Bicalutamide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0877226
TXNIP thioredoxin interacting protein 0.075095
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0634787
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0606155
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0600313
NRIP1 nuclear receptor interacting protein 1 0.0600184
RNF43 ring finger protein 43 0.059156
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0567285
PTBP3 polypyrimidine tract binding protein 3 0.0557081
MACC1 metastasis associated in colon cancer 1 0.0548674
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0525578
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0516268
ZMYND8 zinc finger, MYND-type containing 8 0.0514321
PRELID2 PRELI domain containing 2 0.0509343
NCKAP5 NCK-associated protein 5 0.0499091
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0495144
DSPP dentin sialophosphoprotein 0.0475937
H1-0 H1.0 linker histone 0.0470724
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0470339
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0469817
RHOBTB3 Rho-related BTB domain containing 3 0.0451822
MEIS2 Meis homeobox 2 0.0442161
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0439985
STK24 serine/threonine kinase 24 0.0429917
RUNX1 runt-related transcription factor 1 0.0423104
MKI67 marker of proliferation Ki-67 0.0417395
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0415853
SYNE2 spectrin repeat containing, nuclear envelope 2 0.039884
TMEM62 transmembrane protein 62 0.0386466
EHF ets homologous factor 0.0383553
IFNGR1 interferon gamma receptor 1 0.0382548
RBM39 RNA binding motif protein 39 0.0371925
IL20RA interleukin 20 receptor, alpha 0.0368727
DSCAM Down syndrome cell adhesion molecule 0.0361142
MYH9 myosin, heavy chain 9, non-muscle 0.0358586
USP54 ubiquitin specific peptidase 54 0.0351858
TC2N tandem C2 domains, nuclear 0.0349311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.034828
ARRDC3 arrestin domain containing 3 0.0348279
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0347669
BHLHE40 basic helix-loop-helix family, member e40 0.0347575
CENPF centromere protein F, 350/400kDa 0.0343606
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0343559
OGA O-GlcNAcase 0.0342637
ITGA6 integrin, alpha 6 0.0340941
TJP2 tight junction protein 2 0.0340618
SPATS2L spermatogenesis associated, serine-rich 2-like 0.033763
GRK3 G protein-coupled receptor kinase 3 0.0329194
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0325475
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0306071
TMEM51 transmembrane protein 51 0.0300241
KLF3 Kruppel-like factor 3 (basic) 0.0295824
NDRG1 N-myc downstream regulated 1 0.0294604
ERRFI1 ERBB receptor feedback inhibitor 1 0.0285188
RNF149 ring finger protein 149 0.0283182
DENND4C DENN/MADD domain containing 4C 0.0278916
ZDHHC20 zinc finger, DHHC-type containing 20 0.0273967
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0271812
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0269238
SORBS1 sorbin and SH3 domain containing 1 0.0267698
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.0267062
FOXP1 forkhead box P1 0.0266773
CCNL1 cyclin L1 0.0266662
SREBF2 sterol regulatory element binding transcription factor 2 0.0266238
MECOM MDS1 and EVI1 complex locus 0.026293
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0259442
AHNAK AHNAK nucleoprotein 0.0257142
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0255884
SPRED1 sprouty-related, EVH1 domain containing 1 0.0249565
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0245658
ARHGAP32 Rho GTPase activating protein 32 0.0245544
DUSP16 dual specificity phosphatase 16 0.0243884
AOPEP aminopeptidase O (putative) 0.0238639
SPATA13 spermatogenesis associated 13 0.0237057
ADD3 adducin 3 (gamma) 0.0236812
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0236084
ABHD2 abhydrolase domain containing 2 0.0234118
TRIM2 tripartite motif containing 2 0.02334
MYO1E myosin IE 0.0232874
PTEN phosphatase and tensin homolog 0.0232791
BCLAF1 BCL2-associated transcription factor 1 0.0232635
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0232373
GRAMD2B GRAM domain containing 2B 0.023192
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0229886
ETNK1 ethanolamine kinase 1 0.0226858
ARHGAP5 Rho GTPase activating protein 5 0.0225798
BICRAL BICRA like chromatin remodeling complex associated protein 0.0224877
UBAC2 UBA domain containing 2 0.0223494
ESRP1 epithelial splicing regulatory protein 1 0.0219909
CD46 CD46 molecule, complement regulatory protein 0.021841
NPEPPS aminopeptidase puromycin sensitive 0.0214584
TMPRSS4 transmembrane protease, serine 4 0.0212583
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.021164
KDM3A lysine (K)-specific demethylase 3A 0.0209084
TUBGCP3 tubulin, gamma complex associated protein 3 0.0209078
DST dystonin 0.0206557
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0205727
SFTPA2 surfactant protein A2 0.0205641
XPO1 exportin 1 0.0200774
ATP10B ATPase, class V, type 10B 0.0199423

decreased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 -0.172189
EGR1 early growth response 1 -0.139629
RNF213 ring finger protein 213 -0.119985
LYZ lysozyme -0.119284
ANXA2 annexin A2 -0.11517
GMDS GDP-mannose 4,6-dehydratase -0.104039
PLSCR2 phospholipid scramblase 2 -0.103741
GCLC glutamate-cysteine ligase, catalytic subunit -0.0987703
RAB7A RAB7A, member RAS oncogene family -0.0983889
TPT1 tumor protein, translationally-controlled 1 -0.0947949
EPSTI1 epithelial stromal interaction 1 (breast) -0.0929073
LMO7 LIM domain 7 -0.0917913
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0896223
STS steroid sulfatase (microsomal), isozyme S -0.084936
PERP PERP, TP53 apoptosis effector -0.0770294
SP100 SP100 nuclear antigen -0.0723887
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.072013
EXT1 exostosin glycosyltransferase 1 -0.071143
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0710993
TM4SF19 transmembrane 4 L six family member 19 -0.0674744
PKM pyruvate kinase, muscle -0.0654227
C6ORF132 chromosome 6 open reading frame 132 -0.0648547
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0646721
FNDC3B fibronectin type III domain containing 3B -0.0637229
IGFBP3 insulin-like growth factor binding protein 3 -0.0616385
ACTG1 actin gamma 1 -0.0614496
NPSR1 neuropeptide S receptor 1 -0.0611514
MCL1 myeloid cell leukemia 1 -0.0600508
LCN2 lipocalin 2 -0.058534
RIGI RNA sensor RIG-I -0.0558539
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0556738
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0547477
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0544866
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0536776
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0530035
AHI1 Abelson helper integration site 1 -0.0516111
MAP7 microtubule-associated protein 7 -0.05098
AREG amphiregulin -0.0504304
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0501381
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0501078
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0496779
SQSTM1 sequestosome 1 -0.0489731
AKAP13 A kinase (PRKA) anchor protein 13 -0.0488086
NABP1 nucleic acid binding protein 1 -0.0471265
POU2F2 POU class 2 homeobox 2 -0.0469416
ANKRD10 ankyrin repeat domain 10 -0.0467109
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0461064
TSHZ2 teashirt zinc finger homeobox 2 -0.0456972
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.045368
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0453333
UBAP2 ubiquitin associated protein 2 -0.0427973
IFI6 interferon, alpha-inducible protein 6 -0.0427884
HM13 histocompatibility (minor) 13 -0.0415206
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0408944
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.040048
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0394062
MAML2 mastermind-like 2 (Drosophila) -0.0390818
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0388022
RPL23 ribosomal protein L23 -0.0387616
LAMA4 laminin, alpha 4 -0.0385889
MX1 MX dynamin-like GTPase 1 -0.0384551
RPL35A ribosomal protein L35a -0.0380008
CATSPERB catsper channel auxiliary subunit beta -0.0378984
MX2 MX dynamin-like GTPase 2 -0.0378095
PTMA prothymosin, alpha -0.0362576
POTEF POTE ankyrin domain family, member F -0.0362458
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.036017
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0360105
SMAD3 SMAD family member 3 -0.0359731
GK glycerol kinase -0.0352698
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0351208
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0349872
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0348809
TNS4 tensin 4 -0.0348094
SPAG9 sperm associated antigen 9 -0.0344938
LOC112694756 uncharaterized LOC112694756 -0.0343765
TJP1 tight junction protein 1 -0.0343282
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0341318
PARD3 par-3 family cell polarity regulator -0.0339783
RPL34 ribosomal protein L34 -0.0335604
PRKCA protein kinase C, alpha -0.0335063
EZR ezrin -0.0331409
DIAPH1 diaphanous-related formin 1 -0.0330185
TM4SF1 transmembrane 4 L six family member 1 -0.0323946
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0316264
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.031324
LPP LIM domain containing preferred translocation partner in lipoma -0.0312669
HLA-B major histocompatibility complex, class I, B -0.0311815
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0309844
HKDC1 hexokinase domain containing 1 -0.0308691
CUX1 cut-like homeobox 1 -0.0299413
MORF4L2 mortality factor 4 like 2 -0.0299264
SETX senataxin -0.0298741
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0295153
MUC20 mucin 20, cell surface associated -0.0291551
IRF1 interferon regulatory factor 1 -0.0290402
SPDYA speedy/RINGO cell cycle regulator family member A -0.0289688
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0289579
RPS24 ribosomal protein S24 -0.0289317
FBXO39 F-box protein 39 -0.0287429