence similarity 13, member A 0.0342142
GLS2 glutaminase 2 (liver, mitochondrial) 0.0341561
CUL3 cullin 3 0.0341225
TFG TRK-fused gene 0.0340712
BCLAF1 BCL2-associated transcription factor 1 0.03396
RTN4 reticulon 4 0.0339005
ASXL1 additional sex combs like transcriptional regulator 1 0.0338362
KMT2E lysine (K)-specific methyltransferase 2E 0.0334033
NAMPT nicotinamide phosphoribosyltransferase 0.0333409
NKTR natural killer cell triggering receptor 0.0330851
FTH1 ferritin, heavy polypeptide 1 0.0319587
YAP1 Yes-associated protein 1 0.0319209
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0319178
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0314723
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313836
SRP54 signal recognition particle 54kDa 0.0312541
PCBP2 poly(rC) binding protein 2 0.0309002
MSN moesin 0.0306503
SETD5 SET domain containing 5 0.0303564
RPS12 ribosomal protein S12 0.0299866
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0298439
PIAS1 protein inhibitor of activated STAT, 1 0.0296157
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0292971
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.028753
CD44 CD44 molecule (Indian blood group) 0.0286208
RNF145 ring finger protein 145 0.028339
AHCTF1 AT hook containing transcription factor 1 0.0281092
UGCG UDP-glucose ceramide glucosyltransferase 0.027971
ADM adrenomedullin 0.0279435
RPL3 ribosomal protein L3 0.0277599
TXNRD1 thioredoxin reductase 1 0.0276677
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0276556
RAD23B RAD23 homolog B (S. cerevisiae) 0.0276299
MKI67 marker of proliferation Ki-67 0.0275093
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0272688
PAPOLA poly(A) polymerase alpha 0.0269588
DIAPH1 diaphanous-related formin 1 0.0268792
TRA2A transformer 2 alpha homolog (Drosophila) 0.0267958
RAB6A RAB6A, member RAS oncogene family 0.0267685
CCNL1 cyclin L1 0.0266722
NCAPD2 non-SMC condensin I complex, subunit D2 0.0263304
SKIC3 SKI3 subunit of superkiller complex 0.0261979
SEPTIN2 septin 2 0.0261829
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0261817
ACIN1 apoptotic chromatin condensation inducer 1 0.0261747
ACBD3 acyl-CoA binding domain containing 3 0.0259743
SET SET nuclear proto-oncogene 0.0258845
CANX calnexin 0.0257709
ATP13A3 ATPase type 13A3 0.0257673
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0257602
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0257601
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0257504
SEC24A SEC24 family member A 0.0256527
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0256009
KDM2A lysine (K)-specific demethylase 2A 0.0252481
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0247311
MATR3 matrin 3 0.0246947
CKAP2 cytoskeleton associated protein 2 0.0245682
FMNL2 formin-like 2 0.024548
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0245354

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126672
TPT1 tumor protein, translationally-controlled 1 -0.121817
AHNAK AHNAK nucleoprotein -0.091523
FNDC3B fibronectin type III domain containing 3B -0.0854168
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0784244
TMSB10 thymosin beta 10 -0.0719006
MACF1 microtubule-actin crosslinking factor 1 -0.0653054
ASPH aspartate beta-hydroxylase -0.0627903
HMGA2 high mobility group AT-hook 2 -0.0595903
LPP LIM domain containing preferred translocation partner in lipoma -0.0538656
TRIO trio Rho guanine nucleotide exchange factor -0.0533867
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0520608
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0513132
DPYD dihydropyrimidine dehydrogenase -0.048258
INTS6 integrator complex subunit 6 -0.0463276
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.045164
DST dystonin -0.0434221
RNF213 ring finger protein 213 -0.0425667
OSMR oncostatin M receptor -0.0421549
CAVIN1 caveolae associated protein 1 -0.0410415
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0410382
FMN1 formin 1 -0.0409585
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0409341
LOC112694756 uncharaterized LOC112694756 -0.040805
SH3KBP1 SH3-domain kinase binding protein 1 -0.0405542
SLC38A2 solute carrier family 38, member 2 -0.0389724
ZBTB20 zinc finger and BTB domain containing 20 -0.0381081
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0373442
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0370781
CLIP1 CAP-GLY domain containing linker protein 1 -0.0367993
NIBAN2 niban apoptosis regulator 2 -0.0363961
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0361023
AHNAK2 AHNAK nucleoprotein 2 -0.0348782
RPL35A ribosomal protein L35a -0.0341078
SMAD3 SMAD family member 3 -0.0337073
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0332643
ANKRD11 ankyrin repeat domain 11 -0.0331082
PRKCA protein kinase C, alpha -0.0328904
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0326979
ATG7 autophagy related 7 -0.0321868
SMYD3 SET and MYND domain containing 3 -0.0320358
MYOF myoferlin -0.0315244
ATM ATM serine/threonine kinase -0.0311005
SAMD4A sterile alpha motif domain containing 4A -0.0306734
PHF3 PHD finger protein 3 -0.0306309
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0305889
BICD1 bicaudal D homolog 1 (Drosophila) -0.0299129
ATG10 autophagy related 10 -0.029526
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0292639
RAI14 retinoic acid induced 14 -0.0290509
ACER3 alkaline ceramidase 3 -0.0288408
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0287775
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.028631
GLCCI1 glucocorticoid induced 1 -0.0285691
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0285364
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0279581
PCED1B PC-esterase domain containing 1B -0.0279352
BCAR3 breast cancer anti-estrogen resistance 3 -0.0277012
RPLP2 ribosomal protein, large, P2 -0.0276882
SDCCAG8 serologically defined colon cancer antigen 8 -0.0276031
TRIM56 tripartite motif containing 56 -0.0275129
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.02748
FLNA filamin A, alpha -0.0274234
AEBP2 AE binding protein 2 -0.0269443
ANGPTL4 angiopoietin-like 4 -0.0268842
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0266792
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0263743
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0263635
PLEK2 pleckstrin 2 -0.0262879
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0258681
IGF2 insulin-like growth factor 2 -0.0257394
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0257217
ANO6 anoctamin 6 -0.0257014
TM4SF1 transmembrane 4 L six family member 1 -0.0255641
RPL23 ribosomal protein L23 -0.0253223
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0252827
SUMF1 sulfatase modifying factor 1 -0.0252685
PRH1 proline-rich protein HaeIII subfamily 1 -0.0249827
EGFR epidermal growth factor receptor -0.0248927
UBB ubiquitin B -0.0246632
HLA-C major histocompatibility complex, class I, C -0.0246347
PRR16 proline rich 16 -0.0246102
NT5E 5'-nucleotidase, ecto (CD73) -0.0245246
PDE4D phosphodiesterase 4D, cAMP-specific -0.0244802
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0244722
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0243968
TBL1X transducin (beta)-like 1X-linked -0.0243379
CMIP c-Maf inducing protein -0.0243042
RIN2 Ras and Rab interactor 2 -0.0242172
NDRG1 N-myc downstream regulated 1 -0.0237164
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0237059
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0234022
ZMYND8 zinc finger, MYND-type containing 8 -0.0230766
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0230073
FRMD6 FERM domain containing 6 -0.0228979
FBXL7 F-box and leucine-rich repeat protein 7 -0.0227512
GPATCH8 G patch domain containing 8 -0.0225334
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0224225
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0223146
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0221159