Bicalutamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.125878
PTPRD protein tyrosine phosphatase, receptor type, D 0.0970845
VCL vinculin 0.074111
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0714399
DST dystonin 0.062415
SLITRK6 SLIT and NTRK-like family, member 6 0.0618448
ITPRID2 ITPR interacting domain containing 2 0.0560081
VMP1 vacuole membrane protein 1 0.0557185
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0551295
LSAMP limbic system-associated membrane protein 0.0526106
LINGO2 leucine rich repeat and Ig domain containing 2 0.0468984
PCBP3 poly(rC) binding protein 3 0.0428824
FAM13A family with sequence similarity 13, member A 0.0427311
PLAT plasminogen activator, tissue 0.0417987
SYT1 synaptotagmin I 0.0391616
ZBTB20 zinc finger and BTB domain containing 20 0.0383356
MEF2A myocyte enhancer factor 2A 0.03781
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0377084
SIK2 salt-inducible kinase 2 0.0370649
VEGFA vascular endothelial growth factor A 0.0367083
RPTOR regulatory associated protein of MTOR, complex 1 0.036678
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0365889
CRH corticotropin releasing hormone 0.0361089
BPTF bromodomain PHD finger transcription factor 0.0355563
NRG1 neuregulin 1 0.0309665
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0309503
TPST1 tyrosylprotein sulfotransferase 1 0.0302198
PLPP1 phospholipid phosphatase 1 0.0301263
TLE4 transducin-like enhancer of split 4 0.0297667
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0296628
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0295866
PACS1 phosphofurin acidic cluster sorting protein 1 0.0293804
ZSWIM6 zinc finger, SWIM-type containing 6 0.0292276
RAD51B RAD51 paralog B 0.0289995
FMN1 formin 1 0.0289965
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0286545
PTPRM protein tyrosine phosphatase, receptor type, M 0.0282838
CALD1 caldesmon 1 0.0279954
FNDC3A fibronectin type III domain containing 3A 0.0278982
ADGRB3 adhesion G protein-coupled receptor B3 0.0276435
PDE4D phosphodiesterase 4D, cAMP-specific 0.0273212
MACF1 microtubule-actin crosslinking factor 1 0.0269388
STK38L serine/threonine kinase 38 like 0.0265965
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0265278
GLCCI1 glucocorticoid induced 1 0.0264804
COL4A5 collagen, type IV, alpha 5 0.0259873
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0258742
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0258716
PDE10A phosphodiesterase 10A 0.0257011
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0253966
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0249614
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0249092
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0247195
PTPRK protein tyrosine phosphatase, receptor type, K 0.0246223
NPAS2 neuronal PAS domain protein 2 0.0243215
ANTXR1 anthrax toxin receptor 1 0.0243007
TENT5A terminal nucleotidyltransferase 5A 0.0242534
SENP6 SUMO1/sentrin specific peptidase 6 0.0236883
MBD5 methyl-CpG binding domain protein 5 0.0233644
NBEA neurobeachin 0.0231514
N4BP2L2 NEDD4 binding protein 2-like 2 0.022959
ASPH aspartate beta-hydroxylase 0.0227066
LPP LIM domain containing preferred translocation partner in lipoma 0.0225823
KLHL13 kelch-like family member 13 0.0225604
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0222661
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0222332
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0221905
PSD3 pleckstrin and Sec7 domain containing 3 0.0220501
AKAP9 A kinase (PRKA) anchor protein 9 0.0212794
GREM2 gremlin 2, DAN family BMP antagonist 0.0212074
BICD1 bicaudal D homolog 1 (Drosophila) 0.0207853
NREP neuronal regeneration related protein 0.0207393
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0205424
ATRNL1 attractin-like 1 0.0204144
AHR aryl hydrocarbon receptor 0.0200848
IGFBP3 insulin-like growth factor binding protein 3 0.0200787
SLIT2 slit homolog 2 (Drosophila) 0.019796
IGFBP5 insulin-like growth factor binding protein 5 0.0197642
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0196499
CNTN4 contactin 4 0.0195738
FLT1 fms-related tyrosine kinase 1 0.0195652
CADM1 cell adhesion molecule 1 0.0195063
GOLGB1 golgin B1 0.0194403
RNF150 ring finger protein 150 0.01944
NALF1 NALCN channel auxiliary factor 1 0.0190519
BCAS3 breast carcinoma amplified sequence 3 0.019027
MBTD1 mbt domain containing 1 0.0189408
SMYD3 SET and MYND domain containing 3 0.0189344
SLC35F3 solute carrier family 35, member F3 0.0187988
COL4A6 collagen, type IV, alpha 6 0.0186316
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0185138
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0184368
EXT1 exostosin glycosyltransferase 1 0.0183045
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0180416
TMF1 TATA element modulatory factor 1 0.0178336
SLC38A2 solute carrier family 38, member 2 0.0178197
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0177445
ATXN1 ataxin 1 0.017656
PDLIM5 PDZ and LIM domain 5 0.0176327
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0174883

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.491432
IGF2 insulin-like growth factor 2 -0.139926
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115056
PTMA prothymosin, alpha -0.101321
VIM vimentin -0.0956231
LPIN1 lipin 1 -0.0903109
ACTG1 actin gamma 1 -0.0849698
RPL23 ribosomal protein L23 -0.0724912
LMNA lamin A/C -0.0581206
COL1A1 collagen, type I, alpha 1 -0.0569571
TRIB2 tribbles pseudokinase 2 -0.0557178
RPS24 ribosomal protein S24 -0.053467
RPL38 ribosomal protein L38 -0.0506184
RPLP1 ribosomal protein, large, P1 -0.0496726
NAMPT nicotinamide phosphoribosyltransferase -0.044858
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.042842
NPEPPS aminopeptidase puromycin sensitive -0.0417591
TPT1 tumor protein, translationally-controlled 1 -0.0415737
NAP1L1 nucleosome assembly protein 1-like 1 -0.0382298
CCND1 cyclin D1 -0.0375551
KDM3A lysine (K)-specific demethylase 3A -0.036086
HELZ helicase with zinc finger -0.0356871
SQSTM1 sequestosome 1 -0.0344095
COL3A1 collagen, type III, alpha 1 -0.0342185
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.033481
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.033269
KPNB1 karyopherin (importin) beta 1 -0.032547
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0325212
MATR3 matrin 3 -0.0318843
EIF1 eukaryotic translation initiation factor 1 -0.0317734
RPL35A ribosomal protein L35a -0.031677
TRIO trio Rho guanine nucleotide exchange factor -0.0313311
PTK2 protein tyrosine kinase 2 -0.0310448
TMSB10 thymosin beta 10 -0.0309339
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0307455
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0307146
ANXA2 annexin A2 -0.0305541
RPL4 ribosomal protein L4 -0.0303434
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0298862
VDAC1 voltage-dependent anion channel 1 -0.0296309
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0295978
USP3 ubiquitin specific peptidase 3 -0.0295843
ARF1 ADP-ribosylation factor 1 -0.0293972
RPLP0 ribosomal protein, large, P0 -0.0284818
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0283856
ZMYM2 zinc finger, MYM-type 2 -0.0282256
GNAS GNAS complex locus -0.0279997
EEF2 eukaryotic translation elongation factor 2 -0.0278875
AOPEP aminopeptidase O (putative) -0.027773
H3-3B H3.3 histone B -0.0273777
HMGB2 high mobility group box 2 -0.0269938
HMGA1 high mobility group AT-hook 1 -0.0269674
FOXK2 forkhead box K2 -0.0265383
CLTC clathrin, heavy chain (Hc) -0.0262218
WDR45B WD repeat domain 45B -0.0261641
LMAN1 lectin, mannose-binding, 1 -0.0256634
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0256236
GARS1 glycyl-tRNA synthetase 1 -0.0254215
SEPTIN2 septin 2 -0.0252374
SPAG9 sperm associated antigen 9 -0.0251316
GOLGA4 golgin A4 -0.0250844
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0250519
UBE2O ubiquitin-conjugating enzyme E2O -0.0246447
ZFAND3 zinc finger, AN1-type domain 3 -0.0243201
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0242139
IARS1 isoleucyl-tRNA synthetase 1 -0.0239568
SEPTIN9 septin 9 -0.0239527
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0235863
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0235317
KMT2C lysine (K)-specific methyltransferase 2C -0.0231859
SSBP2 single-stranded DNA binding protein 2 -0.0228012
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0227903
OGA O-GlcNAcase -0.0226856
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0224933
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0223114
RPL34 ribosomal protein L34 -0.0222325
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.022074
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.022037
S100A6 S100 calcium binding protein A6 -0.0220198
LOC112694756 uncharaterized LOC112694756 -0.0219093
RAD21 RAD21 homolog (S. pombe) -0.0216927
ANKRD10 ankyrin repeat domain 10 -0.0211333
NCOR1 nuclear receptor corepressor 1 -0.0209984
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0208981
SOS1 son of sevenless homolog 1 (Drosophila) -0.0208738
FBXL20 F-box and leucine-rich repeat protein 20 -0.0207068
CANX calnexin -0.0205524
MARCHF6 membrane associated ring-CH-type finger 6 -0.0204971
IER3 immediate early response 3 -0.0204923
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0202948
CDC27 cell division cycle 27 -0.0200935
MAP4 microtubule-associated protein 4 -0.0196903
CALU calumenin -0.0196311
RPS27A ribosomal protein S27a -0.0196098
ATXN2L ataxin 2-like -0.019378
CRABP2 cellular retinoic acid binding protein 2 -0.0193733
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0193506
FTL ferritin, light polypeptide -0.0192482
RPS21 ribosomal protein S21 -0.0189671
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0189431