Bicalutamide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.120215
DOCK5 dedicator of cytokinesis 5 0.100489
VCL vinculin 0.0899781
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0852316
FOXO1 forkhead box O1 0.0843293
BCL2L1 BCL2-like 1 0.0821664
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0733917
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0723483
MT2A metallothionein 2A 0.0690173
MBNL1 muscleblind-like splicing regulator 1 0.0664439
ITGA6 integrin, alpha 6 0.0655044
NDRG1 N-myc downstream regulated 1 0.0651204
MACF1 microtubule-actin crosslinking factor 1 0.0636038
PDLIM5 PDZ and LIM domain 5 0.062753
MSN moesin 0.0596402
DST dystonin 0.0538876
LUZP1 leucine zipper protein 1 0.0534429
PDE4D phosphodiesterase 4D, cAMP-specific 0.0527884
CAPRIN2 caprin family member 2 0.0527155
ASPH aspartate beta-hydroxylase 0.0516764
TXNIP thioredoxin interacting protein 0.0488801
TSC22D1 TSC22 domain family, member 1 0.0470652
BCAR3 breast cancer anti-estrogen resistance 3 0.0443843
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0434745
EFNA5 ephrin-A5 0.0427653
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0426938
MYH9 myosin, heavy chain 9, non-muscle 0.0420348
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0419574
SEPTIN9 septin 9 0.041688
CDK6 cyclin-dependent kinase 6 0.0414347
CD44 CD44 molecule (Indian blood group) 0.0405383
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0396298
PLAT plasminogen activator, tissue 0.0394507
PICALM phosphatidylinositol binding clathrin assembly protein 0.0391285
PALLD palladin, cytoskeletal associated protein 0.0381933
AHNAK AHNAK nucleoprotein 0.0377959
OSMR oncostatin M receptor 0.037534
RASAL2 RAS protein activator like 2 0.0371461
MCL1 myeloid cell leukemia 1 0.0370415
INTS6 integrator complex subunit 6 0.0369231
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0357045
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.03566
ALCAM activated leukocyte cell adhesion molecule 0.0349541
BLCAP bladder cancer associated protein 0.0349225
SETX senataxin 0.0347626
CUL4B cullin 4B 0.0336747
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0335054
CLIC4 chloride intracellular channel 4 0.0328475
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0326929
RIGI RNA sensor RIG-I 0.0322036
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0316867
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0313129
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0313067
ITPRID2 ITPR interacting domain containing 2 0.0312787
SLC45A4 solute carrier family 45, member 4 0.0309018
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0307206
DGKH diacylglycerol kinase, eta 0.0307032
DPYD dihydropyrimidine dehydrogenase 0.0296385
YBX3 Y box binding protein 3 0.0293977
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0293306
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.029203
MAML2 mastermind-like 2 (Drosophila) 0.0290082
SULF1 sulfatase 1 0.028907
MYOF myoferlin 0.0286119
NEK7 NIMA-related kinase 7 0.0284018
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0283991
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0281848
SLC38A2 solute carrier family 38, member 2 0.0275214
FOXP1 forkhead box P1 0.0274865
ANO6 anoctamin 6 0.0271952
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0271873
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0264242
VMP1 vacuole membrane protein 1 0.0263464
IFITM3 interferon induced transmembrane protein 3 0.0263166
EGR1 early growth response 1 0.0254789
ATXN1 ataxin 1 0.0254351
FN1 fibronectin 1 0.0253748
NCEH1 neutral cholesterol ester hydrolase 1 0.0253446
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0251995
MBD5 methyl-CpG binding domain protein 5 0.0251537
LAMC2 laminin, gamma 2 0.0248644
JMJD1C jumonji domain containing 1C 0.0248244
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0247323
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0246876
IFI16 interferon, gamma-inducible protein 16 0.0245904
EXT1 exostosin glycosyltransferase 1 0.0245824
LNPEP leucyl/cystinyl aminopeptidase 0.0244399
ATM ATM serine/threonine kinase 0.0243102
AOPEP aminopeptidase O (putative) 0.023809
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0235259
RIN2 Ras and Rab interactor 2 0.0231212
NCOA3 nuclear receptor coactivator 3 0.0230161
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0229914
AKAP9 A kinase (PRKA) anchor protein 9 0.0228418
EFNB2 ephrin-B2 0.0227832
PRELID2 PRELI domain containing 2 0.0227828
CEMIP cell migration inducing protein, hyaluronan binding 0.0224745
RABGAP1L RAB GTPase activating protein 1-like 0.0224721
BPTF bromodomain PHD finger transcription factor 0.0222452
SERINC3 serine incorporator 3 0.02221

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.105179
PTMA prothymosin, alpha -0.088343
HSPG2 heparan sulfate proteoglycan 2 -0.0645363
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0634843
TRIO trio Rho guanine nucleotide exchange factor -0.0620654
MEF2A myocyte enhancer factor 2A -0.0504879
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.048689
SQLE squalene epoxidase -0.0485745
NAV2 neuron navigator 2 -0.0440152
ANXA1 annexin A1 -0.0437823
KIAA1217 KIAA1217 -0.0436649
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0423505
PGK1 phosphoglycerate kinase 1 -0.0403115
MTSS1 metastasis suppressor 1 -0.0383038
GOLGA4 golgin A4 -0.037742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0375701
GNAS GNAS complex locus -0.0364985
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0357542
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0350163
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0347211
DLG1 discs, large homolog 1 (Drosophila) -0.0342806
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0323523
MARCHF6 membrane associated ring-CH-type finger 6 -0.0318818
OGA O-GlcNAcase -0.0304647
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0304117
KDM3A lysine (K)-specific demethylase 3A -0.0301966
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0296195
PLEC plectin -0.0292726
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0286956
NUP58 nucleoporin 58 -0.0285285
GRB10 growth factor receptor-bound protein 10 -0.0285081
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0284906
FSCN1 fascin actin-bundling protein 1 -0.0281716
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.027988
RLF rearranged L-myc fusion -0.0276381
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0274849
ITCH itchy E3 ubiquitin protein ligase -0.0274307
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0273832
HELZ helicase with zinc finger -0.0263219
GARS1 glycyl-tRNA synthetase 1 -0.0261405
CANX calnexin -0.0254811
BHLHE40 basic helix-loop-helix family, member e40 -0.0254353
FTH1 ferritin, heavy polypeptide 1 -0.0253583
STC1 stanniocalcin 1 -0.0253084
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0252636
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0249145
SPAG9 sperm associated antigen 9 -0.0246781
MATR3 matrin 3 -0.0246747
RPS8 ribosomal protein S8 -0.0246406
NAP1L1 nucleosome assembly protein 1-like 1 -0.024464
USP3 ubiquitin specific peptidase 3 -0.0241237
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0240302
SQSTM1 sequestosome 1 -0.0240132
ABI3BP ABI family, member 3 (NESH) binding protein -0.0237741
ARF1 ADP-ribosylation factor 1 -0.0236472
KRT6A keratin 6A, type II -0.0235957
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0234578
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.023452
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0230133
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0229677
DSTN destrin (actin depolymerizing factor) -0.0226594
TRA2A transformer 2 alpha homolog (Drosophila) -0.0225915
CLU clusterin -0.0225588
NOP58 NOP58 ribonucleoprotein -0.0225262
LAMA5 laminin, alpha 5 -0.0223748
CDC73 cell division cycle 73 -0.0221698
SUCO SUN domain containing ossification factor -0.0220272
ANKRD10 ankyrin repeat domain 10 -0.021943
ZMYM2 zinc finger, MYM-type 2 -0.0214176
SLMAP sarcolemma associated protein -0.0211308
RPS6 ribosomal protein S6 -0.0209961
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0209839
FLNA filamin A, alpha -0.0208498
PDIA3 protein disulfide isomerase family A, member 3 -0.0208217
ANKRD11 ankyrin repeat domain 11 -0.0207367
SRP54 signal recognition particle 54kDa -0.0206079
USP12 ubiquitin specific peptidase 12 -0.0205284
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0204342
SDCBP syndecan binding protein (syntenin) -0.0203394
KCMF1 potassium channel modulatory factor 1 -0.0202271
LMAN1 lectin, mannose-binding, 1 -0.0196744
KLF5 Kruppel-like factor 5 (intestinal) -0.0196453
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0194299
KDM5B lysine (K)-specific demethylase 5B -0.0193008
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0192992
LOC112694756 uncharaterized LOC112694756 -0.0190525
COG5 component of oligomeric golgi complex 5 -0.0189871
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0188047
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0184386
TKT transketolase -0.0182067
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0181706
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.017995
TMSB4X thymosin beta 4, X-linked -0.017978
HMGA1 high mobility group AT-hook 1 -0.0179185
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0175009
CSDE1 cold shock domain containing E1, RNA-binding -0.0174975
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0174901
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0174764
WSB1 WD repeat and SOCS box containing 1 -0.0174175
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.017411