Bicalutamide_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0980428
B2M beta-2-microglobulin 0.0869283
MYH9 myosin, heavy chain 9, non-muscle 0.0648936
LOXL2 lysyl oxidase-like 2 0.0627921
PRELID2 PRELI domain containing 2 0.0627583
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0558437
COL6A3 collagen, type VI, alpha 3 0.0544641
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0495261
COL5A1 collagen, type V, alpha 1 0.0469381
MT1X metallothionein 1X 0.0469017
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0461495
MACF1 microtubule-actin crosslinking factor 1 0.0459794
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0449322
TMSB10 thymosin beta 10 0.0447251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423775
AVL9 AVL9 homolog (S. cerevisiase) 0.0417316
TRIO trio Rho guanine nucleotide exchange factor 0.0384213
SNX9 sorting nexin 9 0.038338
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0358563
SFTPA2 surfactant protein A2 0.0357898
HLA-B major histocompatibility complex, class I, B 0.0339085
FMNL2 formin-like 2 0.0335086
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0330951
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0327765
TPM3 tropomyosin 3 0.0326994
COL5A2 collagen, type V, alpha 2 0.0318207
PLAUR plasminogen activator, urokinase receptor 0.0315862
COL4A1 collagen, type IV, alpha 1 0.0313956
HLA-A major histocompatibility complex, class I, A 0.0313157
AFF3 AF4/FMR2 family, member 3 0.0310409
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0309188
COL3A1 collagen, type III, alpha 1 0.0308803
SDC4 syndecan 4 0.0308698
CXCL3 chemokine (C-X-C motif) ligand 3 0.0307597
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0306193
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0303225
IL1RAP interleukin 1 receptor accessory protein 0.0301016
SCAF11 SR-related CTD-associated factor 11 0.0300924
ARRDC3 arrestin domain containing 3 0.0299574
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297736
XPO1 exportin 1 0.0294532
NBAS neuroblastoma amplified sequence 0.0293882
LAMB1 laminin, beta 1 0.0293817
ABLIM3 actin binding LIM protein family, member 3 0.0293416
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0291423
EIF1 eukaryotic translation initiation factor 1 0.0290792
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0290765
MSN moesin 0.0290048
NRXN3 neurexin 3 0.0289834
KLHL7 kelch-like family member 7 0.0289357
TNIP1 TNFAIP3 interacting protein 1 0.0288594
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0287657
NAMPT nicotinamide phosphoribosyltransferase 0.0287544
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.028649
ATP13A3 ATPase type 13A3 0.0283985
PHF21A PHD finger protein 21A 0.0282561
SUCO SUN domain containing ossification factor 0.027836
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0275685
EHBP1 EH domain binding protein 1 0.0274542
CD59 CD59 molecule, complement regulatory protein 0.0273486
HILPDA hypoxia inducible lipid droplet-associated 0.0271011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0266844
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.026578
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0265168
RPS3 ribosomal protein S3 0.0264994
IGFBP6 insulin-like growth factor binding protein 6 0.0263677
NBEA neurobeachin 0.0261801
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0261318
MTREX Mtr4 exosome RNA helicase 0.0258531
ANLN anillin, actin binding protein 0.0258308
ERBIN erbb2 interacting protein 0.0255493
FAM219A family with sequence similarity 219, member A 0.0253404
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0253386
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0252303
TPM2 tropomyosin 2 (beta) 0.0252186
RINT1 RAD50 interactor 1 0.0249109
ZBTB35 zinc finger and BTB domain containing 35 0.0246815
RNF145 ring finger protein 145 0.0245761
PALLD palladin, cytoskeletal associated protein 0.0245041
ZEB1 zinc finger E-box binding homeobox 1 0.0242993
SMYD3 SET and MYND domain containing 3 0.0242965
ITGAV integrin, alpha V 0.0242556
ALK anaplastic lymphoma receptor tyrosine kinase 0.024177
COL7A1 collagen, type VII, alpha 1 0.0240279
FBXO11 F-box protein 11 0.0239138
RAI1 retinoic acid induced 1 0.0238501
MYOF myoferlin 0.023835
AHNAK AHNAK nucleoprotein 0.0237644
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0237431
INHBA inhibin, beta A 0.0236085
NAV2 neuron navigator 2 0.0234885
IFRD1 interferon-related developmental regulator 1 0.023471
PERP PERP, TP53 apoptosis effector 0.0234571
GPC6 glypican 6 0.0232243
IGFBP7 insulin-like growth factor binding protein 7 0.0231334
OPTN optineurin 0.0230607
ZEB2 zinc finger E-box binding homeobox 2 0.0228062
MPHOSPH9 M-phase phosphoprotein 9 0.0226362
ARHGAP5 Rho GTPase activating protein 5 0.0225576
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0225535

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.312344
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134573
EXT1 exostosin glycosyltransferase 1 -0.12757
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0953731
FAM13A family with sequence similarity 13, member A -0.0935463
TGFBI transforming growth factor, beta-induced, 68kDa -0.0814053
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0799101
POTEF POTE ankyrin domain family, member F -0.0710427
ENO1 enolase 1, (alpha) -0.0696931
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0691169
CD44 CD44 molecule (Indian blood group) -0.0682426
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0656747
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0642329
VIM vimentin -0.0640146
F3 coagulation factor III (thromboplastin, tissue factor) -0.0625834
PSD3 pleckstrin and Sec7 domain containing 3 -0.0623239
LOX lysyl oxidase -0.0564435
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0564244
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.055538
ANKRD17 ankyrin repeat domain 17 -0.0545378
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0544657
TPT1 tumor protein, translationally-controlled 1 -0.0533987
MT2A metallothionein 2A -0.0528138
AFF4 AF4/FMR2 family, member 4 -0.051031
COG5 component of oligomeric golgi complex 5 -0.0504645
CAV1 caveolin 1, caveolae protein, 22kDa -0.0496256
HMGA2 high mobility group AT-hook 2 -0.0494866
TRA2A transformer 2 alpha homolog (Drosophila) -0.0483249
PKM pyruvate kinase, muscle -0.0472649
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0472353
TBC1D23 TBC1 domain family, member 23 -0.0467022
LDHA lactate dehydrogenase A -0.0466139
KMT2E lysine (K)-specific methyltransferase 2E -0.0463759
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0462778
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0460468
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0442748
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0433128
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0431654
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0421797
RLF rearranged L-myc fusion -0.0420459
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0417167
BBS9 Bardet-Biedl syndrome 9 -0.0416782
SEPTIN7 septin 7 -0.0416206
FTL ferritin, light polypeptide -0.0401917
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0396584
BRWD3 bromodomain and WD repeat domain containing 3 -0.0392048
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0389772
STC1 stanniocalcin 1 -0.038852
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0387783
MED13L mediator complex subunit 13-like -0.0387364
HIPK2 homeodomain interacting protein kinase 2 -0.0370678
MBNL1 muscleblind-like splicing regulator 1 -0.0365235
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0359732
IKBIP IKBKB interacting protein -0.0359696
LMAN1 lectin, mannose-binding, 1 -0.0358061
RPL26 ribosomal protein L26 -0.0357378
CD99 CD99 molecule -0.0357316
RAB31 RAB31, member RAS oncogene family -0.0354927
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0354252
RNF24 ring finger protein 24 -0.0352571
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0351218
TXNRD1 thioredoxin reductase 1 -0.0349423
THOC2 THO complex 2 -0.0343052
YIPF5 Yip1 domain family, member 5 -0.0340771
SEC24D SEC24 family member D -0.0332143
ARF4 ADP-ribosylation factor 4 -0.0330061
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0326572
NUP54 nucleoporin 54kDa -0.0322929
IL6 interleukin 6 -0.0322173
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0322008
CALU calumenin -0.0319952
TUBB tubulin, beta class I -0.0318306
POMP proteasome maturation protein -0.0314147
CANX calnexin -0.0309998
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0306114
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0305993
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0305542
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0305518
WNT5A wingless-type MMTV integration site family, member 5A -0.030404
BIRC6 baculoviral IAP repeat containing 6 -0.0303942
WDFY3 WD repeat and FYVE domain containing 3 -0.0301664
ACBD6 acyl-CoA binding domain containing 6 -0.0301522
ZMYND8 zinc finger, MYND-type containing 8 -0.0300342
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0299233
CADM1 cell adhesion molecule 1 -0.0299085
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0298399
CDK6 cyclin-dependent kinase 6 -0.0297133
ADNP activity-dependent neuroprotector homeobox -0.0296253
STC2 stanniocalcin 2 -0.0296102
EFNA5 ephrin-A5 -0.0294682
SCFD1 sec1 family domain containing 1 -0.0290721
FTH1 ferritin, heavy polypeptide 1 -0.0289628
SPDYA speedy/RINGO cell cycle regulator family member A -0.0289473
SAMD9 sterile alpha motif domain containing 9 -0.0286002
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.028339
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0283054
MTDH metadherin -0.0282604
RPL32 ribosomal protein L32 -0.0281967
TPM4 tropomyosin 4 -0.0281867
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0280571