Bicalutamide_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.229216
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.126043
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.100422
IGFBP3 insulin-like growth factor binding protein 3 0.0826472
COL8A1 collagen, type VIII, alpha 1 0.0671199
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0512166
DST dystonin 0.0474446
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0422262
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0416336
TRIO trio Rho guanine nucleotide exchange factor 0.0374038
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.036325
TPM3 tropomyosin 3 0.0344825
NFE2L1 nuclear factor, erythroid 2-like 1 0.0299391
VEGFA vascular endothelial growth factor A 0.0266871
SAMD9 sterile alpha motif domain containing 9 0.0265857
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0262846
ADAM9 ADAM metallopeptidase domain 9 0.0259033
COL5A1 collagen, type V, alpha 1 0.0227397
MSN moesin 0.0222232
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0221103
RAI14 retinoic acid induced 14 0.0207399
COL4A1 collagen, type IV, alpha 1 0.0201837
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0201507
FAM13A family with sequence similarity 13, member A 0.0194162
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0192059
PDE4D phosphodiesterase 4D, cAMP-specific 0.0190873
ELL2 elongation factor, RNA polymerase II, 2 0.0187907
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0183085
NAV1 neuron navigator 1 0.0182375
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0181646
TNIP1 TNFAIP3 interacting protein 1 0.0181408
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0180663
MCFD2 multiple coagulation factor deficiency 2 0.017889
ZFP36L1 ZFP36 ring finger protein-like 1 0.0176263
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0174025
ASPH aspartate beta-hydroxylase 0.0172366
CLU clusterin 0.0167601
MYH9 myosin, heavy chain 9, non-muscle 0.0162835
TXNIP thioredoxin interacting protein 0.0162346
TMF1 TATA element modulatory factor 1 0.016005
VEGFC vascular endothelial growth factor C 0.0157469
HDAC9 histone deacetylase 9 0.01551
ITPRID2 ITPR interacting domain containing 2 0.0153143
EZR ezrin 0.0151886
FN1 fibronectin 1 0.015145
ARL15 ADP-ribosylation factor-like 15 0.0148914
MX2 MX dynamin-like GTPase 2 0.0147278
ANKRD36 ankyrin repeat domain 36 0.0145991
SETD5 SET domain containing 5 0.0143782
ARRDC3 arrestin domain containing 3 0.0141032
RSAD2 radical S-adenosyl methionine domain containing 2 0.014053
ERRFI1 ERBB receptor feedback inhibitor 1 0.0138651
GOLM1 golgi membrane protein 1 0.0134853
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0132389
UBXN4 UBX domain protein 4 0.0131439
LIMCH1 LIM and calponin homology domains 1 0.0128823
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0128582
SYTL3 synaptotagmin-like 3 0.0128543
SPDL1 spindle apparatus coiled-coil protein 1 0.0128357
RYR2 ryanodine receptor 2 (cardiac) 0.0124923
BHLHE40 basic helix-loop-helix family, member e40 0.0122646
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0121291
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0120608
UBA6 ubiquitin-like modifier activating enzyme 6 0.0120604
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0119591
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0119535
ZNF292 zinc finger protein 292 0.0119482
SLC22A23 solute carrier family 22, member 23 0.0119424
BCLAF1 BCL2-associated transcription factor 1 0.0119365
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0116699
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0115787
PSD3 pleckstrin and Sec7 domain containing 3 0.0115419
FER fer (fps/fes related) tyrosine kinase 0.0114865
B2M beta-2-microglobulin 0.0113793
DSTN destrin (actin depolymerizing factor) 0.0113661
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0113255
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0112948
OPTN optineurin 0.0111692
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0110967
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0110264
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0108814
ANO6 anoctamin 6 0.0107162
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0106971
MAP1B microtubule-associated protein 1B 0.0106557
PLAT plasminogen activator, tissue 0.0106212
ATF4 activating transcription factor 4 0.0106089
EHBP1 EH domain binding protein 1 0.0104913
HILPDA hypoxia inducible lipid droplet-associated 0.0104616
ENO2 enolase 2 (gamma, neuronal) 0.0104552
TENT5A terminal nucleotidyltransferase 5A 0.0104138
LAMB1 laminin, beta 1 0.0103318
TNNT1 troponin T type 1 (skeletal, slow) 0.0102521
DSPP dentin sialophosphoprotein 0.0102384
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0100278
ANKRD36C ankyrin repeat domain 36C 0.00994051
KDM6A lysine (K)-specific demethylase 6A 0.00987657
SRRM1 serine/arginine repetitive matrix 1 0.00987278
ZFP36 ZFP36 ring finger protein 0.00985384
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.00977671
MACF1 microtubule-actin crosslinking factor 1 0.00968644

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.262079
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227472
VIM vimentin -0.185847
TMSB10 thymosin beta 10 -0.159623
SQSTM1 sequestosome 1 -0.0904629
MT2A metallothionein 2A -0.0809253
LOX lysyl oxidase -0.0764211
CSTB cystatin B (stefin B) -0.0753214
LMNA lamin A/C -0.0710536
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0707199
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0693012
S100A10 S100 calcium binding protein A10 -0.0673368
THBS2 thrombospondin 2 -0.0659215
CCND1 cyclin D1 -0.0650253
TPT1 tumor protein, translationally-controlled 1 -0.0647453
PODXL podocalyxin-like -0.0646629
ACTG1 actin gamma 1 -0.0592113
S100A6 S100 calcium binding protein A6 -0.0578555
PTMA prothymosin, alpha -0.0573641
ANXA2 annexin A2 -0.0566209
LOC112694756 uncharaterized LOC112694756 -0.0560718
FBXL7 F-box and leucine-rich repeat protein 7 -0.0520842
NAP1L1 nucleosome assembly protein 1-like 1 -0.0511936
FBN1 fibrillin 1 -0.0459871
HLA-B major histocompatibility complex, class I, B -0.0459114
TMSB4X thymosin beta 4, X-linked -0.0432819
RHOBTB3 Rho-related BTB domain containing 3 -0.04229
HLA-E major histocompatibility complex, class I, E -0.0420239
LOXL2 lysyl oxidase-like 2 -0.0414682
AHNAK AHNAK nucleoprotein -0.0413123
CAVIN1 caveolae associated protein 1 -0.041048
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0407021
RPL23 ribosomal protein L23 -0.0401116
RPS24 ribosomal protein S24 -0.0395608
EIF1 eukaryotic translation initiation factor 1 -0.0395488
VDAC1 voltage-dependent anion channel 1 -0.0395169
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0387781
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0385583
HDLBP high density lipoprotein binding protein -0.0373532
RPL35A ribosomal protein L35a -0.037128
RPLP1 ribosomal protein, large, P1 -0.0367001
FTH1 ferritin, heavy polypeptide 1 -0.0359162
RAB1A RAB1A, member RAS oncogene family -0.0353374
RPL28 ribosomal protein L28 -0.035173
CANX calnexin -0.0350835
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0350499
RPS3 ribosomal protein S3 -0.0338776
FSTL1 follistatin-like 1 -0.0338761
S100A4 S100 calcium binding protein A4 -0.033652
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0334352
ARF1 ADP-ribosylation factor 1 -0.0326775
NAV2 neuron navigator 2 -0.0324668
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0323839
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0317998
LDHA lactate dehydrogenase A -0.031637
FLNA filamin A, alpha -0.0314176
RPL12 ribosomal protein L12 -0.0311715
TPM4 tropomyosin 4 -0.031074
ANKRD10 ankyrin repeat domain 10 -0.0309215
UBC ubiquitin C -0.0303213
EEF2 eukaryotic translation elongation factor 2 -0.0302858
KDM3A lysine (K)-specific demethylase 3A -0.0297763
SLC38A1 solute carrier family 38, member 1 -0.0297698
BACE2 beta-site APP-cleaving enzyme 2 -0.0297637
DLG1 discs, large homolog 1 (Drosophila) -0.0292789
COL3A1 collagen, type III, alpha 1 -0.0292669
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0292034
PGK1 phosphoglycerate kinase 1 -0.0286086
TAOK1 TAO kinase 1 -0.0284266
ZNF207 zinc finger protein 207 -0.0283654
HIP1 huntingtin interacting protein 1 -0.0281108
TAGLN2 transgelin 2 -0.0279576
RPL34 ribosomal protein L34 -0.0278441
CAPN2 calpain 2, (m/II) large subunit -0.0271428
BBX bobby sox homolog (Drosophila) -0.0269629
RACK1 receptor for activated C kinase 1 -0.0269336
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.026878
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0267255
RPLP2 ribosomal protein, large, P2 -0.0265278
RPL26 ribosomal protein L26 -0.0264417
RPS8 ribosomal protein S8 -0.0262822
CD99 CD99 molecule -0.0258838
RPS5 ribosomal protein S5 -0.0255886
TUBB tubulin, beta class I -0.0255638
DPYSL2 dihydropyrimidinase-like 2 -0.0253284
HLA-C major histocompatibility complex, class I, C -0.0252215
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0248803
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0247416
RPL19 ribosomal protein L19 -0.0244489
GNAS GNAS complex locus -0.0243349
PRRC2C proline-rich coiled-coil 2C -0.0242131
RPS19 ribosomal protein S19 -0.0239556
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -0.0239248
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0237714
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.023401
RAB7A RAB7A, member RAS oncogene family -0.0232951
RPLP0 ribosomal protein, large, P0 -0.0231788
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0228641
RPS16 ribosomal protein S16 -0.0228265
UBE2I ubiquitin-conjugating enzyme E2I -0.0226795