Bicalutamide_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bicalutamide perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bicalutamide_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANKRD28 ankyrin repeat domain 28 0.0753535
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0719828
TPX2 TPX2, microtubule-associated 0.0696825
YAP1 Yes-associated protein 1 0.0688653
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0658577
BIRC3 baculoviral IAP repeat containing 3 0.0589427
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0589187
ZNF292 zinc finger protein 292 0.0582004
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0572601
RBM39 RNA binding motif protein 39 0.056897
MKI67 marker of proliferation Ki-67 0.0561627
CENPF centromere protein F, 350/400kDa 0.0543434
GOLGA4 golgin A4 0.0514373
DIAPH3 diaphanous-related formin 3 0.0510301
PUM2 pumilio RNA-binding family member 2 0.0508882
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0499632
CHD1 chromodomain helicase DNA binding protein 1 0.0491448
SMC4 structural maintenance of chromosomes 4 0.0479593
PDE4D phosphodiesterase 4D, cAMP-specific 0.0477583
SETD5 SET domain containing 5 0.046944
BASP1 brain abundant, membrane attached signal protein 1 0.0460551
ANLN anillin, actin binding protein 0.0457844
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0457411
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0445287
YBX3 Y box binding protein 3 0.043498
SMYD3 SET and MYND domain containing 3 0.0418158
VMP1 vacuole membrane protein 1 0.0417508
MRE11 MRE11 homolog, double strand break repair nuclease 0.0416497
XPO1 exportin 1 0.0411173
MIS18BP1 MIS18 binding protein 1 0.0404631
FNIP1 folliculin interacting protein 1 0.0404626
DSCAM Down syndrome cell adhesion molecule 0.0397058
CEP295 centrosomal protein 295kDa 0.0395576
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378358
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0370244
NAMPT nicotinamide phosphoribosyltransferase 0.0361319
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0360751
FAM3C family with sequence similarity 3, member C 0.0359209
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0357797
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0357444
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0355403
ELL2 elongation factor, RNA polymerase II, 2 0.0351746
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0342071
TXNIP thioredoxin interacting protein 0.0340129
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0332101
STK24 serine/threonine kinase 24 0.0331211
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0328078
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0326406
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0325936
PHF20 PHD finger protein 20 0.0324499
CKAP5 cytoskeleton associated protein 5 0.0319753
SEPTIN7 septin 7 0.0315543
RABGAP1 RAB GTPase activating protein 1 0.0314724
CENPE centromere protein E, 312kDa 0.0311169
BCLAF1 BCL2-associated transcription factor 1 0.0310403
NUP153 nucleoporin 153kDa 0.0310162
MCTP1 multiple C2 domains, transmembrane 1 0.0309684
GOLT1B golgi transport 1B 0.0307121
CKAP2 cytoskeleton associated protein 2 0.0306222
NIPBL Nipped-B homolog (Drosophila) 0.0305442
DERA deoxyribose-phosphate aldolase (putative) 0.030385
SNX14 sorting nexin 14 0.0303843
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0303061
TAOK3 TAO kinase 3 0.0302905
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0302285
NKTR natural killer cell triggering receptor 0.0301809
JMJD1C jumonji domain containing 1C 0.030025
SPAG9 sperm associated antigen 9 0.0298052
RSRC2 arginine/serine-rich coiled-coil 2 0.0297292
MYH9 myosin, heavy chain 9, non-muscle 0.0296782
TOP2B topoisomerase (DNA) II beta 180kDa 0.0296218
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0293112
SGO2 shugoshin 2 0.0291849
GOLGB1 golgin B1 0.0290116
TBC1D15 TBC1 domain family, member 15 0.0289511
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0287997
RB1CC1 RB1-inducible coiled-coil 1 0.0287067
LMO7 LIM domain 7 0.0285866
HMGB2 high mobility group box 2 0.0285045
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0284926
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0284279
AKAP12 A kinase (PRKA) anchor protein 12 0.0283183
ATP13A3 ATPase type 13A3 0.0281079
USP47 ubiquitin specific peptidase 47 0.0280865
NCAPD2 non-SMC condensin I complex, subunit D2 0.0280825
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0278626
PDS5A PDS5 cohesin associated factor A 0.0277293
PARP4 poly (ADP-ribose) polymerase family, member 4 0.027485
TXNRD1 thioredoxin reductase 1 0.0273773
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0272884
ERBIN erbb2 interacting protein 0.0272552
R3HDM1 R3H domain containing 1 0.0271474
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 0.0271298
ZFR zinc finger RNA binding protein 0.0269857
HDAC9 histone deacetylase 9 0.0266811
APLP2 amyloid beta (A4) precursor-like protein 2 0.0266178
USP15 ubiquitin specific peptidase 15 0.0265558
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.026473
DNER delta/notch-like EGF repeat containing 0.0264164
TENT2 terminal nucleotidyltransferase 2 0.0262351

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.133342
TMSB10 thymosin beta 10 -0.0909517
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0860145
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0825759
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0819369
HMGA2 high mobility group AT-hook 2 -0.0783196
LDHA lactate dehydrogenase A -0.0776845
PRKCA protein kinase C, alpha -0.0710103
FNDC3B fibronectin type III domain containing 3B -0.0676904
IGF2 insulin-like growth factor 2 -0.0654354
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0652406
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0637065
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0606705
LOC112694756 uncharaterized LOC112694756 -0.0570843
INTS6 integrator complex subunit 6 -0.0565106
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0561332
ANGPTL4 angiopoietin-like 4 -0.0542254
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0454579
PRR16 proline rich 16 -0.0443556
AHNAK AHNAK nucleoprotein -0.0443126
RAI14 retinoic acid induced 14 -0.0434238
PODXL podocalyxin-like -0.0401705
ANXA2 annexin A2 -0.0399365
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0396104
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0391841
ZBTB20 zinc finger and BTB domain containing 20 -0.0390975
COL5A1 collagen, type V, alpha 1 -0.0388475
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.038323
PRSS23 protease, serine, 23 -0.0382951
PCED1B PC-esterase domain containing 1B -0.038071
ACTG1 actin gamma 1 -0.0372631
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0365472
AEBP2 AE binding protein 2 -0.0364987
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0360859
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0353036
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0345412
FLNB filamin B, beta -0.0345353
TM4SF1 transmembrane 4 L six family member 1 -0.0344616
NPAS2 neuronal PAS domain protein 2 -0.033705
SH3KBP1 SH3-domain kinase binding protein 1 -0.0332344
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0328899
FLNA filamin A, alpha -0.0323544
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0312771
DENND1A DENN/MADD domain containing 1A -0.0311553
RNF213 ring finger protein 213 -0.0308911
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0308358
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0307249
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0301534
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0297348
SLC38A2 solute carrier family 38, member 2 -0.0293148
TRIO trio Rho guanine nucleotide exchange factor -0.0291085
IER3 immediate early response 3 -0.0287868
KDM4B lysine (K)-specific demethylase 4B -0.0287056
CAVIN1 caveolae associated protein 1 -0.028313
GPC5 glypican 5 -0.0274579
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0274121
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0273689
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0272735
KLF12 Kruppel-like factor 12 -0.027195
MACF1 microtubule-actin crosslinking factor 1 -0.0271926
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0271699
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0269533
PTK2 protein tyrosine kinase 2 -0.0269017
CCND1 cyclin D1 -0.0268507
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0266843
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0264343
PURA purine-rich element binding protein A -0.0252889
EXT1 exostosin glycosyltransferase 1 -0.0252827
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0252712
FNDC3A fibronectin type III domain containing 3A -0.0249142
UBB ubiquitin B -0.0248611
FMN1 formin 1 -0.0248281
PLEC plectin -0.0245912
ASPH aspartate beta-hydroxylase -0.024563
ABR active BCR-related -0.0242744
STXBP1 syntaxin binding protein 1 -0.0241708
THBS1 thrombospondin 1 -0.0240218
PGK1 phosphoglycerate kinase 1 -0.0238797
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0238553
POTEF POTE ankyrin domain family, member F -0.0233905
SLC35F3 solute carrier family 35, member F3 -0.0232896
SKI SKI proto-oncogene -0.0232112
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0231451
NAV3 neuron navigator 3 -0.0231091
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.022942
LPP LIM domain containing preferred translocation partner in lipoma -0.0228299
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0227165
S100A10 S100 calcium binding protein A10 -0.0225825
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0225739
KLF3 Kruppel-like factor 3 (basic) -0.0225162
TRIM56 tripartite motif containing 56 -0.0223918
ZFP36L1 ZFP36 ring finger protein-like 1 -0.02223
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0222095
CMIP c-Maf inducing protein -0.0221758
AHNAK2 AHNAK nucleoprotein 2 -0.0219607
LMNA lamin A/C -0.0218303
CANX calnexin -0.021726
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0216467
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0212891
TRAF3 TNF receptor-associated factor 3 -0.0212642