Bicalutamide_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0965401
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0964913
ADAM10 ADAM metallopeptidase domain 10 0.0918283
ZNF608 zinc finger protein 608 0.0762464
TXNRD1 thioredoxin reductase 1 0.0622427
VCL vinculin 0.0605393
PKM pyruvate kinase, muscle 0.0571443
PRELID2 PRELI domain containing 2 0.0562746
DSCAM Down syndrome cell adhesion molecule 0.0548032
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0540992
TJP1 tight junction protein 1 0.0510427
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0485953
EZR ezrin 0.0438712
TMEM65 transmembrane protein 65 0.042388
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0387161
EIF4A2 eukaryotic translation initiation factor 4A2 0.0360714
MACROD2 MACRO domain containing 2 0.0343038
EEF1G eukaryotic translation elongation factor 1 gamma 0.0328357
TTC3 tetratricopeptide repeat domain 3 0.0328095
NCEH1 neutral cholesterol ester hydrolase 1 0.0327119
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0316973
RPL3 ribosomal protein L3 0.0313622
EIF4B eukaryotic translation initiation factor 4B 0.031329
ASPH aspartate beta-hydroxylase 0.0312404
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0301711
PRPF38B pre-mRNA processing factor 38B 0.0287287
FNIP1 folliculin interacting protein 1 0.028685
TBC1D5 TBC1 domain family, member 5 0.0286086
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0280697
AKAP9 A kinase (PRKA) anchor protein 9 0.0275141
SEC23A Sec23 homolog A (S. cerevisiae) 0.0268637
EFNA5 ephrin-A5 0.0258927
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0246704
FHIT fragile histidine triad 0.024613
GOLGB1 golgin B1 0.0245479
SMYD3 SET and MYND domain containing 3 0.0241784
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238453
ZBTB20 zinc finger and BTB domain containing 20 0.0238119
TXNIP thioredoxin interacting protein 0.0237769
SFTPA2 surfactant protein A2 0.0236854
MBD5 methyl-CpG binding domain protein 5 0.0236344
AHCYL2 adenosylhomocysteinase-like 2 0.0234686
PDGFC platelet derived growth factor C 0.0234198
TBC1D22A TBC1 domain family, member 22A 0.0233605
AHNAK AHNAK nucleoprotein 0.0229693
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0228702
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0225824
SOX6 SRY (sex determining region Y)-box 6 0.0221983
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0221247
APLP2 amyloid beta (A4) precursor-like protein 2 0.0217973
SLC38A2 solute carrier family 38, member 2 0.0213736
ANKMY2 ankyrin repeat and MYND domain containing 2 0.0212526
TMF1 TATA element modulatory factor 1 0.0210726
USP47 ubiquitin specific peptidase 47 0.0209804
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0209204
ZNF638 zinc finger protein 638 0.0208888
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0207868
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206326
SPRY2 sprouty homolog 2 (Drosophila) 0.0202109
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.020058
RAB27B RAB27B, member RAS oncogene family 0.0200196
ARRDC3 arrestin domain containing 3 0.0199717
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0195171
PYGB phosphorylase, glycogen; brain 0.0193383
YEATS2 YEATS domain containing 2 0.0192344
ARL15 ADP-ribosylation factor-like 15 0.0192312
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0188541
PLK2 polo-like kinase 2 0.0187155
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0187047
GOLGA4 golgin A4 0.0186062
ZNF217 zinc finger protein 217 0.0182987
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0182924
FLNB filamin B, beta 0.0180896
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0180749
CDK19 cyclin-dependent kinase 19 0.0179355
METTL15 methyltransferase like 15 0.0178086
FAM91A1 family with sequence similarity 91, member A1 0.0176477
ANKRD36 ankyrin repeat domain 36 0.0174674
ANKRD36B ankyrin repeat domain 36B 0.0172922
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0171133
PSAT1 phosphoserine aminotransferase 1 0.0168804
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0168199
SBF2 SET binding factor 2 0.0167247
ANXA3 annexin A3 0.0166929
XRN1 5'-3' exoribonuclease 1 0.016485
TAS2R14 taste receptor, type 2, member 14 0.0163034
UBC ubiquitin C 0.016189
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0159337
SNX14 sorting nexin 14 0.0158432
PDCD6IP programmed cell death 6 interacting protein 0.0158379
CRYBG3 beta-gamma crystallin domain containing 3 0.0158041
EEF2 eukaryotic translation elongation factor 2 0.0158014
PLPP3 phospholipid phosphatase 3 0.0157507
SOS1 son of sevenless homolog 1 (Drosophila) 0.0157168
TM9SF4 transmembrane 9 superfamily protein member 4 0.0153173
USP34 ubiquitin specific peptidase 34 0.0152955
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0151441
RB1CC1 RB1-inducible coiled-coil 1 0.0151176
PHF21A PHD finger protein 21A 0.0150705
BBS9 Bardet-Biedl syndrome 9 0.0148461

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.193831
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140547
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113583
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.103646
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0849929
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0844525
SSBP2 single-stranded DNA binding protein 2 -0.0778243
FOXP1 forkhead box P1 -0.0768045
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0639636
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.06335
BMP10 bone morphogenetic protein 10 -0.0632514
PDE4B phosphodiesterase 4B, cAMP-specific -0.0593838
RPL35A ribosomal protein L35a -0.0571606
DLG1 discs, large homolog 1 (Drosophila) -0.055546
NAP1L1 nucleosome assembly protein 1-like 1 -0.0522589
RPS8 ribosomal protein S8 -0.0487869
EPS8 epidermal growth factor receptor pathway substrate 8 -0.047314
ACTG1 actin gamma 1 -0.046188
ZFAND3 zinc finger, AN1-type domain 3 -0.0454425
NAMPT nicotinamide phosphoribosyltransferase -0.0424773
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0423014
TPT1 tumor protein, translationally-controlled 1 -0.040558
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0403052
KMT2E lysine (K)-specific methyltransferase 2E -0.0390247
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0387163
DIAPH3 diaphanous-related formin 3 -0.0387156
WSB1 WD repeat and SOCS box containing 1 -0.0373671
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0368677
NUP58 nucleoporin 58 -0.0353404
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0348533
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0345541
HSPB1 heat shock 27kDa protein 1 -0.0331186
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0325479
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0323176
RHEB Ras homolog enriched in brain -0.0318757
ECT2 epithelial cell transforming 2 -0.0314286
RPL34 ribosomal protein L34 -0.0313319
RPS24 ribosomal protein S24 -0.0313137
HMGB1 high mobility group box 1 -0.0304174
ELOVL5 ELOVL fatty acid elongase 5 -0.0303868
RPL13A ribosomal protein L13a -0.0298805
RPLP1 ribosomal protein, large, P1 -0.0292082
NEBL nebulette -0.0287708
RPS19 ribosomal protein S19 -0.0286488
RPL23 ribosomal protein L23 -0.028138
ZNF438 zinc finger protein 438 -0.0279126
B2M beta-2-microglobulin -0.0273282
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0272496
UNC13A unc-13 homolog A (C. elegans) -0.0271403
DPYD dihydropyrimidine dehydrogenase -0.027121
KIF5B kinesin family member 5B -0.0268341
RPL5 ribosomal protein L5 -0.0265287
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0264201
RPLP2 ribosomal protein, large, P2 -0.0260159
RBM39 RNA binding motif protein 39 -0.026001
GARS1 glycyl-tRNA synthetase 1 -0.0259091
MATR3 matrin 3 -0.0258483
RAB1A RAB1A, member RAS oncogene family -0.025833
RBM8A RNA binding motif protein 8A -0.0256837
GLI3 GLI family zinc finger 3 -0.0255265
MKI67 marker of proliferation Ki-67 -0.0252844
ANKRD17 ankyrin repeat domain 17 -0.0251284
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0249674
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0247929
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0247684
PTK2 protein tyrosine kinase 2 -0.0244907
PNISR PNN-interacting serine/arginine-rich protein -0.0244573
RPL31 ribosomal protein L31 -0.0244412
RPS21 ribosomal protein S21 -0.0243183
RLF rearranged L-myc fusion -0.0243181
PARD3 par-3 family cell polarity regulator -0.0243146
USP3 ubiquitin specific peptidase 3 -0.0239864
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0239586
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0238353
CUX1 cut-like homeobox 1 -0.0235549
RPS3 ribosomal protein S3 -0.0234565
DEK DEK proto-oncogene -0.0233997
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0233865
LMAN1 lectin, mannose-binding, 1 -0.0232628
PDE7B phosphodiesterase 7B -0.0230284
ANKRD11 ankyrin repeat domain 11 -0.0229604
RPL38 ribosomal protein L38 -0.0227771
RPL37A ribosomal protein L37a -0.022706
PRRC2C proline-rich coiled-coil 2C -0.0226991
SEPTIN7 septin 7 -0.0223978
RPL36 ribosomal protein L36 -0.0220018
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0219592
ENO1 enolase 1, (alpha) -0.0218419
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0217188
KPNB1 karyopherin (importin) beta 1 -0.0216285
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0215417
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0214642
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0214105
RPS25 ribosomal protein S25 -0.0212066
IPO7 importin 7 -0.0211775
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0210544
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.020784
PKP4 plakophilin 4 -0.0207828
ASXL1 additional sex combs like transcriptional regulator 1 -0.0207633
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0206795