Bicalutamide_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.12398
DSPP dentin sialophosphoprotein 0.0317358
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0259214
ASPH aspartate beta-hydroxylase 0.0215768
ERRFI1 ERBB receptor feedback inhibitor 1 0.0207391
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0197684
SAMD4A sterile alpha motif domain containing 4A 0.0184313
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0174422
VEGFA vascular endothelial growth factor A 0.016889
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0160821
VCL vinculin 0.0152717
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0143386
EHBP1 EH domain binding protein 1 0.0142281
PLIN2 perilipin 2 0.0135695
ATXN1 ataxin 1 0.0131929
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0114477
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0110496
TNS1 tensin 1 0.0108803
FRMD5 FERM domain containing 5 0.0107565
DST dystonin 0.0103932
CP ceruloplasmin (ferroxidase) 0.0103475
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.00952713
STK39 serine threonine kinase 39 0.0094909
DLC1 DLC1 Rho GTPase activating protein 0.00933819
MPZL2 myelin protein zero-like 2 0.00921952
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00912578
PTPRM protein tyrosine phosphatase, receptor type, M 0.0091113
STC2 stanniocalcin 2 0.00907027
CD109 CD109 molecule 0.00887966
PCGF5 polycomb group ring finger 5 0.00860531
GPC6 glypican 6 0.00824085
RIN2 Ras and Rab interactor 2 0.00817147
FILIP1L filamin A interacting protein 1-like 0.00807916
ARFGEF3 ARFGEF family member 3 0.00789063
ARHGAP9 Rho GTPase activating protein 9 0.00781785
FAM13A family with sequence similarity 13, member A 0.00780785
PARP4 poly (ADP-ribose) polymerase family, member 4 0.00778854
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0076874
RIGI RNA sensor RIG-I 0.00767795
ARL5B ADP-ribosylation factor-like 5B 0.00761508
ZHX2 zinc fingers and homeoboxes 2 0.00759431
PRELID2 PRELI domain containing 2 0.00753952
IGFBP3 insulin-like growth factor binding protein 3 0.00743808
DISC1 disrupted in schizophrenia 1 0.00737492
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00734546
DTNA dystrobrevin, alpha 0.00728761
BZW1 basic leucine zipper and W2 domains 1 0.00726884
SPATA13 spermatogenesis associated 13 0.00719518
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0071401
FHL2 four and a half LIM domains 2 0.00713982
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00700894
RAD51B RAD51 paralog B 0.00699494
NGLY1 N-glycanase 1 0.00697585
MXI1 MAX interactor 1, dimerization protein 0.00686829
NPAS2 neuronal PAS domain protein 2 0.00683885
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.006838
SPATS2L spermatogenesis associated, serine-rich 2-like 0.00666472
KIAA1217 KIAA1217 0.00646572
CPQ carboxypeptidase Q 0.00646255
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00645133
VCAN versican 0.00639352
PEG3 paternally expressed 3 0.00630593
BCAR3 breast cancer anti-estrogen resistance 3 0.0062987
BHLHE40 basic helix-loop-helix family, member e40 0.00628442
CYTH1 cytohesin 1 0.00628075
ZNF804A zinc finger protein 804A 0.00626556
RNASET2 ribonuclease T2 0.00622772
LAMA4 laminin, alpha 4 0.00620234
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00619555
TAFA5 TAFA chemokine like family member 5 0.00617715
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00613401
BMERB1 bMERB domain containing 1 0.00607697
RAB6A RAB6A, member RAS oncogene family 0.00604545
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.00598349
NREP neuronal regeneration related protein 0.00597173
ARHGAP21 Rho GTPase activating protein 21 0.00584467
JPH2 junctophilin 2 0.00582992
STK38L serine/threonine kinase 38 like 0.00579114
ZFP36L2 ZFP36 ring finger protein-like 2 0.005778
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00573463
STK17A serine/threonine kinase 17a 0.00569028
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00567001
FAM110C family with sequence similarity 110, member C 0.00564998
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.00564197
KDM7A lysine (K)-specific demethylase 7A 0.00562436
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.00560812
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 0.00558881
MX2 MX dynamin-like GTPase 2 0.00549417
PDLIM5 PDZ and LIM domain 5 0.00547822
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.00546425
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.00543499
RYR2 ryanodine receptor 2 (cardiac) 0.00539338
JMY junction mediating and regulatory protein, p53 cofactor 0.00536349
PTBP3 polypyrimidine tract binding protein 3 0.0053403
SDC2 syndecan 2 0.00531682
ATP10A ATPase, class V, type 10A 0.00528017
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00526311
SH3RF1 SH3 domain containing ring finger 1 0.00521454
MX1 MX dynamin-like GTPase 1 0.00507215
ANXA3 annexin A3 0.00502079

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.364209
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.192237
C3 complement component 3 -0.178458
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.144899
APOB apolipoprotein B -0.123441
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0973017
ENO1 enolase 1, (alpha) -0.0895487
FN1 fibronectin 1 -0.0860802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0818468
MT2A metallothionein 2A -0.0733122
IGFBP1 insulin-like growth factor binding protein 1 -0.0700582
TIMP1 TIMP metallopeptidase inhibitor 1 -0.066711
EEF2 eukaryotic translation elongation factor 2 -0.0636329
GPC3 glypican 3 -0.0582301
RPS27A ribosomal protein S27a -0.0560873
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0534151
RPL23 ribosomal protein L23 -0.0524669
FTL ferritin, light polypeptide -0.0506993
IGF2 insulin-like growth factor 2 -0.0502129
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0485109
UBC ubiquitin C -0.0473222
RPLP1 ribosomal protein, large, P1 -0.0465814
RPS12 ribosomal protein S12 -0.0461127
RPS8 ribosomal protein S8 -0.0459002
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0450216
LOC112694756 uncharaterized LOC112694756 -0.0434478
RPS6 ribosomal protein S6 -0.0419049
PCBP2 poly(rC) binding protein 2 -0.0403494
RPS24 ribosomal protein S24 -0.0402871
RPL11 ribosomal protein L11 -0.038887
CCL20 chemokine (C-C motif) ligand 20 -0.0384695
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0380596
APOE apolipoprotein E -0.037843
RPL37A ribosomal protein L37a -0.0376824
EPAS1 endothelial PAS domain protein 1 -0.0373023
TPT1 tumor protein, translationally-controlled 1 -0.0366599
NKD1 naked cuticle homolog 1 (Drosophila) -0.0359043
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0352621
RPS19 ribosomal protein S19 -0.0332224
LRMDA leucine rich melanocyte differentiation associated -0.0330717
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0318464
RACK1 receptor for activated C kinase 1 -0.0317461
AHSG alpha-2-HS-glycoprotein -0.031617
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0312526
TMSB10 thymosin beta 10 -0.0307533
FBF1 Fas (TNFRSF6) binding factor 1 -0.0304723
RPS3 ribosomal protein S3 -0.0304678
FNDC3B fibronectin type III domain containing 3B -0.0303022
CFB complement factor B -0.0293307
NAP1L1 nucleosome assembly protein 1-like 1 -0.0284224
RPL5 ribosomal protein L5 -0.0281674
RPL9 ribosomal protein L9 -0.0274595
RPL34 ribosomal protein L34 -0.0273968
RPL12 ribosomal protein L12 -0.0272659
RPLP0 ribosomal protein, large, P0 -0.0265769
SVIL supervillin -0.0261663
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0258491
RPS21 ribosomal protein S21 -0.0256996
RPS14 ribosomal protein S14 -0.0254159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0253877
SLC38A2 solute carrier family 38, member 2 -0.0252112
JUN jun proto-oncogene -0.0249905
RPL35A ribosomal protein L35a -0.0249018
SDC4 syndecan 4 -0.024763
LDHA lactate dehydrogenase A -0.0246636
SOD2 superoxide dismutase 2, mitochondrial -0.0244229
RRBP1 ribosome binding protein 1 -0.0243443
RPS5 ribosomal protein S5 -0.0243135
RPL26 ribosomal protein L26 -0.024125
RPLP2 ribosomal protein, large, P2 -0.0239423
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0238339
PKM pyruvate kinase, muscle -0.0237056
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0234687
PRRC2C proline-rich coiled-coil 2C -0.0232992
ICAM1 intercellular adhesion molecule 1 -0.0232234
CEMIP2 cell migration inducing hyaluronidase 2 -0.0231734
USP34 ubiquitin specific peptidase 34 -0.0227396
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0227385
RPL31 ribosomal protein L31 -0.0226767
TOP1 topoisomerase (DNA) I -0.0224433
RPS13 ribosomal protein S13 -0.0221044
B2M beta-2-microglobulin -0.0219627
RPL28 ribosomal protein L28 -0.0219338
RPS29 ribosomal protein S29 -0.0218237
RPS25 ribosomal protein S25 -0.0217833
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0217355
APOA2 apolipoprotein A-II -0.0214942
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0213033
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0211317
ELL2 elongation factor, RNA polymerase II, 2 -0.0210624
PEG10 paternally expressed 10 -0.0208097
RPS16 ribosomal protein S16 -0.0205128
CST3 cystatin C -0.0204172
PDIA3 protein disulfide isomerase family A, member 3 -0.0203722
AMBP alpha-1-microglobulin/bikunin precursor -0.0202589
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0200343
KTN1 kinectin 1 (kinesin receptor) -0.0200144
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0197724
SEPTIN9 septin 9 -0.0197113
IGF1R insulin-like growth factor 1 receptor -0.0196494