Bicifadine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/47953
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Genes

200 proteins with high or low expression in Bicifadine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MYH7 myosin, heavy chain 7, cardiac muscle, beta 8.24
DNAH12 dynein, axonemal, heavy chain 12 1.18
ALPK3 alpha-kinase 3 0.93
HIST2H2AA3 histone cluster 2, H2aa3 0.88
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.75
RIPK4 receptor-interacting serine-threonine kinase 4 0.72
C12ORF66 chromosome 12 open reading frame 66 0.65
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.63
PIP prolactin-induced protein 0.56
TTLL4 tubulin tyrosine ligase-like family member 4 0.55
DEPDC1B DEP domain containing 1B 0.55
ACTN2 actinin, alpha 2 0.53
WNT10B wingless-type MMTV integration site family, member 10B 0.52
YAF2 YY1 associated factor 2 0.49
BRD7 bromodomain containing 7 0.47
CEP63 centrosomal protein 63kDa 0.46
RGN regucalcin 0.45
COA5 cytochrome c oxidase assembly factor 5 0.45
SYN2 synapsin II 0.44
SYNGAP1 synaptic Ras GTPase activating protein 1 0.42
IFT22 intraflagellar transport 22 0.42
TSC22D2 TSC22 domain family, member 2 0.42
PARPBP PARP1 binding protein 0.4
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.4
ZNF160 zinc finger protein 160 0.4
FAM20C family with sequence similarity 20, member C 0.39
ODC1 ornithine decarboxylase 1 0.38
SLC41A3 solute carrier family 41, member 3 0.37
PRDM4 PR domain containing 4 0.35
FUS FUS RNA binding protein 0.35
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.34
COQ4 coenzyme Q4 0.34
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.34
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.33
CDC20 cell division cycle 20 0.33
TAZ tafazzin 0.33
PABPC1 poly(A) binding protein, cytoplasmic 1 0.33
ARMCX5 armadillo repeat containing, X-linked 5 0.33
KIAA1107 KIAA1107 0.32
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 0.32
CNTLN centlein, centrosomal protein 0.31
SET SET nuclear proto-oncogene 0.31
BMP4 bone morphogenetic protein 4 0.31
FAM241B family with sequence similarity 241 member B 0.31
TRIM44 tripartite motif containing 44 0.3
C8ORF76 chromosome 8 open reading frame 76 0.3
M1AP meiosis 1 associated protein 0.3
ZNF407 zinc finger protein 407 0.3
FBRSL1 fibrosin-like 1 0.3
MRFAP1 Morf4 family associated protein 1 0.3
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 0.3
DEDD death effector domain containing 0.29
AMD1 adenosylmethionine decarboxylase 1 0.29
SCARA3 scavenger receptor class A, member 3 0.29
SH2D5 SH2 domain containing 5 0.29
FZD1 frizzled class receptor 1 0.29
MAGEF1 melanoma antigen family F1 0.29
ATXN7L1 ataxin 7-like 1 0.28
IVNS1ABP influenza virus NS1A binding protein 0.28
KIAA0586 KIAA0586 0.28
LPIN2 lipin 2 0.28
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.28
GMCL2 germ cell-less 2, spermatogenesis associated 0.28
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 0.27
GMDS GDP-mannose 4,6-dehydratase 0.27
FZD3 frizzled class receptor 3 0.27
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.27
ENO1 enolase 1, (alpha) 0.27
TTC17 tetratricopeptide repeat domain 17 0.27
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.27
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.27
RNF6 ring finger protein (C3H2C3 type) 6 0.27
MYLK myosin light chain kinase 0.27
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.27
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.27
JUN jun proto-oncogene 0.27
SLC25A39 solute carrier family 25, member 39 0.26
HGH1 HGH1 homolog (S. cerevisiae) 0.26
CST6 cystatin E/M 0.26
ENDOV endonuclease V 0.26
GTF3A general transcription factor IIIA 0.26
FAM89A family with sequence similarity 89, member A 0.26
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.26
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.26
GEMIN6 gem (nuclear organelle) associated protein 6 0.26
CDC42SE2 CDC42 small effector 2 0.26
KDM3A lysine (K)-specific demethylase 3A 0.26
AZI2 5-azacytidine induced 2 0.26
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.26
METTL22 methyltransferase like 22 0.26
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.25
KIF20A kinesin family member 20A 0.25
SPRTN SprT-like N-terminal domain 0.25
CERK ceramide kinase 0.25
HAL histidine ammonia-lyase 0.25
ANKRD10 ankyrin repeat domain 10 0.25
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.25
JPH1 junctophilin 1 0.25
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.25
TEDC2 tubulin epsilon and delta complex 2 0.25

low expression

Symbol Name Standardized Value
DEDD2 death effector domain containing 2 -0.91
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -0.58
RAB40C RAB40C, member RAS oncogene family -0.58
FGB fibrinogen beta chain -0.58
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.49
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.49
STK16 serine/threonine kinase 16 -0.47
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -0.45
HYKK hydroxylysine kinase -0.43
FKBP14 FK506 binding protein 14, 22 kDa -0.43
C6ORF47 chromosome 6 open reading frame 47 -0.42
ADCK1 aarF domain containing kinase 1 -0.42
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -0.41
ZNF594 zinc finger protein 594 -0.39
TPPP tubulin polymerization promoting protein -0.38
HBA1 hemoglobin, alpha 1 -0.37
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.37
H1-0 H1.0 linker histone -0.37
ATP9B ATPase, class II, type 9B -0.35
BAIAP2 BAI1-associated protein 2 -0.35
PPP1R2B PPP1R2 family member B -0.35
GDF15 growth differentiation factor 15 -0.35
MACC1 metastasis associated in colon cancer 1 -0.35
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -0.35
BORCS7 BLOC-1 related complex subunit 7 -0.34
NECAB3 N-terminal EF-hand calcium binding protein 3 -0.34
APOE apolipoprotein E -0.34
ACTN3 actinin, alpha 3 (gene/pseudogene) -0.33
C18ORF32 chromosome 18 open reading frame 32 -0.33
CHPF2 chondroitin polymerizing factor 2 -0.32
PTBP1 polypyrimidine tract binding protein 1 -0.32
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.32
IL6ST interleukin 6 signal transducer -0.32
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -0.31
MCRIP1 MAPK regulated corepressor interacting protein 1 -0.31
FN1 fibronectin 1 -0.31
IRF9 interferon regulatory factor 9 -0.31
ABHD3 abhydrolase domain containing 3 -0.31
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.31
FAM219A family with sequence similarity 219, member A -0.31
TMEM135 transmembrane protein 135 -0.31
NEB nebulin -0.3
CARD8 caspase recruitment domain family, member 8 -0.3
TTC9C tetratricopeptide repeat domain 9C -0.3
MISO1 mitochondrial inner membrane subdomain organizer 1 -0.3
ACTA1 actin, alpha 1, skeletal muscle -0.29
VAMP3 vesicle-associated membrane protein 3 -0.29
SNAP91 synaptosomal-associated protein, 91kDa -0.29
DMD dystrophin -0.29
NLRP1 NLR family, pyrin domain containing 1 -0.29
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.28
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.28
ACE angiotensin I converting enzyme -0.28
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.27
CYBA cytochrome b-245, alpha polypeptide -0.27
ABHD2 abhydrolase domain containing 2 -0.27
NEBL nebulette -0.27
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -0.27
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.27
MYADM myeloid-associated differentiation marker -0.26
CCDC158 coiled-coil domain containing 158 -0.26
USP48 ubiquitin specific peptidase 48 -0.26
UBAC2 UBA domain containing 2 -0.26
TSPAN15 tetraspanin 15 -0.26
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.26
ADARB1 adenosine deaminase, RNA-specific, B1 -0.25
COL6A3 collagen, type VI, alpha 3 -0.25
IGSF8 immunoglobulin superfamily, member 8 -0.25
NCKAP5L NCK-associated protein 5-like -0.25
TMPPE transmembrane protein with metallophosphoesterase domain -0.25
SLC38A9 solute carrier family 38, member 9 -0.25
TSPAN4 tetraspanin 4 -0.25
ZBTB12 zinc finger and BTB domain containing 12 -0.25
ZNF672 zinc finger protein 672 -0.25
AAMDC adipogenesis associated, Mth938 domain containing -0.25
PYGM phosphorylase, glycogen, muscle -0.25
TIMP3 TIMP metallopeptidase inhibitor 3 -0.25
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -0.25
CORO2B coronin, actin binding protein, 2B -0.24
TPM1 tropomyosin 1 (alpha) -0.24
SLC22A18 solute carrier family 22, member 18 -0.24
H1-2 H1.2 linker histone, cluster member -0.24
LENG9 leukocyte receptor cluster (LRC) member 9 -0.24
CAPZB capping protein (actin filament) muscle Z-line, beta -0.24
TMEM41B transmembrane protein 41B -0.24
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.24
VCPKMT valosin containing protein lysine (K) methyltransferase -0.24
CCN2 cellular communication network factor 2 -0.24
ELF4 E74-like factor 4 (ets domain transcription factor) -0.24
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.23
CPN1 carboxypeptidase N, polypeptide 1 -0.23
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.23
MT-CO2 cytochrome c oxidase subunit II -0.23
PTGES prostaglandin E synthase -0.23
C1QTNF3 C1q and tumor necrosis factor related protein 3 -0.23
RBM20 RNA binding motif protein 20 -0.23
NEO1 neogenin 1 -0.23
DOLK dolichol kinase -0.23
DNLZ DNL-type zinc finger -0.23
F5 coagulation factor V (proaccelerin, labile factor) -0.23